Alleviation of severe inflammatory responses in LPS-exposed mice by Schisantherin A
Keywords: MAPK ها; Schisantherin A; LPS; ALI; MAPKs; NF-κB
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Exposure to ethanol and nicotine induces stress responses in human placental BeWo cells
Keywords: MAPK ها; Human trophoblastic cells; ER-stress; GRP78/BiP; MAPKs; ROS; Placental toxicity;
Molecular characterization and immunomodulatory activity of sulfated fucans from Agarum cribrosum
Keywords: MAPK ها; NO; nitric oxide; iNOS; inducible NO synthase; TNF-α; tumor necrosis factor-α; COX-2; cyclooxygenase-2; IL; interleukin; NF-κB; nuclear factor-kappa B; MAPKs; mitogen-activated protein kinases; ERK; including extracellular signal-regulated kinases; JNK
Research ReportSer/thr phosphatases tonically attenuate the ERK-dependent pressor effect of ethanol in the rostral ventrolateral medulla in normotensive rats
Keywords: MAPK ها; BP; blood pressure; HR; heart rate; OKA; okadaic acid; ACSF; artificial cerebrospinal fluid; MAPKs; mitogen-activated protein kinases; ERK; extracellular signal-regulated kinase; RVLM; rostral ventrolateral medulla; SHRs; spontaneously hypertensive; WKY;
Extracellular polysaccharide from Bacillus sp. strain LBP32 prevents LPS-induced inflammation in RAW 264.7 macrophages by inhibiting NF-κB and MAPKs activation and ROS production
Keywords: MAPK ها; EPS; Inflammation; NF-κB; MAPKs; ASK1; ROS;
Toll-like receptor 4-mediated ROS signaling pathway involved in Ganoderma atrum polysaccharide-induced tumor necrosis factor-α secretion during macrophage activation
Keywords: MAPK ها; ATCC; American Type Culture Collection; CM-DCFH; carboxyl-DCFH; CR3; complement receptor 3; FBS; fetal bovine serum; HRP; horseradish peroxidase; IKK; IκB kinase; IRAK; interleukin-1 receptor associated kinase; LPS; lipopolysaccharide; MAPKs; mitogen-act
Ursolic acid protects mouse liver against CCl4-induced oxidative stress and inflammation by the MAPK/NF-κB pathway
Keywords: MAPK ها; COX-2; cyclooxygenase-2; CYP2E1; cytochrome P450 2E1; ERK; the extracellular-receptor kinases; IL-1β; interleukin-1beta; JNK; the c-Jun N-terminal kinases; NF-κB; nuclear factor-κB; MAPKs; mitogen-activated protein kinases; UA; ursolic acid; ROS; react
Gomisin A inhibits lipopolysaccharide-induced inflammatory responses in N9 microglia via blocking the NF-κB/MAPKs pathway
Keywords: MAPK ها; Gomisin A; Microglia; LPS; NF-κB; MAPKs; ROS;
Extracts of Actinidia arguta stems inhibited LPS-induced inflammatory responses through nuclear factor-κB pathway in Raw 264.7 cells
Keywords: MAPK ها; Stems of Actinidia arguta; Antiinflammation; NF-κB; MAPKs; Raw 264.7 cells; cDNA; complementray DNA; COX-2; cyclooxygease 2; DMEM; Dulbecco Modified Eagle Medium; ELISA; enzyme-linked immunosorbant assay; IL-6; interleukin 6; mRNA; messenger RNA; NF-κB;
Tussilagone inhibits dendritic cell functions via induction of heme oxygenase-1
Keywords: MAPK ها; Tussilagone; Dendritic cells; NF-κB; MAPKs; Heme oxygenase-1;
Ginsenoside Rg1 inhibits platelet activation and arterial thrombosis
