Serum Levels of Matrix Metalloproteinase-2 as a Marker of Intimal Hyperplasia
Keywords: MMPs; intimal hyperplasia; biomarkers
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Molecular changes following topical photodynamic therapy using methyl aminolaevulinate in mouse skin
Keywords: Photodynamic therapy; Methyl aminolaevulinate; MMPs; Collagen; Cytokines
Osteopontin: Role in extracellular matrix deposition and myocardial remodeling post-MI
Keywords: Osteopontin; ECM; MMPs; Myocardial infarction; Myocardial remodeling
EMMPRIN and its ligand cyclophilin A regulate MT1-MMP, MMP-9 and M-CSF during foam cell formation
Keywords: EMMPRIN; Cyclophylin A; MMPs; Atherosclerosis; Foam cells; CD34+ progenitor cells;
Noninvasive Limb Ischemic Preconditioning Protects Against Myocardial I/R Injury in Rats
Keywords: remote preconditioning; late preconditioning; noninvasive limb ischemic preconditioning; cardioprotection; CK-MB; cTnI; SOD; MMPs
Muscle fascia and force transmission
Keywords: Muscle; Connective tissue; Extracellular matrix; Mechanical function; Myofascial force transmission; Endomysium; Perimysium; MMPs; ECM turnover
Association of matrix metalloproteinases with MRI indices of brain ischemia and aging
Keywords: MMPs; Brain MRI; Framingham; Brain aging
Third generation of matrix metalloprotease inhibitors: Gain in selectivity by targeting the depth of the S1â² cavity
Keywords: MMPs; Zinc protease; Selective inhibitors; S1â² loop conformational variability; P1, P2, P3 and P1â², P2â², P3â²; designate inhibitor (or substrate) residues amino-terminal and carboxy-terminal of the scissile bond respectively; S1, S2, S3 and S1â²,
Inhibitory effects of γ-tocotrienol on invasion and metastasis of human gastric adenocarcinoma SGC-7901 cells
Keywords: γ-Tocotrienol; Invasion; Metastasis; SGC-7901 cells; MMPs
Lysophosphatidic acid (LPA) effects on endometrial carcinoma in vitro proliferation, invasion, and matrix metalloproteinase activity
Keywords: LPA; Endometrial cancer; HEC-1A; MMPs; Invasion; uPA
Exercise ameliorates serum MMP-9 and TIMP-2 levels in patients with type 2 diabetes
Keywords: Exercise; Type 2 diabetes; MMPs; TIMPs; Fibrinogen; HsCRPExercice physique; Diabète de type 2; MMPs; TIMPs; Fibrinogène; HsCRP
Imbalance between matrix metalloproteinases and tissue inhibitor of metalloproteinases in hypertensive vascular remodeling
Keywords: Hypertension; Matrix metalloproteinases; MMPs; Tissue inhibitor of metalloproteinases; TIMPs; Vascular remodeling;
Correlated expression profile of extracellular matrix-related molecules during the inflammatory response of the teleost fish gilthead seabream
Keywords: AGs, acidophilic granulocytes; Cq, quantification cycle; EE2, 17α-ethynylestradiol; MCs, macrophages; VaDNA, genomic DNA from Vibrio anguillarumCollagen; Extracellular matrix; Gene expression correlations; Innate immune response; Integrins; MMPs; TIMPs; T
Non-apoptotic Fas signaling regulates invasiveness of glioma cells and modulates MMP-2 activity via NFκB-TIMP-2 pathway
Keywords: Fas signaling; Fas ligand; Glioma; Microglia; Invasiveness; MMPs; Transcription factors;
Mechanical load inhibits IL-1 induced matrix degradation in articular cartilage
Keywords: Cartilage; Mechanobiology; Load; IL-1; MMPs; ADAMTS
Changes in the expression of MMP-3, MMP-9, TIMP-1 and aggrecan in the condylar cartilage of rats induced by experimentally created disordered occlusion
Keywords: TIMP-1; MMPs; Aggrecan; Temporomandibular joint (TMJ); Osteoarthritis (OA); Cartilage
Inhibition of arachidonic acid metabolism decreases tumor cell invasion and matrix metalloproteinase expression
Keywords: NSAIDs; COX; LOX; Aspirin; Sulindac; NS-398; NDGA; ETYA; MMPs; Cell invasion; Head and neck cancer; Colon cancer
Comparative study of the characteristics and properties of tendinocytes derived from three tendons in the equine forelimb
Keywords: Horse; MMPs; Tendinocyte; Tendons in forelimb; Tendonitis; TNFα
