Low nigrostriatal reserve for motor parkinsonism in nonhuman primates
Keywords: Parkinsonism; MPTP; Substantia nigra; Dopamine;
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Lipid-like components released from degenerating dopaminergic neurons trigger the dynamic migration of microglia
Keywords: MPTP; Dopaminergic neurons; Parkinson's disease; Microglial migration; Lipid signal;
Ezrin functionality and hypothermic preservation injury in LLC-PK1 cells
Keywords: ERM proteins; Kidney donation; Mitochondria; mPTP
Nitric oxide affects immune cells bioenergetics
Keywords: CsA; cyclosporine A; DMSO; dimethyl sulfoxide; DO; dissolved oxygen; GLUT; glucose transporter; IL-2; interleukin-2; iNOS; inducible nitric oxide synthase; MPTP; mitochondrial permeability transition pore; NO; nitric oxide; NSAID; non-steroidal anti-infla
Photobiomodulation enhances nigral dopaminergic cell survival in a chronic MPTP mouse model of Parkinson's disease
Keywords: Hypothalamus; Zona incerta; Substantia nigra; Periaqueductal grey matter; Neuroprotection; 3V; third ventricle; ATP; adenosine-5â²-triphosphate; CPuputamen complex; caudate-; LED; light emitting device; L; lateral region of the SNc; LED; light emitting
Neuroprotection by the multitarget iron chelator M30 on age-related alterations in mice
Keywords: AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; APP; amyloid precursor protein; DFO; defferoxamine; DA; dopamine; MAO; monoamine oxidase; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; OS; Oxidative stress; PD; Parkinson's disease; PSEN;
Mitochondrial distribution of neuroglobin and its response to oxygen-glucose deprivation in primary-cultured mouse cortical neurons
Keywords: BK; bongkrekic acid; CsA; cyclosporine A; Cyc1; cytochrome c1; DIDS; 4,4â²-diisothiocyano-2,2â²-stilbenedisulfonic acid; EDTA; ethylenediaminetetraacetic acid; EM; electron microscopy; LDH; lactate dehydrogenase; mPTP; mitochondria permeability transiti
Signal transduction pathway activity compensates dopamine D2/D3 receptor density changes in Parkinson's disease: a preliminary comparative human brain receptor autoradiography study with [3H]raclopride and [35S]GTPγS
Keywords: ARG; autoradiography; DAT; dopamine transporter; GTPγS; guanosine 5â²-O-[gamma-thio]triphosphate; l-DOPA; L-3,4-dihydroxyphenylalanine; MAO-B; Monoamine oxidase B; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; OD; optical density; PD; Parkinson's
Treadmill exercise ameliorates dopaminergic neuronal loss through suppressing microglial activation in Parkinson's disease mice
Keywords: Parkinson's disease; MPTP; Exercise; CD11b; CD200; MAPKs signaling;
Neuroprotective effects of riluzole in early phase Parkinson's disease on clinically relevant parameters in the marmoset MPTP model
Keywords: Riluzole; MPTP; Marmoset; Behavior; Sleep; Dopamine; Parkinson's disease;
Mechanisms in cancer-chemotherapeutic drugs-induced peripheral neuropathy
Keywords: CIPN; cancer chemotherapy-induced peripheral neuropathy; CGRP; calcitonin gene related peptide; cGMP; cyclic guanosine monophosphate; CRPS-I; complex regional pain syndrome; Cyt C; cytochrome C; DRG; dorsal root ganglia; ERK; extracellular signal regulate
Mitochondrial aquaporin-8 knockdown in human hepatoma HepG2 cells causes ROS-induced mitochondrial depolarization and loss of viability
Keywords: ROS; reactive oxygen species; AQP; aquaporin; AQP8; aquaporin-8; mtAQP8; mitochondrial aquaporin-8; SCR; scrambled siRNA1 sequence; DCFH-DA; 2â²,7â²-dichlorodihydrofluorescein diacetate; TMRM; tetramethylrhodamine methyl ester; MTT; 3-(4,5-dimethyl-2-yl
Brain-resident microglia predominate over infiltrating myeloid cells in activation, phagocytosis and interaction with T-lymphocytes in the MPTP mouse model of Parkinson disease
Keywords: Microglia; Phagocyte; Lymphocyte; Antigen presentation; MPTP; Parkinson disease;
