دانلود مقالات ISI درباره Uloq + ترجمه فارسی

اعتبار سنجی روش اسپکترومتری جرم کروماتوگرافی مایع سریع و سریع برای اندازه گیری همزمان 40 داروهای ضد افسردگی یا متابولیت های آنها در پلاسما

Validation of a simple, fast liquid chromatography-tandem mass spectrometry method for the simultaneous quantification of 40 antidepressant drugs or their metabolites in plasma

Keywords: ACN; acetonitrile; AD; antidepressant; AP; antipsychotic; CAL; calibration; R2; coefficient of determination; CV; coefficient of variation; CE; collision energy; cpd; compound of interest; CI; confidence interval; dMRM; dynamic multiple reaction mode; ESI

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2018 سفارش ترجمه

توسعه و اعتبار سنجی طیف سنجی جرمی کروماتوگرافی-دو بعدی برای اندازه گیری لوربینکتینین در پلاسما و ادرار انسان

Development and validation of a liquid chromatography-tandem mass spectrometry assay for the quantification of lurbinectedin in human plasma and urine

Keywords: CV; coefficient of variation; CS; calibration standard; DMSO; dimethylsulfoxide; EMA; European Medicine Agency; FDA; Food and Drug Administration; GCP; Good Clinical Practice; GLP; Good Laboratory Practice; IS; internal standard; K3EDTA; tripotassium ethy

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2018 سفارش ترجمه

مدیریت چرخه زندگی از روش های تحلیلی

Life cycle management of analytical methods

Keywords: AMMS; accurate mass spectrometry; AQbD; analytical quality-by-design; ASME; American Society of Mechanical Engineers; ATP; analytical target profile; CQA; critical quality attributes; DoE; design of experiments; DQ; design qualification; DS; design space;

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2018 سفارش ترجمه

الگوریتم مونتاژ دوم برای تعیین مقدار هموگلوبین آزاد در پلاسمای انسانی

A second-derivate fitting algorithm for the quantification of free hemoglobin in human plasma

Keywords: fHb; free hemoglobin; EMA; European Medicines Agency; HEBI-Fit; Hemoglobin Bilirubin Fit; QC; Quality control; CV; Coefficient of variation; LLOQ; Lower limit of quantification; ULOQ; Upper limit of quantification;

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2018 سفارش ترجمه

تعیین مهار کننده های ترانس کپینتاز معکوس نوکلئوزیدی / تودیکال در مایعات پلاسما و مغز و نخاع توسط کروماتوگرافی مایع فوق العاده با فشار بالا همراه با طیف سنجی جرمی دو طرفه

Determination of nucleosidic/tidic reverse transcriptase inhibitors in plasma and cerebrospinal fluid by ultra-high-pressure liquid chromatography coupled with tandem mass spectrometry

Keywords: 3TC; lamivudine; ABC; abacavir; ACN; acetonitrile; aCSF; artificial cerebrospinal fluid; CNS; central nervous system; CSF; cerebrospinal fluid; ER; extraction recovery; ESI; electrospray ionization; FA; formic acid; FTC; emtricitabine; FWHM; full width at

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2018 سفارش ترجمه

Lipidomics by ultrahigh performance liquid chromatography-high resolution mass spectrometry and its application to complex biological samples

Keywords: Cer; ceramide; CL; cardiolipin; DG; diacylglycerol; EIC; extracted ion chromatogram; FTICR; fourier transform ion cyclotron resonance; FWHM; full width half maximum; HexCer; hexosyl ceramide; HPLC; high performance liquid chromatography; LC/MS; liquid chr

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

غربالگری سمی شناختی نیمه رسمی اتوماتیک در سه ماتریس بیولوژیکی با استفاده از کروماتوگرافی گردش جوی / طیف سنجی جرمی با وضوح بالا

Fully automated semi-quantitative toxicological screening in three biological matrices using turbulent flow chromatography/high resolution mass spectrometry

