دانلود مقالات ISI درباره Lkb1 + ترجمه فارسی

Hepatitis B virus (HBV) X protein-mediated regulation of hepatocyte metabolic pathways affects viral replication

Keywords: HBV; Hepatitis B virus; HCC; Hepatocellular carcinoma; HBx; HBV X protein; cccDNA; Covalently closed circular DNA; ORF; Open reading frame; mTORC1; Mammalian target of rapamycin (mTOR) complex 1; TSC2; Tuberous-sclerosis complex-2; AMPK; AMP-activated pro

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

Oocyte activation and latent HIV-1 reactivation: AMPK as a common mechanism of action linking the beginnings of life and the potential eradication of HIV-1

Keywords: AMP-activated protein kinase (AMPK); Oocyte; HIV-1 latency; Hutchinson-Gilford progeria syndrome (HGPS); LKB1; CaMKK2; Phospholipase C zeta (PLCζ); Phospholipase C-gamma 1 (PLCγ1); Bryostatin; Resveratrol; Metformin; Retinoic acid;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

Evolving Lessons on the Complex Role of AMPK in Normal Physiology and Cancer

Keywords: AMPK; cancer; mTOR; LKB1; metformin; oncogenic stress

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2016 سفارش ترجمه

Functional characterization of AMP-activated protein kinase signaling in tumorigenesis

Keywords: AMPK; Energy deprivation; Kinase; LKB1; Tumorigenesis; Mouse models; Metformin;

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2016 سفارش ترجمه

Rapamycin requires AMPK activity and p27 expression for promoting autophagy-dependent Tsc2-null cell survival

Keywords: AMPK; 5′ AMP-activated protein kinase; Atg13; autophagy-related protein 13; CDK; cyclin-dependent kinase; DAPI; 4′,6-diamidino-2-phenylindole; DMEM; Dulbecco's modified eagle's medium; DMSO; dimethyl sulfoxide; FDA; US Food and Drug Administration; GF

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2016 سفارش ترجمه

The Crabtree and Warburg effects: Do metabolite-induced regulations participate in their induction?

Keywords: 2HG; 2-hydroxyglutarate; 6PGD; 6-phosphogluconate dehydrogenase; ACC; acetyl-CoA carboxylase; ANT; adenine nucleotide translocase; ADP; adenosine diphosphate; AMP; adenosine monophosphate; AMPK; AMPKinase; ATP; adenosine triphosphate; Fru6P; fructose 6 ph

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2016 سفارش ترجمه

AMPK/Snf1 signaling regulates histone acetylation: Impact on gene expression and epigenetic functions

Keywords: ACAT1; acetoacetyl-CoA thiolase; ACC; acetyl-CoA carboxylase; AICAR; 5-aminoimidazole-4-carboxamide ribonucleoside; AMPK; AMP-activated protein kinase; ATAC; Ada-two-A-containing; BET; bromodomains and extra-terminal motif; BMAL1; PAS domain-containing pr

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2016 سفارش ترجمه

Methylisoindigo preferentially kills cancer stem cells by interfering cell metabolism via inhibition of LKB1 and activation of AMPK in PDACs

Keywords: Indirubin; Meisoindigo; Pancreatic cancer stem cell; CSC drug; LKB1 inactivation; AMPK activation; PDAC; CD133; 2-DG; 2-deoxyglucose; ACC; acetyl-CoA carboxylase; AMPK; 5′ AMP-activated protein kinase; CHK2; check point kinase 2; DM; Dorsomorphin; ESA;

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2016 سفارش ترجمه

DEC1 negatively regulates AMPK activity via LKB1

Keywords: DEC1; AMPK; LKB1; Clock gene;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Condensed catechins and their potential health-benefits

Keywords: ACE; angiotensin I-converting enzyme; AMPK; AMP-activated protein kinase; AUC; area under the curve; BGL; blood glucose level; CaMKK; Ca2+/camodulin-dependent protein kinase kinase; COX; cyclooxygenases; EC; (−)-epicatechin; EDRF; endothelium derived-re

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

LKB1 and AMPKα1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemia

Keywords: LKB1; AMPK; Glucagon secretion; PPG; Knockout; Alpha cellAMPK, AMP-activated protein kinase; LKB1, liver kinase B1; T2D, Type 2 diabetes; PPG, preproglucagon promoter; AICAR, aminoimidazole carboxamide ribonucleotide

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Activated AMPK boosts the Nrf2/HO-1 signaling axis-A role for the unfolded protein response