Keywords: MAPK ها; COX; cyclooxygenase; CDDPs; Compound Danshen Dripping Pills; SAA; salvianolic acid A; PNS; panax notoginsenosides; Rg1; ginsenoside Rg1; PARs; proteinase-activated receptors; PLCβ; phospholipase C β; PKC; protein kinase C; MAPKs; mitogen-activated prote
Effects of peroxisome proliferator-activated receptor γ in simvastatin antiplatelet activity: Influences on cAMP and mitogen-activated protein kinases
Keywords: MAPK ها; PPARs; peroxisome proliferator-activated receptors; cAMP; cyclic adenosine monophosphate; VASP; vasodilator-stimulated phosphoprotein; MAPKs; mitogen-activated protein kinases; ERK; extracellular signal-regulated kinase; JNK; c-Jun N-terminal kinase; LDL;
A novel microRNA regulates osteoclast differentiation via targeting protein inhibitor of activated STAT3 (PIAS3)
Keywords: MAPK ها; miRNAs; microRNAs; PIAS3; protein inhibitor of activated STAT3; M-CSF; macrophage colony stimulating factor; RANKL; receptor activator of nuclear factor-κB ligand; RANK; receptor activator of NF-κB; OPG; osteoprotegerin; MAPKs; mitogen-activated protein
The phospholipase D pathway mediates the inflammatory response of the retinal pigment epithelium
Keywords: MAPK ها; ARPE-19 cells; Retinal pigment epithelium (RPE); Inflammation; Phospholipase D (PLD); Cyclooxygenase-2; AA; arachidonic acid; AMD; age-related macular degeneration; COX; cyclooxygenase; DAG; diacylglycerol; DR; diabetic retinopathy; EGFP; enhanced green f
The neuroprotective effects of cordycepin inhibit glutamate-induced oxidative and ER stress-associated apoptosis in hippocampal HT22 cells
Keywords: MAPK ها; Caffeine; adenosine A2A antagonist; CHOP; C/EBP homologous protein; DPCPX; 8-cyclopentyl-1,3-dipropylxanthine, adenosine A1 antagonist; Cor; cordycepin; ER; endoplasmic reticulum; Glu; glutamate; IRE1α; inositol-requiring enzyme 1α; MAPKs; mitogen-activ
Silencing of PKCη induces cycle arrest of EBV+ B lymphoma cells by upregulating expression of p38-MAPK/TAp73/GADD45α and increases susceptibility to chemotherapeutic agents
Keywords: MAPK ها; EBV; Epstein-Barr virus; MAPKs; mitogen-activated protein kinases; GADD45; growth arrest and DNA damage-inducible gene 45; TAp73; transcriptionally active p73; PKCη; p38-MAPK; TAp73; GADD45α; Cell cycle arrest; EBV+ lymphoma;
Redox regulation of MMP-3/TIMP-1 ratio in intestinal myofibroblasts: Effect of N-acetylcysteine and curcumin
Keywords: MAPK ها; MMPs; Matrix metalloproteinases; TIMPs; Tissue inhibitors of metalloproteinases; CD; Crohn׳s disease; ISEMFs; Intestinal subepithelial myofibroblasts; GSH; Glutathione; GSH/GSSG ratio; Glutathione/oxidized glutathione ratio; NAC; N-acetylcysteine; (TNF)Î
Mechanism of uptake of ZnO nanoparticles and inflammatory responses in macrophages require PI3K mediated MAPKs signaling
Keywords: MAPK ها; AFI; absolute fluorescence intensity; CR; complement receptors; DMSO; dimethyl sulphoxide; DLS; dynamic light scattering; ELISA; enzyme linked immunosorbent assay; FBS; fetal bovine serum; MR; mannose receptors; MAPKs; mitogen-activated protein kinases; P
Age-related activation of MKK/p38/NF-κB signaling pathway in lung: From mouse to human