Keywords: COFRAC; French Accreditation Committee; LC-DAD; liquid chromatography-diode array detector; GC-MS; gas chromatography-mass spectrometry; LC-MS; liquid chromatography-mass spectrometry; HRMS; high resolution mass spectrometry; THC-COOH; 11-Nor-9-ca

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2016 سفارش ترجمه

اندازه گیری غلظت کل و آزاد داکتاکسل در پلاسمای انسانی با استفاده از اسپکترومتری جرمی کروماتوگرافی مایع

Measurement of total and free docetaxel concentration in human plasma by ultra-performance liquid chromatography-tandem mass spectrometry

Keywords: DCX; docetaxel; PK; phamacokinetic; PD; pharmacodynamic; HPLC; high-performance liquid chromatography; UV; ultraviolet; MS/MS; tandem mass spectrometry; UPLC; ultra-performance liquid chromatography; MTBE; methyl t-butyl ether; LC; liquid chromatography;

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2016 سفارش ترجمه

ارزیابی غیر مستقیم آنتی بادی های ضد عفونی خنثی با استفاده از داده های آزمایش های فارماکوکینتیک

Indirect assessment of neutralizing anti-drug antibodies utilizing pharmacokinetic assay data

Keywords: ADA; anti-drug antibody; ACP; assay cutpoint; CDM; compact disc microstructures; CDR; complementary determining region; Fc; Fragment crystallizable; F/T; ratio of free to total drug concentrations; iNAb; indirect NAb assessment; LLRD; lower limit of relia

دانلود رایگان متن کامل مقاله ISI 49 صفحه سال انتشار : 2016 سفارش ترجمه

اندازه گیری همزمان دو آلکالوئید کانتینونی پیکاسما کواسیوئید در پلاسما موش با اسپکترومتری جرمی کروماتوگرافی مایع و کاربرد آن در مطالعه فارماکوکینتیک موش

Simultaneous quantification of two canthinone alkaloids of Picrasma quassioides in rat plasma by liquid chromatography-tandem mass spectrometry and its application to a rat pharmacokinetic study

Keywords: CID; collision-induced dissociation; FDA; Food and Drug Administration; IS; internal standard; LLOQ; lower limit of quantification; MRM; multiple reaction monitoring; QC; quality control; RE; relative error; RSD; relative standard deviation; SRM; selected

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2015 سفارش ترجمه

تعیین کروماتوگرافی مایع با عملکرد بالا پرولیفلوکساسین و پنج ناخالصی مرتبط در فرمولاسیون دارویی

High performance liquid chromatography determination of prulifloxacin and five related impurities in pharmaceutical formulations

Keywords: CV; coefficient of variation; LOD; limit of detection; LOQ; limit of quantification; QC; quality control; ULOQ; upper limit of quantification; HPLC-UV/vis; Method development; Prulifloxacin; Ulifloxacin; Synthetic process impurities;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Supercritical fluid extraction (SFE) of ketamine metabolites from dried urine and on-line quantification by supercritical fluid chromatography and single mass detection (on-line SFE-SFC-MS)

Keywords: CYP; cytochrome P450; DHK; dehydronorketamine; KET; ketamine; NK; norketamine; KET-d4; ketamine-d4; HNK; hydroxynorketamine; SFE; supercritical fluid extraction; SFC-MS; supercritical fluid chromatography single quadrupole mass spectrometry; LC-MS/MS;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2018 سفارش ترجمه

Extractability-mediated stability bias and hematocrit impact: High extraction recovery is critical to feasibility of volumetric adsorptive microsampling (VAMS) in regulated bioanalysis

Keywords: VAMS; volumetric absorptive microsampling; Ht; hematocrit; LLE; liquid-liquid extraction; GLP; good laboratory practice; LC-MS/MS; liquid chromatography coupled with triple quadrupole mass spectrometry; LLOQ; lower limit of quantification; ULOQ; upper

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

Determination of 12 commonly found compounds in DUID cases in whole blood using fully automated supported liquid extraction and UHPLC-MS/MS

Keywords: DUID; driving under influence of drugs; UHPLC-MS/MS; ultra high performance liquid chromatography-tandem mass spectrometry; SLE; supported liquid extraction; IS; internal standard; QC; quality control; ESI; electrospray ionization; R2; the coefficient of

