Aberrant mTOR activation in senescence and aging: A mitochondrial stress response?
Keywords: Mitochondria; Aging; ROS; mTOR; Senescence; p70S6K; S6 kinase; p53;
مقالات ISI (ترجمه نشده)
مقالات زیر هنوز به فارسی ترجمه نشده اند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
p70S6K is regulated by focal adhesion kinase and is required for Src-selective autophagy
Keywords: FAK; PDK1; Akt; p70S6K; S6; Autophagosomes;
Platycodin D triggers autophagy through activation of extracellular signal-regulated kinase in hepatocellular carcinoma HepG2 cells
Keywords: PD; Platycodin D; CQ; chloroquine; DMSO; dimethylsulfoxide; MTT; 3-[4,5-Dimethyl-2-thiazolyl]-2,5-diphenyltetrazolium bromide; MDC; monodansylcadaverin; ERK; extracellular signal-regulated kinase; BAF; bafilomycin A1; LC3; microtubule-associated protein 1
Interleukin-1β plays a role in the pathogenesis of mesial temporal lobe epilepsy through the PI3K/Akt/mTOR signaling pathway in hippocampal neurons
Keywords: Inflammation; Interleukin-1β; MTLE; Epilepsy; Hippocampus; Neuron; Phosphatidylino-sitol 3-kinase; p70S6K; mTOR
PLD1 activation mediates Amb a 1-induced Th2-associated cytokine expression via the JNK/ATF-2 pathway in BEAS-2B cells
Keywords: Ambrosia artemisiifolia; PLD1; JNK; p70S6K; IL-13; IL-5;
Docosahexaenoic acid inhibits proteolytic processing of sterol regulatory element-binding protein-1c (SREBP-1c) via activation of AMP-activated kinase
Keywords: SREBP; Sterol regulatory element binding protein; AMPK; AMPK-activated kinase; DHA; Docosahexaenoic Acid; PUFA; Polyunsaturated fatty acids; Akt; Akt/Protein Kinase B; mTORC1; Mammalian target of rapamycin complex 1; p70S6K; p70S6Kinase; T2DM; Type II Dia
MicroRNA-7: A miRNA with expanding roles in development and disease
Keywords: ACK1; activated CDC42 kinase 1; BASP1; brain abundant, membrane attached signal protein 1; c-Myc; v-Myc avian myelocytomatosis viral oncogene homolog; CD57; cluster of differentiation 57; CD44; cluster of differentiation 44; ciRS-7; circular RNA sponge fo
Roles of oxidative stress and the ERK1/2, PTEN and p70S6K signaling pathways in arsenite-induced autophagy
Keywords: Arsenite; Oxidative stress; Autophagy; p70S6K; ERK1/2;
The palladacycle, AJ-5, exhibits anti-tumour and anti-cancer stem cell activity in breast cancer cells
Keywords: BCS; breast cancer cell; ER; oestrogen receptor; CSC; cancer stem cell; FACS; fluorescence activated cell sorting; γH2AX; gamma-histone 2AX; mTOR; mammalian/mechanistic target of rapamycin; PARP; poly(ADP-ribose) polymerase; BCL-2; B-cell lymphoma-2; Bax
The integrated role of ACh, ERK and mTOR in the mechanisms of hippocampal inhibitory avoidance memory
Keywords: 4E-BPs; 4E binding proteins; ACh; acetylcholine; AD; Alzheimer's Disease; APP; amyloid precursor protein; CaMKII; Ca2+/calmodulin-dependent protein kinase II; CREB; cAMP response element-binding protein; DG; dentate gyrus; eEF1A; eukaryotic Elongation F
Effects of hepatic protein tyrosine phosphatase 1B and methionine restriction on hepatic and whole-body glucose and lipid metabolism in mice
Keywords: GSH; Glutathione; HPRT; Hypoxanthine-guanine phosphoribosyltransferase; IR; Insulin receptor; MR; Methionine restriction; mTORC1; Mechanistic target of rapamycin complex 1; NAFLD; Non-alcoholic fatty liver disease; p70S6K; p70 ribosomal S6 kinase; PIP3; P
Redox modulation of mitochondriogenesis in exercise. Does antioxidant supplementation blunt the benefits of exercise training?
