Keywords: Morphine; L-AP4; CPPG; Memory retention; Mice;
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Determination of L-AP4-bound human mGlu8 receptor amino terminal domain structure and the molecular basis for L-AP4's group III mGlu receptor functional potency and selectivity
Keywords: L-Glutamate; L-AP4; Human mGlu8 receptor ATD; X-ray; Selectivity;
mGlu4 allosteric modulation for treating Parkinson's disease
Keywords: Parkinson's disease; Dyskinesia; Glutamate; Dopamine; mGlu4; 6-OHDA; 6-hydroxydopamine; ADX88178; 4-methyl-N-[5-methyl-4-(1H-pyrazol-4-yl)-1,3-thiazol-2-yl]pyrimidin-2-amine; AIM; abnormal involuntary movements; CODA-RET; complemented donor acceptor reson
Orexin-B modulates synaptic transmission of rod bipolar cells in rat retina
Keywords: Orexin; Retinal rod bipolar cell; GABA receptor; Neuromodulation; BCs; bipolar cells; BIC; bicuculline; Bis-IV; bisindolylmaleimide IV; CPPG; (RS)-α-cyclopropyl-4-phosphor- nophenylalycine; DAG; diacylglycerol; DLG; dorsal lateral geniculate nucleus; DT-
Beta-arrestin1 and 2 differently modulate metabotropic glutamate receptor 7 signaling in rat developmental sevoflurane-induced neuronal apoptosis
Keywords: AMN082; N,Nâ²-bis(diphenylmethyl)-1,2-ethanediamine dihydrochloride; CBP; CREB binding protein; CNS; central nervous system; CREB; cyclic adenosine 3â²,5â²-monophosphate response element binding protein; Curcumin; diferuloylmethane; DIV; days in vitro;
Metabotropic glutamate receptors are involved in the detection of IMP and l-amino acids by mouse taste sensory cells
Keywords: AIDA; (RS)-1-aminoindan-1,5-dicarboxylic acid; Arg; l-arginine; CNQX; cyano-7-nitroquinoxaline-2,3-dione; CPPG; (RS)-α-cyclopropyl-4-phosphonophenylglycine; CTA; conditioned taste aversion; d-AP5; d-(â)-2-amino-5-phosphonopentanoic acid; DHPG; (S)-3,5-
Group II metabotropic glutamate receptor antagonism prevents the antiallodynic effects of R-isovaline
Keywords: ANOVA; analysis of variance; CGP52432; (3-[[[(3,4-dichlorophenyl)methyl]amino]propyl]diethoxymethyl)phosphinic acid; CI; confidence interval; CNS; central nervous system; GABA; γ-aminobutyric acid; GPCRs; G-protein-coupled receptors; l-AP4; l-(+)-2-amino
Melatonin modulates M4-type ganglion-cell photoreceptors
Keywords: d-AP5; d-(â)-2-amino-5-phosphonopentanoic acid; DNQX; 6,7-dinitroquinoxaline-2,3-dione; EGTA; ethylene glycol tetraacetic acid; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; ipRGC; intrinsically photosensitive retinal ganglion cell; l-AP4;
l-Cysteine and l-AP4 microinjections in the rat caudal ventrolateral medulla decrease arterial blood pressure
Keywords: ABP; arterial blood pressure; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole-propionate; CNQX; 6-cyano-7-nitroquinoxaline-2, 3-dione; CPPG; alpha-cyclopropyl-4-phosphonophenyl glycine; CVLM; caudal ventrolateral medulla; HR; heart rate; l-AP4; l-2-amino-4-
Selective regulation of recombinantly expressed mGlu7 metabotropic glutamate receptors by G protein-coupled receptor kinases and arrestins
Keywords: mGlu7 receptors; GRK; Arrestins; MAP kinases; Jun kinases; Signaling regulation; GPCR; G protein-coupled receptor; mGlu; metabotropic glutamate receptor; GRK; G protein-coupled receptor kinase; FSK; forskolin; L-AP4; l-2-amino-4-phosphonobutanoate; MAPK;
Development of allosteric modulators of GPCRs for treatment of CNS disorders