Keywords: MAPK ها; ALI; acute lung injury; ANOVA; analysis of variance; BALF; bronchoalveolar lavage fluid; COPD; chronic obstructive pulmonary disease; DAB; 3, 3â²-diaminobenzidine tetrahydrochloride; DAPI; 4â², 6-diamidino-2-phenylindole; DMSO; dimethyl sulphoxide; ERKs
HIF-1α inhibition blocks the cross talk between multiple myeloma plasma cells and tumor microenvironment
Keywords: MAPK ها; HIF-1α; Multiple myeloma; Tumor microenvironment; Cell adhesion; MAPKs
Eupafolin inhibits PGE2 production and COX2 expression in LPS-stimulated human dermal fibroblasts by blocking JNK/AP-1 and Nox2/p47phox pathway
Keywords: MAPK ها; APO; apocynin; TLR; toll like receptor; COX-2; cyclooxygenase-2; Nox; NADPH oxidase; Tan; tanshinone; PGE; prostaglandin; LPS; lipopolysaccharide; MAPKs; mitogen-activated protein kinases; NAC; N-acetylcysteine; DCF-DA; dihydrodichlorofluorescein diacetat
Hypoxia inducible factor-1α mediates iron uptake which induces inflammatory response in amoeboid microglial cells in developing periventricular white matter through MAP kinase pathway
Keywords: MAPK ها; Hypoxia; Microglia; Iron; Cytokines; HIF-1α; MAPKs; Deferoxamine; KC7F2;
α-Dihydroxychalcone-glycoside (α-DHC) isolated from the heartwood of Pterocarpus marsupium inhibits LPS induced MAPK activation and up regulates HO-1 expression in murine RAW 264.7 macrophage
Keywords: MAPK ها; Phenolic glycosides; Antioxidants; Cytotoxicity; Inflammation; MAPKs; ARE regulated genes
NFAT as cancer target: Mission possible?
Keywords: MAPK ها; ADP; adenosine di-phosphate; AICD; activation-induced cell death; AKAP79; A-kinase anchor protein 79; Ang-2; angiopoietin-2; AP1; activator protein 1; ARRE-2; antigen receptor response element-2; BMP4; bone morphogenetic protein 4; CABIN1; calcineurin-bin
Pseudoginsenoside-F11 (PF11) exerts anti-neuroinflammatory effects on LPS-activated microglial cells by inhibiting TLR4-mediated TAK1/IKK/NF-κB, MAPKs and Akt signaling pathways
Keywords: MAPK ها; PF11; Microglia; TLR4; NF-κB; MAPKs; Akt; PF11; pseudoginsenoside-F11; COX-2; cyclooxygenase-2; iNOS; inducible nitric oxide synthase; IL; interleukin; PGE2; prostaglandin E2; LPS; lipopolysaccharide; MAPKs; mitogen-activated protein kinases; TLR4; toll-
Genetic deletion of MT1/MT2 melatonin receptors enhances murine cognitive and motor performance
Keywords: MAPK ها; aCSF; artificial cerebrospinal fluid; ADHD; attention deficit/hyperactivity disorder; ANOVA; analysis of variance; C3B6; mice with a combination C3H/He and C57BL/6 background; cDNA; complementary deoxyribonucleic acid; CAT; catalase; CREB; cAMP response e
Anti-inflammatory effects of trans-1,3-diphenyl-2,3-epoxypropane-1-one mediated by suppression of inflammatory mediators in LPS-stimulated RAW 264.7 macrophages
Keywords: MAPK ها; Trans-1,3-diphenyl-2,3-epoxypropan-1-one (DPEP); Anti-inflammatory; Macrophage; NF-κB; MAPKs;
Akebia saponin PA induces autophagic and apoptotic cell death in AGS human gastric cancer cells
Keywords: MAPK ها; Akebia saponin PA; Autophagy; Apoptosis; mTOR; MAPKs;
Ang II induces capillary formation from endothelial cells via the AT1R-dependent inositol requiring enzyme 1 pathway
Keywords: MAPK ها; Angiotension II; GRP78; IRE1; MAPKs; AT1 receptor; Angiogenesis;
