دانلود مقالات ISI درباره ثبات متابولیک + ترجمه فارسی

Design, synthesis and biological evaluation of new hybrid anticonvulsants derived from N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide and 2-(2,5-dioxopyrrolidin-1-yl)butanamide derivatives

Keywords: ثبات متابولیک; Pyrrolidine-2,5-dione; Hybrid compounds; Anticonvulsant activity; In vivo studies; In vitro studies; Metabolic stability;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

1-Heteroaryl-3-phenoxypropan-2-ones as inhibitors of cytosolic phospholipase A2α and fatty acid amide hydrolase: Effect of the replacement of the ether oxygen with sulfur and nitrogen moieties on enzyme inhibition and metabolic stability

Keywords: ثبات متابولیک; Cytosolic phospholipase A2α; Fatty acid amide hydrolase; Indole-5-carboxylic acid; Benzotriazole; Inhibitors; Metabolic stability; Cytochrome P450; Carbonyl reductase; Short chain dehydrogenase/reductase; Aldo-keto reductase;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Blood-brain barrier permeable anticholinesterase aurones: Synthesis, structure-activity relationship, and drug-like properties

Keywords: ثبات متابولیک; Aurones; Acetylcholinesterase inhibitors; Structure-activity relationship; Blood-brain barrier permeability; Metabolic stability; Drug-like properties;

دانلود رایگان متن کامل مقاله ISI 109 صفحه سال انتشار : 2015 سفارش ترجمه

A novel proteolysis-resistant cyclic helix B peptide ameliorates kidney ischemia reperfusion injury

Keywords: ثبات متابولیک; Cyclic helix B peptide; Metabolic stability; Kidney ischemia reperfusion injury; Autophagy; Apoptosis; Inflammation

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Novel benzimidazole derivatives as phosphodiesterase 10A (PDE10A) inhibitors with improved metabolic stability

Keywords: ثبات متابولیک; PDE10A inhibitor; Schizophrenia; Benzimidazole; Imidazopyridine; Metabolic stability;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Coupling ultra-high-pressure liquid chromatography with mass spectrometry for in-vitro drug-metabolism studies

Keywords: ثبات متابولیک; ADC; Analog-to-digital converter; ADMET; Absorption, distribution, metabolism, excretion and toxicity; APCI; Atmospheric pressure chemical ionization; CYP; Cytochrome P450; DDI; Drug-drug interaction; DMPK; Drug metabolism and pharmacokinetics; DT; Dwell

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2014 سفارش ترجمه

Synthesis of acylated glycoconjugates as templates to investigate in vitro biopharmaceutical properties

Keywords: ثبات متابولیک; CuAAC; copper-catalysed azide-alkyne cycloaddition; CE; carboxylesterase; c log P; calculated Log P; HLMs; human liver microsomes; HSA; human serum albumin; CYP450; cytochrome P450; Carbohydrate; Prodrug; Esterase; Metabolic stability; Click chemistr

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Discovery and optimization of arylsulfonyl 3-(pyridin-2-yloxy)anilines as novel GPR119 agonists

Keywords: ثبات متابولیک; GPR119 agonist; Type 2 diabetes; Metabolic stability; SAR optimization;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Design and synthesis of 2-N-substituted indazolone derivatives as non-carboxylic acid glycogen synthase activators

Keywords: ثبات متابولیک; Glycogen synthase; Enzyme activation; Type 2 diabetes (T2D); Metabolic stability; Indazolone; N-arylation and cyclization;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Synthesis and in vitro evaluation of glycosyl derivatives of luteinizing hormone-releasing hormone (LHRH)

Keywords: ثبات متابولیک; Luteinizing hormone-releasing hormone; Carbohydrate moieties; Peptide modification; Permeability; Metabolic stability;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Identification of RC-33 as a potent and selective σ1 receptor agonist potentiating NGF-induced neurite outgrowth in PC12 cells. Part 2: g-Scale synthesis, physicochemical characterization and in vitro metabolic stability

