Inhibition effect of Guizhi-Fuling-decoction on the invasion of human cervical cancer
Keywords: Cervical cancer; Invasion; MMPs; TIMPs; Traditional Chinese medicine
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Diagnosis and Quantitation of Fibrosis
Keywords: APRI; AST to platelet ratio index; ECM; extracellular matrix; HA; hyaluronic acid; MMPs; matrix metalloproteinases; MRE; magnetic resonance elastography; NAFLD; nonalcoholic fatty liver disease; NASH; nonalcoholic steatohepatitis; PIIINP; procollagen type
Matrix metalloproteinases and tissue inhibitors of metalloproteinases expression in human cerebral ruptured and unruptured aneurysm
Keywords: BSA; bovine serum album; DEPC; diethypyrocarbonate; DSA; digital substraction angiography; ECM; extracellular matrix; ELISA; enzyme-linked immunosorbent assay; GAPDH; glutaraldehyde 3-phosphate dehydrogenase; HRP; Horseradish peroxides; ISUIA; Internation
Local and systemic pathophysiological alterations induced by a serine proteinase from the venom of the snake Bothrops jararacussu
Keywords: Thrombin-like; Bothrops jararacussu; MMPs; Serine proteinase; Defibrin(ogen)ation
Cutaneous MMPs are differently modulated by environmental stressors in old and young mice
Keywords: Ozone; UV; Cigarette smoke; Skin; MMPs; TIMPs;
Doxycycline attenuated lung injury by its biological effect apart from its antimicrobial function
Keywords: Gelatinase; MMPs; Streptococcus pneumoniae; ECM; LPS
Doxycycline inhibits MMPs via modulation of plasminogen activators in focal cerebral ischemia
Keywords: Cerebral ischemia; Doxycycline; MMPs; Plasminogen activator; Rat; TIMP
Resveratrol inhibits macrophage expression of EMMPRIN by activating PPARγ
Keywords: EMMPRIN; PPARγ; MMPs; Resveratrol; Macrophages
Functional expression of CXC chemokine recepter-4 mediates the secretion of matrix metalloproteinases from mouse hepatocarcinoma cell lines with different lymphatic metastasis ability
Keywords: CXCR4; Murine hepatocarcinoma; Lymphatic metastasis; MMPs
Antrodia cinnamomea fruiting bodies extract suppresses the invasive potential of human liver cancer cell line PLC/PRF/5 through inhibition of nuclear factor κB pathway
Keywords: Antrodia cinnamomea; Invasion; Liver cancer; MMPs; NF-κB
Effects of PKF242-484 and PKF241-466, novel dual inhibitors of TNF-alpha converting enzyme and matrix metalloproteinases, in a model of intestinal reperfusion injury in mice
Keywords: Inflammation; Neutrophils; TNF-α; TACE; MMPs; Systemic inflammatory response syndrome; FN-439
Infection and the role of inflammation in preterm premature rupture of the membranes
Keywords: pPROM; prematurity; inflammation; MMPs; cytokines; apoptosis; genetic associations
Overexpression of MMP9 in macrophages attenuates pulmonary fibrosis induced by bleomycin
Keywords: MMPs; Lung fibrosis; IGFBP3; TIMPs;
A critical appraisal of methods used in early clinical development of novel drugs for the treatment of asthma
Keywords: Clinical trials; Asthma; Non-invasive methodology; Airway inflammation; AHR; airway hyperresponsiveness; AMP; adenosine 5â² monophosphate; ASM; airway smooth muscle; ATS; American Thoracic Society; BAL; bronchoalveolar lavage; BPT; bronchoprovocation tes
Matrix metalloproteinases (MMPs): Chemical–biological functions and (Q)SARs
Keywords: MMPs; Apoptosis; Chemical–biological interactions; Hydrophobicity; Molar refractivity; QSARs
Molecular and cellular basis of rheumatoid joint destruction
Keywords: Synovial fibroblasts; Rheumatoid arthritis; p38δ; NFkB; L1; TLRs; Microparticles; TNFα; MMPs; SCID mouse; Gene transfer
Alteplase treatment affects circulating matrix metalloproteinase concentrations in patients with ST segment elevation acute myocardial infarction
Keywords: MMPs; matrix metalloproteinases; rtPA; recombinant tissue plasminogen activator; STEMI; ST segment elevation myocardial infarction; ECG; electrocardiogram; CK; creatine kinase; CRP; C-reactive protein; CAD; coronary artery disease; 95% CI; 95% confidence
Serum insulin-like growth factor-axis and matrix metalloproteinases in patients with rheumatic arthritis or rheumatic heart disease
Keywords: Endocrine system; GH-IGF-axis; MMPs; Rheumatic heart disease
Normal mode analysis as a prerequisite for drug design: Application to matrix metalloproteinases inhibitors
Keywords: Matrix metalloproteinases; MMPs; Normal mode analysis (NMA); Docking; Target flexibilityNMA, normal mode analysis; MMPs, matrix metalloproteinases; TIMPs, tissue inhibitors of MMPs; ECM, extra-cellular matrix; SD, steepest descent; ABNR, adopted basis New
Role of PTHrp and PTHrp-engaged pathways in MCF-7 cells migration/invasion
Keywords: PTHrp; PKA; PKC; MMPs; MCF-7; Invasivity
Calcitonin is involved in cartilage homeostasis: Is calcitonin a treatment for OA?