Keywords: 5MPEP; 5-methyl-6-(phenylethynyl)-pyridine; 6-OHDA; 6-hydroxydopamine; 7TMR; seven transmembrane receptor; 77-LH-28-1; 1-[3-(4-butyl-1-piperidinyl)propyl]-3,4-dihydro-2(1H)-quinolinone; AC-42; 4-n-butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl]-piperidine; ACh
Potentiation of mGlu7 receptor-mediated glutamate release at nerve terminals containing N and P/Q type Ca2+ channels
Keywords: mGlu7 receptor; Glutamate release potentiation; N and P/Q Ca2+ channels; Hippocampal nerve terminal; Cerebrocortical nerve terminals; N-type Ca2+ channel KO mice; mGlu7 receptor; metabotropic glutamate receptor 7; l-AP4; L(+) phosphonobutyrate; PLC; phosp
Metabotropic glutamate subtype 7 and 8 receptors oppositely modulate cardiac nociception in the rat nucleus tractus solitarius
Keywords: ACSF; artificial cerebrospinal fluid; AMN082; N,N'-diphenylmethyl-1,2-ethanediamine dihydrochloride; DCPG; (S)-3,4-dicarboxyphenylglycine; EMG; electromyogram; GABA; γ-aminobutyric acid; l-AP4; l-(+)-2-Amino-4-phosphonobutyric acid; mGluRs; metabotropi
The effects of metabotropic glutamate receptor 7 allosteric agonist N,Nâ²-dibenzhydrylethane-1,2-diamine dihydrochloride on developmental sevoflurane neurotoxicity: role of extracellular signal-regulated kinase 1 and 2 mitogen-activated protein kinase si
Keywords: mGluRs; sevoflurane; neurotoxicity; MAPK; learning and memory; hippocampus; AMN082; N,Nâ²-dibenzhydrylethane-1,2-diamine dihydrochloride; EDTA; ethylenediaminetetraacetic acid; ERK1/2; extracellular signal-regulated kinase 1 and 2; FCM; Flow cytometry; H
Induction of theta-frequency oscillations in the rat medial septal diagonal band slice by metabotropic glutamate receptor agonists
Keywords: metabotropic glutamate receptors; septal region; theta oscillation; ACPD; (1S, 3R)-1-aminocyclopentane-1,3-dicarboxylic acid; ACSF; artificial cerebrospinal fluid; ChAT; choline acetyltransferase; CPCCOEt; 7-(hydroxyimino) cyclopropa[b]chromen-1a-carboxyl
Lipopolysaccharide-stimulated interleukin-10 release from neonatal spinal cord microglia is potentiated by glutamate
Keywords: inflammation; lipopolysaccharide; microglia; APDC; (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate; BAPTA-AM; 1,2-bis(2-aminophenoxy)ethane-N,N,Nâ²,Nâ²-tetraacetic acid tetrakis(acetoxymethyl ester); chelerythrine chloride; 1,2-dimethoxy-N-methyl(1,3)benzo
Selective activation of metabotropic glutamate receptor 7 induces inhibition of cellular proliferation and promotes astrocyte differentiation of ventral mesencephalon human neural stem/progenitor cells
Keywords: Ventral mesencephalon; Stem cell; Neural/stem cell progenitor; Glutamate; Metabotropic glutamate receptor; Proliferation; Differentiation; l-AP4; AMN082
Calcium-induced calcium release contributes to synaptic release from mouse rod photoreceptors
Keywords: Ca-induced Ca2+ release; ryanodine; outer retina; synaptic transmission; CICR; calcium-induced calcium release; CPPG; (RS)-a-cyclopropyl-4-phosphonophenylglycine; ER; endoplasmic reticulum; l-AP4; l-(+)-2-amino-4-phosphonobutyric acid; OPL; outer plexifor
Antagonism of metabotropic glutamate receptor 4 receptors by (RS)-α-cyclopropyl-4-phosphonophenylglycine alters the taste of amino acids in rats