Involvement of NF-κB and Bcl2/Bax signaling pathways in the apoptosis of MCF7 cells induced by a xanthone compound Pyranocycloartobiloxanthone A
Keywords: MMP; mitochondrial membrane potential; HSP; heat shock proteins; NF-κB; nuclear factor-kappa B; TNF-α; tumor necrosis factor alpha; ROS; reactive oxygen species; DCFH-DA; 2â²,7â²-dichlorofluorescin diacetate; MPTP; mitochondrial membrane transition po
Susceptibility to a parkinsonian toxin varies during primate development
Keywords: CSF; cerebrospinal fluid; DA; dopamine; E; embryonic day; GADPH; glyceraldehyde-3-phosphate dehydrogenase; HVA; homovanillic acid; ir; immunoreactivity; MPP+; 1-methyl-pyridinium; MPTP; 1-methyl-4-phenyltetrahydropyridine; P; postnatal day; ROS; reactive
High-fat diet exacerbates MPTP-induced dopaminergic degeneration in mice
Keywords: ARA; arachidonic acid; BDNF; brain-derived neurotrophic factor; CD; control diet; DA; dopamine; DAT; dopamine transporter; DHA; docosahexaenoic acid; DOPAC; 3,4-dihydroxyphenylacetic acid; DPA; docosapentaenoic acid; DTA; docosatetraenoic acid; GDNF; glia
Research ReportInhibition of mitochondrial permeability transition pore opening contributes to the neuroprotective effects of ischemic postconditioning in rats
Keywords: IPost; ischemic postconditioning; MPTP; mitochondrial permeability transition pore; NDS; neurological deficit scores; MAPK; mitogen-activated protein kinase; RISK; reperfusion injury salvage kinase; VDAC; voltage-dependent anion channel; ANT; adenine nucl
Stimulation of cytosolic and mitochondrial calcium mobilization by indomethacin in Caco-2 cells: Modulation by the polyphenols quercetin, resveratrol and rutin
Keywords: 2-APB; 2-Aminoethoxydiphenyl borate; QUE; quercetin; RES; resveratrol; RUT; rutin; PPs; polyphenols; IP3R; inositol trisphosphate receptors; RyR; ryanodine receptors; EGTA; ethylene glycol tetraacetic acid; GI; gastrointestinal; INDO; indomethacin; MMP; m
Ogg1 null mice exhibit age-associated loss of the nigrostriatal pathway and increased sensitivity to MPTP
Keywords: DNA damage; DNA repair; 7,8-Dihydroxy-2â²-deoxyguanine; Ogg1; Aging; Parkinson's disease; MPTP;
A30P α-synuclein impairs dopaminergic fiber regeneration and interacts with L-DOPA replacement in MPTP-treated mice
Keywords: α-synuclein; MPTP; Dopamine; Regeneration; Striatum; L-DOPA;
Isoorientin induces apoptosis through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway in HepG2 cancer cells
Keywords: HepG2 cells; human hepatoblastoma cancer cell line; ROS; reactive oxygen species; NO; nitric oxide; mPTP; mitochondrial permeability transition pore; MMP; mitochondrial membrane potential; PARP; poly (ADP-ribose) polymerase; NAC; N-acetylcystein; 1400W; N
Anxiety in Parkinson's disease: A critical review of experimental and clinical studies
Keywords: Parkinson's disease; Anxiety; Clinical studies; Animal models; Review; BLA; basolateral nucleus of the amygdala; BDZs; benzodiazepines; CNS; central nervous system; DSM; Diagnostic and Statistical Manual of Mental Disorders; DA; dopamine; DOPAC; 3,4-dih
Features of cadmium and calcium uptake and toxicity in rainbow trout (Oncorhynchus mykiss) mitochondria
Keywords: ANT; adenine nucleotide translocase; BKA; bongkrekic acid; CsA; cyclosporin A; CyP-D; cyclophilin D; DTT; dithiothreitol; ETC; electron transport chain; FCCP; carbonylcyanide-p-trifluoromethoxyphenylhydrazone; MCU; mitochondrial calcium uniporter; MIB; mi
Signaling pathways mediating the neuroprotective effects of sex steroids and SERMs in Parkinson’s disease
Keywords: Estradiol; Neuroprotection; MPTP; Signaling; Akt; ERK; Estrogen receptor; Striatum; Substantia nigra; SERMs
Recovery of hypothalamic tuberoinfundibular dopamine neurons from acute toxicant exposure is dependent upon protein synthesis and associated with an increase in parkin and ubiquitin carboxy-terminal hydrolase-L1 expression