Keywords: Articular cartilage; Calcitonin; Calcitonin receptor; MMPs; CTX-II; Chondrocytes; Osteoarthritis; Treatment
MMP-2 in the left rat ventricle is increased by growth hormone
Keywords: Heart; Rat; Growth hormone; Connective tissue; MMPs; Stereology;
Intraplaque MMP-8 levels are increased in asymptomatic patients with carotid plaque progression on ultrasound
Keywords: MMPs; Carotid atherosclerosis; Ischaemic stroke
Thermal aging: A new concept of skin aging
Keywords: Photoaging; MMPs; Extracellular matrix
Temporal relationship between MMP production and angiogenic process in HUVECs
Keywords: MMPs; Aspirin; TIMPs; Angiogenesis; HUVECs;
17β-estradiol modulation of angiotensin II-stimulated response in cardiac fibroblasts
Keywords: Heart; Fibroblasts; Angiotensin II; 17β-estradiol; Estrogen; Integrins; MMPs; MAP kinase; Collagen gel contraction
Matrix metalloproteinases and tissue inhibitors of metalloproteinases in coxsackievirus-induced myocarditis
Keywords: Myocarditis; MMPs; Coxsackievirus B3; Extracellular matrix; TIMPs
Bovine chondrocyte behaviour in three-dimensional type I collagen gel in terms of gel contraction, proliferation and gene expression
Keywords: Bovine chondrocyte; Collagen gel; Cartilage repair; Tissue engineering; MMPs; Integrins
Making the cut: Protease-mediated regulation of angiogenesis
Keywords: MMPs; ADAMs/ADAMTS; ECM; Angiogenic growth factors; TIMPs; RECK;
Distinct modes of collagen type I proteolysis by matrix metalloproteinase (MMP) 2 and membrane type I MMP during the migration of a tip endothelial cell: Insights from a computational model
Keywords: Angiogenesis; Tissue inhibitor of metalloproteinase 2; Mmps; Type I collagen; Extracellular matrix; Theoretical model; Mathematical model
A Comparison of Six Statins on the Development of Intimal Hyperplasia in a Human Vein Culture Model
Keywords: Intimal hyperplasia; Saphenous vein; MMPs; Organ culture;
Prognostic value of serum vascular endothelial growth factor (VEGF) and plasma activity of matrix metalloproteinase (MMP) 2 and 9 in lymphoma-affected dogs
Keywords: NHL; VEGF; MMPs; Prognosis; Animal model; Dog;
EGCG inhibits activation of the insulin-like growth factor-1 receptor in human colon cancer cells
Keywords: Colon cancer cells; EGCG; IGF/IGF-1R; IGFBP-3; MMPs; Tea catechins; Insulin-like growth factor receptor;
Gelatinases (MMP-2 and MMP-9) are preferentially expressed by Th1 vs. Th2 cells
Keywords: Chemokines; Gelatinases; MMPs; Multiple sclerosis; Th1 and Th2 cells;
Reduced expression of progesterone receptor-B in the endometrium of women with endometriosis and in cocultures of endometrial cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin
Keywords: Progesterone receptor; endometrium; endometriosis; TCDD; MMPs;
Antimetastatic effect of prodigiosin through inhibition of tumor invasion
Keywords: ECM; extracellular matrix; MMPs; matrix metalloproteinases; BS; bovine serum; i.p.; intraperitoneally; i.v.; intravenously; MTT; 3-[4,5-dimethyl-thiazol-2-yl]2,5-diphenyltetrazolium bromide; EC50; half effective concentration; SDS-PAGE; sodium dodecyl sul
Elastolytic activity and alveolar epithelial type-1 cell damage after chronic LPS inhalation: Effects of dexamethasone and rolipram
