دانلود مقالات ISI درباره Pbpk + ترجمه فارسی

Development of a human physiologically based pharmacokinetic (PBPK) model for phthalate (DEHP) and its metabolites: A bottom up modeling approach

Keywords: DEHP; MEHP; Pharmacokinetics; PBPK; Human health risk assessment; IVIVE; Endocrine disruptors; Human biomonitoring;

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2018 سفارش ترجمه

A minimal physiologically based pharmacokinetic model that predicts anti-PEG IgG-mediated clearance of PEGylated drugs in human and mouse

Keywords: Polyethylene glycol; Anti-drug antibodies; ADA; PEG; Anti-PEG antibodies; PBPK;

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2018 سفارش ترجمه

Evaluation of the whole body physiologically based pharmacokinetic (WB-PBPK) modeling of drugs

Keywords: Absorption; Distribution; Elimination; Metabolism; PBPK; WBPBPK;

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2018 سفارش ترجمه

A strategy for systemic toxicity assessment based on non-animal approaches: The Cosmetics Europe Long Range Science Strategy programme

Keywords: ADME; absorption, distribution, metabolism, elimination; AOP; adverse outcome pathway; EFSA; European Food and Safety Agency; EURL ECVAM; European Union Reference Laboratory for Alternatives to Animal Testing; FDA; US Food and Drug Administration; IATA; I

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2018 سفارش ترجمه

Mechanistic Physiologically Based Pharmacokinetic Modeling of the Dissolution and Food Effect of a Biopharmaceutics Classification System IV Compound-The Venetoclax Story

Keywords: amorphous; absorption, distribution, metabolism, and excretion (ADME); bioavailability; food effect; physiologically based pharmacokinetic modeling; clinical pharmacokinetics; intestinal absorption; passive diffusion/transport; drug interaction; ASD; Amor

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2018 سفارش ترجمه

Cell cultures in drug discovery and development: The need of reliable in vitro-in vivo extrapolation for pharmacodynamics and pharmacokinetics assessment

Keywords: 3Rs; Reduction, Replacement, Refinement; PBPK; physiologically based pharmacokinetic; 2D; two-dimensional; 3D; three-dimensional; HTS; high-throughput screening; IVIVE; in vitro-in vivo extrapolation; ADME; absorption, distribution, metabolism and excreti

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2018 سفارش ترجمه

Minimal physiologically-based pharmacokinetic model to investigate the effect of pH dependent FcRn affinity and the endothelial endocytosis on the pharmacokinetics of anti-VEGF humanized IgG1 antibody in cynomolgus monkey

Keywords: AIC; Akaike Information Criterion; ATA; anti-therapeutic antibody; AUC; area under the curve; CLe; antibody clearance in endothelial space; CDP; Complex Dedrick Plot; CV; coefficient of variations; FR; recycling fraction of IgG; F1; modulation factor of m

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2018 سفارش ترجمه

Pharmacokinetics of [14C]-Benzo[a]pyrene (BaP) in humans: Impact of Co-Administration of smoked salmon and BaP dietary restriction

Keywords: Pharmacokinetics; Benzo[a]pyrene; Accelerator mass spectrometry; Dietary polycyclic aromatic hydrocarbons; ADME; absorption distribution metabolism and excretion; AFB1; aflatoxin B1; AMS; accelerator mass spectrometry; ATDSR; Agency for Toxic Substances a

دانلود رایگان متن کامل مقاله ISI 51 صفحه سال انتشار : 2018 سفارش ترجمه

Imaging techniques to study drug transporter function in vivo

Keywords: ABC; ATP-binding cassette; AD; Alzheimer's disease; ADME; absorption, distribution, metabolism and elimination; ATP; adenosine triphosphate; AUC; area under the curve; BBB; blood-brain barrier; BCRP; breast cancer resistance protein; BPND; non-displaceabl

دانلود رایگان متن کامل مقاله ISI 69 صفحه سال انتشار : 2018 سفارش ترجمه

Use of biorelevant dissolution and PBPK modeling to predict oral drug absorption

Keywords: Biorelevant dissolution; Weak base; PBPK modeling; BCS class II; pH dependent solubility; ACAT; advanced compartmental absorption and transit model; ADAM; advanced dissolution, absorption and metabolism model; API; active pharmaceutical ingredient; ASD;

دانلود رایگان متن کامل مقاله ISI 76 صفحه سال انتشار : 2018 سفارش ترجمه

Mechanistic prediction of food effects for Compound A tablet using PBPK model

Keywords: Food effects; PBPK; ACAT; Prediction; Pharmacokinetic;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