Keywords: Parkin; Ubiquitin carboxy-terminal hydrolase-L1 Parkinson disease; MPTP; Tuberoinfundibular; Nigrostriatal; Recovery;
Programmed cell death in C. elegans, mammals and plants
Keywords: PCD; programmed cell death; TUNEL; terminal deoxynucleotidyl transferase mediated dUTP nick-end labeling; CARD; caspase recruitment domain; DED; death effector domain; DISC; death-inducing signaling complex; Bcl-2; B-cell-lymphoma; OMM; outer mitochondria
5-HT2A receptor levels increase in MPTP-lesioned macaques treated chronically with L-DOPA
Keywords: Parkinson's disease; Serotonin; 5-HT2A receptors; Dyskinesia; Autoradiography; MPTP; Macaque;
Mitochondrial permeability transition pore opening induces the initial process of renal calcium crystallization
Keywords: COM; calcium oxalate monohydrate; CsA; cyclosporine A; EG; ethylene glycol; 4-HNE; 4-hydroxy-2-nonenal; mPTP; mitochondrial permeability transition pore; MDA; malondialdehyde; 8-OHdG; 8-hydroxy-2â²-deoxyguanosine; OPN; osteopontin; PLOM; polarized light
Regulation and protection of mitochondrial physiology by sirtuins
Keywords: Acetyl-CoA; acetyl-coenzyme A; AceCS2; acetyl-coenzyme A synthethase 2; ACC; Acetyl-CoA carboxylase; ADP; adenosine diphosphate; AIF; apoptosis-inducing factor; AMPK; 5â² adenosine monophosphate-activated protein kinase; ANT; adenine nucleotide transloca
Meta-analysis of genetic and environmental Parkinson's disease models reveals a common role of mitochondrial protection pathways
Keywords: Acetylcholinesterase; Alpha-synuclein; HSP70; Microarray; MPTP; Parkinson's disease;
Effects of dopamine and serotonin antagonist injections into the striatopallidal complex of asymptomatic MPTP-treated monkeys
Keywords: AC; anterior commissure; BP; binding potential; CA; Cercopithecus aethiops; Cb; calbindin; CN; caudate nucleus; DA; dopamine; GPe; external segment of the globus pallidus; MPTP; 1-methyl-4-phenyl-1.2.3.6-tetrahydropyridine; MF; Macaca fascicularis; MRI; m
Mitochondrial dysfunction in ALS
Keywords: AEOL-10150; manganese [III] tetrakis[N-Nâ²-diethylimidazolium-2-yl]porphyrin; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole propinate; ALS; amyotrophic lateral sclerosis; CCS; copper chaperone for superoxide dismutase; DMPO; 3,4-dihydro-2,3-dimethyl-2H-p
Receptor for advanced glycation endproducts (RAGE) deficiency protects against MPTP toxicity
Keywords: MPTP; NF-κB; Parkinson's disease; RAGE; Neuroprotection; Microglia; Astrocytes;
Pharmacologic magnetic resonance imaging (phMRI): Imaging drug action in the brain
Keywords: 7-NI; 7-nitroindazole; BBB; blood brain barrier; BOLD; blood oxygenation level dependent; CBF; cerebral blood flow; CBV; cerebral blood volume; CFT; ((2β-carbomethoxy-3β-(4-fluorophenyl) tropane); CMRglc; cerebral metabolic rate glucose; DA; dopamine; f
Animal models of l-DOPA–induced dyskinesia: an update on the current options
Keywords: l-DOPA-induced dyskinesia; 6-OHDA; MPTP; animal models; abnormal involuntary movements; Parkinson's diseaseAIMs, abnormal involuntary movements; LID, l-DOPA-induced dyskinesia; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MFB, medial forebrain bund
Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease-resemblance to the effect of amphetamine drugs of abuse
Keywords: α-syn; α-synuclein; ASK1; Apoptosis signaling-regulating kinase 1; CMA; Chaperone-mediated autophagy; DAT; Dopamine transporter; ETC; Electron transport chain; iPS; Induced pluripotent stem; LAMP-2A; Lysosome-associated membrane protein 2A; LB; Lewy bod
Social enrichment attenuates nigrostriatal lesioning and reverses motor impairment in a progressive 1-methyl-2-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease
Keywords: Dopamine; Striatum; MPTP; Social enrichment; Tyrosine hydroxylase;