Molecular insights and therapeutic targets for blood–brain barrier disruption in ischemic stroke: Critical role of matrix metalloproteinases and tissue-type plasminogen activator
Keywords: Blood–brain barrier; Neurovascular unit; tPA; MMPs; Ischemic stroke; Signaling pathways
Purification of a peptide from seahorse, that inhibits TPA-induced MMP, iNOS and COX-2 expression through MAPK and NF-κB activation, and induces human osteoblastic and chondrocytic differentiation
Keywords: Bioactive peptide; Seahorse; Arthritis; Differentiation; MMPs; MAPK/NF-kB;
Matrix metalloproteinase-dependent shedding of intercellular adhesion molecule-5 occurs with long-term potentiation
Keywords: telencephalin; NMDA; MMPs; dendrite; plasticity; sheddingADAM, A disintegrin and metalloproteinase; AMPA, α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate; CAM, cell adhesion molecule; ICAM-5, intercellular adhesion molecule-5; LTP, long term potentiati
Activity-dependent remodeling of chondroitin sulfate proteoglycans extracellular matrix in the hypothalamo-neurohypophysial system
Keywords: plasticity; extracellular matrix; critical period; synaptogenesis; rearrangement; AVP; arginine vasopressin; ChABC; chondroitinase ABC; CNS; central nervous system; CSPGs; chondroitin sulfate proteoglycans; CS-4-PG; chondroitin-4-sulfate-containing PG; CS
Engineering proteolytically-degradable artificial extracellular matrices
Keywords: ECM mimics; ECM analogs; Protease sensitive; Cell responsive; Proteolytic degradation; Enzymatic cleavage; 2D; Two-dimensional; 3D; Three-dimensional; A; Alanine; AAc; Acrylic acid; ADAM-TS; ADAMs with thrombospondin motifs; ADAMs; Metalloprotease-disinte
Calculation of binding free energies for non-zinc chelating pyrimidine dicarboxamide inhibitors with MMP-13
Keywords: MMPs; Molecular dynamics; Protein–ligand binding; Energy decomposition; MM-GBSA
Antitumor and antimetastatic activities of Rhizoma Paridis saponins
Keywords: CTX; cyclophosphamide; H&E; histological examination; HES; histological examination score; HIS; immunohistochemical score; Mets; metastases; MMP; matrix metalloproteinase; mRNA; messenger RNA; PCR; polymerase chain reaction; RPS; rhizoma paridis saponin;
Matrix metalloproteinase-7 and -13 expression associate to cisplatin resistance in head and neck cancer cell lines
Keywords: Predictive markers; Gene Ontology; Head and neck cancer; Cisplatin; Microarray; MMPs
The role of ADAMs in disease pathophysiology
Keywords: ADAMs; MMPs; Proteases; Disease; Cancer
Statin prevents plaque disruption in apoE-knockout mouse model through pleiotropic effect on acute inflammation
Keywords: Atherosclerosis; Plaque; Inflammation; MMPs; Matrix protein
Protective effects of butanol fraction from Betula Platyphyla var. japonica on cartilage alterations in a rabbit collagenase-induced osteoarthritis
Keywords: Butanol fraction from the bark of Betula platyphylla var. japonica; Cartilage alternations; MMPs; TIMP-1; PGE2; Cyclooxygenase
The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3
Keywords: ADAM; adamalysin; ADAMTS; adamalysin with thrombospondin motifs; cat; catalytic domain; CysR; cysteine-rich; Dis; disintegrin; LRP; low-density lipoprotein receptor-related protein; MMP; matrix metalloproteinase; N-TIMP; N-terminal domain of TIMP; RAP; re
Curcumin inhibits cell proliferation of MDA-MB-231 and BT-483 breast cancer cells mediated by down-regulation of NFκB, cyclinD and MMP-1 transcription
Keywords: Curcuma longa; Curcumin; NFκB; MMPs; CyclinD1/CDK4
Celastrol suppresses allergen-induced airway inflammation in a mouse allergic asthma model
Keywords: Inflammatory cytokine; MMPs; TIMPs; MAP kinase; NF-κB
Temporal changes in MMP mRNA expression in the lens epithelium during anterior subcapsular cataract formation
Keywords: lens; cataract; MMPs; ASC; EMT; TGFβ
Tumor-stroma interactions influence cytokine expression and matrix metalloproteinase activities in paired primary and metastatic head and neck cancer cells
Keywords: Cell invasion; Collagen; Cytokine; Fibroblast; Head and neck cancer; MMPs; Stromal-epithelial interaction;