Keywords: AHR; Airway hyperreactivity; BALF; bronchoalveolar lavage fluid; cAMP; adenosine 3â², 5â² cyclic monophosphate; COPD; chronic obstructive pulmonary disease; DMSO; dimethylsulphoxide; ECL; enhanced chemiluminescence; FEV1; Forced expiratory volume in 1 s
Human preterm amnion cells cultured in 3-dimensional collagen I and fibrin matrices for tissue engineering purposes
Keywords: Amnion epithelial and mesenchymal cells; Three-dimensional cell-matrix system; Collagen I; Fibrin; MMPs;
Therapeutic effects of PG201, an ethanol extract from herbs, through cartilage protection on collagenase-induced arthritis in rabbits
Keywords: PG201; Herbal medicine; Osteoarthritis; Collagenase-induced arthritis; Cartilage protection; Proteoglycan; MMPs; TIMP-2; Inflammatory mediators;
Interleukin-6 increases rat metalloproteinase-13 gene expression through Janus kinase-2-mediated inhibition of serine/threonine phosphatase-2A
Keywords: AP1; activator protein 1; IL-6; Interleukin-6; JAK; Janus kinase; JNK; c-Jun-N-terminal kinase; MAP; mitogen-activated protein; MMPs; Matrix metalloproteinases; PKC; protein kinase C; PP2A; serine/threonine phosphatase 2A; PP2AC; catalytic subunit of PP2A
Silibinin inhibits cell invasion through inactivation of both PI3K-Akt and MAPK signaling pathways
Keywords: ECM; extracellular matrix; ERK; extracellular signal-regulated kinase; MAPK; mitogen activator protein kinase; MMPs; matrix mtealloproteinases; MMP-2; matrix metalloproteinase-2; MMP-9; matrix metalloproteinase-9; u-PA; urokinase-plasminogen activator; Si
Inhibitory effect of DA-125, a new anthracyclin analog antitumor agent, on the invasion of human fibrosarcoma cells by down-regulating the matrix metalloproteinases
Keywords: DMEM; Dulbecco's modified Eagle's medium; ECM; extracellular matrix; EMSA; electrophoretic mobility shift assay; MMPs; matrix metalloproteinases; MT1-MMP; membrane type metalloproteinase; NF-κB; nuclear factor κB; RT-PCR; reverse transcriptase-polymeras
Comparison of the chondrosarcoma cell line SW1353 with primary human adult articular chondrocytes with regard to their gene expression profile and reactivity to IL-1β
Keywords: Chondrocytes; Cartilage; Cell line; Expression analysis; MMPs;
The novel targets for anti-angiogenesis of genistein on human cancer cells
Keywords: CAM; chick chorioallantoic membrane; COX-2; cyclooxygenase-2; MMPs; matrix metalloproteinases; PAI-1; plasminogen activator inhibitor-1; PDGF; platelet-derived growth factor; RT-PCR; reverse transcription-polymerase chain reaction; TSP-1; thrombospondin-1
Matrix metalloproteinase inhibition impairs the processing, formation and mineralization of dental tissues during mouse molar development
Keywords: Tooth; Dentin; Enamel; Dentin sialoprotein (DSP); Amelogenin; MMPs; Marimastat;
Gene profiling the response to kainic acid induced seizures
Keywords: Neurotransmitters, modulators, transporters, and receptors; Excitatory amino acids: excitotoxicity; Agt; angiotensinogen; Akt; protein kinase B; Aldr1; aldehyde reductase 1; ANPEP; alanyl aminopeptidase N; ATF4; activating transcription factor 4; Bax; BCl
Brain, aging and neurodegeneration: Role of zinc ion availability
Keywords: [Ca++]i; intracellular Ca++ concentration; [Zn++]b; zinc concentration in the blood; [Zn++]e; extracellular free zinc ion concentration; [Zn++]i; intracellular free zinc ion concentration; [Zn++]s; synaptic zinc; Aβ; amyloid beta-peptide; AD; Alzheimer d