IFNγ mediates DUOX2 expression via a STAT-independent signaling pathway
Keywords: چگونه; Dual oxidase; DUOX; Gamma interferon; JAK; STAT; Signaling
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Molecular networks in respiratory epithelium carcinomas
Keywords: چگونه; Respiratory epithelium carcinomas; EGFR; Ras; Raf; MAPK; PI3K; Akt; JAK; STAT; PLC; PKC
Inflammatory cytokines regulate microRNA-155 expression in human retinal pigment epithelial cells by activating JAK/STAT pathway
Keywords: چگونه; RPE; retinal pigment epithelium; HRPE; human retinal pigment epithelial; JAK; Janus family kinases; STAT; signal transducers and activators of transcription; JNK; c-Jun N-terminal kinase; NF-κB; nuclear factor kappa-light-chain-enhancer of activated B ce
Cancer-Associated Myeloproliferation: Old Association, New Therapeutic Target
Keywords: چگونه; ARG; arginase; ATRA; all-trans-retinoic acid; CSF; colony-stimulating factor; EG; endocrine gland; G-CSF; granulocyte-CSF; IL; interleukin; iNOS; inducible nitric oxide synthase; JAK; Janus kinase; MDSC; myeloid-derived suppressor cell; PKR; prokineticin;
A receptor-independent, cell-based JAK activation assay for screening for JAK3-specific inhibitors
Keywords: چگونه; JAK; Janus kinase; STAT; Signal transducer and activator of transcription; IL; Interleukin; γc chain; Common γ chain; TEL; Translocated Ets Leukemia/ETV6; GM-CSF; Granulocyte macrophage colony-stimulating factor; MEK; Mitogen-activated protein kinase/ex
Expression of CD45 isoforms correlates with differential proliferative responses of peripheral CD4+ and CD8+ T cells
Keywords: چگونه; T cells; Protein tyrosine phosphatase; CD45; Cell proliferation; Jak; STAT; IL-2
Mathematical modelling of interferon-γ signalling in pancreatic stellate cells reflects and predicts the dynamics of STAT1 pathway activity
Keywords: چگونه; STAT; signal transducer and activator of transcription; IFN; interferon; PSC; pancreatic stellate cell; SOCS; suppressor of cytokine signalling; ECM; extracellular matrix; JAK; Janus kinase; IRF; interferon regulatory factor; IMDM; Iscove's modified Dulbe
Expression and characterization of the JAK kinase and STAT protein from brine shrimp, Artemia franciscana
Keywords: چگونه; JAK; STAT; DNA binding; Brine shrimp; Artemia franciscana
IL-4-mediated transcriptional regulation of human CYP2E1 by two independent signaling pathways
Keywords: چگونه; ChIP; chromatin immunoprecipitation; CYP; cytochrome P450; Elk1; member of ETS oncogene family; FOXO1; forkhead box protein O1; IL-4; interleukin-4; IL-4R; interleukin-4 receptor; IRS; insulin receptor substrate; JAK; janus protein kinase; MAPK; mitogen-a
Defining the role of the JAK-STAT pathway in head and neck and thoracic malignancies: Implications for future therapeutic approaches
Keywords: چگونه; Head and neck cancer; Lung cancer; EGFR; IL-6; Signaling pathways; JAK; STAT
IFN-γ activated JAK1 shifts CD40-induced cytokine profiles in human antigen-presenting cells toward high IL-12p70 and low IL-10 production
Keywords: چگونه; Dendritic cells; Monocytes; B-cells; Endothelial cells; CD40; CD40L; JAK; Tyk2; STAT; NF-κB; IRF-1; IRF-8; IL-12; IL-10
Characterization of a dominant-active STAT that promotes tumorigenesis in Drosophila
Keywords: چگونه; STAT; JAK; Unpaired; Drosophila; Constitutively active; In vitro reporter; In vivo reporter; Structure function; Signal transduction
A Multitude of Kinases-Which are the Best Targets in Treating Rheumatoid Arthritis?
