Keywords: μm; micrometer; °C; degree Celsius; Ac; acetone; AcN; acetonitrile; AUC; area under curve; BCS; Biopharmaceutics Classification System; CC; calibration curve; CFR; CO2 flow rate; cm; centimeter; Cmax; maximum plasma concentration; CO2; carbon dioxide; C
مقالات ISI (ترجمه نشده)
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A validated LC-MS/MS method for simultaneous determination of linagliptin and metformin in spiked human plasma coupled with solid phase extraction: Application to a pharmacokinetic study in healthy volunteers
Keywords: ALG; alogliptin; AUC0-t and AUC0-â; the areas under the plasma concentration-time curve; Cmax; maximum plasma concentration; DPP-IV; dipeptidyl peptidase; ER; extraction recovery; GIP; glucose-dependent insulinotropic polypeptide; GLP 1; glucagon-
Quantitative analysis of the cyclic peptide GG-8-6 in rat plasma using LC-MS/MS and its application to a pharmacokinetic study
Keywords: LC-MS/MS; liquid chromatographic method with tandem mass spectrometric detection; HCC; hepatocellular carcinoma; GG-8-6; cyclo-(Val1-Leu2-Pro3-Ile4-Leu5-Leu6-Leu7-Val8-Leu9); UV; ultraviolet; IS; internal standard; A6; cyclo-(Val1-Leu2-Pro3-Ala4-Leu5-Leu6
A rapid and simple HPLC-MS/MS method for the simultaneous quantification of valproic acid and its five metabolites in human plasma and application to study pharmacokinetic interaction in Chinese epilepsy patients
Keywords: VPA; valproic acid; UGT; uridine diphosphate glucuronosyltransferases; HPLC; MS/MS high performance liquid chromatography tandem mass spectrometry; HPLC; high-performance liquid chromatography; GC-MS; gas chromatograph tandem mass spectrometry; SRM; sel
Effect of Tinospora cordifolia aqua-alcoholic extract on pharmacokinetic of Glibenclamide in rat: An herb-drug interaction study
Keywords: TC; Tinospora cordifolia; TCE; Tinospora cordifolia extract; CYP; Cytochrome P450; CAM; complementary and alternative medicine; IS; internal standard; LLOQ-QC; quality control sample at lowest limit of quantification level; LQC; low quality control sample
Rapid determination of 3â², 4â²-dimethoxy flavonol-3-β-d-glucopyranoside in rat plasma by LC-MS/MS method followed by protein precipitation
Keywords: LC-MS/MS; liquid chromatography/tandem mass spectrometry; LLOQ; lower limit of quantification; IS; internal standard; QC; quality control; DF3G; 3â²,4â²-dimethoxy flavonol-3-β-d-glucopyranoside; HPLC; high performance liquid chromatography; SD; standar
Identification of metabolites of MDR-1339, an inhibitor of β-amyloid protein aggregation, and kinetic characterization of the major metabolites in rats
Keywords: AD; alzheimer's disease; AUCINF; area under the concentration time curve from time zero to the last sampling time plus the extrapolated area (i.e., the last concentration divided by the elimination rate constant); AUClast; area under the concentration t
Simultaneous determination of acetaminophen and oxycodone in human plasma by LC-MS/MS and its application to a pharmacokinetic study
Keywords: LLOQ; lower limit of quantification; LQC; low quality control; MQC; middle quality control; HQC; high quality control; Acetaminophen; Oxycodone; LC-MS/MS; Human plasma; Pharmacokinetics;
Brain disposition, metabolism and behavioral effects of the synthetic opioid AH-7921 in rats
Keywords: AH-7921; Analgesia; Metabolism; Pharmacokinetics; Rewarding effect; 2-Prop; iso-propylic alcohol; ACN; acetronitrile; ANOVA; analysis of variance; AUC; area under the curve; BBB; blood-brain-barrier; CID; collision-induced dissociation; Cmax; peak concent
A dried blood spot assay with UPLC-MS/MS for the simultaneous determination of E6005, a phosphodiesterase 4 inhibitor, and its metabolite in human blood
Keywords: B/P; blood to-plasma ratio; DBS; dried blood spot; HQC; high QC; IS; internal standard; LLOQ; lower limit of quantification; LQC; low QC; MQC; middle QC; QC; quality control; RE; relative error; RSD; relative standard deviation; ULOQ; upper limit of quant
Pharmacokinetic profile of cefbuperazone in healthy Chinese volunteers after single and multiple drip intravenous infusion by HPLC-MS/MS
