Aneuploidy in Lewy body diseases
Keywords: مگس های نوروفیبریلیال; Aneuploidy; β-amyloid plaques; Lewy bodies; Lewy body diseases; Neurofibrillary tangles; Neuronal degeneration;
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Activated human microglia stimulate neuroblastoma cells to upregulate production of beta amyloid protein and tau: implications for Alzheimer's disease pathogenesis
Keywords: مگس های نوروفیبریلیال; Amyloid precursor protein; Tauopathy; Ibuprofen; Aspirin; Glutathione; Neurofibrillary tangles; IL-10;
Reconstituted mother tinctures of Gelsemium sempervirens L. improve memory and cognitive impairment in mice scopolamine-induced dementia model
Keywords: مگس های نوروفیبریلیال; AD; Alzheimer׳s disease; Aβ; amyloid β; AChE; acetylcholinesterase; ANOVA; analysis of variance; ANSM; Agence Nationale de Sécurité des Médicaments (French); APP; amyloid precursor protein; b-APP; b-amyloid precursor protein; ATCI; acetylthiocholine
Inhibition of PMCA activity by tau as a function of aging and Alzheimer's neuropathology
Keywords: مگس های نوروفیبریلیال; AD; Alzheimer´s disease; Aβ; amyloid-β peptide; MV; membrane vesicles; NFTs; neurofibrillary tangles; PMCA; plasma membrane Ca2+-ATPase; SERCA; sarco(endo)plasmic reticulum Ca2+-ATPase; SPCA; secretory pathway Ca2+-ATPase; Tau; Calcium; PMCA; Aging; Al
Herbs to curb cyclic nucleotide phosphodiesterase and their potential role in Alzheimer's disease
Keywords: مگس های نوروفیبریلیال; cAMP; cyclic adenosine monophosphate; cGMP; cyclic guanosine monophosphate; AD; Alzheimer's disease; PDE; phosphodiesterases; Aβ; amyloid beta; NFTs; neurofibrillary tangles; FAD; familial Alzheimer's disease; SAD; sporadic Alzheimer's disease; APP
Autophagy in neurodegenerative diseases: From pathogenic dysfunction to therapeutic modulation
Keywords: مگس های نوروفیبریلیال; Aβ; amyloid beta; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; APP; amyloid precursor protein; ATP; adenosine triphosphate; Bci3; Bax cannel inhibitor 3; cAMP; cyclic adenosine monophosphate; CMA; chaperone-mediated autophagy; DLB; dement
14th Annual Meeting of the Safety Pharmacology Society: Threading through peripheral and central nervous system presentations
Keywords: مگس های نوروفیبریلیال; Aβ; Aβ-amyloid protein; AANEM; American Academy of Neuromuscular and Electrodiagnostic Medicine; AAN; American Academy of Neurology; AD; Alzheimer's Disease; API; Alzheimer's Prevention Initiative-APOE4; ADF; Abuse Deterrent Formulations; ADNI; Alzheime
p-Tau immunotherapy reduces soluble and insoluble tau in aged 3xTg-AD mice
Keywords: مگس های نوروفیبریلیال; Tau; Phosphorylated tau; Neurofibrillary tangles; Immunotherapy; Beta-amyloid; Alzheimer's disease;
Oleuropein aglycone counteracts Aβ42 toxicity in the rat brain
Keywords: مگس های نوروفیبریلیال; AD; Alzheimer's disease; ChAT; choline acetyltransferase; OLE; oleuropein aglycone; NBM; nucleus basalis magnocellularis; Aβ; amyloid β; NFT; neurofibrillary tangles; GFAP; glial fibrillary acid protein; Iba 1; ionized calcium binding adaptor molecule;
Why Alzheimer trials fail: removing soluble oligomeric beta amyloid is essential, inconsistent, and difficult
Keywords: مگس های نوروفیبریلیال; Alzheimer's disease; Clinical trial failures; Neurotoxic soluble oligomers; Soluble ABeta amyloid; Correlation of soluble oligomers with cognitive decline; Synapses; Cognitive decline; Autopsies; Senile plaques; Interrelationship of senile plaque amyloid