Keywords: چگونه; MAPKs; Tyrosine kinases; IKK; Jak; Syk; Small-molecule inhibitors;
In vivo regulation of the allergic response by the IL-4 receptor α chain immunoreceptor tyrosine-based inhibitory motif
Keywords: چگونه; IL-4 receptor; IL-4; IL-13; immunoreceptor tyrosine-based inhibitory motif; Src homology 2 domain-containing protein tyrosine phosphatase 1; IgE; allergic airway inflammation; asthma; AHR; Airway hyperresponsiveness; alum; Aluminum potassium phosphate;
Cross-talk between adipose and gastric leptins for the control of food intake and energy metabolism
Keywords: چگونه; ACTH; adrenocorticotropic hormone; ADIPOR1/2; adiponectin receptor1/2; AgRP; agouti related protein; AMPK; AMP-activated protein kinase; BSDL; bile salt-dependent lipase; cAMP; cyclic adenosine-monophosphate; CART; cocaine amphetamine related transcript;
Neuroprotection of interleukin-6 against NMDA attack and its signal transduction by JAK and MAPK
Keywords: چگونه; Interleukin-6; Neuroprotection; Cerebellar granule neurons; NMDA; JAK; MAPK
Vitronectin inhibits plasminogen activator inhibitor-1-induced signalling and chemotaxis by blocking plasminogen activator inhibitor-1 binding to the low-density lipoprotein receptor-related protein
Keywords: چگونه; CN I; collagen I; ECM; extra-cellular matrix; DAPI; 4â²,6-diamidino-2-phenylindole; FITC; fluorescein isothiocyanate; FN; fibronectin; Jak; Janus kinase; LRP; low-density lipoprotein receptor-related protein; PAI-1; plasminogen activator inhibitor-1; RAP
Selective regulation of interleukin-10 production via Janus kinase pathway in murine conventional dendritic cells
Keywords: چگونه; Dendritic cells; Toll-like receptors; Cytokines; Signal transduction; JAK; STAT; PI3K; Akt; MAPK; NF-κB
Myxoma virus selectively disrupts type I interferon signaling in primary human fibroblasts by blocking the activation of the Janus kinase Tyk2
Keywords: چگونه; Poxvirus; Antiviral; STAT1; Jak; Immune evasion
The JAK and STAT family members of the mandarin fish Siniperca chuatsi: Molecular cloning, tissues distribution and immunobiological activity
Keywords: چگونه; Mandarin fish; JAK; STAT; Signal pathway; Poly(I:C)
The epidermal growth factor receptor ligand amphiregulin is a negative regulator of hepatic acute-phase gene expression
Keywords: چگونه; APR; acute-phase reaction; APP; acute-phase protein; IL; interleukin; EGFR; epidermal growth factor receptor; AR; amphiregulin; OSM; oncostatin M; STAT; signal transducer and activator of transcription; TNF; tumour necrosis factor; JAK; Janus-activated ki
Interferon α increases metalloproteinase-13 gene expression through a polyomavirus enhancer activator 3-dependent pathway in hepatic stellate cells
Keywords: چگونه; AP1; activator protein-1; Col1a1; collagen α1(I); DMEM; Dulbecco's minimum essential medium; ECM; extracellular matrix; FCS; fetal calf serum; GAPDH; glyceraldehydes 3-phosphate dehydrogenase; HSC; hepatic stellate cells; IFN; interferon; JAK; Janus ty
A Polymorphism in MAPKAPK3 Affects Response to Interferon Therapy for Chronic Hepatitis C
Keywords: چگونه; GAS; interferon-γ-activated site; IFN; interferon; IFNAR1; type I interferon receptor-1; ISRE; interferon-stimulated response element; JAK; Janus-activated kinase; MAP; mitogen-activated protein; MAPKAPK; mitogen-activated protein kinase-activated pr
Suppressor of cytokine signaling-1 reduces high glucose-induced TGF-β1 and fibronectin synthesis in human mesangial cells
Keywords: چگونه; High glucose; SOCS-1; JAK2/STAT; Glomerular mesangial cell; SOCS; suppressor of cytokine signaling; HG; high glucose; HMC; human mesangial cell; DN; diabetic nephropathy; ECM; extracellular matrix; JAK; Janus kinase; STAT; signal transducers and activator
Leptin Regulates Gallbladder Genes Related to Gallstone Pathogenesis in Leptin-Deficient Mice
Keywords: چگونه; ABC; ATP-binding cassette; ACh; acetylcholine; CCK; cholecystokinin; HMG-CoA; 3-hydroxy 3-methylglutaryl coenzyme A; Ig; immunoglobulin; JAK; Janus kinase; NPY; neuropeptide Y; PCR; polymerase chain reaction; SMC; smooth muscle cell; STAT; signal transcri