Keywords: ACC; acetyl-CoA carboxylase; AMPK; AMP-activated kinase; ARE; antioxidant response element; βTrcP1; β-transducin-repeat containing protein 1; CaMKK; calcium calmodulin-dependent kinase kinase; CHO; Chinese hamster ovary; DCF; dichlorofluorescein; DMSO;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Sirtuins in vascular diseases: Emerging roles and therapeutic potential

Keywords: ACE; angiotensin converting enzyme; AICAR; 5-amino-4-imidazolecarboxamide riboside; AMPK; AMP-activated protein kinase; Ang II; angiotensin II; ApoE; apolipoprotein E; AT1R; angiotensin II type 1 receptor; ATM; ataxia telangiectasia mutated; ATP; adenosin

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Honokiol activates the LKB1-AMPK signaling pathway and attenuates the lipid accumulation in hepatocytes

Keywords: ACC; acetyl-CoA carboxylase; AMPK; AMP-activated protein kinase; ATGL; adipose triglyceride lipase; CaMKK; calcium/calmodulin-dependent protein kinase kinase; FAS; fatty acid synthase; FFA; free fatty acid; HFD; high fat diet; Hon; honokiol; LKB1; liver k

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Oxidative stress activates AMPK in cultured cells primarily by increasing cellular AMP and/or ADP

Keywords: AMPK; AMP-activated protein kinase; CaMKK; calmodulin-dependent kinase kinase; GO; glucose oxidase; LKB1; liver kinase B1; AMP; ADP; AMP-activated protein kinase; Hydrogen peroxide; Oxidative stress;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Expression and transcriptional profiling of the LKB1 tumor suppressor in cervical cancer cells

Keywords: LKB1; Cervical carcinoma; Gene expression profiling; INPP4B; Phosphatidyl inositol signaling

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Alterations of LKB1 and KRAS and risk of brain metastasis: Comprehensive characterization by mutation analysis, copy number, and gene expression in non-small-cell lung carcinoma

Keywords: NSCLC; Brain Metastasis; Prognostic model; LKB1; KRAS;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Phenotypes associated with inherited and developmental somatic mutations in genes encoding mTOR pathway components

Keywords: mTOR; Mamalian target of rapamycin; PI3K; phosphoinositide 3-kinase related kinase; mTORC1; mTOR complex 1; mTORC2; mTOR complex 2; AMP; Adenosine monophosphate; ATP; Adenosine triphosphate; S6K; ribosomal S6 Kinase; 4E-BP1; eukaryotic initiation factor 4

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Fluoxetine suppresses AMP-activated protein kinase signaling pathway to promote hepatic lipid accumulation in primary mouse hepatocytes

Keywords: FLX; fluoxetine; SSRI; selective serotonin reuptake inhibitors; AMPK; AMP-activated protein kinase; LKB1; liver kinase B1; AICAR; 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside; Compound C; 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

LKB1 inactivation sensitizes non-small cell lung cancer to pharmacological aggravation of ER stress

Keywords: LKB1; Lung cancer; Treatment; UPR; ER stress;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

A high isoflavone diet decreases 5′ adenosine monophosphate-activated protein kinase activation and does not correct selenium-induced elevations in fasting blood glucose in mice

Keywords: AMPK; Adenosine monophosphate-activated protein kinase; LKB1; Liver kinase B1; ACC; Acetyl-CoA carboxylase; Se; Selenium; GLUT4; Glucose transporter type 4; IR; Insulin resistance; Cyt C; Cytochrome c; UCP3; Uncoupling protein 3; SMSC; Se-methylselenocy

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Cocoa flavonoids attenuate high glucose-induced insulin signalling blockade and modulate glucose uptake and production in human HepG2 cells

Keywords: AKT/PKB; protein kinase B; AMPK; 5′-AMP-activated protein kinase; BrdU; 5-bromo-2′-deoxyuridine; CaMMK; Ca2+/calmodulin-dependent protein kinase kinase; CPE; cocoa phenolic extract; EC; (−)-epicatechin; EGCG; epigallocatechin gallate; ERK; extracell

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Glabridin induces glucose uptake via the AMP-activated protein kinase pathway in muscle cells

Keywords: ACC; acetyl CoA carboxylase; ACO; acyl CoA oxidase; AICAR; 5-amino-1-β-d-ribofuranosyl-imidazole-4-carboxamide; AMPK; adenosine monophosphate-activated protein kinase; AS160; Akt substrate 160 kDa; BSA; bovine serum albumin; CaMKII; Ca2+/calmodulin-depe

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

LKB1 Loss Induces Characteristic Patterns of Gene Expression in Human Tumors Associated with NRF2 Activation and Attenuation of PI3K-AKT