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2018 سفارش ترجمه

A rapid, simple, and high-throughput UPLC-MS/MS method for simultaneous determination of bioactive constituents in Salvia miltiorrhiza with positive/negative ionization switching

Keywords: CV; coefficient of variance; ESI; electrospray ionization; LC; liquid chromatography; LOQ; limit of quantification; LOD; limit of detection; LLOQ; lower limit of quantification; MRM; multiple reaction monitoring; MS; mass spectrometer; MS/MS; tandem mass

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2018 سفارش ترجمه

Development and validation of a sensitive and rapid UHPLC-MS/MS method for the simultaneous quantification of the common active and inactive metabolites of vicagrel and clopidogrel in human plasma

Keywords: AUC; area under the concentration-time curve; Cmax; maximum plasma concentration; EDTA; ethylenediaminetetraacetic acid; EMA; European Medicines Agency; ESI; electrospray ionization; H1, H2, H3, H4; the thiol metabolite isomers of clopidogrel; HPLC; hig

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2018 سفارش ترجمه

Brain disposition, metabolism and behavioral effects of the synthetic opioid AH-7921 in rats

Keywords: AH-7921; Analgesia; Metabolism; Pharmacokinetics; Rewarding effect; 2-Prop; iso-propylic alcohol; ACN; acetronitrile; ANOVA; analysis of variance; AUC; area under the curve; BBB; blood-brain-barrier; CID; collision-induced dissociation; Cmax; peak concent

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2018 سفارش ترجمه

A dried blood spot assay with UPLC-MS/MS for the simultaneous determination of E6005, a phosphodiesterase 4 inhibitor, and its metabolite in human blood

Keywords: B/P; blood to-plasma ratio; DBS; dried blood spot; HQC; high QC; IS; internal standard; LLOQ; lower limit of quantification; LQC; low QC; MQC; middle QC; QC; quality control; RE; relative error; RSD; relative standard deviation; ULOQ; upper limit of quant

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2018 سفارش ترجمه

Selective and accurate C5 acylcarnitine quantitation by UHPLC-MS/MS: Distinguishing true isovaleric acidemia from pivalate derived interference

Keywords: IVA; isovaleric acidemia; SCADD; short chain acyl-CoA dehydrogenase deficiency; GAI; glutaric acidemia type I; SCX; strong cation exchange; SPE; solid-phase extraction; LLOQ; lower limit of quantitation; ULOQ; upper limit of quantitation; CAP; College of

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Development and validation of an ELISA method for the quantification of nivolumab in plasma from non-small-cell lung cancer patients

Keywords: ALP; Alkaline Phosphatase; ALT; alanine transaminase; AST; aspartate aminotransferase; BSA; Bovine Serum Albumin; CRP; C-Reactive Protein; CV; Coefficient of Variation; ECOG; Eastern Cooperative Oncology Group; EMA; European Medicines Agency; FDA; Food an

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Quantification of IDP-73152, a novel antibiotic, in plasma from mice, rats and humans using an ultra-high performance liquid chromatography/tandem mass spectrometry method for use in pharmacokinetic studies

Keywords: AUC0→24; area under the curve from time zero to 24 h; AUC0→∞; area under the curve from time zero to infinity; AUMC0→∞; the area under the first moment curve from time zero to infinity; CL; clearance; Cmax; maximum concentration; IS; internal s

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

A new fluorescence-based method for characterizing in vitro aerosol exposure systems

Keywords: CMAG; condensation monodisperse aerosol generator; DSF; disodium fluorescein; VC24/48; Vitrocell® 24/48 aerosol exposure system; PBS; phosphate buffered saline; PM; particulate matter; GVP; gas-vapor phase; APS; aerodynamic particle sizer; e-cigarettes;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Sex-specific and inter-individual differences in biomarkers of selenium status identified by a calibrated ELISA for selenoprotein P