Keywords: Akt; protein kinase B; AMPK; 5â²-AMP-activated protein kinase; AP-1; activator protein 1; COX IV; cytochrome c oxidase; CuZnSOD; copper/zinc superoxide dismutase; DMSO; dimethyl sulfoxide; eNOS; endothelial nitric oxide synthase; ERK; extracellular signa
Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells
Keywords: 4E-BP1; eukaryotic initiation factor 4E binding protein 1; AMPK; 5â²-AMP-activated protein kinase; APC; adenomatous polyposis coli; CK1; casein kinase 1; CM; conditioned medium; eIF4E; eukaryotic initiation factor 4E; GSK3β; glycogen synthase kinase-3β
Increasing leucine concentration stimulates mechanistic target of rapamycin signaling and cell growth in C2C12 skeletal muscle cells
Keywords: Amino acids; Anabolic signaling; C2C12; Skeletal muscle; mTOR; Protein synthesis; ANOVA; analysis of variance; 4E-BP1; eukaryotic initiation factor 4E-binding protein 1; FBS; fetal bovine serum; mTOR; mechanistic target of rapamycin; mTORC1; mechanistic t
p70S6 kinase is a critical node that integrates HER-family and PI3 kinase signaling networks
Keywords: p70S6K; p70S6 kinase; PI3K; phosphoinositide-3-kinase; RPPA; Reverse Phase Protein Array; mTOR; mammalian target of rapamycin; MAPK; mitogen activated protein kinase; EGFR; epidermal growth factor receptor; NSCLC; non-small cell lung cancer; RTK; receptor
Post-transcriptional regulation of autophagy in C2C12 myotubes following starvation and nutrient restoration
Keywords: ACC; acetyl-CoA carboxylase; Akt/PKB; protein kinase B; AMPK; AMP-activated protein kinase; ANOVA; analysis of variance; Atg; autophagy-related gene; Bnip3; B-cell lymphoma 2 interacting protein 3; DMEM; Dulbecco's modified Eagle medium; DPBS; Dulbecco's
WIF1 can effectively co-regulate pro-apoptotic activity through the combination with DKK1
Keywords: WIF1; Wnt inhibitory factor-1; Dvl; disheveled; FRP; Frizzled-related protein; DKK1; Dickkopf-1; VEGF; vascular endothelial growth factor; bFGF; basic fibroblast growth factor; FITC; fluorescein isothiocyanate; PI; propidium iodide; p70S6K; p70 ribosomal
Insulin-sensitizing and insulin-mimetic activities of Sarcopoterium spinosum extract
Keywords: AMPK; AMP-activated protein kinase; BAD; Bcl 2-antagonist of cell death; 2-DG; 2-deoxy-d-glucose; FoxO; forkhead transcription factor; GSK3β; glycogen synthase kinase 3β; IBMX; isobutylmethylxanthine; IKK; inhibitor of nuclear factor kappa-B kinase; IR;
Fisetin inhibits human melanoma cell growth through direct binding to p70S6K and mTOR: Findings from 3-D melanoma skin equivalents and computational modeling
Keywords: Fisetin; AKT; mTOR; p70S6K; Melanoma
p70S6 kinase mediates breast cancer cell survival in response to surgical wound fluid stimulation
Keywords: Breast cancer; p70S6K; mTOR; Xenograft; Survival; Proliferation;
mTOR/p70S6K signaling distinguishes routine, maintenance-level autophagy from autophagic cell death during influenza A infection
Keywords: Influenza; Cell death; Autophagy; Apoptosis; mTORC1/2; p70S6K; Rapamycin; Torin1;
Rapamycin preserves the follicle pool reserve and prolongs the ovarian lifespan of female rats via modulating mTOR activation and sirtuin expression
Keywords: P70S6K; ribosomal protein S6 kinase; mTOR; the mammalian target of rapamycin; SIRT; silent information regulator; Tsc; tuberous sclerosis complex; mTORC1; the mammalian target of rapamycin complex 1; POF; premature ovarian failure; PTEN; phosphatase and t
PI3-kinase/Akt/mTOR signaling: Impaired on/off switches in aging, cognitive decline and Alzheimer's disease
Keywords: AD; Alzheimer's disease; Aβ; amyloid-β; APP; amyloid precursor protein; 4EBP1; eukaryotic translation initiation factor 4E (eIF-4E)-binding protein-1; FOXO; Forkhead box-O class transcription factors; FMRP; Fragile-X mental retardation protein; GSK3β;
Wogonoside induces autophagy in MDA-MB-231 cells by regulating MAPK-mTOR pathway
Keywords: 3-MA; 3-methyladenine; AO; acridine orange; MAP-LC3; microtubule-associated protein-light chain 3; MDC; monodansylcadaverine; mTOR; mammalian target of rapamycin; p70S6K; p70-S6 kinase; PKCδ; protein kinase Cδ; TEM; transmission electron microscopy; Wog