Keywords: umami; glycine; l-serine; l-arginine; condition taste aversion; taste transduction; AP5; d(-)-2-amino-5-phosphonophenylglycine; CPPG; (RS)-α-cyclopropyl-4-phosphonophenylglycine; CS; conditioned stimulus; CTA; conditioned taste aversion; GMP; guanosine
Effects of activation of group III metabotropic glutamate receptors on spinal synaptic transmission in a rat model of neuropathic pain
Keywords: CNQX; 6-cyano-7-nitroquinoxaline-2,3-dione; CPPG; (RS)-α-cyclopropyl-4-phosphonophenylglycine; eEPSCs; evoked excitatory postsynaptic current; GDP-β-S; guanosine 5â²-O-(2-thiodiphosphate); IPSC; inhibitory postsynaptic current; l-AP4; l(+)-2-amino-4-ph
Metabotropic glutamate receptors mGluR4 and mGluR8 regulate transmission in the lateral olfactory tract–piriform cortex synapse
Keywords: Metabotropic glutamate receptors; Group III mGluRs; l-AP4; DCPG; PHCCC; Lateral olfactory tract; Piriform cortex
Intrapallidal metabotropic glutamate receptor activation in a rat model of Parkinson's disease: Behavioral and histological analyses
Keywords: ACPD; 1-aminocyclopentane-1S,3R-dicarboxylic acid; 6-OHDA; 6-hydroxydopamine; DAPI; 4â², 6-diamidino-2-phenylindole, dilactate; EP; entopeduncular nucleus; EPSPs; excitatory postsynaptic potentials; GABA; gamma-aminobutyric acid; GP; globus pallidus; IPS
Group III mGluR regulation of synaptic transmission at the SC-CA1 synapse is developmentally regulated
Keywords: Metabotropic glutamate receptor; Group III; Hippocampus; DCPG; L-AP4
Glutamate-dependent translational regulation in cultured Bergmann glia cells: Involvement of p70S6K
Keywords: p70S6K; glutamate receptors; Bergmann glia; mTOR; translational control; Akt I; 1L-6-hydroxymethyl-chiro-inositol 2-(R)-2-O-methyl-3-O-octadecylcarbonate; AMPA; amino α-3-hydroxy-5-methyl-4-isoaxazolepropionate; ANOVA; analysis of variance; BAPTA-AM; 1,2
Immunoreactivity for the group III receptor subtype mGluR4a in the visual layers of the rat superior colliculus
Keywords: glutamate; metabotropic receptor; neurotransmission; visual system; preembedding immunocytochemistry; electron microscopy; ABC; avidin-biotin complex; BDA; biotin dextran amine; DAB; 3,3â²-diaminobenzidine; l-AP4; l-2-amino-4-phosphonobutyric acid; mGluR
Modulation of retino-collicular transmission by Group III metabotropic glutamate receptors at different ages during development
Keywords: Superior colliculus; mGlu4; mGlu8; mGlu7; Retino-collicular transmission; L-AP4; Development; Presynaptic receptors; Metabotropic glutamate receptors;
Inhibition of Transient Lower Esophageal Sphincter Relaxation and Gastroesophageal Reflux by Metabotropic Glutamate Receptor Ligands
Keywords: GABA; γ-aminobutyric acid; GERD; gastroesophageal reflux disease; L-AP4; L-(+)-2-amino-4-phosphonobutyric acid; mGluR; metabotropic glutamate receptor; MPEP; 2-methyl-6-(phenylethynyl)-pyridine; MTEP; 3-([2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine; NMDA;
N-methyl-d-aspartate receptors and large conductance calcium-sensitive potassium channels inhibit the release of opioid peptides that induce μ-opioid receptor internalization in the rat spinal cord
Keywords: dorsal horn; dynorphin; enkephalin; internalization; mu-opioid receptor; opioid; aCSF; artificial cerebrospinal fluid; ANOVA; analysis of variance; AP-5; dl-2-amino-5-phosphonopentanoic acid; BK(Ca2+); large conductance Ca2+-sensitive K+ channels; CCK; ch