Keywords: ثبات متابولیک; σ1 Agonist; In silico study; Synthetic scale-up; Physicochemical properties; Metabolic stability;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Design and synthesis of N-alkyldeoxynojirimycin derivatives with improved metabolic stability as inhibitors of BVDV and Tacaribe virus

Keywords: ثبات متابولیک; N-Alkyldeoxynojirimycin; Sulfonamide; Urea; Oxazolidinone; Metabolic stability; Antiviral; BVDV; Tacaribe;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Novel ureidopropanamide based N-formyl peptide receptor 2 (FPR2) agonists with potential application for central nervous system disorders characterized by neuroinflammation

Keywords: ثبات متابولیک; Formyl peptide receptor 2; Neuroinflammation; Ureidopropanamides; Microglia; Metabolic stability; Blood-brain barrier permeation; FPR2; Formyl peptide receptor 2; NO; nitric oxide; IL-1β; interleukin 1β; LPS; lipopolysaccharide; TNF-α; tumor necrosis f

دانلود رایگان متن کامل مقاله ISI 61 صفحه سال انتشار : 2017 سفارش ترجمه

Functionalized indoleamines as potent, drug-like inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt)

Keywords: ثبات متابولیک; Isoprenylcysteine carboxyl methyltransferase (Icmt) inhibitors; Indoleamines; Antiproliferative activity; Solubility; PAMPA permeability; Drug-like properties; Metabolic stability

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Design, synthesis and biological evaluation of 2-substituted quinolines as potential antileishmanial agents

Keywords: ثبات متابولیک; 2-Substituted quinolines; Antileishmanial activity; Luciferase assay; Liver microsomes; Metabolic stability

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

(4-Phenoxyphenyl)tetrazolecarboxamides and related compounds as dual inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL)

Keywords: ثبات متابولیک; Fatty acid amide hydrolase; Monoacylglycerol lipase; Inhibitors; Maleimides; Thiazolidinediones; Tetrazolecarboxamides; Metabolic stability

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Biologically active ester derivatives as potent inhibitors of the soluble epoxide hydrolase

Keywords: ثبات متابولیک; sEH; soluble epoxide hydrolase; EET; epoxyeicosatrienoic acid; EDCI; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide; DMAP; 4-dimethylaminopyridine; sEH; sEH inhibitors; Substituted urea-ester derivatives; Metabolic stability;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2012 سفارش ترجمه

Exploration of cathepsin S inhibitors characterized by a triazole P1-P2 amide replacement

Keywords: ثبات متابولیک; Cathepsin S; Reversible covalent inhibitors; Triazole; SAR; Metabolic stability;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Design, synthesis, and structure–activity relationships of novel spiro-piperidines as acetyl-CoA carboxylase inhibitors

Keywords: ثبات متابولیک; Acetyl-CoA carboxylase; ACC; Spiro-piperidine; Metabolic stability; Lipophilicity

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Potent and orally efficacious benzothiazole amides as TRPV1 antagonists

Keywords: ثبات متابولیک; TRPV1 antagonist; Benzothiazoles; Metabolic stability; In vivo pain models;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Discovery of novel and potent heterocyclic carboxylic acid derivatives as protein tyrosine phosphatase 1B inhibitors

Keywords: ثبات متابولیک; Protein tyrosine phosphatase 1B; Diabetes; Carboxylic acid; Heterocycle; Metabolic stability

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

In vitro stability and in vivo anti-inflammatory efficacy of synthetic jasmonates

Keywords: ثبات متابولیک; Methyl jasmonate analogs; Anti-inflammatory activity; Metabolic stability

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design

Keywords: ثبات متابولیک; Metabolic stability; Human liver microsomes; Human hepatocytes; Intrinsic clearance; Hepatic transporters; Drug discovery; ADME; Absorption, distribution, metabolism, and excretion; AO; Aldehyde oxidase; BCRP; Breast cancer resistance protein; CYP; Cytoch