Cerium oxide nanoparticles induce cytotoxicity in human hepatoma SMMC-7721 cells via oxidative stress and the activation of MAPK signaling pathways
Keywords: MAPK ها; CeO2 nanoparticles; Cytotoxicity; Oxidative stress; MAPKs;
Effects of Hominis placenta on LPS-induced cell toxicity in BV2 microglial cells
Keywords: MAPK ها; Hominis placenta (HP); Neuroinflammation; Microglial cells; MAPKs; LPS; HP; Hominis placenta; LPS; lipopolysaccharide; JNK; c-Jun N-terminal kinase; ERK; p42/44MAP kinase; iNOS; inducible NO synthase; COX2; cyclooxygenase 2;
Inhibitory effect of Coptis chinensis on inflammation in LPS-induced endotoxemia
Keywords: MAPK ها; Coptis chinensis; Lipopolysaccharide (LPS); IL-6; NF-κB; MAPKs;
PPARγ inhibits inflammation and RANKL expression in epoxy resin-based sealer-induced osteoblast precursor cells E1 cells
Keywords: MAPK ها; PPARγ; AH26; Anti-inflammation; MAPKs; NF-κB; RANKL;
Zinc chloride exposure increases heme oxygenase-1 expression in MDPC-23 odontoblast-like cells
Keywords: MAPK ها; Akt; amino kinase terminal; DMSO; dimethyl sulfoxide; ERK; extracellular signal-regulated protein kinase; HO-1; heme oxygenase-1; JNK; c-Jun NH2-terminal kinase; MAPKs; mitogen-activated protein kinases; MK-2; MAPK-activated protein kinase-2; NF-κB; nucl
Tyrosol exhibits negative regulatory effects on LPS response and endotoxemia
Keywords: MAPK ها; Tyrosol; Cytokines; Endotoxemia; TNF-α; NF-κB; MAPKs;
A polysaccharide isolated from Pueraria lobata enhances maturation of murine dendritic cells
Keywords: MAPK ها; Pueraria lobata; Dendritic cell maturation; MAPKs; NK-κB; TLR4;
Phillyrin attenuates LPS-induced pulmonary inflammation via suppression of MAPK and NF-κB activation in acute lung injury mice
Keywords: MAPK ها; Phillyrin; LPS; ALI; MAPKs; NF-κB;
The aerial part of Taraxacum coreanum extract has an anti-inflammatory effect on peritoneal macrophages in vitro and increases survival in a mouse model of septic shock
Keywords: MAPK ها; Taraxacum coreanum; Inflammation; iNOS; MAPKs; STAT1;
Bisabolangelone inhibits dendritic cell functions by blocking MAPK and NF-κB signaling
Keywords: MAPK ها; BISA; bisabolangelone; DCs; dendritic cells; ERK; extracellular signal-regulated kinase; IκB; inhibits NF-κB; JNK; C-Jun N-terminal kinase; MAPK; mitogen-activated protein kinase; Bisabolangelone; Dendritic cells; NF-κB; MAPKs;
Antitumor efficacy of piperine in the treatment of human HER2-overexpressing breast cancer cells
Keywords: MAPK ها; AKT; protein kinase B; FAS; fatty acid synthase; HER2; human epidermal growth factor receptor 2; MAPKs; mitogen-activated protein kinases; MMP-2/-9; matrix metalloproteinase (MMP)-2/-9; EGF; epidermal growth factor; PARP; poly-ADPribose polymerase; SREBP-
Research reportActivations of GABAergic signaling, HSP70 and MAPK cascades are involved in baicalin's neuroprotection against gerbil global ischemia/reperfusion injury
Keywords: MAPK ها; Baicalin; GABAergic signaling; HSP70; MAPKs; Global cerebral ischemia;
Bacillus amyloliquefaciens SC06 inhibits ETEC-induced pro-inflammatory responses by suppression of MAPK signaling pathways in IPEC-1 cells and diarrhea in weaned piglets