Apoptosis induction by 4-nerolidylcatechol in melanoma cell lines
Keywords: 4-Nerolidylcatechol; Pothomorphe umbellata; Melanoma; Invasion; Cytotoxicity; Apoptosis; MMPs
Nerve growth factor and its receptors TrkA and p75 are upregulated in the brain of mdx dystrophic mouse
Keywords: angiogenesis; blood–brain barrier; mdx mouse; MMPs; NGF; VEGFAQP4, aquaporin-4; BB, blocking buffer; BBB, blood–brain barrier; BSA, bovine serum albumin; CNS, central nervous system; CSF, cerebrospinal fluid; DAP, dystrophin-associated protein; DMD, Duche
p38 mitogen-activated kinase (MAPK) is essential for equine neutrophil migration
Keywords: TLR; toll-like receptor; COX-2; cyclooxygenase 2; IL1-β; interleukin 1-β; IL-6; interleukin-6; DRD; differential mRNA display; MAIL; molecule possessing ankyrin-repeats induced by lipopolysaccharide; MMPs; matrix metalloproteinase enzymes; ROS; reactive
Adenovirus-mediated transfer of siRNA against PAI-1 mRNA ameliorates hepatic fibrosis in rats
Keywords: PAI-1; plasminogen activator inhibitor-1; siRNA; small interfering RNA; DMN; dimethylnitrosamine; BDL; bile duct ligation; MMPs; matrix metalloproteinases; ECM; extracellular matrix; uPA; urokinase type plasminogen activator; tPA; tissue-type plasminogen
Tissue inhibitor of metalloproteinase-1 modulates allergic lung inflammation in murine asthma
Keywords: Asthma; Bronchial hyperreactivity; TIMP-1; MMPs; Airway remodeling; Intercellular matrix
Cellular and molecular pathways linking inflammation and cancer
Keywords: COX-2; cycloxygenase-2; TGFβ; transforming growth factor-β; HIF-1; hypoxia inducible factor 1; STAT-3; signal transducers and activator of transcription-3; TAMs; tumour-associated macrophages; TNFalpha; tumour necrosis factor alpha; TEMs; Tie2-expressin
Transient pulmonary fibrogenic effect induced by intratracheal instillation of ultrafine amorphous silica in A/J mice
Keywords: Ultrafine amorphous silica; Pulmonary fibrosis; Cytokines; MMPs; TIMP-1
Expression and distribution of MMPs and TIMPs in human uveal melanoma
Keywords: immunohistochemistry; leukocytes; MMPs; TIMPs; tumour-scleral interface; uveal melanoma; vasculature;
Sinomenine ameliorates arthritis via MMPs, TIMPs, and cytokines in rats
Keywords: Sinomenine; Collagen-induced arthritis; Cytokines; MMPs; TIMPs
Matrix metalloproteinases-1 and -2, and tissue inhibitor of metalloproteinase-2 production is abnormal in bone marrow stromal cells of multiple myeloma patients
Keywords: Multiple myeloma; MMPs; TIMPs; Bone marrow stroma
The role of collagenases in experimental pulmonary fibrosis
Keywords: MMPs; ECM; Pulmonary fibrosis; Bleomycin; Collagenase
Defining therapeutic targets for liver fibrosis: Exploiting the biology of inflammation and repair
Keywords: Liver fibrosis; Myofibroblast; Antifibrotic; Hepatic stellate cell; Mesenchymal stem cell; Liver injury; Apoptosis; Matrix degradation; Matrix synthesis; Inflammation; TIMPs; MMPs; Macrophages; Fibrosis resolution; Therapy
Membrane-type-1 matrix metalloproteinase, matrix metalloproteinase 2, and tissue inhibitor of matrix proteinase 2 in prostate cancer: identification of patients with poor prognosis by immunohistochemistry
Keywords: Prostate; Neoplasms; MMPs; Immunohistochemistry; Disease-free survival
Chlorotyrosine promotes human aortic smooth muscle cell migration through increasing superoxide anion production and ERK1/2 activation
Keywords: Chlorotyrosine; l-Tyrosine; Smooth muscle cell migration; PDGFR-B; MMPs; Integrin; Superoxide anion; ERK1/2
An integrated high-performance liquid chromatography–mass spectrometry system for the activity-dependent analysis of matrix metalloproteases
Keywords: Metalloprotease; Proteomics; HPLC; Mass spectrometry; Affinity chromatography; MMPs; Activity-based analysis; Targeted proteomics; Automated online analysis system
Synthetic active site-directed inhibitors of metzincins: Achievement and perspectives
Keywords: MMPs; Matrix metalloproteinase; Zinc protease; Inhibitor; Hydroxamate; Phosphinic peptide; Inhibitor design; ADAM; ADAMTS