Thrombopoietin inhibits nerve growth factor-induced neuronal differentiation and ERK signalling
Keywords: چگونه; EGF; epidermal growth factor; EPO; erythropoietin; ERK; extracellular signal-regulated kinase; FCS; fetal calf serum; GSK; glycogen synthase kinase; JAK; Janus kinase; JNK; c-Jun N-terminal kinase; HS; horse serum; LIF; leukaemia inhibitory factor; MAPK;
Development of a pharmacologically improved peptide agonist of the leptin receptor
Keywords: چگونه; Ab; antibody; ANOVA; analysis of variance; ATCC; American Type Culture Collection; BBB; blood-brain barrier; BSA; bovine serum albumin; CNS; central nervous system; CRH; cytokine receptor homology; DMEM; Dulbecco's modified Eagle's medium; ELISA; enzyme
The JAK kinases: Not just another kinase drug discovery target
Keywords: چگونه; Review; JAK; Kinase inhibitors; Myeloproliferative disorders; Cancer;
Research ReportLeptin-dependent STAT3 phosphorylation in postnatal mouse hypothalamus
Keywords: چگونه; AHA; anterior hypothalamic area; ARC; arcuate nucleus; BBB; blood-brain barrier; DMH; dorsomedial hypothalamic nucleus; i.p.; intraperitoneal; JAK; Janus kinase; LHA; lateral hypothalamic area; MPO; medial preoptic area; P; postnatal day; STAT3; signal
Paradigm shifts in the cell biology of STAT signaling
Keywords: چگونه; cav-1; caveolin-1; CHC; clathrin heavy chain; GFP; green fluorescent protein tag (YFP and CFP represent analogous yellow and cyan tags); HRS; hepatocyte growth factor-regulated tyrosine kinase substrate; IFN; interferon; IL; interleukin; IRF; interferon r
Receptor mosaics of neural and immune communication: Possible implications for basal ganglia functions
Keywords: چگونه; Ab; amyloid-beta protein; ABGA; antibasal ganglia antibody; AD; Alzheimer's disease; AGE; advanced glycation endproducts; AIDS; acquired immunodeficiency syndrome; ALS; amyotrophic lateral sclerosis; CA; cornu ammonis; CB; cannabinoid; CD; cluster designa
Genetyczne modyfikacje receptora IL-4 i ich znaczenie dla rozwoju chorób uwarunkowanych atopiÄ
Keywords: چگونه; atopia; genetyka chorób atopowych; receptor dla IL-4; polimorfizmy; atopy; genetics of atopic disorders; IL-4; IL-4Rα gene polymorphism; AP-1; activator protein-1; ATF; activating transcriptor factor; CHR; cytokine binding region; CREB; c-AMP response e
Interferon gamma-dependent transactivation of epidermal growth factor receptor
Keywords: چگونه; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; IFNγ; interferon gamma; IFNγR; interferon gamma receptor; JAK; Janus kinase; STAT; signal transducer and activator of transcription; TGF-α; transforming growth factor-α; HB-EGF; hep
Truncated pStat5B is associated with the Idd4 locus in NOD mice
Keywords: چگونه; Stat5B; Diabetes; NOD; Autoimmune diseases; Phosphorylation; Constitutive; JAK; Idd4
Impact of transient stress and stress enzymes on development
Keywords: چگونه; Stress; Stress enzymes; Embryonic stem cells; Trophoblast stem cells; Blastocyst; Implantation; Hypoxia; FGF; Oct4; Cdx2; Polycombs; SAPK/JNK1/2; P38MAPK; ERK/MAPK7; JAK; Fetal origins of adult disease (FOAD)
Growth hormone prevents acute liver injury induced by cardiopulmonary bypass in a rat model
Keywords: چگونه; 18; 25; APP; acute-phase protein; APR; acute-phase response; CPB; cardiopulmonary bypass; GH; growth hormone; GHBP; growth hormone-binding protein; IGF; insulin-like growth factor; JAK; Janus kinase; NF; nuclear factor; SAA; serum amyloid A; STAT; signa
GFP reporters detect the activation of the Drosophila JAK/STAT pathway in vivo
Keywords: چگونه; STAT; JAK; Unpaired; Drosophila; In vivo reporter; Eye; Wing; Antennal and leg imaginal discs; Embryogenesis; Larva; Gene expression; Transgene; Signal transduction
Histamine affects STAT6 phosphorylation via its effects on IL-4 secretion: Role of H1 receptors in the regulation of IL-4 production
