nNOS mediated mitochondrial injury in LPS stimulated oligodendrocytes
Keywords: Oligodendrocyte; LPS; nNOS; iNOS; Demyelination; Mitochondria;
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Rat brain pro-oxidant effects of peripherally administered 5Â nm ceria 30 days after exposure
Keywords: 3NT; protein bound 3-nitrotyrosine; Ce; cerium; Cat; catalase; EELS; electron energy loss spectroscopy; ENM; engineered nanomaterial; GR; glutathione reductase; GPx; glutathione peroxidase; H2O2; hydrogen peroxide; Hsp70; heat shock protein 70; HNE; prote
Inhibitory effects of aurentiacin from Syzygium samarangense on lipopolysaccharide-induced inflammatory response in mouse macrophages
Keywords: LPS; lipopolysaccharide; NO; nitric oxide; iNOS; inducible nitric oxide synthase; TNF-α; tumor necrosis factor-α; IL-6; interleukin-6; EMSA; electrophoretic mobility shift assay; NF-κB; nuclear factor-κB; ChIP; chromatin immunoprecipitation; IKK; I-κ
Anti-inflammatory activity of Korean thistle Cirsium maackii and its major flavonoid, luteolin 5-O-glucoside
Keywords: AMT; 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine hydrochloride; COX-2; cyclooxygenase-2; DCF; 2â²,7â²-dichlorofluorescein; DCFH; 2â²,7â²-dichlorodihydrofluorescein; DCFH-DA; 2â²,7â²-dichlorodihydrofluorescein diacetate; DHR 123; dihydrorhodamine 12
Ferric citrate CYP2E1-independently promotes alcohol-induced apoptosis in HepG2 cells via oxidative/nitrative stress which is attenuated by pretreatment with baicalin
Keywords: iNOS; inducible nitric oxide synthase; RNS; reactive nitrogen species; ROS; reactive oxygen species; ALD; alcohol liver disease; CYP2E1; Cytochrome P450 2E1; 4-HNE; 4-hydroxy-2-nonenal; Ba; baicalin; Et; ethanol; Fc; ferric citrate; NO; nitric oxide; MTT;
Cell-type dependent response of melanoma cells to aloe emodin
Keywords: AE; aloe emodin; ROS; reactive oxygen species; CFSE; carboxyfluorescein diacetate succinimidyl ester; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; iNOS; inducible nitric oxide synthase; DOXO; doxorubicin; Pct; paclitaxel; F.I.C.; fra
Rutin inhibits β-amyloid aggregation and cytotoxicity, attenuates oxidative stress, and decreases the production of nitric oxide and proinflammatory cytokines
Keywords: AD; Alzheimer's disease; Aβ; β-amyloid peptide; ThT; thioflavin T; TEM; transmission electron microscope; DCFH-DA; 2â²,7â²-dichlorfluorescein-diacetate; MTT; 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide; ROS; reactive oxygen species; G
Emerging role of microglial kinin B1 receptor in diabetic pain neuropathy
Keywords: AGE; Advanced glycation end product; AMPA-R; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; ATP; Adenosine-5â²-triphosphate; B1R; Kinin B1 receptor; B2R; Kinin B2 receptor; BDNF; Brain derived neurotrophic factor; BK; Bradykinin; CCL2; C
Impaired recruitment of neuroprotective microglia and T cells during acute neuronal injury coincides with increased neuronal vulnerability in an amyotrophic lateral sclerosis model
Keywords: ALS; amyotrophic lateral sclerosis; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GDNF; glial cell line-derived neurotrophic factor; Iba1; ionized calcium-binding adaptor molecule 1; IGF-1; insulin-like growth factor 1; iNOS; inducible nitric oxide syn
Myelophil ameliorates brain oxidative stress in mice subjected to restraint stress