MicroRNA-922 promotes tau phosphorylation by downregulating ubiquitin carboxy-terminal hydrolase L1 (UCHL1) expression in the pathogenesis of Alzheimer's disease
Keywords: مگس های نوروفیبریلیال; AD; Alzheimer's disease; APP; Aβ (β-Amyloid) precursor protein; BACE1; β-amyloid cleavage enzyme 1; miRs; MicroRNAs; NFTs; neurofibrillary tangles; 3â²UTRs; 3â²-untranslated regions; UCHL1; ubiquitin carboxy-terminal hydrolase L1; miR-922; UCHL1; p
Antisense oligonucleotide against GSK-3β in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease
Keywords: مگس های نوروفیبریلیال; Aβ; amyloid-beta; AD; Alzheimer's disease; BBB; blood-brain barrier; BSA; bovine serum albumin; GSK-3β; glycogen synthase kinase-3β; GST; glutathione S-transferase; ICV; intracerebroventricularly; NFTs; neurofibrillary tangles; Nrf2; nuclear factor-E
Early-onset cognitive deficits and axonal transport dysfunction in P301S mutant tau transgenic mice
Keywords: مگس های نوروفیبریلیال; NFTs, neurofibrillary tangles; FTLD, frontotemporal lobar degeneration; MT, microtubule; WT, wild type; Tg, transgenic; SEM, standard error of the meanTau; Axonal transport; Tg mouse model; Neurofibrillary tangles; Frontotemporal lobar degeneration; Alzhe
Inactivation of brain Cofilin-1 by age, Alzheimer's disease and γ-secretase
Keywords: مگس های نوروفیبریلیال; AD; Alzheimer's disease; APP; amyloid precursor protein; APP/PS1; APPKM670/671NL/PS1L166P transgenic mice; APPKO; amyloid precursor protein knockout mice; Aβ; Amyloid-β peptides; Cofilin1; Cofilin isoform 1; CpdE; Compound E; DIV; days in vitro; DMSO; d
Human apolipoprotein E4 modulates the expression of Pin1, Sirtuin 1, and Presenilin 1 in brain regions of targeted replacement apoE mice
Keywords: مگس های نوروفیبریلیال; AD; Alzheimer's disease; apoE; apoliporpotein E; apoE TR mice; human apoE3- and apoE4-targeted replacement mice; APP; amyloid precursor protein; Aβ; amyloid beta peptide; BDNF; Brain-derived Neurotrophic Factor; DDCt; Delta-Delta Ct; EDTA; ethylenedi
Pterostilbene attenuates lipopolysaccharide-induced learning and memory impairment possibly via inhibiting microglia activation and protecting neuronal injury in mice
Keywords: مگس های نوروفیبریلیال; LPS; lipopolysaccharide; DCX; Doublecortin; AD; Alzheimer's disease; Ab; Amyloid b; TLR; toll-like receptor; NO; nitric oxide; TNF-a; tumor necrosis factor-a; IL-6; interleukin 6; LTP; long-term potentiation; NFTs; neurofibrillary tangles; APP; amyloid
Review - Part of the Special Issue: Alzheimer's Disease - Amyloid, Tau and BeyondAlzheimer disease: Epidemiology, diagnostic criteria, risk factors and biomarkers
Keywords: مگس های نوروفیبریلیال; Neuropathological; Neurofibrillary tangles; Biomarkers;
Neurogenesis in neurological and psychiatric diseases and brain injury: From bench to bedside
Keywords: مگس های نوروفیبریلیال; 6-OHDA; 6-hydroxydopamine; 7-OH-DPAT; 7-hydroxy-N,N-di-n-propyl-2-aminotetralin; AD; Alzheimer's disease; ADAM; a disintegrin and metalloproteinase; APH-1; anterior pharynx-defective 1; ApoE4; apolipoprotein E É4 allele; APP; amyloid precursor protein; A
Is Alzheimer's disease related to metabolic syndrome? A Wnt signaling conundrum
Keywords: مگس های نوروفیبریلیال; AMPK; AMP-activated protein kinase; STAT; activator of transcription; AGE; advanced glycation end products; AD; Alzheimer's disease; APP; amyloid precursor protein; Aβ; amyloid-β peptide; ACE; angiotensin converting enzyme; Ang I; angiotensin I; AR-II;
CB2 receptor and amyloid pathology in frontal cortex of Alzheimer's disease patients
