Keywords: پرک; CA; chloroacetic acid; LDH; lactate dehydrogenase; ER; endoplasmic reticulum; GRP; glucose-regulated protein; CHOP; C/EBP homologous protein; XBP-1; X-box binding protein 1; ATF; activation transcription factor; PERK; protein kinase R-like ER kinase; IRE-
مقالات ISI پرک (ترجمه نشده)
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Keywords: پرک; ASK1; apoptosis signal-regulating kinase; ALS; amyotrophic lateral sclerosis; Apaf-1; apoptotic protease-activating factor; ATF6; activating transcription factor 6; Atg12; autophagy-related gene 12; C9ORF72; chromosome 9 open reading frame 72; CHIP; carbo
Keywords: پرک; ATF6; activating transcription factor 6; CHOP; C/EBP homologous protein; CNS; central nervous system; ER; endoplasmic reticulum; ERS; endoplasmic reticulum stress; GRP78; 78-kDa glucose-regulated protein; IRE1; inositol-requiring enzyme 1; JNK; c-JUN NH2-
Keywords: پرک; ER; endoplasmic reticulum; UPR; unfolded protein response; AD; Alzheimer's disease; APP; amyloid precursor protein; GRP78/BiP; chaperone glucose-regulated protein 78; PERK; protein kinase RNA (PKR)-like ER kinase; ATF6; activating transcription factor 6;
Keywords: پرک; mitochondrial proteostasis; mitochondrial quality control; unfolded protein response (UPR); PERK; eIF2α phosphorylation
Keywords: پرک; ANOVA; analysis of variance; ATF-4; activating transcription factor-4; ATF-6; activating transcription factor-6; C/EBP; CCAAT/enhancer-binding protein; CHOP; C/EBP homologous protein; eIf2α; eukaryotic translation initiation factor 2 subunit α; ER; endo
Keywords: پرک; ALDH2; aldehyde dehydrogenase 2; ANT; adenine nucleotide transportor; AR; aldose reductase; AMPK; AMP-activated protein kinase; ATF6; activating transcription factor 6; ATG; AuTophaGy; ATM; ataxia-telangiectasia mutate; COPD; chronic obstructive pulmonary
Keywords: پرک; ASK1; apoptosis signal-regulating kinase 1; ATF4; activating transcription factor 4; ATF6; activating transcription factor 6; Bcl-2; B-cell lymphoma 2; BiP; binding immunoglobulin protein; bZIP; basic leucine zipper; CDK; cyclin-dependent kinase; CDKI; CD
Keywords: پرک; ATF6; activating transcription factor 6; BiP; heat shock 70 kDa protein 5 (glucose-regulated protein, 78 kDa); GSMA; gel shift mobility assay; HO-1; heme oxygenase 1; IL-1β; interleukin 1 beta; IRE1α; inositol-requiring protein 1; NF-κB; nuclear fact
Keywords: پرک; PSPC; purple sweet potato color; HFD; high-fat diet; NAFLD; nonalcoholic fatty liver disease; T2D; type 2 diabetes; ER stress; endoplasmic reticulum stress; TG; triglyceride; TC; total cholesterol; ALT; alanine aminotransferase; AST; aspartate aminotransf
Keywords: پرک; 4E-BP1; eIF4E binding protein 1; 5â²-UTR; 5â²-untranslated region; AMPK; AMP-activated protein kinase; eIF; eukaryotic initiation factor; GCN2; general-control nonderepressible; GEF; guanine nucleotide exchange factor; GSK-3; glycogen synthase kinase-3;
Keywords: پرک; ATF4; activating transcription factor 4 (also designated as CREB-2, cAMP response element (CRE) binding protein2); ATF6; activating transcription factor 6; BSA; bovine serum albumin; CHOP; CCAAT/enhancer-binding protein-homologous protein; CNS; central ne
Keywords: پرک; AD; Alzheimer's disease; AIF; apoptosis-inducing factor; AM; acetoxymethyl ester; APP; amyloid precursor protein; ATF; activating transcription factor; Aβ; amyloid-beta; BBB; blood-brain barrier; bFGF; basic fibroblast growth factor; CHOP; CAAT/enhance