Keywords: ANOVA; analysis of variance; COMT; catechol-O-methyl transferase; CNS; central nervous system; CFS; chronic fatigue syndromes; GEAC; gallic acid equivalent antioxidant capacity; GSH; total glutathione; GSH-Px; glutathione peroxidase; GSH-Rd; glutathione r
Mycobacterium indicus pranii downregulates MMP-9 and iNOS through COX-2 dependent and TNF-α independent pathway in mouse peritoneal macrophages in vitro
Keywords: Mycobacterium indicus pranii; Macrophages; MMP-9; COX-2; iNOS;
Rational design, synthesis, and pharmacological properties of pyranochalcone derivatives as potent anti-inflammatory agents
Keywords: Anti-inflammation; NO production; iNOS; Paw edema; Pyranochalcones; Adjuvant-induced arthritis;
Altered functions of natural killer cells in response to L-Arginine availability
Keywords: CAT; cationic amino acid transporter; CD25; α-chain IL-2 receptor; EGFP; enhanced green fluorescent protein; eNOS; endothelial nitric-oxide synthase; iNOS; inducible nitric-oxide synthase; KIR; killer Ig-like receptors; L-Arg; L-Arginine; MFI; mean fluor
Intramolecular hydrogen bonding: A potential strategy for more bioavailable inhibitors of neuronal nitric oxide synthase
Keywords: CNS; central nervous system; NO; nitric oxide; nNOS; neuronal nitric oxide synthase; eNOS; endothelial nitric oxide synthase; iNOS; inducible nitric oxide synthase; BBB; blood-brain barrier; H-bond; hydrogen bond; l-NNA; l-N-nitroarginine; H4B; tetrahyd
Cardiovascular effects and molecular targets of resveratrol
Keywords: 4-HNE; 4-hydroxy-2-nonenal; ADMA; asymmetric dimethylarginine; AMPK; AMP-activated protein kinase; ApoE; apolipoprotein E; ARE; antioxidant response element; BH4; tetrahydrobiopterin; Cav-1; caveolin-1; COX-1; cyclooxygenase 1; CREB; cAMP response element
Differentiation and gene expression profile of tumor-associated macrophages
Keywords: TAM; tumor-associated macrophage; M1; classically activated macrophages; M2; alternatively activated macrophages; iNOS; inducible nitric oxide synthetase; RUNX1; runt-related transcription factor 1; NF-κB; nuclear factor kappaB; IRF8; interferon regulato
Agmatine selectively improves behavioural function in aged male Sprague-Dawley rats
Keywords: Aβ; amyloid beta; ADC; arginine decarboxylase; ANOVA; analysis of variance; DG; dentate gyrus; EC; entorhinal cortex; eNOS; endothelial nitric oxide synthase; IL; interleukin; iNOS; inducible nitric oxide synthase; i.p; intraperitoneal; nNOS; neuronal ni
Research ReportGenistein inhibits aggregation of exogenous amyloid-beta1-40 and alleviates astrogliosis in the hippocampus of rats
Keywords: AD; Alzheimer's disease; iNOS; inducible nitric oxide synthase; nNOS; neuronal nitric oxide synthase; CA1; cornu ammonis 1; CA2; cornu ammonis 2; CA3; cornu ammonis 3; Aβ; amyloid beta; DGlb; lateral blade of dentate gyrus; DGmb; medial blade of dentate
Gene delivery of antioxidant enzymes inhibits human immunodeficiency virus type 1 gp120-induced expression of caspases
Keywords: AD; Alzheimer's disease; AIDS; Acquired Immune Deficiency Syndrome; ALS; amyotrophic lateral sclerosis; APAF-1; apoptotic protease activating factor 1; BUGT; human bilirubin-uridine 5â²-diphosphate-glucuronosyl-transferase; CNS; central nervous system;
Chronic intermittent hypoxia induces atherosclerosis by NF-κB-dependent mechanisms