AOPs in hazard characterization for human health

Keywords: Mode of action; Adverse outcome pathways; Key event; Key event relationship; Weight of evidence; Quantitation; AO; adverse outcome; AOP; adverse outcome pathway; AOP-KB; adverse outcome pathway knowledge base; B/H; Bradford-Hill; EAGMST; OECD Extended Adv

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Virtual bioequivalence for achlorhydric subjects: The use of PBPK modelling to assess the formulation-dependent effect of achlorhydria

Keywords: Bioequivalence; Achlorhydria; Levothyroxine; Nifedipine; PBPK; In vitro-in vivo correlation;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Prediction of renal transporter-mediated drug-drug interactions for a drug which is an OAT substrate and inhibitor using PBPK modelling

Keywords: AUC; area under the curve; DDI; drug-drug interaction; fu; fraction unbound; IC50; inhibition constant; IV; intravenous; IVIVE; in vitro/in vivo extrapolation; Ki; inhibition constant; OAT; organic anion transporter; PBPK; physiologically based pharmacoki

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Effects of dronedarone, amiodarone and their active metabolites on sequential metabolism of arachidonic acid to epoxyeicosatrienoic and dihydroxyeicosatrienoic acids

Keywords: AUDA; 212-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]-dodecanoic acid; 4-HBP; 4-hydroxybenzophenone; ACN; acetonitrile; CLother(AA); aggregate clearance of other pathways of AA; CLother(EET); aggregate clearance of other pathways of EET; AA; arac

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Quantitative Analysis of Complex Drug-Drug Interactions Between Repaglinide and Cyclosporin A/Gemfibrozil Using Physiologically Based Pharmacokinetic Models With In Vitro Transporter/Enzyme Inhibition Data

Keywords: clinical trial simulations; drug interactions; pharmacokinetics; physiologically based pharmacokinetic modeling; organic anion-transporting polypeptide transporters; CYP enzymes; AUC; area under the blood concentration-time curve; AUCR; area under the b

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2017 سفارش ترجمه

Evaluation of Drug-Drug Interaction Potential Between Sacubitril/Valsartan (LCZ696) and Statins Using a Physiologically Based Pharmacokinetic Model

Keywords: physiologically based pharmacokinetic modeling; transporters; statin; absorption; organic anion-transporting polypeptide; drug-drug interaction; AUC; area under the plasma concentration-time curve; Cmax; maximum plasma concentration; CLint,T; transporter-

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2017 سفارش ترجمه

Simulations of Cytochrome P450 3A4-Mediated Drug-Drug Interactions by Simple Two-Compartment Model-Assisted Static Method

Keywords: bioavailability; cytochrome P450; drug interaction; dynamic simulation; first pass metabolism; hepatic clearance; intestinal metabolism; pharmacokinetics; simulations; parallel tube model; Ae (Ae,oral); dose fractions of urinary excreted unchanged drug af

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2017 سفارش ترجمه

IMI - oral biopharmaceutics tools project - evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds

Keywords: API; active pharmaceutical ingredient; AUC; area under the curve; BCS; biopharmaceutics classification system; BP; blood-to-plasma ratio; Cmax; maximum concentration; CL; clearance; Do; dose number according to BCS; DDI; drug-drug interaction; EFPIA; Euro

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2017 سفارش ترجمه

IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes

Keywords: AFE; Average Fold Error; AAFE; Absolute Average Fold Error; API; Active pharmaceutical ingredient; AUC; Area under the curve; BCS; Biopharmaceutics classification system; BE; Bioequivalence; BP; Blood-to-plasma ratio; CCC; Concordance Correlation Coeffici

دانلود رایگان متن کامل مقاله ISI 49 صفحه سال انتشار : 2017 سفارش ترجمه

IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results

Keywords: API; Active pharmaceutical ingredient; AUC; Area under the curve; BCS; Biopharmaceutics classification system; BE; Bioequivalence; BP; Blood-to-plasma ratio; CL; Clearance; CL/F; Apparent clearance; Cmax; Maximum concentration; Do; Dose number; fa; Fracti

دانلود رایگان متن کامل مقاله ISI 50 صفحه سال انتشار : 2017 سفارش ترجمه

Quantitative Analyses of the Influence of Parameters Governing Rate-Determining Process of Hepatic Elimination of Drugs on the Magnitudes of Drug-Drug Interactions via Hepatic OATPs and CYP3A Using Physiologically Based Pharmacokinetic Models

Keywords: cytochrome P450; drug interaction; hepatic clearance; mathematical model; organic anion-transporting polypeptide transporters; pharmacokinetics; AUC; area under the plasma concentration-time curve; CL; clearance; CLint,all; overall hepatic intrinsic cle

دانلود رایگان متن کامل مقاله ISI 55 صفحه سال انتشار : 2017 سفارش ترجمه

Breast Cancer Resistance Protein Abundance, but Not mRNA Expression, Correlates With Estrone-3-Sulfate Transport in Caco-2