Rapid activation of FAK/mTOR/p70S6K/PAK1-signaling controls the early testosterone-induced actin reorganization in colon cancer cells
Keywords: DEX; Dexamethasone; FAK; Focal Adhesion Kinase; HSA; human serum albumin; iAR; intracellular androgen receptor; mTOR; mammalian target of rapamycin; mAR; membrane androgen receptor; PAK1; p21-activated kinase 1; p70S6K; S6 kinase; PFA; paraformaldehyde; P
Effect of treadmill exercise on the BDNF-mediated pathway in the hippocampus of stressed rats
Keywords: Treadmill exercise; Immobilization stress; BDNF; PI3K; MTOR; Synaptic proteins; BDNF; Brain-derived neurotrophic factor; PI3K; Phosphatidylinositol 3-kinase; GSK-3β; Glycogen synthase kinase-3β; mTOR; mammalian target of rapamycin; p70S6K; p70 ribosomal
Intracerebroventricular administration of ouabain, a Na/K-ATPase inhibitor, activates mTOR signal pathways and protein translation in the rat frontal cortex
Keywords: 4E-BP; eukaryotic translation initiation factor 4E binding protein; aCSF; artificial cerebrospinal fluid; ANOVA; analysis of variance; BDNF; brain-derived neurotrophic factor; DAPI; 4â²,6â²-diamidino-2-phenylindole; EGFR; epidermal growth factor recepto
β-Adrenergic system, a backstage manipulator regulating tumour progression and drug target in cancer therapy
Keywords: FAK; focal adhesion kinase; PKA; protein kinase A; BAD; BCL2-associated death protein; VEGF; vascular endothelial growth factor; PlGF; placenta-derived growth factor; PDGF; platelet-derived growth factor; TGF-β; transforming growth factor β; HIF-1α; hy
The immunosuppressive agents rapamycin, cyclosporin A and tacrolimus increase lipolysis, inhibit lipid storage and alter expression of genes involved in lipid metabolism in human adipose tissue
Keywords: aP2; fatty acid binding protein 4; ATGL; adipose triacylglycerol lipase; BMI; body mass index; CGI-58; α/β-hydrolase domain containing 5; CNI; calcineurin inhibitor; CsA; cyclosporin A; DGAT1; diglyceride acyltransferase 1; FAS; fatty acid synthase; FFA
Quantitative proteomic analysis of the inhibitory effects of CIL-102 on viability and invasiveness in human glioma cells
Keywords: CIL-102; Fumarate hydratase; ROS; JNK1/2; p70S6K;
Nox4 and diabetic nephropathy: With a friend like this, who needs enemies?
Keywords: 20-HETE; 20-hydroxyeicosatetraenoic acid; AA; arachidonic acid; AGE; advanced glycation end-product; Akt/PKB; Akt/protein kinase B; AMPK; AMP-activated protein kinase; Ang II; angiotensin II; AOPP; advanced oxidation protein product; AT1; angiotensin II t
Dysregulation of cannabinoid CB1 receptor and associated signaling networks in brains of cocaine addicts and cocaine-treated rodents
Keywords: Akt; protein kinase B; ANCOVA; analyses of covariance; CB; cannabinoid; CB2xP; mice overexpressing CB2 receptors; F1; cytosolic fraction; F2; membrane fraction; F3; nuclear fraction; F4; cytoskeletal fraction; FAAH; fatty acid amide hydrolase; GRK; G prot
Impaired lipid accumulation in the liver of Tsc2-heterozygous mice during liver regeneration
Keywords: TSC; tuberous sclerosis; mTOR; mammalian target of rapamycin; GAP; GTPase-activating protein; MAPK; mitogen-activated protein kinase; p90 RSK; p90 ribosomal S6 kinase; ERK; extracellular signal-regulated kinase; P70S6K; p70 ribosomal S6 kinase; AMPK; 5â²
Signaling pathways mediating the effects of insulin-like growth factor-I in bovine muscle satellite cells
Keywords: Muscle; IGF-I; PI3K; ERK; p70S6K
Myogenic differentiation and lipid-raft composition of L6 skeletal muscle cells are modulated by PUFAs
Keywords: Cell membrane lipid; Fatty acid; Membrane microdomains; Myogenic differentiation; p70S6K;
Proteasome inhibition-induced p38 MAPK/ERK signaling regulates autophagy and apoptosis through the dual phosphorylation of glycogen synthase kinase 3β
Keywords: GSK3; p70S6K; MAPK; MG132; Autophagy
The inhibitory effect of CIL-102 on the growth of human astrocytoma cells is mediated by the generation of reactive oxygen species and induction of ERK1/2 MAPK
