Development of a validated LC-APCI-MS/MS method to study the plasma and tumor distribution of CHO-PTX intravenous lipid emulsion

Plasma and tumor CHO-PTX levels and the radio of CHO-PTX concentration in tumor/plasma at 0.25, 3, 24, and 120 h after a single intravenous administration of CHO-PTX lipid emulsions at a dose equivalent to 20  mg/kg paclitaxel to mice with MDA-MB-231 human breast tumor xenografts. Each point represents the mean ± SD (n = 5).