Keywords: ABCA1; ATP-binding cassette transporter A1; ApoE-KO; mice lacking apoliporotein E gene; CCL2; chemokine ligand 2; CIH; chronic intermittent hypoxia; EMSA; electrophoretic mobility shift assay; FcO2; fractional oxygen concentration; HCD; high cholesterol d
Role of inducible nitric oxide synthase in mitochondrial depolarization and graft injury after transplantation of fatty livers
Keywords: ALT; alanine aminotransferase; eNOS; endothelial nitric oxide synthase; FG; fatty liver grafts; hpf; high power field; iNOS; inducible nitric oxide synthase; I/R; ischemia/reperfusion; JNK; c-Jun N-terminal kinase; LG; lean liver grafts; MPT; mitochondria
Pulsed acoustic cellular expression as a protective therapy against I/R injury in a cremaster muscle flap model
Keywords: ESW; Extracorporeal shock waves; ESWT; Extracorporeal shock wave technology; I/R; Ischemia/reperfusion; PACE; Pulsed acoustic cellular expression; RBC; Red blood cells; VEGF; Vascular Endothelial Growth Factor; vWF; von Willebrand factor; iNOS; inducible
Comparison of cytotoxic and inflammatory responses of pristine and functionalized multi-walled carbon nanotubes in RAW 264.7 mouse macrophages
Keywords: CNTs; carbon nanotubes; SWCNTs; single-walled carbon nanotubes; MWCNTs; multi-walled carbon nanotubes; COOH; carboxylate; PEG; polyethylene glycol; LDH; lactate dehydrogenase; FITR; fourier transform infrared spectroscopy; XPS; X-ray photoelectron spectro
Regulation of alternative macrophage activation in the liver following acetaminophen intoxication by stem cell-derived tyrosine kinase
Keywords: STK; stem cell-derived tyrosine kinase; IL; interleukin; MCP-1; monocyte chemoattractant protein-1; NAPQI; N-acetyl-p-benzoquinone-imine; Cyp; cytochrome P450; TNFα; tumor necrosis factor-α; TNFR; tumor necrosis factor receptor; HO-1; heme oxygenase-1;
Suppressive effects of coumarins from Mammea siamensis on inducible nitric oxide synthase expression in RAW264.7 cells
Keywords: Mammea siamensis; Mammeasin; Coumarin; NO production inhibitor; iNOS
In vitro and in vivo anti-inflammatory activities of Polygonum hydropiper methanol extract
Keywords: Ph-ME; methanol extract of Polygonum hydropiper L.; PGE2; prostaglandin E2; NO; nitric oxide; COX; cyclooxygenase; iNOS; inducible NO synthase; (TNF)-α; tumour necrosis factor; ERK; extracellular signal-related kinase; TLR; Toll-like receptors (TLR); MAP
Analysis of the immune response in infections of the goldfish (Carassius auratus L.) with Mycobacterium marinum
Keywords: Mycobacteria; Fish; Macrophage; Respiratory burst; Nitric oxide; NADPH; iNOS; Cytokines; Cytokine receptors
Anti-inflammatory effects of phlorofucofuroeckol B-rich ethyl acetate fraction obtained from Myagropsis myagroides on lipopolysaccharide-stimulated RAW 264.7 cells and mouse edema
Keywords: Anti-inflammation; COX-2; Ear edema; iNOS; Myagropsis myagroides; NF-κB;
α7 Nicotinic acetylcholine receptor agonist attenuates neuropathological changes associated with intracerebral hemorrhage in mice
Keywords: ICH; intracerebral hemorrhage; iNOS; inducible isoform of nitric oxide synthase; MRI; magnetic resonance imaging; nAChR; nicotinic acetylcholine receptor; SDS; sodium dodecyl sulfate; TUNEL; terminal deoxynucleotidyl transferase-mediated dUTP nick-end lab
Cannabinoids ameliorate disease progression in a model of multiple sclerosis in mice, acting preferentially through CB1 receptor-mediated anti-inflammatory effects