Keywords: IS; internal standard; LLOQ; lower limit of quantification; ULOQ; upper limit of quantification; LQC; low quality control; HQC; high quality control; RSD; relative standard deviation; Cefbuperazone; HPLC-MS/MS; Pharmacokinetic; Excretion;
A highly sensitive LC-MS/MS method for determination of ketoconazole in human plasma: Application to a clinical study of the exposure to ketoconazole in patients after topical administration
Keywords: LLOQ; lower limit of quantification; IS; internal standard; QC; quality control; LQC; low QC; MQC; medium QC; HQC; high QC; MRM; multiple reaction monitoring; RE; relative error; RSD; relative standard deviation; LC-MS/MS; Ketoconazole; Systemic exposur
Tandem mass spectrometry multiplex analysis of methylated and non-methylated urinary Gb3 isoforms in Fabry disease patients
Keywords: OMIM; Online Mendelian Inheritance in Man; α-GAL A; α-galactosidase A; ERT; enzyme replacement therapy; CFDI; Canadian Fabry Disease Initiative; Gb3 or GL-3; globotriaosylceramide; CTH; ceramide trihexoside; Ga2; galabiosylceramide; CDH; ceramide dihexo
A LC-MS/MS method for the determination of stachyose in rat plasma and its application to a pharmacokinetic study
Keywords: HPLC; high performance liquid chromatography; HPLC-RID; high performance liquid chromatography with refractive index detector; HPLC-ELSD; high performance liquid chromatography with evaporative light scattering detector; LC-MS; liquid chromatograph-mass
Development of a validated LC-APCI-MS/MS method to study the plasma and tumor distribution of CHO-PTX intravenous lipid emulsion
Keywords: CHO-PTX; paclitaxel-2â²-carbonyl-cholesterol; DTX; docetaxel; IS; internal standard; ESI; electrospray ionization; MRM; multiple reaction monitoring; MTBE; methyl tert-butyl ether; LC-APCI-MS/MS; liquid chromatography atmospheric-pressure chemical ioni
High-performance liquid chromatography-tandem mass spectrometry method for the determination of perampanel, a novel α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist in human plasma
Keywords: AED; anti-epileptic drugs; AMPA; α-amin-3-hydroxyl-5methyl-4isoxazolepropionic acid; AUC; area under the plasma concentration-time curve; AUC0-inf; AUC extrapolated to infinity; AUC0-last; AUC to the last time points; AUMC; area under the first mom
Detection of drug specific circulating immune complexes from in vivo cynomolgus monkey serum samples
Keywords: ADA; anti-drug antibody; ALT; alanine aminotransferase; AST; aspartate aminotransferase; BSA; bovine serum albumin; BUN; blood urea nitrogen; CP; cut point; CREA; creatinine; FcγR; Fc-gamma receptor; HQC; high quality control sample; HPLC; high pressure
Bioanalytical method for the simultaneous determination of d- and l-serine in human plasma by LC/MS/MS
Keywords: d- and l-serine; Bioanalytical method; LC/MS/MS; Biomarker; Surrogate matrix; Enantiomer separation; NMDA; N-methyl-d-aspartate; GC; gas chromatography; MS; mass spectrometry; HPLC; high-performance liquid chromatography; OPA; o-phthaldialdehyde; LC; liqu
Bioanalytical method for evaluating the pharmacokinetics of the GCP-II inhibitor 2-phosphonomethyl pentanedioic acid (2-PMPA)
Keywords: GCP-II; glutamate carboxypeptidase-II; PSMA; prostate specific membrane antigen; NAALADase; N-acetylated-alpha-linked acidic dipeptidase; NAAG; N-acetyl-aspartyl glutamate; 2-PMPA; 2-phosphonomethyl pentanedioic acid; 2-PMSA; 2-phosphonomethyl succinic ac
Fast LC-MS/MS analysis of free oxysterols derived from reactive oxygen species in human plasma and carotid plaque
Keywords: LC-MS/MS; liquid chromatography tandem mass spectrometry; ROS; reactive oxygen species; 7-α/β-OHC; 7-α- and 7-β-hydroxycholesterol; 7-KC; 7-ketocholesterol; 5,6-α-EC; 5,6-α-epoxycholesterol; 5,6-β-EC; 5,6-β-epoxycholesterol; Triol; cholestane-3Î
Liquid chromatography-mass spectrometry (LC-MS) of steroid hormone metabolites and its applications
Keywords: 3α-Diol-17G; 3α-hydroxy-5α-androstane-17β-glucuronide; 3β-Diol-17G; 3β-hydroxy-5α-androstane-17β-glucuronide; 3α-Diol-17S; 3α-hydroxy-5α-androstane-17β-sulfate; 3β-Diol-17S; 3β-hydroxy-5α-androstane-17β-sulfate; DHT; dihydrotestosterone; D