Keywords: Ab; antibody; CV; coefficient of variation; ELISA; enzyme-linked immunosorbent assay; GPX3; glutathione peroxidase 3; LLOQ; lower limit of quantification; LOD; limit of detection; LRP; lipoprotein receptor-related protein; mAb; monoclonal antibody; pAb; p

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Inter-laboratory skin distribution study of 4-n-butyl resorcinol: The importance of liquid chromatography/mass spectrometry (HPLC-MS/MS) bioanalytical validation

Keywords: ACN; acetonitrile; AD; applied dose; APCI; atmospheric pressure chemical ionization; De; dermis; Ep; epidermis; ER; extraction recovery; ESI; electrospray ionization; FA; formic acid; IS; internal standard; LC; liquid chromatography; LLOQ; lower limit of

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2017 سفارش ترجمه

Simultaneous quantification of estrogens, their precursors and conjugated metabolites in human breast cancer cells by LC-HRMS without derivatization

Keywords: 3β-HSD; 3β-hydroxysteroiddehydrogenase; 17β-HSD; 17β-hydroxysteroiddehydrogenase; AD; androstenedione; DHEA; dehydroepiandrosterone; DHEA-S; dehydroepiandrosterone-3-sulfate; DMEM; Dulbecco's Modified Eagle Medium F-12; DMSO; dimethylsulfoxide; DPBS;

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2017 سفارش ترجمه

Andrographolide-loaded nanoparticles for brain delivery: Formulation, characterisation and in vitro permeability using hCMEC/D3 cell line

Keywords: AG; andrographolide; ATM; adsorptive-mediated transcytosis; BBB; blood-brain barrier; BSA; bovine serum albumin; CNS; central nervous system; DLS; Dynamic Light Scattering; DMSO; dimethyl sulfoxide; ECA; ethylcyanoacrylate; EE; encapsulation efficiency; E

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2017 سفارش ترجمه

Chemistry and analysis of HNE and other prominent carbonyl-containing lipid oxidation compounds

Keywords: Acr-dG; 1,N2-propanodeoxyguanosine; AGEs; advanced glycation end-product; ALEs; advanced lipoxidation end product; ApoB100; apolipoprotein B100; ApoE; apolipoprotein E; ARP; aldehyde reactive probe; AspN; endoproteinase AspN (flavastacin); βLG; β-lactog

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2017 سفارش ترجمه

Pharmacokinetic profile of cefbuperazone in healthy Chinese volunteers after single and multiple drip intravenous infusion by HPLC-MS/MS

Keywords: IS; internal standard; LLOQ; lower limit of quantification; ULOQ; upper limit of quantification; LQC; low quality control; HQC; high quality control; RSD; relative standard deviation; Cefbuperazone; HPLC-MS/MS; Pharmacokinetic; Excretion;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Validation of UHPLC-MS/MS methods for the determination of kaempferol and its metabolite 4-hydroxyphenyl acetic acid, and application to in vitro blood-brain barrier and intestinal drug permeability studies

Keywords: 4-HPAA; 4-hydroxyphenyl acetic acid; ACN; acetonitrile; BSA; bovine serum albumin; Cal; calibrator; CCl; cell layer capacitance; CNS; central nervous system; CV%; coefficient of variation; CPT-cAMP; 8-(4-chlorophenylthio)-adenosine-3′,5′-cyclic monoph

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Development of a validated LC-APCI-MS/MS method to study the plasma and tumor distribution of CHO-PTX intravenous lipid emulsion

Keywords: CHO-PTX; paclitaxel-2′-carbonyl-cholesterol; DTX; docetaxel; IS; internal standard; ESI; electrospray ionization; MRM; multiple reaction monitoring; MTBE; methyl tert-butyl ether; LC-APCI-MS/MS; liquid chromatography atmospheric-pressure chemical ioni

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2016 سفارش ترجمه

An UPLC-MS/MS method coupled with automated on-line SPE for quantification of tacrolimus in peripheral blood mononuclear cells

Keywords: TAC; tacrolimus; TDM; therapeutic drug monitoring; MS; mass; MS/MS; tandem mass; UPLC; ultra performance liquid chromatography; HPLC; high performance liquid chromatography; LC; liquid; ESI+; positive electrospray ionization; PBMC; peripheral blood mononu