Keywords: Cannabinoids; CB1 receptors; Multiple sclerosis; EAE mice; Inflammation; COX-2; iNOS; TNF-α; Cell infiltrationCFA, complete Freund's adjuvant; CNS, Central Nervous System; COX-2, cyclooxygenase-2; CREAE, chronic relapsing experimental autoimmune encephalo
Nitrative DNA damage induced by multi-walled carbon nanotube via endocytosis in human lung epithelial cells
Keywords: CNT; carbon nanotube; ROS; reactive oxygen species; RNS; reactive nitrogen species; NO; nitric oxide; O2â; superoxide; ONOOâ; peroxynitrite; MWCNT; multi-walled CNT; DMEM; Dulbecco's modified Eagle's medium; FBS; fetal bovine serum; MTT; 3-(4,5-dimeth
Retinoid metabolism and its effects on the vasculature
Keywords: ADH; alcohol dehydrogenase; ADMA; asymmetric dimethylarginine; AP-1; activated protein-1; apo14; β-apo-14â²-carotenal; ARVM; adult rat ventricular myocytes; ATBC; Alpha-tocopherol Beta-carotene Cancer Prevention Study; atRA; all-trans retinoic acid; BCO
A self-propelling cycle mediated by reactive oxide species and nitric oxide exists in LPS-activated microglia
Keywords: CAT; catalase; CNS; central nervous system; DCFH-DA; 2â²7â²-dichlorodihydrofluororescein diacetate; DMSO; dimethylsulfoxide; DPI; diphenyleneiodonium sulfate; FBS; fetal bovine serum; HBSS; Hank's balanced salt solution; IFN-γ; interferon-γ; IL-1β;
Synthesis, biological evaluation and molecular docking studies of 3-(triazolyl)-coumarin derivatives: Effect on inducible nitric oxide synthase
Keywords: Coumarin; Anti-inflammatory; Neutrophils; Molecular docking; 3-(Triazolyl)-coumarins; Click chemistry; iNOS
Nitric oxide - A versatile key player in cochlear function and hearing disorders
Keywords: ABR; auditory brainstem response; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ATP; adenosine triphosphate; DAF; 4,5-diaminofluorescein diacetate; dB; decibel; eNOS; endothelial nitric oxide synthase; EP; endocochlear potential; FAD; flavi
Extracellular cysteine (Cys)/cystine (CySS) redox regulates metabotropic glutamate receptor 5 activity
Keywords: Extracellular cysteine (Cys)/cystine (CySS); Metabotropic glutamate receptor 5; Parkinson's disease; AMS; 4-Acetamide-4â²-maleimidylstilbene-2,2â²-disulfonic acid, disodium salt; BCA; Bradford Protein Assay; CRD; cysteine-rich domain; Cys; cysteine; C
Optimizing thiadiazole analogues of resveratrol versus three chemopreventive targets
Keywords: ARE; antioxidant response element; BBO; multinuclear broadband observe; CD; concentration to double QR1 activity; DMEM; Dulbecco's Modified Eagle Medium; DRE; dioxin response element; IC50; sample concentration which causes 50% inhibition; DPPH; 2,2-dip
Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms
Keywords: AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; CTLA-4; cytotoxic T-lymphocyte antigen 4; FACS; fluorescence-activated cell sorting; Foxp3; forkhead-box transcription factor; GFP; green fluorescent protein; IL-4; interleukin 4; IL-10; interle
pknE, a serine/threonine kinase of Mycobacterium tuberculosis modulates multiple apoptotic paradigms
Keywords: pknE; Apoptosis; Arginase; iNOS; Gene expression;
The intestinal microbiota are necessary for stressor-induced enhancement of splenic macrophage microbicidal activity
