Keywords: اتصال غیر اختصاصی; Single-domain antibody; Rabbit heavy chain variable region; Physicochemical improvement; Amino acid substitution; Thermal stability; Non-specific binding; Colloidal stability;
مقالات ISI اتصال غیر اختصاصی (ترجمه نشده)
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Keywords: اتصال غیر اختصاصی; Biosensing; Electrohydrodynamics; Immunoassay; Non-specific binding; Sensor fouling;
Keywords: اتصال غیر اختصاصی; Amiodarone; Atenolol; Blood sampling methods; Dual cannulation; Itraconazole; Jugular vein; Non-specific binding; Rat pharmacokinetic studies;
Keywords: اتصال غیر اختصاصی; Immuno-assay; Dengue virus detection; Non-specific binding;
Keywords: اتصال غیر اختصاصی; Food structure; Macronutrients; Starch; Protein; Lipids; In vitro hydrolysis; Non-specific binding;
Keywords: اتصال غیر اختصاصی; Sorghum; Polyphenols; Antioxidant capacity; Oxidative stress; Pasta; Durum; B0; maximum binding; CP; control pasta; DNPH; 2,4-dinitrophenylhydrazine; GAE; gallic acid equivalents; H2O2; hydrogen peroxide; NSB; non-specific binding; pNpp; p-nitrophenyl pho
Keywords: اتصال غیر اختصاصی; Non-specific binding; Proteomics; Peptidomics; Nano chromatography coupled tandem mass-spectrometryNSB, non-specific binding; BB, basic buffer; AbsRate, absorption rate; InitInt, initial intensity; RT, retention time; GuHCl, guanidine-hydrochloride
Keywords: اتصال غیر اختصاصی; Biotin-binding protein; Cell-free extract; Isoelectric point; Lentinula edodes; Non-specific binding
Keywords: اتصال غیر اختصاصی; Hyaluronidase inhibitor; Non-specific binding; Concentration–response curve; DMSO; Perturbation
Development of a safe and scalable route towards a tau PET tracer precursor
Keywords: اتصال غیر اختصاصی; calcd; calculated; h; hour(s); IPC; in-process control; min; minutes; NFT; neurofibrillary tangle; NSB; non-specific binding; NT; neutropil thread; r.t.; ambient (room) temperature; Buchwald-Hartwig amination; CH activation; Diazacarbazole; Direct arylati
Intact cellular structure in cereal endosperm limits starch digestion in vitro
Keywords: اتصال غیر اختصاصی; Wheat; Sorghum; Intact cells; Starch digestion; Non-specific binding;
Discovery of hyaluronidase inhibitors from natural products and their mechanistic characterization under DMSO-perturbed assay conditions
Keywords: اتصال غیر اختصاصی; Hyaluronidase inhibitor; Non-specific binding; DMSO; Concentration-response curve; Catechin;
Inhibition of human UDP-glucuronosyltransferase enzymes by lapatinib, pazopanib, regorafenib and sorafenib: Implications for hyperbilirubinemia
Keywords: اتصال غیر اختصاصی; DDI; drug-drug interaction; β-EST; β-estradiol; HLM; human liver microsomes; IV-IVE; in vitro-in vivo extrapolation; KI; kinase inhibitor; 4MU; 4-methylumbelliferone; LAP; lapatinib; NSB; non-specific binding; PAZ; pazopanib; PRO; propofol; REG; r
Double positive effect of adding hexaethyelene glycol when optimizing the hybridization efficiency of a microring DNA detection assay
Keywords: اتصال غیر اختصاصی; Surface functionalization; DNA detection; Microring resonator; Non-specific binding; Backfilling; Probe orientation;
Characterisation of a novel, high affinity and selective αvβ6 integrin RGD-mimetic radioligand
Keywords: اتصال غیر اختصاصی; αvβ6; alpha-v beta-6; RGD; arginyl-glycinyl-aspartic acid; CHAPS; 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate; DPU; Discovery Performance Unit; DMSO; dimethyl sulphoxide; ELISA; enzyme-linked immunosorbent assay; FCS; foetal calf serum; HE
Radiosynthesis and in vitro validation of 3H-NS14492 as a novel high affinity alpha7 nicotinic receptor radioligand