Keywords: Caco-2 cells; proteomics; liquid chromatography; mass spectrometry; intestinal absorption; efflux pumps; ABC transporters; ABC; ATP-dependent binding cassette; BCRP; breast cancer resistance protein; BSA; bovine serum albumin; E-3-S; estrone-3-sulfate; HB

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Clinical Exposure Boost Predictions by Integrating Cytochrome P450 3A4-Humanized Mouse Studies With PBPK Modeling

Keywords: clinical pharmacokinetics; CYP enzymes; drug interaction; drug metabolizing enzymes; elimination; hepatic clearance; interspecies scaling; physiologically based pharmacokinetic modeling; preclinical pharmacokinetics; simulations; AUC; area under the plasm

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Inhalation exposure or body burden? Better way of estimating risk – An application of PBPK model

Keywords: PBPK; Benzene; Body burden; Health risk; Occupational exposure

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Pharmacokinetic bias analysis of the epidemiological associations between serum polybrominated diphenyl ether (BDE-47) and timing of menarche

Keywords: PBDE; BDE-47; PBPK; Menarche; Environmental exposure;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Prediction of in vivo developmental toxicity by combination of Hand1-Luc embryonic stem cell test and metabolic stability test with clarification of metabolically inapplicable candidates

Keywords: EST; embryonic stem cell test; ECVAM; European Center for the Validation of Alternative Methods; PBPK; physiologically based pharmacokinetics; MIC; metabolically inapplicable candidate; PBS; phosphate buffered saline; DMSO; dimethyl sulfoxide; MD; maximum

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Lung Retention by Lysosomal Trapping of Inhaled Drugs Can Be Predicted In Vitro With Lung Slices

Keywords: pharmacokinetics; pulmonary drug delivery; tissue partition; distribution; pulmonary; IT; intratracheal; PBPK; physiologically based pharmacokinetic; PK; pharmacokinetic; t1/2; half-life; V0; volume of the airspaces in the lung slices; Vu,lung; unbound dr

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

A Physiologically Based Pharmacokinetic Model to Describe Artemether Pharmacokinetics in Adult and Pediatric Patients

Keywords: clinical pharmacokinetics; CYP enzymes; drug metabolizing enzymes; elimination; hepatic clearance; interspecies scaling; physiologically based pharmacokinetic modeling; preclinical pharmacokinetics; simulations; AUC; area under the plasma concentration-ti

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

PBPK modeling and simulation in drug research and development

Keywords: PBPK; PK prediction; Absorption; Metabolism; Drug-drug interaction; Special population;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Variation in predicted internal concentrations in relation to PBPK model complexity for rainbow trout

Keywords: Fish toxicity; PBPK; Internal concentration; Tissue partitioning; Rainbow trout;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Development of an integrated multi-species and multi-dose route PBPK model for volatile methyl siloxanes - D4 and D5

Keywords: Octamethylcyclotetrasiloxane; Decamethylcyclopentasiloxane; D4; D5; Siloxane; PBPK; Kinetics; Risk assessment; Cyclic volatile methyl siloxane; Pharmacokinetics; Physiologically based pharmacokinetic model;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

Deriving Biomonitoring Equivalents for selected E- and P-series glycol ethers for public health risk assessment

Keywords: Biomonitoring Equivalents; Biomonitoring; PBPK; Exposure assessment; Risk assessment;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

PBPK model of methotrexate in cerebrospinal fluid ventricles using a combined microdialysis and MRI acquisition

Keywords: CSF; cerebrospinal fluid; MTX; methotrexate; PET; positron emission tomography; PBPK; Physiologically Based Pharmacokinetics; MRI; magnetic resonance imaging; IM; intramuscular administration; IV; intravenous administration; Gd-DOTA; gadolinium chelate; A

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

Modelling the exposure to chemicals for risk assessment: a comprehensive library of multimedia and PBPK models for integration, prediction, uncertainty and sensitivity analysis - the MERLIN-Expo tool

Keywords: MERLIN-Expo; Exposure; Multimedia modelling; PBPK; Uncertainty;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2016 سفارش ترجمه

Approaches for describing and communicating overall uncertainty in toxicity characterizations: U.S. Environmental Protection Agency's Integrated Risk Information System (IRIS) as a case study

Keywords: 4-VCH; 4-vinylcyclohexene; ARA; Alliance for Risk Assessment; ATSDR; Agency for Toxic Substances and Disease Registry; BEs; biomonitoring equivalents; BMD; benchmark dose; BMDL; benchmark dose lower confidence limit; CCl4; carbon tetrachloride; CDC; Cente