Keywords: Microbiota; Stress; Social disruption; Macrophage; Microbicidal activity; Peroxynitrite; IL-1β; TNF-α; iNOS; Superoxide; Peptidoglycan;
Differential immune response of rainbow trout (Oncorhynchus mykiss) at early developmental stages (larvae and fry) against the bacterial pathogen Yersinia ruckeri
Keywords: Early life stages; Larvae; Innate immunity; IgT; CD8; Cytokines; Acute phase proteins; IL-22; iNOS
Mechanisms mediating effects of nitric oxide on perifornical lateral hypothalamic neurons
Keywords: aCSF; artificial cerebrospinal fluid; BF; basal forebrain; BIC; bicuculline, a GABAA receptor antagonist; cGMP; cyclic guanosine monophosphate; CPT; 8-cyclopentyl-1,3-dimethylxanthine (an adenosine A1 receptor antagonist); EEG; electroencephalogram; GABA;
Molecular mechanism of the anti-inflammatory activity of a natural diarylnonanoid, malabaricone C
Keywords: AP-1; activator protein-1; COX-2; cyclooxygenase-2; IKK; IκB kinase; IRAK-4; IL-1 receptor-associated kinase-4; iNOS; inducible nitric oxide synthase; IL; interleukin; LPS; lipopolysaccharide; mal C; malabaricone C; MAP; mitogen-activated protein; MAPK;
The genus Commiphora: A review of its traditional uses, phytochemistry and pharmacology
Keywords: ABTS; 2,2â²-azino-di-[3-ethylbenzthiazoline sulphonate]; ALP; alkaline phosphatase; ALT; alanine aminotransferase; AST; aspartate aminotransferase; COX; cyclooxygenase; CNS; central nervous system; DPPH; 2,2-diphenyl-1-picrylhydrazyl; FXR; farnesoid X re
Which Neuroprotective Agents are Ready for Bench to Bedside Translation in the Newborn Infant?
Keywords: 7-NI; 7-nitroindazole; AA; Ascorbic acid; BH4; Tetrahydrobiopterin; DHA; Dehydroascorbic acid; eNOS; Endothelial nitric oxide synthase; Epo; Erythropoietin; FDA; US Food and Drug Administration; NAC; N-acetylcysteine; iNOS; Inducible nitric oxide synthase
Ginsenoside Rg1 protection against β-amyloid peptide-induced neuronal apoptosis via estrogen receptor α and glucocorticoid receptor-dependent anti-protein nitration pathway
Keywords: β-Amyloid; Receptor nuclear translocation; Ginsenoside Rg1; Protein tyrosine nitration; ERK1/2 phosphorylation; Ach; acetylcholine; AD; Alzheimer's disease; AO; acridine orange; Aβ25-35; β-amyloid peptide25-35; carboxy-DCFDA; 5-(and-6)-carboxy-2â
Characterization of dual agonists for kinin B1 and B2 receptors and their biased activation of B2 receptors
Keywords: CP; carboxypeptidase; kB1R; kinin B1 receptor; kB2R; bradykinin B2 receptor; [Ca2Â +]i; intracellular calcium concentration; PBS; phosphate buffered saline; DMEM; Dulbecco's Modified Eagle's Medium; GPCR; G protein-coupled receptor; BK; bradykinin; KD; ka
Neuroprotective and memory enhancing properties of a dual agonist of the FGF receptor and NCAM
Keywords: BBB; blood brain barrier; CGN; cerebellar granule neurons; EAE; experimental autoimmune encephalomyelitis; FGFR; fibroblast growth factor receptor; HRP; horseradish peroxidase; Ig; immunoglobulin; iNOS; inducible nitric oxide synthase; LPS; lipopolysaccha
Attenuation of acute nitrogen mustard-induced lung injury, inflammation and fibrogenesis by a nitric oxide synthase inhibitor
Keywords: Vesicants; Oxidative stress; iNOS; Nitric oxide; Pulmonary toxicity; Macrophages;
The use of anti-COX2 siRNA coated onto PLGA nanoparticles loading dexamethasone in the treatment of rheumatoid arthritis
Keywords: siRNA; Dexamethasone; COX-2; iNOS; PLGA nanoparticles