Keywords: چگونه; Th1; T-helper type 1 lymphocyte; Th2; T-helper type 2 lymphocyte; STAT; Signal Transducer and Activator of Transcription; PMA; phorbol 12 myristate 13-acetate; H1 receptor; histamine receptor 1; H2 receptor; histamine receptor 2; H3 receptor; histamine re
Innate immune evasion by hepatitis C virus and West Nile virus
Keywords: چگونه; LGP2; IPS-1; IRF-3; MAVS; RIG-I; Interferon; JAK; STAT
Nonreceptor Tyrosine Kinases in Prostate
Keywords: چگونه; Nonreceptor tyrosine kinase; prostate cancer; Src; FAK; ETK; Abl; v-Abl Abelson murine leukemia viral oncogene homolog; At; androgenindependent; Aid; v-akt murine thymoma viral oncogene homolog 1; AR; androgen receptor; ARG; Abelson-related gene; Bcr; bre
Cloning and characterizing of the ovine MX1 gene promoter/enhancer region
Keywords: چگونه; Ovine; Pregnancy; GTPase; MX1; Antiviral; Interferon; Endometrium; ISRE; Positive and negative regulatory region; Promoter; IFN; interferon; oGE; ovine glandular epithelial cells; CL; corpus luteum; ER; estrogen receptor; PR; progesterone receptor; OTR; o
Signal transducer and activator of transcription signals in allergic disease
Keywords: چگونه; Allergy; STAT; cytokine; JAK-STAT; review; CRM; Chromosome region maintenance/exportin; FOXP3; Forkhead box P3; JAK; Janus kinase; LMB; Leptomycin B; NES; Nuclear export signal; SH; SRC homology; SLIM; STAT-interacting LIM protein; SNP; Single nucleotide
Divergent activities of interferon-alpha subtypes against intracellular hepatitis C virus replication
Keywords: چگونه; AP1; activator protein 1; CRE; cAMP response element; GAS; interferon-gamma activation sequence; HCV; hepatitis C virus; IFN; interferon; ISRE; interferon stimulation response element; JAK; janus kinase; SRE; serum response element; STAT; signal transduce
Mutational analysis reveals separable DNA binding and trans-activation of Drosophila STAT92E
Keywords: چگونه; JAK; STAT; SH2 domain; DNA binding; Transcriptional activation
Biology of Platelet-Derived Growth Factor and Its Involvement in Disease
Keywords: چگونه; bFGF; basic fibroblast growth factor; CMML; chronic myelomonocytic leukemia; DFPS; dermatofibrosarcoma protuberans; EC; endothelial cell; EGF; epidermal growth factor; FIP1L1; Fip1-like 1; FS; fibrosarcomatous; GIST; gastrointestinal stromal tumor; HES; h
Susceptibility to exogenously added interferon-β protein depends on intracellular interferon-β mRNA level in human glioma cells
Keywords: چگونه; Human interferon (HuIFN)-β; Antiproliferative effect; siRNA for HuIFN-β; HuIFN; human interferon; JAK; Janus kinases; STAT; signal transducer and activation transcription; IRF; interferon regulatory factor; ISGF; interferon stimulated gene factor; AAF;
SHP-1 regulates STAT6 phosphorylation and IL-4-mediated function in a cell type-specific manner
Keywords: چگونه; IL-4 receptor expression; Signaling; Viable motheaten; IL-4R; IL-4 receptor; SHP-1; SH2 domain-containing protein tyrosine phosphatase-1; mev/mev; Viable motheaten mice; STAT6; Signal transducer and activator of transcription; Jak; Janus kinase;
Oncostatin M causes eotaxin-1 release from airway smooth muscle: Synergy with IL-4 and IL-13
Keywords: چگونه; Signal transducer and activator of transcription 3; extracellular signal-regulated kinase; c-Jun N-terminal kinase; IL-4Rα; monocyte chemoattractant protein 1; vascular endothelial growth factor; CNTF; Ciliary neutrophic factor; ERK; Extracellular signal
Sensing and signaling during infection in Drosophila
Keywords: چگونه; DAP; diaminopimelic acid; DD; death domain; DREDD; death-related ced-3/Nedd2-like DD; FADD; Fas-associated DD-containing protein; GNBP; Gram-negative binding protein; IκB; inhibitory NF-κB; IKK; IκB kinase; JNK; Jun amino-terminal kinase; JAK; Janus fa
Leptin potentiates ADP-induced [Ca2+]i increase via JAK2 and tyrosine kinases in a megakaryoblast cell line
Keywords: چگونه; JAK; Janus-activating kinase; Ob-Ra; the short form of the leptin receptor; Ob-Rb; the long form of the leptin receptor; Leptin; Platelets; Thrombosis/embolism; Obesity; Coronary disease;