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2016 سفارش ترجمه

Aligning the 3Rs with new paradigms in the safety assessment of chemicals

Keywords: 3Rs; replacement, refinement and reduction of animals in research; AOP; adverse outcome pathway; EURL-ECVAM; European Union Reference Laboratory for Alternatives to Animal Testing; ICCVAM; Interagency Coordinating Committee on the Validation of Alternativ

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

A novel model to characterize postnatal exposure to lipophilic environmental toxicants and application in the study of hexachlorobenzene and infant growth

Keywords: HCB; hexachlorobenzene; LEM; lactation exposure model; PBPK; physiologically-based pharmacokinetic; HUMIS; Norwegian birth cohort study; CI; confidence interval; Postnatal exposure; HCB; Modeling; Infant growth; Linear mixed model;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

A preliminary regional PBPK model of lung metabolism for improving species dependent descriptions of 1,3-butadiene and its metabolites

Keywords: 1,3-Butadiene; Physiologically - based pharmacokinetic model; PBPK; Lung metabolism;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

A case study on quantitative in vitro to in vivo extrapolation for environmental esters: Methyl-, propyl- and butylparaben

Keywords: Methylparaben; Propylparaben; Butylparaben; IVIVE; PBPK;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

A Paradigm Shift in Pharmacokinetic-Pharmacodynamic (PKPD) Modeling: Rule of Thumb for Estimating Free Drug Level in Tissue Compared with Plasma to Guide Drug Design

Keywords: ADME; unbound fraction; pharmacokinetics; pharmacodynamics; disposition; distribution; partition coefficients; PBPK; PKPD;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Parameterization of small intestinal water volume using PBPK modeling

Keywords: PBPK; physiologically-based pharmacokinetic; FDA; US Food and Drug Administration; ACAT; advanced compartmental absorption and transit; ADAM; advanced dissolution, absorption, and metabolism; CAT; compartmental absorption and transit; SIWV; small intestin

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Improving in vitro to in vivo extrapolation by incorporating toxicokinetic measurements: A case study of lindane-induced neurotoxicity

Keywords: MEA; microelectrode array; PBPK; physiologically based pharmacokinetic; IVIVE; in vitro to in vivo extrapolation; GC-μECD; gas chromatograph micro electron capture detector; GABA; γ-aminobutyric acid; EC50; effective concentration 50%; RSD; relative sta

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Expression of xenobiotic transporters in the human renal proximal tubule cell line RPTEC/TERT1

Keywords: 4-Di-1-ASP; 4-(4-(Dimethylamino)styryl)-N-Methylpyridinium Iodide; CsA; Cyclosporine A; primary hPT; human primary proximal tubule cells; MATE; multidrug and toxin extrusion proteins; OAT; organic anion transporter; OATP; organic anion polypeptide transpo

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Development of a physiologically-based pharmacokinetic model of 2-phenoxyethanol and its metabolite phenoxyacetic acid in rats and humans to address toxicokinetic uncertainty in risk assessment

Keywords: Dosimetry; Ethylene glycol phenyl ether; PBPK; Pharmacokinetics; Toxicokinetics; Uncertainty factors; GFR; glomerular filtration rate; LOAEL; lowest observable adverse effect level; NOAEL; no observable adverse effect level; PBPK; physiologically-based ph

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Estimation of in vivo dose of dermally applied chemicals leading to estrogen/androgen receptor-mediated toxicity from in vitro data—Illustration with four reproductive toxicants

Keywords: In vitro–in vivo extrapolation; Reverse dosimetry; Dermal exposure; Skin permeation; PBPK; CALUX

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Quantitative in vitro to in vivo extrapolation of tissues toxicity

Keywords: ADME; absorption, distribution, metabolism, and excretion; ARE; antioxidant responses elements; BBB; blood brain barrier; CsA; cyclosporine A; CYP; cytochrome P450; EPA; Environmental Protection Agency; GCL; glutamate cysteine ligase; GCLC; glutamate cyst

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Development of a physiologically based pharmacokinetic model for assessment of human exposure to bisphenol A

Keywords: Bisphenol A; BPA; Physiologically based pharmacokinetic model; PBPK; Human

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2015 سفارش ترجمه

Reprint of PopGen: A virtual human population generator

Keywords: Virtual human population generator; Population variability; QIVIVE; PBPK; Reverse dosimetry;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2015 سفارش ترجمه

(Q)SAR modelling of nanomaterial toxicity: A critical review

Keywords: AES; Auger electron spectroscopy; AFM; atomic force microscopy; ANNs; artificial neural networks; APO or Apop.; apoptosis; ATP; adenosine triphosphate (ATP); BET; Brunauer-Emmett-Teller; BSAI; biological surface adsorption index; CNTs; carbon nanotube

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2015 سفارش ترجمه