Keywords: Genomics; LKB1; NRF2; PI3K/AKT;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Alpha-lipoic acid improves high-fat diet-induced hepatic steatosis by modulating the transcription factors SREBP-1, FoxO1 and Nrf2 via the SIRT1/LKB1/AMPK pathway

Keywords: ACC; acetyl-CoA carboxylase; ALA; alpha-lipoic acid; ALT; alanine aminotransferase; AICAR; 5-aminoimidazole-4-carboxamide riboside; AMPK; AMP-activated protein kinase; AST; aspartate aminostransferase; ATGL; adipose triacylglycerol lipase; CaMKK; Ca2+/cal

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Aspirin attenuates vinorelbine-induced endothelial inflammation via modulating SIRT1/AMPK axis

Keywords: VNR; vinorelbine; SIRT1; sirtuin 1; AMPK; AMP-activated protein kinase; PKC; protein kinase C; LKB1; protein liver kinase B1; TAK1; TGF-β-activated kinase-1; TAB1; TAK-binding protein-1; ROS; reactive oxygen species; DCF-AM; 2′,7′-dichlorofluorescein

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

New insights into Notch1 regulation of the PI3K-AKT-mTOR1 signaling axis: Targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia

Keywords: ADAM; a disintegrin and metalloprotease; AICAR; 5-aminoimidazole-4-carboxamide ribonucleotide; AKT; protein kinase B (PKB); ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; AMPK; adenosine monophosphate (AMP) activated protein kinase; ANK;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

AMPK-α1 functions downstream of oxidative stress to mediate neuronal atrophy in Huntington's disease

Keywords: 3D; three-dimensional; ACC; acety-CoA carboxylase; AD; Alzheimer's disease; AICAR; aminoimidazole carboxamide riboside; AMPK; AMP-activated protein kinase; ALS; amyotrophic lateral sclerosis; ATM; ataxia telangiectasia mutated; CaMKII; Ca2 +/calmodulin-d

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

Research ReportOver-expression of the Sirt3 sirtuin Protects neuronally differentiated PC12 Cells from degeneration induced by oxidative stress and trophic withdrawal

Keywords: AMPK; AMP-activated protein kinase; AU; arbitrary units; GD; glucose deprivation; GFP; green fluorescent protein; HEK293; human embryonic kidney 293 cell line; LKB1; liver kinase B1; NGF; nerve growth factor; OGD; oxygen-glucose deprivation; PBS; phosph

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2014 سفارش ترجمه

mTOR signaling in tumorigenesis

Keywords: mTOR; the mechanistic target of rapamycin or the mammalian target of rapamycin; PIKK; phosphoinositide 3-kinase related protein kinase; ATM; ataxia-telangiectasia mutated; ATR; ataxia-telangiectasia and rad3-related; DNAPK; DNA-dependent protein kinase; R

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2014 سفارش ترجمه

Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway

Keywords: PI3K pathway; Targeted therapy; Predictive biomarkers; 4EBP1; 4E-binding protein 1; AKT; protein kinase-B; AMPK; AMP-activated protein kinase; COSMIC; Catalogue of Somatic Mutations in Cancer; eIF4E; eukaryotic initiation factor 4E; ERK; extracellular-sig

دانلود رایگان متن کامل مقاله ISI 56 صفحه سال انتشار : 2014 سفارش ترجمه

Structural insights into the activation of MST3 by MO25

Keywords: LB; Luria-Bertani; MST; mammalian sterile 20 (Ste20)-like kinase; MO25; mouse protein-25; PEI; polyethyleneimine; STRAD; STE20-related adapter protein; YSK1; yeast SPS/STE20-related kinase-1; Protein kinase; LKB1; Signal transduction; Protein structur

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Research ArticleInhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease

Keywords: PFT; pifithrin-α p-nitro; NAFLD; non-alcoholic fatty liver disease; HFD; high-fat diet; ALT; alanine aminotransferase; mCoA; malonyl-CoA; MLYCD; malonyl-CoA decarboxylase; LKB1; liver kinase B1; AMPK; 5′ adenosine monophosphate-activated protein kinase

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Increased dietary fat contributes to dysregulation of the LKB1/AMPK pathway and increased damage in a mouse model of early-stage ethanol-mediated steatosis

Keywords: ACC; acetyl CoA carboxylase; ALD; alcoholic liver disease; ALT; alanine aminotransferase; AMPK; AMP-activated protein kinase; ACLY; ATP citrate lyase; ChREBP; carbohydrate response element binding protein; CYP2E1; cytochrome p450 2E1; ELOVL5; fatty acid e