Closing the gap between clinic and cage: Sensori-motor and cognitive behavioural testing regimens in neurotoxin-induced animal models of Parkinson's disease
Keywords: AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; PACAP; adenylate cyclase activating polypeptide; Aβ; amyloid-β; SNCA [gene]; α-synuclein; α-SYN [protein]; α-synuclein; AD; Alzheimer's disease; CeA; central nucleus of the amygdala; DCS; D
Long-lasting transcriptional refractoriness triggered by a single exposure to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrimidine
Keywords: Cdkn1a; cyclin-dependent kinase inhibitor 1a; CDS; coding sequence; DA; dopamine; DOPAC; 3-4-dihydroxphenylacetic acid; EDTA; ethylenediaminetetraacetic acid; Edg3; endothelial differentiation, sphingolipid G-protein-coupled receptor 3; Fosb; FBJ murine o
Neurotoxin-based models of Parkinson's disease
Keywords: Parkinson's disease; animal models; 6-hydroxydopamine; MPTP; rotenone; paraquatASK1, apoptosis signal-regulating kinase 1; Bax, Bcl2-associated X protein; COMT, catechol-O-methyl transferase; DAT, dopamine transporter; JNK, c-jun N-terminal kinases; l-dop
Alterations in glutathione S-transferase pi expression following exposure to MPP+-induced oxidative stress in the blood of Parkinson's disease patients
Keywords: Oxidative stress; MPTP; Biomarker; Glutathione S-transferase;
Loss of striatal dopaminergic terminals during the early stage in response to MPTP injection in C57BL/6 mice
Keywords: Striatal dopaminergic terminal; MPTP; Immunoisolation; Dopamine transporter; Mouse model;
Impact of exercise on mitochondrial transcription factor expression and damage in the striatum of a chronic mouse model of Parkinson's disease
Keywords: ANOVA; analysis of variance; DA; dopamine; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; MPD; mouse model of Parkinson's disease; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; mtDNA; mitochondrial DNA; PD; Parkinson's disease; PGC-1α; peroxisome
Effect of intermittent washout periods on progressive lesioning of the nigrostriatal pathway with 1-methyl-2-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
Keywords: dopamine; progressive; MPTP; tyrosine hydroxylase; motor control; Parkinson's diseaseCPu, caudate putamen; DA, dopamine; FSR, free-standing rears; PD, Parkinson's disease; SNpc, substantia nigra pars compacta; TH, tyrosine hydroxylase; TH-ir, TH-immunorea
Age- and duration-dependent effects of MPTP on cortical serotonin systems
Keywords: Aging; Dopamine; Mice; MPTP; Norepinephrine; Prefrontal cortex; Serotonin; Striatum;
Dynamic alterations of gene expression of nicotinic acetylcholine receptor α7, α4 and β2 subunits in an acute MPTP-lesioned mouse model
Keywords: MPTP; Mouse model; Parkinson's disease; Nicotinic acetylcholine receptors; mRNA
Mitochondria as target of Quantum dots toxicity
Keywords: CsA; cyclosporine A; ADP; adenosine diphosphate; HP; hematoporphrin; DTT; dithiothreitol; QDs; Quantum dots; MPT; mitochondrial permeability transition; ETC; electron transport chain; MPTP; pearmeability transition pores; ANT; adenine nucleotide transloca
Role of protein kinase C and mitochondrial permeability transition pore in the neuroprotective effect of ceramide in ischemia-induced cell death
Keywords: PKC; protein kinase C; ROS; reactive oxygen species; OGD; oxygen glucose deprivation; mPTP; mitochondrial permeability transition pore; Ceramide; Ischemia; Mitochondria; Neuroprotection;
Granulocyte-colony stimulating factor (G-CSF) enhances recovery in mouse model of Parkinson's disease
Keywords: Granulocyte-colony stimulating factor; MPTP; Parkinson disease; Microglia;
Structure–activity relationship and docking studies of thiazolidinedione-type compounds with monoamine oxidase B
Keywords: Enzyme; Amplex-Red; Kynuramine; Pharmacophore; MPTP