Keywords: ERK, extracellular signal-related kinase; Cdks, cyclin-dependent kinases; ROS, reactive oxygen speciesCIL-102; Glioma; G2/M arrest; ROS; ERK; p70S6K
Anti-cancer properties of glucosamine-hydrochloride in YD-8 human oral cancer cells: Induction of the caspase-dependent apoptosis and down-regulation of HIF-1α
Keywords: Apaf-1; apoptotic protease activating factor-1; Bcl-2; B cell lymphoma-2; Bcl-xL; B cell lymphoma-extra large; DCFH-DA; 2â²,7â²-dichlorofluorescein-diacetate; ECL; enzyme-linked chemiluminescence; FBS; fetal bovine serum; GAPDH; glyceraldehyde-3-phospha
Identification of Ras, Pten and p70S6K homologs in the Pacific oyster Crassostrea gigas and diet control of insulin pathway
Keywords: Crassostrea gigas; Insulin; Ras; Pten; p70S6K; Dietary restriction
Redox-regulating role of insulin: The essence of insulin effect
Keywords: 4-HNE; 4-hydroxynonenal; 8-OHdG; 8-hydroxydeoxyguanosine; 8-OHG; 8-hydroxyguanine; 8-iso-PGF2α; 8-iso-prostaglandin F2α; AD; Alzheimer's disease; AIDS; acquired immunodeficiency syndrome; Akt; protein kinase B; AMI; acute myocardial infarction; APS; a
Akt/mammalian target of rapamycin signaling pathway regulates neurite outgrowth in cerebellar granule neurons stimulated by methylcobalamin
Keywords: ANOVA; one way analysis of variance; CGNs; cerebellar granule neurons; DMEM; Dulbecco's modified Eagle's medium; Icmt; isoprenylcysteine carboxyl methyltransferase; MeCbl; methylcobalamin; mTOR; mammalian target of rapamycin; p70S6K; p70 ribosomal S6 prot
Arsenite induces cell transformation by reactive oxygen species, AKT, ERK1/2, and p70S6K1
Keywords: Arsenic; Transformation; ROS; AKT; ERK; p70S6K;
The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder
Keywords: MDD; major depressive disorder; PFC; prefrontal cortex; NMDA; N-methyl-d-aspartate; NR2A; NMDA receptor subunit 2A; NR2B; NMDA receptor subunit 2B; mGluR5; metabotropic glutamate receptor subtype 5; PSD-95; postsynaptic density-95Â kDa; mTOR; mammalian ta
Modulation of oxidative stress and tau phosphorylation by the mTOR activator phosphatidic acid in SH-SY5Y cells
Keywords: Mammalian target of rapamycin (mTOR); p70S6K; Phosphatidic acid; Tau protein; Oxidative stress; Alzheimer's disease;
Antiapoptotic Intervention in Repeated Blood Cardioplegia: A Porcine Study of Myocardial Function
Keywords: 31; Erk1/2; extracellular signal-regulated kinase; GSK3β; glycogen-synthase kinase; IGF-I/IGF-II; insulin-like growth factor; MEK1/2; mitogen-activated protein kinase; mPTP; mitochondrial permeability transition pore; mTOR; mammalian target of rapamycin;
Identification of MET and SRC Activation in Melanoma Cell Lines Showing Primary Resistance to PLX4032
Keywords: AK; adenylate kinase; AKT; v-akt murine thymoma viral oncogene homolog; ANOVA; analysis of variance; BCRP; breast cancer resistance protein; BRAF; v-raf murine sarcoma viral oncogene homolog B1; CCND1; cyclin D1; CRAF; v-raf-1 murine leukemia viral oncoge
Activation of mTOR signaling pathway contributes to survival of cervical cancer cells
Keywords: mTOR; P70S6K; Cervical cancer; Rapamycin; siRNA
Structure-guided expansion of kinase fragment libraries driven by support vector machine models
Keywords: FBDD; fragment-based drug design; SBDD; structure-based drug design; QSAR; quantitative structure activity relationship; SVM-FP; support vector machine-fingerprints; PPV; positive predicted value; LE; ligand efficiency; HAC; heavy atom count; AMW; atomi
Research ArticleNew insights into the antifibrotic effects of sorafenib on hepatic stellate cells and liver fibrosis
Keywords: HSC; hepatic stellate cell; ECM; extracellular matrix; BDL; bile duct ligation; DMN; dimethylnitrosamine; PDGF; platelet-derived growth factor; ERK; extracellular-signal-regulated kinase; p70S6K; 70-kDa ribosomal S6 kinase; MMP; matrix metalloproteinase;
Novel mechanism of reducing tumourigenesis: Upregulation of the DNA repair enzyme OGG1 by rapamycin-mediated AMPK activation and mTOR inhibition
Keywords: Rapamycin; p70S6K; AMPK; NF-YA; OGG1