Keywords: اتصال غیر اختصاصی; Bmax; maximum density; 125I-BTX; 125I-α-bungarotoxin; Kd; dissociation constant; Ki; inhibition constant; NSB; non-specific binding; OD; optical density; PAM; positive allosteric modulator; SB; specific binding; TB; total binding; TE; tissue equivalent;
PAPP-A and IGFBP-4 fragment levels in patients with ST-elevation myocardial infarction treated with heparin and PCI
Keywords: اتصال غیر اختصاصی; ACS; acute coronary syndrome; CI; confidence interval; CPS; counts per second; CT; carboxy terminal; ECG; electrocardiogram; GAG; glycosaminoglycan; IGF-I; insulin-like growth factor I; IGF-IR; insulin-like growth factor I receptor; IGFBP; insulin-like gr
Lubricin: A versatile, biological anti-adhesive with properties comparable to polyethylene glycol
Keywords: اتصال غیر اختصاصی; Anti-adhesion; Lubricin; Non-specific binding; Biofouling; Quartz crystal microbalance; Surface treatment;
The T-cell-dependent antibody response assay in nonclinical studies of pharmaceuticals and chemicals: Study design, data analysis, interpretation
Keywords: اتصال غیر اختصاصی; APC; antigen presenting cells; AUC; area under the curve; CP; cut point; ECL; electrochemiluminescence; ELISA; enzyme-linked immunosorbent assay; EPA; Environmental Protection Agency; GLP; good laboratory practice; HMW; high molecular weight; HBsAg; Hepat
Comparison [3H]-flumazenil binding parameters in rat cortical membrane using different separation methods, filtration and centrifugation
Keywords: اتصال غیر اختصاصی; TB; Total binding; NSB; Non-specific binding; SB; Specific binding; Radioligand receptor binding assay; [3H]-flumazenil; Liquid scintillation; Filtration; Centrifugation;
Pharmacokinetics, brain distribution and plasma protein binding of carbamazepine and nine derivatives: New set of data for predictive in silico ADME models
Keywords: اتصال غیر اختصاصی; ADME; absorption distribution metabolism and excretion; AEDs; antiepileptic drugs; AUC; area under the plasma drug concentration-time curve; BBB; blood-brain barrier; CBZ; carbamazepine; CBZ-E; carbamazepine-10,11-epoxide; Cmax; maximum peak concentra
Engineering of novel tamavidin 2 muteins with lowered isoelectric points and lowered non-specific binding properties
Keywords: اتصال غیر اختصاصی; Avidin; Biotin-binding; Isoelectric point; Non-specific binding; Protein engineering; Tamavidin
Cysteine-tagged chimeric avidin forms high binding capacity layers directly on gold
Keywords: اتصال غیر اختصاصی; Self-assembled monolayer; Cysteine tagged; Avidin; Biotin; Non-specific binding
Radiotracer properties determined by high performance liquid chromatography: a potential tool for brain radiotracer discovery
Keywords: اتصال غیر اختصاصی; Radiotracer discovery; HPLC; Brain uptake; Lipophilicity; Non-specific binding; SPECT and PET;
TIRF microscopy as a screening method for non-specific binding on surfaces
Keywords: اتصال غیر اختصاصی; Total internal reflection; Fluorescence; Microscopy; Non-specific binding; Surface–particle interaction
A rapid vesicle electrokinetic chromatography method for the in vitro prediction of non-specific binding for potential PET ligands
Keywords: اتصال غیر اختصاصی; AOT; docusate sodium salt; BBB; blood brain barrier; CHI IAM7.4; chromatographic hydrophobicity index values referring to immobilized artificial membrane chromatography at pH 7.4; EKC; electrokinetic chromatography; IAM; immobilized artificial membrane; L
Increased desensitization of dopamine D2 receptor-mediated response in the ventral tegmental area in the absence of adenosine A2A receptors