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Exploring subtype selectivity and metabolic stability of a novel series of ligands for the benzodiazepine binding site of the GABAA receptor

Keywords: ثبات متابولیک; GABAA ligands; Subtype selectivity; Metabolic stability

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Synthesis and evaluation of pyridazinone–phenethylamine derivatives as selective and orally bioavailable histamine H3 receptor antagonists with robust wake-promoting activity

Keywords: ثبات متابولیک; H3R antagonists; Pyridazinone; (R)-2-Methylpyrrolidine; H3 receptor; Metabolic stability

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Discovery of potent, metabolically stable purine CRF-1 antagonists with differentiated binding kinetic profiles

Keywords: ثبات متابولیک; CRF1; CRH1; Corticotropin releasing factor; Corticotropin releasing hormone; Binding kinetics; Slow offset; Offset rate; Metabolic stability

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Potent and selective oxindole-based vasopressin 1b receptor antagonists with improved pharmacokinetic properties

Keywords: ثبات متابولیک; Vasopressin 1b; V1b; SSR149415; Oxindole; Metabolic stability

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Structure-based parallel medicinal chemistry approach to improve metabolic stability of benzopyran COX-2 inhibitors

Keywords: ثبات متابولیک; Cyclooxygenase; COX-2 inhibitor; Benzopyran; Structure-based design; Parallel solid phase synthesis; Structure–activity relationship; Computer-assisted molecular modeling; Free energy perturbation; Metabolic stability

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Synthesis, cytotoxicity, metabolic stability and pharmacokinetic evaluation of fluorinated docetaxel analogs

Keywords: ثبات متابولیک; Fluorinated docetaxel analogs; Cytotoxicity; Metabolic stability; Pharmacokinetics

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Design of novel and potent cPLA2α inhibitors containing an α-methyl-2-ketothiazole as a metabolically stable serine trap

Keywords: ثبات متابولیک; Cytosolic phospholipase A2; Enzyme inhibitor; Serine trap; Keto-thiazole; Metabolic stability

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

In vitro metabolic stability and metabolite profiling of TJ0711 hydrochloride, a newly developed vasodilatory β-blocker, using a liquid chromatography–tandem mass spectrometry method

Keywords: ثبات متابولیک; LC–MS/MS; Metabolic stability; Metabolite profiling; TJ0711 hydrochloride

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Probing metabolic stability of CdSe nanoparticles: Alkaline extraction of free cadmium from liver and kidney samples of rats exposed to CdSe nanoparticles

Keywords: ثبات متابولیک; Free cadmium; Cadmium selenide nanoparticle; Metabolic stability; Tetramethylammonium hydroxide; Extraction; Accumulation; ICP-MS;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

New imidazolidinedione derivatives as antimalarial agents

Keywords: ثبات متابولیک; Antimalarials; Imidazolidinedione; Preparation; Metabolic stability;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Determination of aqueous stability and degradation products of series of coumarin dimers

Keywords: ثبات متابولیک; Aqueous stability; Coumarin dimers; HPLC-DAD–MS analysis; Decomposition rate; Metabolic stability

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Discovery of potent, selective, and orally bioavailable PDE5 inhibitor: Methyl-4-(3-chloro-4-methoxybenzylamino)-8-(2-hydroxyethyl)-7-methoxyquinazolin-6-ylmethylcarbamate (CKD 533)

Keywords: ثبات متابولیک; PDE5; PDE6; PDE11; Enzyme inhibitor; Metabolic stability; Quinazoline; Male erectile dysfunction

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

SAR studies of non-zinc-chelating MMP-13 inhibitors: Improving selectivity and metabolic stability

Keywords: ثبات متابولیک; MMP-13; Non-Zn-chelating inhibitor; SAR; Selectivity; Metabolic stability

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: Improving metabolic stability and reducing ion channel activity