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

High-performance liquid chromatography-tandem mass spectrometry method for the determination of perampanel, a novel α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist in human plasma

Keywords: AED; anti-epileptic drugs; AMPA; α-amin-3-hydroxyl-5methyl-4isoxazolepropionic acid; AUC; area under the plasma concentration-time curve; AUC0-inf; AUC extrapolated to infinity; AUC0-last; AUC to the last time points; AUMC; area under the first mom

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Praziquantel efficacy against Brachylaima sp. metacercariae (Trematoda: Brachylaimidae) parasitizing the edible landsnail Cornu aspersum and its HPLC-MS/MS residue determination

Keywords: Brachylaima; Cornu aspersum; Praziquantel; Efficacy; HPLC-MS/MS; Brachylaimiasis; ADI; acceptable daily intake; CI; confidence intervals; CV; coefficient of variation; CVMP; Committee for Veterinary Medicinal Products; EMA; European Medicines Agency; HPLC

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Determination of asperosaponin VI and its active metabolite hederagenin in rat tissues by LC-MS/MS: Application to a tissue distribution study

Keywords: Asperosaponin VI; Hederagenin; LC-MS/MS; Tissue distribution; A-VI; asperosaponin VI; HG; hederagenin; IS; internal standard; MRM; multiple reaction monitoring; ESI; electrospray ionization; LLOQ; lower limit of quantification; GI; gastrointestinal; ME;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Clinical implications of correlation between peripheral eosinophil count and serum levels of IL-5 and tryptase in acute eosinophilic pneumonia

Keywords: Acute eosinophilic pneumonia; Interleukin-5; Peripheral eosinophil count; Tryptase; AEP; acute eosinophilic pneumonia; BAL; bronchoalveolar lavage; CRP; C-reactive protein; CT; computed tomography; FiO2; fraction of inspired oxygen; Ig; immunoglobulin; IL

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

The development and validation of an immunoassay for the measurement of anti-thymidine phosphorylase antibodies in mouse and dog sera

Keywords: Anti-TP; anti-thymidine phosphorylase; CF; correction factor; CV; coefficient of variation; ECL; electrochemiluminescent; EE-TP; erythrocyte encapsulated thymidine phosphorylase; EMA; European Medicines Agency; FDA; Food and Drug Administration; GLP; Good

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

KOMA: ELISA-microarray calibration and data analysis based on kinetic signal amplification

Keywords: KOMA; Kinetic Operating Microarray Analyzer; ELISA; enzyme-linked immunosorbent assay; FDA; Food and Drug Administration; EDTA; Ethylenediaminetetraacetic acid; TMB; 3,3′,5,5′-tetramethylbenzidine; ATCC; American Type Culture Collection; DMEM; Dulbecc

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Identification and assay of 3′-O-methyltaxifolin by UPLC-MS in rat plasma

Keywords: 3′-O-MTAX; 3′-O-methyltaxifolin; LLOQ; lower limit of quantification; ULOQ; upper limit of quantification; LOD; the limit of detection; RSD; relative standard deviation; IS; internal standard; DMEM; Dulbecco's modified eagle's medium; ESI−; negative

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

A whole blood in vitro cytokine release assay with aqueous monoclonal antibody presentation for the prediction of therapeutic protein induced cytokine release syndrome in humans

Keywords: CD; cluster of differentiation; Cs; calibrator samples; CV; coefficient of variation; Fc; fragment crystallizable; IFN; interferon; IL; interleukin; LLOQ; lower limit of quantification; mAb; monoclonal antibody; MSD; Meso Scale Discovery; PBMCs; periphera

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

A highly sensitive and robust UPLC-MS with electrospray ionization method for quantitation of taxifolin in rat plasma

Keywords: LLOQ; lower limit of quantification; ULOQ; upper limit of quantification; LOD; the limit of detection; IS; internal standard; ESI−; negative-ion electron spectroscopic imaging; SIR; selected ion recording; MRM; multiple reaction monitoring; QC; quality

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه