Detection and pharmacological modulation of nicotinamide mononucleotide (NMN) in vitro and in vivo
Keywords: NAD; PARP; Mitochondria; FK866; NMNAT; NaPRT
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Analysis of apoptosis induced by Caprine Herpesvirus 1 in vitro
Keywords: CpHV-1; Apoptosis; Caspases; Cytochrome c; Bcl-2 family; PARP
Low concentration of arsenic could induce caspase-3 mediated head kidney macrophage apoptosis with JNK–p38 activation in Clarias batrachus
Keywords: Arsenic; Head kidney macrophages; Apoptosis; Caspase; MAPK; PARP
HCT116 cells deficient in p21Waf1 are hypersensitive to tyrosine kinase inhibitors and adriamycin through a mechanism unrelated to p21 and dependent on p53
Keywords: Chx; cycloheximide; PARP; poy(ADP-ribose)polymerase; PI; propidium iodide; p53; Adriamycin; Imatinib; Gefitinib; Apoptosis; HCT116; Myc;
Glutamine Increases Autophagy Under Basal and Stressed Conditions in Intestinal Epithelial Cells
Keywords: BBE; brush border expression; DMEM; Dulbecco's modified Eagle medium; Hsp; heat shock protein; IEC; intestinal epithelial cell; LC3; microtubule-associated protein light chain 3; MAP; mitogen-activated protein; mTOR; mammalian target of rapamycin; PARP; p
Increased Placental Apoptosis in Maternal Food Restricted Gestations: Role of the Fas Pathway
Keywords: Apoptosis; Fas; FasL; Caspases; tBID; PARP
Mode of cytotoxic action of T cell-engaging BiTE antibody MT110
Keywords: Apoptosis; Bispecific antibody; DNA fragmentation; EpCAM; Granzyme; PARP; PerforinEpCAM, epithelial cell adhesion molecule; MHC, major histocompatibility complex; PARP, poly (ADP ribose) polymerase; PBMC, peripheral blood mononuclear cell; PI, propidium i
Deficiency of GMDS Leads to Escape from NK Cell-Mediated Tumor Surveillance Through Modulation of TRAIL Signaling
Keywords: AAL; Aleuria aurantia lectin; bp; base pair; CMA; concanamycin A; FX; GDP-4-keto-6-deoxymannose-3,5-epimerase-4-reductase; GDP; guanosine diphosphate; GMDS; GDP-mannose-4,6-dehydratase; IgG; immunoglobulin G; NK; natural killer; PARP; poly(ADP-ribose) pol
PARP inhibitors: New partners in the therapy of cancer and inflammatory diseases
Keywords: PARP; poly(ADP-ribose); BRCA1/2; Homologous recombination; Angiogenesis; Anticancer therapy; Diabetes; Sepsis; Stroke; Inflammation; Cardiovascular disease; Free radicals
Therapeutic options for triple-negative breast cancers with defective homologous recombination
Keywords: ABC; ATP-binding cassette; APC; Adenomatous, polyposis coli; ATM; Ataxia telangiectasia mutated; ATR; ATM and Rad3-related; BER; base-excision repair; BRCA1; Breast cancer susceptibility gene 1; BRCA2; Breast cancer susceptibility gene 2; CGH; Comparative
A Rationally Designed Histone Deacetylase Inhibitor with Distinct Antitumor Activity against Ovarian Cancer
Keywords: HDAC; histone deacetylase; HDACI; histone deacetylase inhibitor; SAHA; suberoylanilide hydroxamic acid; VPA; valproic acid; AE1/AE3; a mixture of two monoclonal antibodies (AE1 and AE3), with broad specificity against cytokeratins; NOSE; normal ovarian su
Caspase substrates and neurodegenerative diseases
Keywords: Neurodegenerative diseases; Caspases; Substrates; Apoptosis; Survival; Huntingtin; APP; Tau; Preselinins; RasGAP; Rb; PARP
Cell death in the injured brain: Roles of metallothioneins
Keywords: ADP; adenosine diphosphate; AIF; apoptosis-inducing factor; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolyl-propionic acid; Apaf-1; apoptotic protease-activating factor 1; Atg; autophagy gene; Bak; Bcl-2-homologous antagonist/killer; Bax; Bcl-2-associated
Synthesis and SAR of novel, potent and orally bioavailable benzimidazole inhibitors of poly(ADP-ribose) polymerase (PARP) with a quaternary methylene-amino substituent
Keywords: PARP; Poly(ADP-ribose) polymerase; Inhibitor; Benzimidazole; Anticancer
Treatment with insulin inhibits poly(ADP-ribose)polymerase activation in a rat model of endotoxemia
Keywords: Sepsis; Diabetes; Glycemic control; PARP; Oxidative stress; Inflammation; TNF-α
Statins activate a mitochondria-operated pathway of apoptosis in breast tumor cells by a mechanism regulated by ErbB2 and dependent on the prenylation of proteins
Keywords: FPP; farnesylpyrophosphate ammonium salt; GGPP; geranylgeranylpyrophosphate; PARP; poly-(ADP-ribose) polymerase; HMG-CoA; hydroxymethylglutaryl-Coenzyme A; Statin; Apoptosis; Bcl-2; ErbB2; Mitochondria; Prenylation;
Immortalized cortical neurons expressing caspase-cleaved tau are sensitized to endoplasmic reticulum stress induced cell death
Keywords: AD; Alzheimer's disease; NFT; neurofibrillary tangle; ER; endoplasmic reticulum; SERCA; sarco-endoplasmic reticula calcium-ATPase-type pumps; PARP; poly (ADP-ribose) polymerase; ERK; extracellular signal-regulated kinase; TUNEL; Terminal deoxynucleotidyl
Pectenotoxin-2 represses telomerase activity in human leukemia cells through suppression of hTERT gene expression and Akt-dependent hTERT phosphorylation
Keywords: PTX-2; pectenotoxin-2; TRAP; telomeric repeat amplification protocol; ELISA; enzyme-linked immunosorbent assay; ChIP; Chromatin immunoprecipitation; PARP; DNA repair enzyme poly-(ADP-ribose) polymerase; Pectenotoxin-2; hTERT; c-Myc; Sp1; Akt;
Amelioration of neurological and biochemical deficits by peroxynitrite decomposition catalysts in experimental diabetic neuropathy
Keywords: Diabetic neuropathy; Streptozotocin; Peroxynitrite; Oxidative stress; PARP; Nerve blood flow; Motor nerve conduction velocity; Nociception; Allodynia
Pedicularioside A from Buddleia lindleyana inhibits cell death induced by 1-methyl-4-phenylpyridinium ions (MPP+) in primary cultures of rat mesencephalic neurons
Keywords: Parkinson's disease; Pedicularioside A; Mesencephalic neurons; MPP+; Caspase-3; PARP
Protective effects of 4-amino1,8-napthalimide, a poly (ADP-ribose) polymerase inhibitor in experimental diabetic neuropathy
Keywords: Diabetic neuropathy; PARP; 4-ANI; Neuropathic pain
Nicotinamide treatment induces behavioral recovery when administered up to 4 hours following cortical contusion injury in the rat
Keywords: traumatic brain injury; therapy; window of opportunity; vitamin; recovery of function; ANOVA; analysis of variance; CCI; cortical contusion injury; FPI; fluid percussion injury; HFP; Huynh-Feldt probabilities; HPLC; high pressure liquid chromatography; NA
Brief cross-linking of Fas/APO-1 (CD95) triggers engulfment of pre-apoptotic target cells
Keywords: CTL; cytotoxic T lymphocytes; DAPI; 4â²-6-diamidino-2-phenylindole; DEVD-AMC; aspartate-glutamate-valine-aspartate-7-amino-4-methyl-coumarin; FBS; fetal bovine serum; FPRL-1; formyl-peptide receptor-like-1; HMDM; human monocyte-derived macrophages;
Ischemic and inflammatory lung impairment by extracorporeal circulation: Effect of PARP-inhibition by INO1001
Keywords: ARDS; adult respiratory distress syndrome; CPB; cardiopulmonary bypass; ECC; extracorporeal circulation; HE; haematoxylin/eosine; HLM; heart-lung-machine; HSP70; heat shock protein 70; INO1001; indeno-isoquinolinone based poly(ADP-ribose) polymerase-inhib
PARP mediates structural alterations in diabetic cardiomyopathy
Keywords: Diabetic cardiomyopathy; Hyperhexosemia; PARP; p300;
Cadmium activates the mitogen-activated protein kinase (MAPK) pathway via induction of reactive oxygen species and inhibition of protein phosphatases 2A and 5
Keywords: AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; ASK1; apoptosis signal-regulating kinase 1; Cd; cadmium; CM-H2DCFDA; 5-(and-6)-chloromethyl-2â²,7â²-dichlorodihydrofluorescein diacetate; DAPI; 4â²,6-diamidino-2-phenylindole; DMEM; Dulbecco'
Regional remodeling strain and its association with myocardial apoptosis after myocardial infarction in an ovine model
Keywords: ANOVA; analysis of variance; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; LAD; left anterior descending coronary artery; LV; left ventricular; LVEDP; left ventricular end-diastolic pressure; MI; myocardial infarction; PARP; poly (adenosine diphosphate
Mechanisms of cell death induced by 2-chloroadenosine in leukemic B-cells
Keywords: 2-CAdo; 2-chloroadenosine; CdA; 2-chloro-2â²-deoxyadenosine; 2-CATP; 2-chloroATP; CLL; chronic lymphocytic leukaemia; HPLC; high-performance liquid chromatography; ITu; 5-iodotubercidin; NBTI; nitrobenzylthioinosine; PARP; poly(ADP-ribose) polymerase; PI
TcPARP: A DNA damage-dependent poly(ADP-ribose) polymerase from Trypanosoma cruzi
Keywords: Trypanosoma cruzi; PARP; DNA repair signalling; PARG;
A novel poly(ADP-ribose) polymerase inhibitor, ABT-888, radiosensitizes malignant human cell lines under hypoxia
Keywords: Hypoxia; Prostate cancer; Lung cancer; DNA repair; PARP; Radiosensitivity; Molecular inhibitor; Apoptosis; Chemotherapy
Glial reactions and degeneration of myelinated processes in spinal cord gray matter in chronic experimental autoimmune encephalomyelitis
Keywords: multiple sclerosis; inflammation; mouse; degeneration; demyelination; AIF1; allograft inflammatory factor; APC-CC1; adenomatous polyposis coli gene clone CC1; CFA; complete Freund's adjuvant; ChAT; choline acetyl transferase; DAB; diaminobenzidine; EAE; e
Wheat sprout extract induces changes on 20S proteasomes functionality
Keywords: 20S proteasome; Wheat sprout extract; Antioxidant; Polyphenol; Caco cells; 12-O-tetradecanoylphorbol-13-acetate; AE; ellagic acid; AG; gallic acid; AMC; 7-amino-4-methyl-coumarin; AP-N; aminopeptidase-N; BrAAP; branched chain amino acid preferring; C; (+)
Pinocembrin protects rat brain against oxidation and apoptosis induced by ischemia–reperfusion both in vivo and in vitro
Keywords: Oxygen–glucose deprivation; Pinocembrin; Apoptosis; Caspase-3; PARP
Apigenin-induced prostate cancer cell death is initiated by reactive oxygen species and p53 activation
Keywords: Apaf-1; apoptosis protease-activating factor-1; ROS; reactive oxygen species; ERK; extracellular signal-regulated kinase; NF-κB; nuclear factor-κB; IGFBP; insulin-like growth factor binding protein; PARP; poly(ADP)ribose polymerase; MDM; murine double m
The rate of base excision repair of uracil is controlled by the initiating glycosylase
Keywords: BER; base excision repair; cccDNA; covalently closed circular DNA; dRP; deoxyribosephosphate; FEN1; flap endonuclease 1; Lig I; DNA ligase I; Lig III; DNA ligase III; LP; long patch; MBD4; methyl-binding domain 4; nAP; nicked abasic site; PARP; poly-(ADP-
Apoptosis is present in skeletal muscle of cachectic gastro-intestinal cancer patients
Keywords: Apoptosis; Cancer cachexia; MyoD; PARP
VX-induced cell death involves activation of caspase-3 in cultured rat cortical neurons
Keywords: Organophosphorous compound; Rat; Cortical neurons; Programmed cell death caspase-3; PARP
Transforming growth factor beta-1 enhances cytotoxic effect of doxorubicin in human lung adenocarcinoma cells of A549 line
Keywords: Doxorubicin; TGFbeta-1; Apoptosis; Human lung adenocarcinoma A549 cells; DSB; double-strand breaks; PARP; poly(ADP-ribose)polymerase; TGFbeta-1; transforming growth factor beta-1;
Diabetes-induced cerebrovascular dysfunction: Role of poly(ADP-ribose) polymerase
Keywords: Adenosine diphosphate; Acetylcholine; Histamine; Nitroglycerin; Type I diabetes; Brain; Nitric oxide; Rats; PJ-34; PARP; Arterioles; Microcirculation
Calorie restriction in nonhuman primates: assessing effects on brain and behavioral aging
Keywords: locomotor activity; MRI; PET; basal ganglia; neuroprotection; DNA; AL; ad libitum fed; BDNF; brain derived neurotrophic factor; CR; calorie restriction; DA; dopamine; D2R; D2 dopamine receptor; MAP; motor assessment panel; MCI; mild cognitive impairment;
Heteromeric complex formation of ASK2 and ASK1 regulates stress-induced signaling
Keywords: Apoptosis signal-regulating kinase 2; ASK2; Serum-starvation; Stress signaling; Caspase-3; Poly(ADP-ribose) polymerase; PARP; Complex formation
Neither energy collapse nor transcription underlie in vitro neurotoxicity of poly(ADP-ribose) polymerase hyper-activation
Keywords: Neuronal apoptosis; PARP; AIF; Energy failure; Transcription;
Protein trafficking in response to DNA damage
Keywords: ARF; alternative reading frame; ATM; ataxia telangiectasia mutated kinase; ATR; ataxia telangiectasia RAD3-related kinase; DSB; DNA double-strand breaks; Mdm2; murine double minute; MMC; mitomycin C; MDC1; Mediator of DNA damage checkpoint protein 1; PARP
PARP inhibition reduces acute colonic inflammation in rats
Keywords: PARP; Nicotinamide; 1,5-dihydroxyisoquinoline; Cyclooxygenase-2; PGE2
Effect of PJ-34 PARP-Inhibitor on Rat Liver Microcirculation and Antioxidant Status 1
Keywords: ischemia; reperfusion; PARP; PJ-34; liver; laser Doppler flowmeter; apoptosis
Inhibition of telomerase activity by reduction of poly(ADP-ribosyl)ation of TERT and TEP1/TP1 expression in HeLa cells with knocked down poly(ADP-ribose) polymerase-1 (PARP-1) gene
Keywords: Poly(ADP-ribosyl)ation; PARP; PAR; TERT; TEP1/TP1; siRNA; HeLa; NAD+; Telomerase
Multiple pathways regulating the anti-apoptotic protein clusterin in breast cancer
Keywords: Clusterin; Doxorubicin; Breast cancer; Apoptosis; Caspase; PARP; Histone deacetylase; Calpain; Proteasome
Mammalian single-strand break repair: Mechanisms and links with chromatin
Keywords: Chromatin; Base excision repair; XRCCI; PARP; DNA strand break repair
Diabetes increases apoptosis and necrosis in both ischemic and nonischemic human myocardium: Role of caspases and poly-adenosine diphosphate-ribose polymerase
Keywords: 17; 30; 31; AFC; 7-amino-4-trifluoromethyl coumarin; CK; creatine kinase; MTT; 3-[4, 5 dimethylthiazol-2-y1]-2, 5-diphenyltetrazolium bromide; PARP; poly-adenosine diphosphate-ribose polymerase; PI; propidium iodide; SIR; simulated ischemia-reoxygen
Oleandrin induces apoptosis in human, but not in murine cells: Dephosphorylation of Akt, expression of FasL, and alteration of membrane fluidity
Keywords: CHAPS; 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate; DPH; diphenylhexatriene; Fura-2AM; Fura-2 acetoxymethyl ester; FKHR; forkhead transcription factor; JNK; c-Jun-N-terminal kinase; MAPK; mitogen activated protein kinase; NF-AT; nuclear fact