Keywords: مگس های نوروفیبریلیال; CB1 receptor; Aβ levels; Amyloid plaques; Neurofibrillary tangles; Cognitive status; Hypophagia;
Formation of non-toxic Aβ fibrils by small heat shock protein under heat-stress conditions
Keywords: مگس های نوروفیبریلیال; AD; Alzheimer's disease; SPs; senile plaques; NFTs; neurofibrillary tangles; CAA; cerebrovascular amyloid angiopathy; Aβ; amyloid-β peptides; sHsp; small heat shock protein; SpHsp16.0; sHsp from fission yeast Schizosaccharomyces pombe; Amyloid-β; Amy
PI3-kinase/Akt/mTOR signaling: Impaired on/off switches in aging, cognitive decline and Alzheimer's disease
Keywords: مگس های نوروفیبریلیال; AD; Alzheimer's disease; Aβ; amyloid-β; APP; amyloid precursor protein; 4EBP1; eukaryotic translation initiation factor 4E (eIF-4E)-binding protein-1; FOXO; Forkhead box-O class transcription factors; FMRP; Fragile-X mental retardation protein; GSK3β;
Quantitative neurofibrillary tangle density and brain volumetric MRI analyses in Alzheimer's disease presenting as logopenic progressive aphasia
Keywords: مگس های نوروفیبریلیال; Primary progressive aphasia; Logopenic variant of primary progressive aphasia; Alzheimer's disease; Neurofibrillary tangles; Hippocampus; MRI; Apolipoprotein E; TDP-43; Voxel-based morphometry; Alzheimer's dementia;
Decisive role of Reelin signaling during early stages of Alzheimer's disease
Keywords: مگس های نوروفیبریلیال; Aβ; amyloid beta; AD; Alzheimer's disease; AON; anterior olfactory nucleus; ApoER2; apolipoprotein E receptor 2; APP; amyloid precursor protein; Dab-1; Disabled-1; GWA; genome-wide association; LTP; long term potentiation; MCI; mild cognitive impairmen
Lysophosphatidic acid induces increased BACE1 expression and Aβ formation
Keywords: مگس های نوروفیبریلیال; AD; Alzheimer's disease; NFT; neurofibrillary tangles; Aβ; β amyloid; APP; amyloid precursor protein; BACE1; β-site APP cleaving enzyme 1; oxLDL; oxidized low-density lipoprotein; CSF; cerebrospinal fluid; LPA; lysophosphatidic acid; CREB; cAMP respons
Tau protein phosphatases in Alzheimer's disease: The leading role of PP2A
Keywords: مگس های نوروفیبریلیال; AD; Alzheimer's disease; NFT; neurofibrillary tangles; PHF; paired helical filaments; SP; senile plaques; APP; apolipoprotein; PP1; protein phosphatase-1; PP2A; protein phosphatase-2A; PP2B; protein phosphatase-2B; PP5; protein phosphatase-5; PTEN; phosph
Prevention of β-amyloid induced toxicity in human iPS cell-derived neurons by inhibition of Cyclin-dependent kinases and associated cell cycle events
Keywords: مگس های نوروفیبریلیال; iPS cells; induced pluripotent stem cells; hiPS-C4; hiPS cell line UC C0406 iPS-C4; ES cells; embryonic stem cells; NPCs; neural progenitor cells; CCEs; cell cycle events; Aβ; β-amyloid; NFTs; neurofibrillary tangles; APP; amyloid precursor protein; AD;
Tau protein kinases: Involvement in Alzheimer's disease
Keywords: مگس های نوروفیبریلیال; AD; Alzheimer's disease; APP; amyloid precursor protein; Arg; Abl-related gene; SFK; Src family kinase; Aβ; β-amyloid; BBB; blood brain barrier; LD50; lethal dose 50; c-Abl; c-Abelson; Cables; c-Abl-binding adaptator protein; CaMKII; Ca2+/calmodulin-dep
Chitosan oligosaccharides protect rat primary hippocampal neurons from oligomeric β-amyloid 1-42-induced neurotoxicity
Keywords: مگس های نوروفیبریلیال; AD; Alzheimer's disease; Aβ; β-amyloid peptide; APP; amyloid precursor protein; SPs; senile plaques; NFTs; neurofibrillary tangles; ROS; reactive oxygen species; COSs; chitosan oligosaccharides; Aβ42; β-amyloid fragments 1-42; HFIP; 1,1,1,3,3,3-hexafl
