کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5538973 | 1552807 | 2017 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Toxicological evaluation and effective dose selection of eurycomanone, a quassinoid of Eurycoma longifolia plant in fishes
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم آبزیان
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
The study was undertaken to investigate the toxicity level and safe dosage of eurycomanone, a major compound of Eurycoma longifolia plant extract in catfish. For that, combined approaches like, genotoxicity studies, biochemical, molecular and histopathological analysis were followed. The 96 h LD50 of eurycomanone was found to be 391.716 μg/kg (0.3917 μg/g). The sub-acute toxicity levels of eurycomanone at concentrations, 0.274 μg/g (70% LD50; Ed1) and 0.137 μg/g (35% LD50; Ed2) were analysed to determine the safer dose for fish. Significant genotoxic effects (micronuclei and DNA damage) and elevation in biochemical parameters (AST, ALT and LDH) were detected in the Ed1 group than Ed2. Transcript levels of apoptotic genes were significantly more (P < 0.05) in Ed1 than Ed2 and control groups. The histopathological examination suggested that Ed2 caused severe damage to the liver cells of catfish. The above results collectively suggested that the 70% LD50 of eurycomanone was detrimental while 35% was safer for the catfish. This is the first report showing the toxicity levels of eurycomanone on fish. Furthermore, the safe dose could be effectively used to exploit the beneficial effects of this compound as used in higher animals.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Aquaculture - Volume 481, 1 December 2017, Pages 94-102
Journal: Aquaculture - Volume 481, 1 December 2017, Pages 94-102
نویسندگان
Irfan Ahmad Bhat, Pravesh Kumar Rathor, Ishfaq Nazir Mir, Gireesh-Babu P., Mukunda Goswami, Sundaray J.K., Rupam Sharma,