The effects of metabotropic glutamate receptor 7 allosteric agonist N,N′-dibenzhydrylethane-1,2-diamine dihydrochloride on developmental sevoflurane neurotoxicity: role of extracellular signal-regulated kinase 1 and 2 mitogen-activated protein kinase si

▶Activation of mGluR7 with AMN082 attenuated sevoflurane-induced neuronal apoptosis. ▶AMN082 prevented sevoflurane neurotoxicity by modulating caspase-3, Bcl-2, and Bax. ▶Sevoflurane exposure inhibited phospho-ERK1/2 that could be restored by AMN082. ▶MEK inhibitor U0126 abolished the neuronal protective effects of AMN082. ▶AMN082 improved the cognitive defects induced by postnatal sevoflurane exposure.