Molecular events during the induction of neurodegeneration and memory loss in estrogen-deficient rats
Keywords: مگس های نوروفیبریلیال; TAU; Neurofibrillary tangles; Amyloid plaques; Ovariectomy; Hippocampus;
Dissecting the molecular mechanism by which NH2htau and Aβ1-42 peptides impair mitochondrial ANT-1 in Alzheimer disease
Keywords: مگس های نوروفیبریلیال; AA; antimycin A; Aβ; β-amyloid; AD; Alzheimer disease; ANT-1; adenine nucleotide translocator-1; Ap5A; P1,P5-Di(adenosine-5â²)penta-phosphate; ATP D.S.; ATP detecting system; ATR; atractyloside; β-OH; β-hydroxybutyrate; CGCs; cerebellar granule cells
Biological and methodical challenges of blood-based proteomics in the field of neurological research
Keywords: مگس های نوروفیبریلیال; AD; Alzheimer's disease; Aβ; amyloid beta; CSF; cerebrospinal fluid; EDTA; ethylenediaminetetraacetic acid; XML; extensible markup language; HAPs; high-abundance proteins; HPLC; high-performance liquid chromatography; HUPO; Human Proteome Organization; H
Lack of detectable diffuse or neuritic plaques and neurofibrillary tangles in the brains of aged hamsters
Keywords: مگس های نوروفیبریلیال; Alzheimer's disease; Amyloid; Campbell-Switzer silver staining; Immunohistochemistry; Neurofibrillary tangles; Mesocricetus auratus; Neuritic plaques; Syrian golden hamster;
Cerebrospinal fluid apolipoprotein e levels in subacute sclerosing panencephalitis
Keywords: مگس های نوروفیبریلیال; Apolipoprotein E; Subacute sclerosing panencephalitis; Neurofibrillary tangles
2-Styrylindolium based fluorescent probes visualize neurofibrillary tangles in Alzheimer's disease
Keywords: مگس های نوروفیبریلیال; BYUCENOZTGVBAU-UHFFFAOYSA-M; DFMPGFLPNGLYSZ-UHFFFAOYSA-M; YNVCGZRAQOHCEC-UHFFFAOYSA-M; GUNZDBGLCFMCGT-UHFFFAOYSA-M; IPOZUTQBTFRBLZ-UHFFFAOYSA-N; IRPSTTBCEOBEMW-JHGYPSGKSA-M; Alzheimer's disease; Neurofibrillary tangles; Zebrafish; Cytotoxicity; Imaging;
Research reportMicroRNA-195 downregulates Alzheimer's disease amyloid-β production by targeting BACE1
Keywords: مگس های نوروفیبریلیال; AD; Alzheimer's disease; Aβ; amyloid-beta; NFTs; neurofibrillary tangles; APP; amyloid precursor protein; sAPPβ; the secreted beta-form of APP; Aβ; amyloid-beta; BACE1; beta-site APP cleaving enzyme 1; 3â²-UTR; 3â²-untranslated region; sAPPβ; the se
Role of hippocampal CA1 atrophy in memory encoding deficits in amnestic Mild Cognitive Impairment
Keywords: مگس های نوروفیبریلیال; AD; Alzheimer's disease; aMCI; amnestic Mild Cognitive Impairment; CA; Cornu Ammonis; DG; dentate gyrus; HIPER; HIppocampal Encoding/Retrieval Pattern; GM; grey matter; WM; white matter; SVC; small volume correction; 3D; three-dimensional; TGA; transient
PerspectiveAlzheimer's disease: Pathogenesis and prevention
Keywords: مگس های نوروفیبریلیال; Alzheimer's disease; AT8; Brain evolution; Evolutionary medicine; Hyperphosphorylated tau protein; Neurofibrillary tangles; Neuropil threads; Pretangles; Myelination;
Corticosteroids, but not NSAIDs, are associated with less Alzheimer neuropathology
Keywords: مگس های نوروفیبریلیال; Glucocorticoids; Corticosteroids; Nonsteroidal anti-inflammatory drugs (NSAIDs); Neuritic plaques; Neurofibrillary tangles;
Long-term oral lithium treatment attenuates motor disturbance in tauopathy model mice: Implications of autophagy promotion
Keywords: مگس های نوروفیبریلیال; Tau protein; GSK-3; Lithium; Autophagy; Microtubule-associated protein 1 light chain 3; Phosphorylation; Neurofibrillary tangles