Keywords: اتصال غیر اختصاصی; adenosine A2A receptor; dopamine D2 receptor; dopamine neuron; D2 receptor desensitization; A2A receptor knockout mice; ventral tegmental area; aCSF; artificial cerebrospinal fluid; CGS21680; 4-[2-[[6-amino-9-(N-ethyl-β-d-ribofuranuronamidosyl)-9H-purin-
Dalbavancin: Quantification in human plasma and urine by a new improved high performance liquid chromatography–tandem mass spectrometry method
Keywords: اتصال غیر اختصاصی; Dalbavancin HPLC–MS/MS in plasma; Non-specific binding; Pediatric pharmacokinetic sampling; Urine sample collection; Validation; ISR
Anti-BSA antibodies are a major cause of non-specific binding in insulin autoantibody radiobinding assays
Keywords: اتصال غیر اختصاصی; NSB; non-specific binding; BSA; bovine serum albumin; IAA; insulin autoantibodies; SNSC; screen-negative schoolchildren; SPSC; screen-positive schoolchildren.; Insulin autoantibody assays; Non-specific binding; Bovine serum albumin;
Deposition of chemically reactive and repellent sites on biosensor chips for reduced non-specific binding
Keywords: اتصال غیر اختصاصی; PECVD; Amine functionalization; Cycloolefin copolymer; Non-specific binding
Development and validation of sensitive and selective LC–MS/MS methods for the determination of BMS-708163, a γ-secretase inhibitor, in plasma and cerebrospinal fluid using deprotonated or formate adduct ions as precursor ions
Keywords: اتصال غیر اختصاصی; LC–MS; Fomate adduct; Non-specific binding
Evaluation of non-specific binding suppression schemes for neutravidin and alkaline phosphatase at the surface of reticulated vitreous carbon electrodes
Keywords: اتصال غیر اختصاصی; Non-specific binding; Reticulated vitreous carbon; Neutravidin; Sandwich bioassay; Alkaline phosphatase; Linear scan voltammetry
Reducing non-specific binding and uptake of nanoparticles and improving cell targeting with an antifouling PEO-b-PγMPS copolymer coating
Keywords: اتصال غیر اختصاصی; Nanoparticles; Copolymer; Antifouling; Non-specific binding; Reticuloendothelial system; Cancer targeting
Anti-fouling characteristics of surface-confined oligonucleotide strands bioconjugated on streptavidin platforms in the presence of nanomaterials
Keywords: اتصال غیر اختصاصی; Anti-fouling; Non-specific binding; DNA biosensor; Streptavidin SAM; Surface plasmon fluorescence spectroscopy (SPFS); Surface acoustic wave (SAW); Quantum dots (QDs); Surface plasmon resonance (SPR); CdSe nanoparticles; Thiol-biotin;
Sensitive and cost-effective LC–MS/MS method for quantitation of CVT-6883 in human urine using sodium dodecylbenzenesulfonate additive to eliminate adsorptive losses
Keywords: اتصال غیر اختصاصی; CVT-6883; A2B adenosin receptor antagonist; Human urine; Sodium dodecylbenzenesulfonate; SDBS; Adsorptive losses; Non-specific binding; LC–MS/MS; Method validation
Development of a surface plasmon resonance-based assay for the detection of Corynebacterium pseudotuberculosis infection in sheep
Keywords: اتصال غیر اختصاصی; Corynebacterium pseudotuberculosis; Caseous lymphadenitis; Surface plasmon resonance (SPR); Serum; Non-specific binding
Discovery and functional evaluation of diverse novel human CB1 receptor ligands
Keywords: اتصال غیر اختصاصی; CB1; cannabinoid receptor, subtype 1; CB2; cannabinoid receptor, subtype 2; CNS; central nervous system; FFA; free fatty acids; GPCR; G-protein coupled receptor; MMFF; Merck molecular force-field; NA; not available; NSB; non-specific binding; SAR; structu
The influence of protein adsorption on nanoparticle association with cultured endothelial cells