Keywords: MAPK ها; Ba; Bacillus amyloliquefaciens SC06; ETEC; Enterotoxigenic Escherichia coli; MAPKs; mitogen-activated protein kinases; IECs; intestinal epithelial cells; Probiotic Bacillus amyloliquefaciens SC06; Enterotoxigenic Escherichia coli; Pro-inflammatory respons
OSU-A9 inhibits angiogenesis in human umbilical vein endothelial cells via disrupting Akt-NF-κB and MAPK signaling pathways
Keywords: MAPK ها; NF-κB; nuclear factor-kappa B; VEGF; vascular endothelial growth factor; MMPs; matrix metalloproteinases; HUVECs; human umbilical vein endothelial cells; MAPKs; mitogen-activated protein kinases; EGM-2; Endothelial Cell Growth Medium-2; DMSO; dimethyl su
5-AIQ inhibits H2O2-induced apoptosis through reactive oxygen species scavenging and Akt/GSK-3β signaling pathway in H9c2 cardiomyocytes
Keywords: MAPK ها; CAT; catalase; DMEM; Dulbecco's modified Eagle's media; DMSO; dimethylsulfoxide; ERK; extracellular signal regulated kinase; FBS; fetal bovine serum; JNK; c-Jun N-terminal protein kinase; MAPKs; mitogen-activated protein kinases; MTT; 3-(4,5-dimethyl-2-th
Peroxiredoxin V selectively regulates IL-6 production by modulating the Jak2-Stat5 pathway
Keywords: MAPK ها; PrdxV; peroxiredoxin V; LPS; lipopolysaccaride; IL-6; interleukin 6; Jak2; janus kinase 2; Stat5; signal transducer and activator of transcription 5; SOCS1; suppressor of cytokine signaling 1; TNF-α; tumor necrosis factor α; IFN-β; interferon β; RANTE
Anti-inflammatory phenanthrene derivatives from stems of Dendrobium denneanum
Keywords: MAPK ها; Dendrobium denneanum; Orchidaceae phenanthrene; Anti-inflammatory activity; iNOS; NF-κB; MAPKs; Cytotoxic; RAW264.7 cell;
Neuroprotective changes of thalamic degeneration-related gene expression by acupuncture in an MPTP mouse model of parkinsonism: Microarray analysis
Keywords: MAPK ها; MPTP; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; PD; Parkinson's disease; DA; Dopamine; 6-OHDA; 6-Hydroxydopamine; TBS; Tris-buffered saline; TH; tyrosine hydroxylase; SDS-PAGE; sodium dodecyl sulfate-polyacrylamide gel electrophoresis; PVDF; polyvinyl
Oxidative stress induced by P2X7 receptor stimulation in murine macrophages is mediated by c-Src/Pyk2 and ERK1/2
Keywords: MAPK ها; P2X7R; P2X7 receptor channels; LPS; lipopolysaccharide; IL-1β; interleukin-1β; TNFα; tumor necrosis factor α; ROS; reactive oxygen species; JNK; c-Jun N-terminal kinase; ERK1/2; extracellular regulated kinases 1 and 2; MAPKs; mitogen-activated protein
The JNK/NFκB pathway is required to activate murine lymphocytes induced by a sulfated polysaccharide from Ecklonia cava
Keywords: MAPK ها; CFSE; carboxy fluorescein diacetate succinimidyl ester; Con A; concanavalin A; E. cava; Ecklonia cava; ERK; extracellular signal-regulated kinases; DMSO; dimethylsulfoxide; ELISA; enzyme linked immunosorbent assay; EMSA; electrophoretic mobility shift ass
Palmitic acid increases apoptosis of neural stem cells via activating c-Jun N-terminal kinase
Keywords: MAPK ها; BSA; bovine serum albumin; DAPI; 4â², 6-diamidino- 2-phenylindole; E13.5; embryonic day 13.5; ERK1/2; extracellular regulated protein kinase 1/2; FFAs; free fatty acids; GFAP; glial fibrillary acidic protein; JNK; c-Jun N-terminal kinase; MAP2; microtubu