Keywords: پرک; AMPK; AMP activated protein kinase; ECM; extracellular matrix; EGFR; epidermal growth factor receptor; EMT; epithelial-mesenchymal transition; ERK; extracellular signal-regulated kinase; FLIP; FLICE inhibitory protein; FAK; focal adhesion kinase; GSK-3;
Keywords: پرک; ER; endoplasmic reticulum; UPR; unfolded protein response; PERK; double-stranded RNA-activated protein kinase (PKR)-like ER kinase; ATF-6; activating transcription factor 6; IRE1; inositol requiring enzyme 1; Bip; luminal binding protein (also known as GR
Keywords: پرک; siRNA; small interfering RNA; AON; antisense oligonucleotides; shRNA; small hairpin RNA; pDNA; plasmid DNA; CYP3A; cytochrome P450 3A; MDR; multidrug resistance; MDR1; multidrug resistance protein 1; Pgp; P-glycoprotein; TRAIL; tumor necrosis factor-relat
Keywords: پرک; ARE; antioxidant response element; APAP; acetaminophen; EGF; epidermal growth factor; ERK; Extracellular signal-regulated kinase; ECM; extracellular matrix; HO-1; heme oxygenase-1; HSC; hepatic stellate cells; HCC; hepatocellular carcinoma; ITC; isothiocy
TSPA as a novel ATF6α translocation inducer efficiently ameliorates insulin sensitivity restoration and glucose homeostasis in db/db mice
Keywords: پرک; ATF6α; ER stress; Insulin resistance; TSPA; T2DM; Akt; protein kinase B; ATF6; activating transcription factor 6; CHOP; C/EBP-homologous protein; CNX; calnexin; CRT; calreticulin; CREB; cAMP response element binding protein; ER; Endoplasmic reticulum; ER
BCR-ABL tyrosine kinase inhibition induces metabolic vulnerability by preventing the integrated stress response in K562â¯cells
Keywords: پرک; BCR-ABL; Integrated stress response; PERK; GCN2; ATF4;
Overexpression of ST5, an activator of Ras, has no effect on β-cell proliferation in adult mice
Keywords: پرک; Diabetes; β-cell proliferation; ST5 (Suppression Of Tumorigenicity 5); Ras/ERK signaling; ST5; Suppression of Tumorigenicity 5; GEF; Guanine Nucleotide Exchange Factor; ST5 OE; ST5-overexpressing; STZ; streptozotocin; MODY; Maturity Onset Diabetes of the
Targeting the enhanced ER stress response in Marinesco-Sjögren syndrome
Keywords: پرک; Marinesco-Sjögren syndrome; ER stress; Lymphoblastoid cell line; Tunicamycin; Apoptosis; Tauroursodeoxycholic acid; 4-PBA; sodium phenylbutyrate; ATF6α; activating transcription factor 6α; CASP3; caspase-3; DEXA; dexamethasone; EBV; Epstein-Barr virus;
Pancreatic islet-autonomous effect of arsenic on insulin secretion through endoplasmic reticulum stress-autophagy pathway
Keywords: پرک; Arsenic; Endoplasmic reticulum stress; PERK; Autophagy; Insulin secretion;
Eukaryotic translation initiation factor 2 subunit α (eIF2α) inhibitor salubrinal attenuates paraquat-induced human lung epithelial-like A549 cell apoptosis by regulating the PERK-eIF2α signaling pathway
Keywords: پرک; Paraquat; eIF2α inhibitor; Salubrinal; Endoplasmic reticulum stress; Apoptosis; PERK;
Pre-malignant transformation by senescence evasion is prevented by the PERK and ATF6alpha branches of the Unfolded Protein Response
Keywords: پرک; Endoplasmic reticulum; Unfolded protein response; ATF6α; PERK; Senescence; Post-senescence neoplastic emergence; Normal human epidermal keratinocyte; PSNE; Post-Senescence Neoplastic Emergence; UPR; Unfolded Protein Response; NHEK; Normal Human Epidermal
CREB element is essential for unfolded protein response (UPR) mediating the Cu-induced changes of hepatic lipogenic metabolism in Chinese yellow catfish (Pelteobagrus fulvidraco)
Keywords: پرک; ACC; Acetyl-CoA carboxylase; CREB; cAMP-response element binding protein; ATF6; Activating transcription factor 6; ER; endoplasmic reticulum; ERSE; ER stress response element; FAS; Fatty acid synthase; GRP78/BiP; 78-kDa glucose-regulated protein; IRE1; In