Keywords: اتصال غیر اختصاصی; Nanoparticle; Protein adsorption; Non-specific binding; HUVEC (endothelial cells); Polystyrene; Nanotoxicity/nanotoxicology
Binary monolayers of single-stranded oligonucleotides and blocking agent for hybridisation
Keywords: اتصال غیر اختصاصی; SH-ssDNA; Oligonucleotides; Non-specific binding; Surface plasmon resonance; Hybridisation
Characterization of the interaction between furosemide and bovine serum albumin
Keywords: اتصال غیر اختصاصی; Furosemide; Serum albumin–drug interactions; Fluorescence quenching; Bovine serum albumin; Non-specific binding
Non-specific binding and saturation of Polysorbate-20 with aseptic filter membranes for drug substance and drug product during mAb production
Keywords: اتصال غیر اختصاصی; Non-specific binding; Polysorbate-20; Filter membranes
Treatment with haloperidol and diazepam alters GABAA receptor density in the rat brain
Keywords: اتصال غیر اختصاصی; BA; Brodmann's area; BZs; benzodiazepines; DMSO; dimethyl sulfoxide; CA; Cornu ammonis; DG; dentate gyrus; ETE; estimated tissue equivalents; GABA; γ-aminobutyric acid; GABAAR; GABA type A receptors; IP; intraperitoneal; NSB; non-specific binding; TB; to
Evidence for altered post-receptor modulation of the serotonin 2a receptor in schizophrenia
Keywords: اتصال غیر اختصاصی; HTR2A; serotonin2A receptor; ME; membrane-enriched tissue fraction; CE; cytosol-enriched tissue fraction; BA; Brodmann's area; DOI; duration of illness; FRDD; final recorded dose of antipsychotic drug; PMI; postmortem interval; TB; total binding; NSB; non
Calorimetric and Spectroscopic Studies of Hoechst 33258: Self-association and Binding to Non-cognate DNA
Keywords: اتصال غیر اختصاصی; ITC, isothermal titration calorimetrydrug-DNA interactions; isothermal titration calorimetry; non-specific binding; ligand self-association; coupled equilibria; data analysis
Pitfalls of the application of microdialysis in clinical oncology: Controversial findings with docetaxel
Keywords: اتصال غیر اختصاصی; Microdialysis; Non-specific binding; Polyurethane; Docetaxel
Hybridisation of surface-immobilised single-stranded oligonucleotides and polymer monitored by surface plasmon resonance
Keywords: اتصال غیر اختصاصی; SH-ssDNA; Oligonucleotides; Non-specific binding; Repellent; Polymer; Surface plasmon resonance; Hybridisation
The enhanced diffusional mixing for latex immunoagglutination assay in a microfluidic device
Keywords: اتصال غیر اختصاصی; Latex immunoagglutination assay; Diffusional mixing; Microfluidic device; Non-specific binding;
The Role of High Affinity Non-specific DNA Binding by Lrp in Transcriptional Regulation and DNA Organization
Keywords: اتصال غیر اختصاصی; Lrp, leucine-responsive regulatory protein; H-NS, histone-like nucleoid structuring protein; NS, non-specific; Dam, DNA adenine methyltransferase; SELEX, systematic evolution of ligands by exponential enrichmentLrp; non-specific binding; transcriptional r
Non-specific binding to protein A Sepharose and protein G Sepharose in insulin autoantibody assays may be reduced by pre-treatment with glycine or ethanolamine
Keywords: اتصال غیر اختصاصی; PAS, protein A Sepharose; PGS, protein G Sepharose; IAA, insulin autoantibodies; NSB, non-specific binding; GAD, glutamic acid decarboxylase.Insulin autoantibody assays; Non-specific binding; Protein A Sepharose; Protein G Sepharose
Modification of the ultrafiltration technique to overcome solubility and non-specific binding challenges associated with the measurement of plasma protein binding of corticosteroids
Keywords: اتصال غیر اختصاصی; Plasma protein binding; Non-specific binding; Ultrafiltration; Corticosteroids; Fluticasone propionate