Effect of fenpropathrin on the viability and homing ability of worker bees Apis mellifera
Keywords: Fenpropathrin; LD50; Lifespan; Homing ability; GluRA; Nmdar1;
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The Annona muricata leaf ethanol extract affects mobility and reproduction in mutant strain NB327 Caenorhabditis elegans
Keywords: EEAML; Ethanol extract of Annona muricata leaves; DMSO; Dimethylsulfoxide; LD50; Lethal Dose 50; MIC; Minimum Inhibitory Concentration; NGM; Nematode growth medium; MHA; Mueller Hinton Agar; MHB; Mueller Hinton Broth; CLSI; Clinical and Laboratory Standar
Evaluación del efecto tóxico de hongos Basidiomycota en la eclosión de quistes de Artemia franciscana
Keywords: Artemia franciscana; Basidiomycota; CL50; Eclosión; Toxicidad; Artemia franciscana; Basidiomycota; LD50; Hatching; Toxicity;
Comparison of the acute inhibitory effects of Tetrodotoxin (TTX) in rat and human neuronal networks for risk assessment purposes
Keywords: ARfD; acute reference dose; DIV; days in vitro; EFSA; European Food Safety Authority; FBS; fetal bovine serum; hIPSC; human-induced pluripotent stem cell; IC50; half maximal inhibitory concentration; LD50; median lethal dose; LOEAL; lowest observed advers
Vibrio parahaemolyticus a causative bacterium for tail rot disease in ornamental fish, Amphiprion sebae
Keywords: Ornamental fish; Amphiprion sebae; Tail rot; Vibrio parahaemolyticus; LD50;
An easy method for the determination of active concentrations of cholinesterase reactivators in blood samples: Application to the efficacy assessment of non quaternary reactivators compared to HI-6 and pralidoxime in VX-poisoned mice
Keywords: Organophosphorus-nerve agents; Oxime; Cholinesterase; Reactivation; Blood clearance; OPNA; organophosphorus-nerve agents; AChE; acetylcholinesterase; CNS; central nervous system; BBB; blood brain barrier; LD50; lethal dose 50%; 2-PAM; pralidoxime; MRT; Me
Predicting acute contact toxicity of pesticides in honeybees (Apis mellifera) through a k-nearest neighbor model
Keywords: Pesticides; Honey bees; k-NN; In silico models; Acute contact toxicity; EFSA; European Food Safety Authority; US-EPA; Unites States Environmental Protection Agency; k-NN; K-Nearest Neighbor; LD50; Dose killing half the test organisms after a specified tes
Acute and subacute oral toxicity assessment of the oil extracted from Attalea phalerata Mart ex Spreng. pulp fruit in rats
Keywords: APO; Attalea phalerata Mart. ex Spreng. oil; LD50; oral lethal dose; ALT; alanine aminotransferase; AST; aspartate aminotransferase; RDW; red cell distribution width; Attalea phalerata Mart.; Bacuri; Food science; Fatty acids; Carotenoids; Bioactive compo
Mass spectral characterization of tabun-labeled lysine biomarkers in albumin
Keywords: AChE; acetylcholinesterase; u; unified atomic mass unit; hAChE; human AChE; HCD; high-energy collision-induced dissociation; HPLC; high performance liquid chromatography; LD50; median lethal dose; MS/MS; tandem mass spectrometry fragmentation; MWCO; molec
Methods NotesBLaTM 2.0, a Genetic Tool Revealing Preferred Antiparallel Interaction of Transmembrane Helix 4 of the Dual-Topology Protein EmrE
Keywords: TMD; transmembrane domain; EmrE; small multidrug resistance protein of E. coli; N-BLa; N-terminal fragment of β-lactamase; C-BLa; C-terminal fragment of β-lactamase; sfGFP; superfolder green fluorescence protein; LD50; dose of ampicillin permitting the
Mdr1a plays a crucial role in regulating the analgesic effect and toxicity of aconitine by altering its pharmacokinetic characteristics