Keywords: ثبات متابولیک; Serotonin and noradrenaline reuptake inhibitor (SNRI); Stress urinary incontinence; 4-Piperazines; Metabolic stability; Ion channel activity; CYP2D6 metabolism;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Design of potent and selective GSK3β inhibitors with acceptable safety profile and pharmacokinetics

Keywords: ثبات متابولیک; GSK3beta; Tau phosphorylation; Amide hydrolysis; Metabolic stability; Kinase

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

An integrated platform for fully automated high-throughput LC–MS/MS analysis of in vitro metabolic stability assay samples

Keywords: ثبات متابولیک; In vitro ADME; Metabolic stability; High-throughput mass spectrometry; Automation; High-speed robotics

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

The effects of type II binding on metabolic stability and binding affinity in cytochrome P450 CYP3A4

Keywords: ثبات متابولیک; P450; Metabolic stability; Type II binding; 3A4

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2010 سفارش ترجمه

Optimising metabolic stability in lipophilic chemical space: The identification of a metabolically stable pyrazolopyrimidine CRF-1 receptor antagonist

Keywords: ثبات متابولیک; Antagonist; Corticotrophin releasing factor 1; Metabolic stability; G-protein coupled receptor

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2009 سفارش ترجمه

1-(5-Carboxyindol-1-yl)propan-2-ones as inhibitors of human cytosolic phospholipase A2α: Synthesis and properties of bioisosteric benzimidazole, benzotriazole and indazole analogues

Keywords: ثبات متابولیک; Indole; Bioisosters; Cytosolic phospholipase A2α inhibitors; Metabolic stability; Solubility

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Discovery of N-(3-(morpholinomethyl)-phenyl)-amides as potent and selective CB2 agonists

Keywords: ثبات متابولیک; Cannabinoid CB2 receptor agonist; Selectivity; Structure-activity relationship; Metabolic stability; Antiallodynic activity;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Delta agonist hydroxy bioisosteres: The discovery of 3-((1-benzylpiperidin-4-yl){4-[(diethylamino)carbonyl]phenyl}amino)benzamide with improved delta agonist activity and in vitro metabolic stability

Keywords: ثبات متابولیک; Delta agonism; Bioisosteres; Metabolic stability

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Novel imidazole-based histamine H3 antagonists

Keywords: ثبات متابولیک; Histamine H3; Benzoylimidazole; Imidazole; Metabolic stability; Blood–brain barrier penetration

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

On the prediction of hepatic clearance using the diluted plasma in metabolic stability assay

Keywords: ثبات متابولیک; hepatic clearance; intrinsic clearance; metabolic stability; protein binding; microsomal binding; well-stirred model; pharmacokinetics;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

In vitro binding and in vivo biodistribution studies of the neuroprotective peptide humanin using [125I]humanin derivatives

Keywords: ثبات متابولیک; Neuroprotective peptides; Humanin derivatives; [125I]Radiolabeling; In vitro cell binding; In vivo biodistribution; Metabolic stability

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

Itk kinase inhibitors: Initial efforts to improve the metabolical stability and the cell activity of the benzimidazole lead

Keywords: ثبات متابولیک; SAR; Itk inhibitor; Metabolic stability; Liver microsomes

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2008 سفارش ترجمه

1-(2-Phenoxyphenyl)methanamines: SAR for dual serotonin/noradrenaline reuptake inhibition, metabolic stability and hERG affinity

Keywords: ثبات متابولیک; Serotonin; Noradrenaline; Monoamine reuptake inhibitor; Metabolic stability; hERG affinity

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2008 سفارش ترجمه

N-Benzyl-N-(pyrrolidin-3-yl)carboxamides as a new class of selective dual serotonin/noradrenaline reuptake inhibitors

Keywords: ثبات متابولیک; N-benzyl-N-(pyrrolidin-3-yl)carboxamides; Serotonin reuptake; Noradrenaline reuptake; Metabolic profile; Metabolic stability; CYP2D6 inhibition; Lipophilicity; SNRI

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2008 سفارش ترجمه