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders

Keywords: AGRP; agouti-related protein; AMPK; AMP-activated protein kinase; AP-1; activator protein-1; BCL10; B-cell lymphoma/leukemia-10; CIITA; class II, major histocompatibility complex, transactivator; DHA; docosahexaenoic acid; E2F1; transcription factor E2F1;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Galangin inhibits proliferation of HepG2 cells by activating AMPK via increasing the AMP/TAN ratio in a LKB1-independent manner

Keywords: Galangin; Autophagy; AMPK; LKB1; mTOR;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Crosstalk between apoptosis, necrosis and autophagy

Keywords: AIF; Apoptosis Inducing Factor; AMPK; Adenosine Monophosphate activated Kinase; APAF1; Apoptotic Protease Activating Factor 1; BCL-2; B-cell lymphoma 2; BCL-Xl; B-cell lymphoma extra large; BEC1; Beclin-1; BH; Bcl-2 homology; cIAP1; cellular inhibitor of

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Genetic and epigenetic alterations of the LKB1 gene and their associations with mutations in TP53 and EGFR pathway genes in Korean non-small cell lung cancers

Keywords: LKB1; Inactivation; Non-small cell lung cancer

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Acetylcholine-induced AMP-activated protein kinase activation attenuates vasoconstriction through an LKB1-dependent mechanism in rat aorta

Keywords: Acetylcholine (ACh); LKB1; AMPK; Vascular smooth muscle cell (VSMC)

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Targeting LKB1 signaling in cancer

Keywords: LKB1; Peutz–Jeghers syndrome; Sporadic cancer; Rapamycin; Metformin; mTOR

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2013 سفارش ترجمه

The nuclear protein Artemis promotes AMPK activation by stabilizing the LKB1-AMPK complex

Keywords: AMPK; LKB1; Artemis; Signal transduction;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Metformin-induced AMP-activated protein kinase activation regulates phenylephrine-mediated contraction of rat aorta

Keywords: Contraction; Metformin; AMPK; LKB1; MLCK; p-MLC; VSMC

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Metformin impairs the growth of liver kinase B1-intact cervical cancer cells

Keywords: Cervical cancer; Metformin; LKB1; AMPK

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Mitochondrial Ca2+ signals in autophagy

Keywords: mTOR; mammalian target of rapamycin; InsP3R; inositol 1,4,5-trisphosphate receptor; AMPK; adenosine monophosphate activated protein kinase; mTORC1; mammalian target of rapamycin complex 1; GAP; GTPase activating protein; TSC1/TSC2; tuberous sclerosis comp

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

RAGE signaling mediates post-injury arterial neointima formation by suppression of liver kinase B1 and AMPK activity

Keywords: RAGE; AMPK; LKB1; Arterial restenosis; Neointimal hyperplasia;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

14-3-3 Interacts with LKB1 via recognizing phosphorylated threonine 336 residue and suppresses LKB1 kinase function

Keywords: LKB1; 14-3-3; AMPK; Kinase function; Phosphorylation;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

The role of pseudokinases in cancer

Keywords: ALL; Acute Lymphoblastic Leukaemia; AML; Acute Myeloid Leukaemia; AMPK; 5′-Adenosine Monophosphate Activated Protein Kinase; ATF4; Activating Transcriptional Factor 4; ATP; Adenosine-5′-Triphosphate; BTICs; Brain Tumour-Initiating Cells; C/EBPα; CCAA

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Regulation of NAD(P)H oxidases by AMPK in cardiovascular systems

Keywords: 7-KC; 7-ketocholesterol; AAA; abdominal aortic aneurysm; AICAR; 5′-aminoimidazole-4-carboxamide ribonucleoside; AMPK; adenosine monophosphate-activated protein kinase; AngII; angiotensin II; ApoE; apolipoprotein E; BH4; 5,6,7,8-tetrahydrobiopterin; CaMK

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

Potent vasodilation effect of amurensin G is mediated through the phosphorylation of endothelial nitric oxide synthase

Keywords: ACC; acetyl-CoA carboxylase; ACh; acetylcholine; AICAR; 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside; AMPK; adenosine 5′-monophosphate-activated protein kinase; CA-AMPK; constitutive active AMPK; CaMK II; calmodulin-dependent protein kinase II;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه

Oncogenic Pathways, Molecularly Targeted Therapies, and Highlighted Clinical Trials in Non–Small-Cell Lung Cancer (NSCLC)

Keywords: MET; EGFR; EML4-ALK; IGF-1R; KRAS; LKB1; Lung cancer; PI3K; Targeted therapies

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2012 سفارش ترجمه