Keywords: AC; aconitine; AUC; area under concentration-time curve; cTnI; cardia troppnin I; CL; clearance; CK; creatine kinase; LD50; 5% half-lethal dose; LD50; half-lethal dose; NSE; neurone specific enolase; P-gp; P-glycoprotein; S100-β; neuron-enriched S100 bet
The binding effectiveness of anti-r-disintegrin polyclonal antibodies against disintegrins and PII and PIII metalloproteases: An immunological survey of type A, B and AÂ +Â B venoms from Mohave rattlesnakes
Keywords: SVMP; snake venom metalloprotease; ELISA; Enzyme-Linked Immunosorbent Assay; ARDPA; anti-recombinant disintegrin polyclonal antibody; r-Mojastin 1; recombinant mojastin 1; ADAM; a disintegrin and metalloprotease; LD50; Lethal Dose 50; LC-MS; Liquid Chroma
Toxicological evaluation and effective dose selection of eurycomanone, a quassinoid of Eurycoma longifolia plant in fishes
Keywords: Eurycoma longifolia; Fish; LD50; Comet assay; mRNA;
Acute, sub-acute toxicity and antioxidant activities (in vitro and in vivo) of Reichardia picroide crude extract
Keywords: ALP; alkaline phosphatase; ALT; alanine aminotransferase; AST; aspartate aminotransferase; BHT; butylated hydroxytoluene; DPPH; 1,1-diphenyl-2 picrylhydrazyl; DTNB; 5,5 0- dithiobis-(2-nitrobenzoic acid); EC 50; effective concentration; EDTA; ethylenediam
Research paperDeletion of the vacJ gene affects the biology and virulence in Haemophilus parasuis serovar 5
Keywords: NAD; nicotinamide-adenine dinucleotide; LB; Luria-Bertani; TSA; Tryptic Soy Agar; TSB; Tryptic Soy Broth; OD600; optical density at 600Â nm; Kan; kanamycin; MIC; minimal inhibitory concentration; LD50; 50% lethal dose; i.p.; intraperitoneally; ORF; open r
Biometrical evaluation of the performance of the revised OECD Test Guideline 402 for assessing acute dermal toxicity
Keywords: Test guideline; Acute dermal toxicity; Globally Harmonized System (GHS); Biometric evaluation; Animal welfare; ATC; Acute Toxic Class method; FDP; Fixed Dose Procedure; GHS; Globally Harmonized System for Classification and Labelling; LD50; Lethal Dose, 5
Efficacy and safety of “Yahom” as a traditional Thai herbal therapy: A systematic review
Keywords: 2-AA; 2-aminoanthracene; Ach; Acetylcholine; AF2; 2-aminofluorene; Aq; Aqueous; BMI; Body mass index; BP; Blood pressure; BUN; Blood urea nitrogen; CYPs; Cytochromes P450; DBP; Diastolic blood pressure; DPPH; 2,2-diphenyl-1-picrylhydrazyl; ECG; Electrocar
Acute oral toxicity evaluation of aqueous ethanolic extract of Saccharum munja Roxb. roots in albino mice as per OECD 425 TG
Keywords: S. munja roots; LD50; Acute oral toxicity;
Antifungal activity of the essential oil obtained from Cryptocarya alba against infection in honey bees by Nosema ceranae
Keywords: GC-MS; gas chromatography-mass spectrometry; EO; essential oil; INDAP; Instituto de Desarrollo Agropecuario; SAG; Servicio AgrÃcola y Ganadero; OECD; Organization for Economic Co-operation and Development; OIE; Office International des Epizooties; LD50
The toxicity and the acaricidal mechanism against Psoroptes cuniculi of the methanol extract of Adonis coerulea Maxim
Keywords: AChE; Acetylcholinesterase; CAT; Catalase; CLL model; The complementary log-log model; GST; Glutathione-S-transferase; HPLC; High performance liquid chromatography; IC50; : 50% inhibitory concentration; LD50; Median lethal dose; MDA; Malonyldialdehyde;
Human intestine and liver microsomal metabolic differences between C19-diester and monoester diterpenoid alkaloids from the roots of Aconitum carmichaelii Debx.
Keywords: AC; Aconitine; BAC; 14-Benzoylaconine or 8-O-deacetyl aconitine; BHA; 14-Benzoylhypaconine or 8-O-deacetyl hypaconitine; BMA; 14-Benzoylmesaconine or 8-O-deacetyl mesaconitine; CHAPS; 3-[(3-cholamidopropyl) dimethyl-ammonio]-1-propane sulfonate; CYP450s;
The NS3 and NS4A genes as the targets of RNA interference inhibit replication of Japanese encephalitis virus in vitro and in vivo
Keywords: JEV; Japanese encephalitis virus; DENV; dengue virus; HCV; hepatitis C virus; BVDV; bovine viral diarrhea virus; NS3; non-structural 3 protein; C; capsid protein; M; membrane protein; E; envelope protein; min; minute; h; hour; hpt; hours post transfection
Evaluation of the toxicokinetics and apoptotic potential of ethanol extract from Echinodorus macrophyllus leaves in vivo
Keywords: Echinodorus macrophyllus; Acute toxicity; LD50; Comet assay; Micronucleus test; Genotoxicity; Mutagenicity;
Concentrations of neonicotinoid insecticides in honey, pollen and honey bees (Apis mellifera L.) in central Saskatchewan, Canada
Keywords: Risk assessment; Agriculture; Honey bees; Metabolites; Imidaclorpid; LD50;
Effects of linalool and eugenol on the survival of Leishmania (L.) infantum chagasi within macrophages
Keywords: AVL; American visceral leishmaniasis; BALBc; an albino, laboratory-inbred strain of the house mouse; cAMP; 3â²,5â²-cyclic adenosine monophosphate; DMSO; dimethylsulfoxide; EGTA; ethylene glycol tetraacetic acid; FCS; fetal calf serum; HepG2; a perpetual
In vitro potency determination of botulinum neurotoxin B based on its receptor-binding and proteolytic characteristics
Keywords: BINACLE; binding and cleavage assay; BoNT; botulinum neurotoxin; BSA; bovine serum albumin; GT1b; ganglioside GT1b; H-chain; heavy chain; HCc; C-terminal region of the H-chain; L-chain; light chain; LD50; lethal dose for 50% of test animals; NAP; neurotox
Chimpanzee adenovirus vector-based avian influenza vaccine completely protects mice against lethal challenge of H5N1
Keywords: HPAI; highly pathogenic avian influenza; RDE; receptor destroying enzyme; AdHu5; human adenovirus serotype 5; HA; haemagglutinin; AdC7; chimpanzee adenovirus serotype 24; LD50; median lethal dose; Influenza; H5N1; AdC7; Vaccine; Immune responses;
Mosla scabra flavonoids ameliorate the influenza A virus-induced lung injury and water transport abnormality via the inhibition of PRR and AQP signaling pathways in mice
Keywords: MF; total flavonoids extracted from Mosla Scabra; IAV; influenza A virus; LD50; 50% lethal dose; RFQ-PCR; Real-time Fluorescence Quantitative Polymerase Chain Reaction; IC50; 50% influenza virus-inhibitory concentration; HDF-1; 5-hydroxy-6,7-dimethoxyflav
ReviewToxicological properties of fenugreek (Trigonella foenum graecum)
Keywords: Fenugreek; LD50; Toxicity; Teratogenicity; Clinical toxicity; Allergenicity; Antigenicity; Neurotoxicity; Anti-fertility effect; Genotoxicity;
Is sunitinib a Narrow Therapeutic Index Drug? - A systematic review and in vitro toxicology-analysis of Sunitinib vs. Imatinib in cells from different tissues
Keywords: Apoptosis; Drug safety; Imatinib; Narrow Therapeutic Index Drug (NTID); Receptor tyrosine kinase (RTK); Sunitinib; Toxicity; Tyrosine kinase inhibitor (TKI); Cell viability; ALL; acute lymphoblastic leukemia; AUC; area under the curve; b.i.d.; twice daily
Toxicological evaluation of advanced glycation end product Nε-(carboxymethyl)lysine: Acute and subacute oral toxicity studies
Keywords: Nε-(carboxymethyl)lysine; Oral acute toxicity; Subacute toxicity; Oxidative stress; Mice; CML; Nε-(carboxymethyl)lysine; AGEs; advanced glycation endproducts; OECD; Organization for Economic Co-operation and Development; LD50; median lethal dose; RBC; r
Growth hormone is protective against acute methadone-induced toxicity by modulating the NMDA receptor complex
Keywords: AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; CNS; central nervous system; DIV; day(s) in vitro; GH; growth hormone; IGF-1; insulin-like growth factor 1; LD50; 50% lethal dose; LDH; lactate dehydrogenase; LTP; long-term potentiation; MEM; m
Alteration of canonical and non-canonical WNT-signaling by crystalline silica in human lung epithelial cells
Keywords: ACTA2; Actin, alpha, smooth muscle; ANGPTL4; Angiopoietin-like 4; ANOVA; Analysis of variance; AXIN; Axis inhibition protein; BMP; Bone morphogenic protein; BMPR1B; BMP receptor 1B; CACNA2D3; Calcium channel, voltage-dependent, alpha 2/delta subunit 3; CC
Sperm quality and fertility in rats after prenatal exposure to low doses of TCDD: A three-generation study
Keywords: TCDD; Tetrachlorodibenzo-p-dioxin; GD; gestational day; LOAEL; lowest observed adverse effect level; LD50; median lethal dose; PND; post-natal day; Dioxin; Epididymis; Sperm quality; Fertility; Transgenerational effect;
Galactose conjugated platinum(II) complex targeting the Warburg effect for treatment of non-small cell lung cancer and colon cancer
Keywords: Galactose-Pt(II) conjugate; Glucose transporter; Warburg effect; Maximum tolerated dose; Antitumor efficacy; GLUTs; glucose transporters; Gal-Pt; galactose-conjugated 2-chloromalonatoplatinum(II) complex; Oxa; oxaliplatin; Que; quercetin; 5-FU; 5-fluorour
Genotoxicity and subchronic toxicity evaluation of dried Euglena gracilis ATCC PTA-123017
Keywords: Rat; Genotoxicity; Toxicity; Safety; NOAEL; 2-AA; 2-aminoanthracene; ANOVA; analysis of variance; ARA; arachidonic acid; AST; aspartate aminotransferase; DHA; docosahexaenoic acid; EDTA; ethylenediaminetetraacetic acid; EPA; eicosapentaenoic acid; LD50; m
Medicinal plants and natural molecules with in vitro and in vivo activity against rotavirus: A systematic review
Keywords: Diarrhea; Gastroenteritis; Inflammation; Medicinal plants; Natural molecules; Rotavirus; CPE; Cytopathic Effect; ELISA; Enzyme-Linked Immunosorbent Assay; FDA; Food and Drug Administration; FFU; Focus Forming Units; LD50; Lethal Dose 50; MTS; Moderate-Thr
Glucose-functionalized amino-OPEs as biocompatible photosensitizers in PDT
Keywords: Phothodynamic therapy; Phothosensitizer; Oligo(phenylene ethynylene); Singlet oxygen production; Glucose base photosensitizers; OPE; oligo(phenylene ethynylene); PDT; phothodynamic therapy; PS; phothosensitizer; UV; ultraviolet light; UVA; ultraviolet lig
Antinociceptive activity of the essential oil from Artemisia ludoviciana
Keywords: EO; essential oil; HS-SPME; headspace solid phase microextraction; GC-MS; gas chromatography coupled with mass spectrometry; MOR; morphine; ATR; atropine; GLI; glibenclamide; L-NAME; NG-L-nitro arginine methyl ester; NLX; naloxone; CAR; carboxen; PDMS;
Acute and sub-chronic toxicity studies of three plants used in Cameroonian ethnoveterinary medicine: Aloe vera (L.) Burm. f. (Xanthorrhoeaceae) leaves, Carica papaya L. (Caricaceae) seeds or leaves, and Mimosa pudica L. (Fabaceae) leaves in Kabir chicks
Keywords: ALT; alanine amino transferase; AST; aspartate amino transferase; AVLE; Aloe vera leaf extracts; DMSO; dimethyl sulfoxyde; EDTA; ethylene diamine tetra acetate; LD50; medium lethal dose necessary to induce 50% mortality relative to the control value; OECD
Anti-influenza virus effects of crude phenylethanoid glycosides isolated from ligustrum purpurascens via inducing endogenous interferon-γ
Keywords: LPG; Ligustrum purpurascens phenylethanoid glycosides; IFN; Interferon; H1N1; Influenza A Virus H1N1 type; MTT; Methyl Thiazolyl Tetrazolium; MEM; Modified Eagle Medium; MDCK cell; Madin-Darby canine kidney cell; WT mice; wild-type mice; IFN-γâ/âmice
Cornus mas L. (cornelian cherry), an important European and Asian traditional food and medicine: Ethnomedicine, phytochemistry and pharmacology for its commercial utilization in drug industry
Keywords: AAE; ascorbic acid equivalent; AAPH; 2,2â²-Azobis(2-amidinopropane) dihydrochloride; ABTS; 2,2-Azinobis-3-ethylbenzothiazoline-6-sulfonic acid; AD; Alzheimer's disease; AFLP; Amplified fragment length polymorphism; AIP; Atherogenic index parameter; ALP;
Acute and sub-chronic toxicity of glucose-cysteine Maillard reaction products in Sprague-Dawley rats
Keywords: AGEs; advanced glycation end-products; ALB; albumin; ALT; alanine aminotransferase; AST; aspartate aminotransferase; BUN; blood urea nitrogen; CRE; creatinine; FDA; the USA Food and Drug Administration; GLU; glucose; HMF; 5-Hydroxymethyl-2-furfural; LD50;
The molecular mechanisms of sodium metabisulfite on the expression of KATP and L-Ca2+ channels in rat hearts
Keywords: CA; chromosomal aberrations; Ct; threshold cycle; EC; excitation-contraction; FASEB; Federation of American Societies for Experimental Biology; HE; hematoxylin-eosin; KATP; ATP-sensitive K+; Kir6.x; inward-rectifying K+ channel family; L-Ca2+; L-type
Nrf2 promotes survival following exposure to ionizing radiation
Keywords: ARE; antioxidant response element; ARS; acute radiation syndrome; ATM; ataxia telangiectasia mutated; BRCA1; breast cancer type 1 susceptibility protein; ChIP; chromatin immunoprecipitation; CnC; cap 'n׳ collar family of basic leucine zipper transcript
Toxicological evaluation of ferrous N-carbamylglycinate chelate: Acute, Sub-acute toxicity and mutagenicity
Keywords: Iron amino acid chelates; Ferrous N-carbamylglycinate; Acute toxicity; Sub-acute toxicity; Mutagenicity; MMS; Methyl methyl sulfonate; CP; cyclophosphamide; SD; Sprague-Dawley; BMM; bone marrow micronucleus; LD50; median lethal dose; ANOVA; one-way anal
Sesquiterpene lactones of Moquiniastrum polymorphum subsp. floccosum have antineoplastic effects in Walker-256 tumor-bearing rats
Keywords: ALT; alanine aminotransferase; AST; aspartate aminotransferase; Bax; Bcl-2-associated X protein; Bcl-2; B-cell lymphoma 2; Cat; catalase; DNCB; 2,4-dinitrochlorobenzene; EDTA; ethylenediaminetetraacetic acid; EtOAc; ethyl acetate; F1B; dichloromethane fra
Reconstituted mother tinctures of Gelsemium sempervirens L. improve memory and cognitive impairment in mice scopolamine-induced dementia model
Keywords: AD; Alzheimer׳s disease; Aβ; amyloid β; AChE; acetylcholinesterase; ANOVA; analysis of variance; ANSM; Agence Nationale de Sécurité des Médicaments (French); APP; amyloid precursor protein; b-APP; b-amyloid precursor protein; ATCI; acetylthiocholine
Ostreospis cf. ovata blooms in coastal water: Italian guidelines to assess and manage the risk associated to bathing waters and recreational activities
Keywords: Ostreopsis cf. ovata; Palytoxins; Ovatoxins; Bathing waters; Guidelines; Human health risk assessment; PLTX; palytoxin; OVTX; ovatoxin; Ost-D; Ostreocin-D; 42-OH-PLTX; 42-Hydroxy-Palytoxin; LD50; Lethal Dose for 50% of the animals tested; NOAEL; No Observ
Protection of testis through antioxidant action of Mallotus roxburghianus in alloxan-induced diabetic rat model
Keywords: ABC; avidin-biotin-peroxidase complex; AGE; advanced glycation end products; ANOVA; analysis of variance; CAT; catalase; CDNB; 1-chloro-2,4-dinitrobenzene; DAB; 3,3â² diaminobenzidine tetrahydrochloride; DPPH; 1,1-diphenyl-2-picylhydiazyl; DTNB; 5,5-di