Review ArticleSome evolutionary perspectives on Alzheimer's disease pathogenesis and pathology
Keywords: مگس های نوروفیبریلیال; Alzheimer's disease; Dementia; Evolutionary medicine; Amyloid-β plaques; Neurofibrillary tangles; APOE; Comparative biology;
Gene expression levels assessed by CA1 pyramidal neuron and regional hippocampal dissections in Alzheimer's disease
Keywords: مگس های نوروفیبریلیال; 2N; normal disomic littermates; AD; Alzheimer's disease; Aβ; amyloid-β peptide; APP; amyloid-β precursor protein; ANOVA; analysis of variance; ApoE; apolipoprotein E; CH; calcium and potassium channels; CBF; cholinergic basal forebrain; Ct; cycle thres
Involvement and interplay of Parkin, PINK1, and DJ1 in neurodegenerative and neuroinflammatory disorders
Keywords: مگس های نوروفیبریلیال; Aβ; amyloid-β; AD; Alzheimer's disease; AIMP2; aminoacyl tRNA synthetase complex-interacting multifunctional protein 2; CAA; cerebral amyloid angiopathy; CSF; cerebrospinal fluid; EAE; experimental autoimmune encephalomyelitis; ER; endoplasmic reticul
The Molecular Pathology of Alzheimer's Disease
Keywords: مگس های نوروفیبریلیال; Alzheimer's disease; Tau protein; Amyloid-β protein; Neurofibrillary tangles; Plaques; Protein aggregation disorders;
Structural and functional characterization of H2 haplotype MAPT promoter: Unique neurospecific domains and a hypoxia-inducible element would enhance rationally targeted tauopathy research for Alzheimer's disease
Keywords: مگس های نوروفیبریلیال; AD; Alzheimer's disease; AP; activator protein; APOE; apolipoprotein E gene; APP; amyloid β peptide precursor gene; Aβ; amyloid β peptide; bp; base-pair; C/EBP; CCAAT/enhancer binding protein; C6; rat glioblastoma cells; CAT; chloramphenicol acetyltran
T-817MA, a neuroprotective agent, attenuates the motor and cognitive impairments associated with neuronal degeneration in P301L tau transgenic mice
Keywords: مگس های نوروفیبریلیال; AD; Alzheimer's disease; FTDP-17; frontotemporal dementia and parkinsonism linked to chromosome 17; P301L mice; transgenic mice expressing FTDP-17 mutation P301L of human tau; T-817MA; 1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl} azetidin-3-ol maleate;
Substituted 2-aminothiazoles are exceptional inhibitors of neuronal degeneration in tau-driven models of Alzheimer’s disease
Keywords: مگس های نوروفیبریلیال; 2-Aminothiazole; Hantzsch synthesis; Tauopathies; Alzheimer’s disease; Neuronal toxicity; Neurofibrillary tangles
Chronic exercise ameliorates the neuroinflammation in mice carrying NSE/htau23
Keywords: مگس های نوروفیبریلیال; Chronic exercise; Neuroinflammation; NSE/htau23; Neurofibrillary tangles; Gliosis
Microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer's disease
Keywords: مگس های نوروفیبریلیال; AD, Alzheimer's disease; CA, Cornu Ammonis; FFPE, formalin-fixed paraffin-embedded; LCM, laser capture microdissection; MMSE, mini-mental status exam; NFT, neurofibrillary tangleCognitive impairment; Aging; Neurodegeneration; Neurofibrillary tangles; Myel
NOS-mediated morphological and molecular modifications in rats infused with Aβ (1-40), as a model of Alzheimer's disease, in response to a new lipophilic molecular combination codrug-1
Keywords: مگس های نوروفیبریلیال; AD; Alzheimer's disease; AP; amyloid plaques; APP; amyloid precursor protein; BBB; blood-brain barrier; CNS; central nervous system; COX; cyclooxygenase; DAB; diaminobenzidine chromogen; IBU; ibuprofen; LA; R-(α)-lipoic acid; NFTs; neurofibrillary tang