16-O-caffeoyl-16-hydroxylhexadecanoic acid, a medicinal plant-derived phenylpropanoid, induces apoptosis in human hepatocarcinoma cells through ROS-dependent endoplasmic reticulum stress
Keywords: پرک; Hepatocellular carcinoma; Phenylpropanoid; Apoptosis; Endoplasmic reticulum stress; Reactive oxygen species; CHHA; 16-O-caffeoyl-16-hydroxylhexadecanoic acid; ER; endoplasmic reticulum; HCC; hepatocellular carcinoma; ROS; reactive oxygen species; NAC; N-a
Long-term exposure to high-sucrose diet down-regulates hepatic endoplasmic reticulum-stress adaptive pathways and potentiates de novo lipogenesis in weaned male mice
Keywords: پرک; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; ChREBP; carbohydrate-responsive element-binding protein; SREBP-1c; sterol regulatory element-binding protein 1c; SCD1; stearoyl-CoA desaturase-1; FASN; fatty acid synthase; CPT-1α; carnitine palmitoyltrans
Exendin-4, a glucagon-like peptide-1 receptor agonist, reduces hepatic steatosis and endoplasmic reticulum stress by inducing nuclear factor erythroid-derived 2-related factor 2 nuclear translocation
Keywords: پرک; Glucagon-like peptide-1; Exendin-4; Nuclear factor erythroid-derived 2-related factor 2; Endoplasmic reticulum stress; Nonalcoholic fatty liver disease; ATF6; Activation transcription factor-6; Bip; Binding immunoglobulin protein; CHOP; C/EBP homologous p
Oxidants produced by methylglyoxal-modified collagen trigger ER stress and apoptosis in skin fibroblasts
Keywords: پرک; AGE; Advanced glycation end product; ATF4; Activating transcription factor 4; BID; BH3 interacting-domain death agonist; CHOP; CCAAT-enhancer-binding protein homologous protein; COL1A1; Collagen type I α1-chain; DAPI; 4',6-diamidino-2-phenylindole; ECM;
STAT3 contributes to lysosomal-mediated cell death in a novel derivative of riccardin D-treated breast cancer cells in association with TFEB
Keywords: پرک; STAT3; signal transducers and activators of transcription 3; RD-N; Riccardin D-N; CTSB; cathepsin B; LMP; lysosomal membrane permeabilization; LAMP1; lysosome associated membrane protein 1; LM-PCD; lysosomal-mediated programme of cell death; AO; acridine
Targeting PERK signaling with the small molecule GSK2606414 prevents neurodegeneration in a model of Parkinson's disease
Keywords: پرک; PD; Parkinson's disease; SNpc; substantia nigra pars compacta; PrDs; prion-related disorders; UPR; unfolded protein response; ISR; integrated stress response; PERK; RNA-like ER kinase; ATF4; activating of transcription-4; ATF3; activating of transcription
ARID1A Maintains Differentiation of Pancreatic Ductal Cells and Inhibits Development of Pancreatic Ductal Adenocarcinoma in Mice
Keywords: پرک; Oncogene; Pancreatic Cancer; Transcriptional Regulator; Tumorigenesis; 2D; 2-dimensional; 3D; 3-dimensional; ATP; adenosine triphosphate; IPMN; intraductal papillary mucinous neoplasm; MCN; mucinous cystic neoplasm; PI3K; phosphatidylinositol 3-kinase; Pa
Aberrant endoplasmic reticulum stress mediates coronary artery spasm through regulating MLCK/MLC2 pathway
Keywords: پرک; ER; endoplasmic reticulum; CAS; coronary artery spasm; MLCK; myosin light chain kinase; MLC2; myosin II regulatory light chain; VSMCs; vascular smooth muscle cells; 4-PBA; 4-phenylacetic acid; Tm; tunicamycin; UPR; unfolded protein reaction; IRE1; inosito
Naloxone precipitated morphine withdrawal and clock genes expression in striatum: A comparative study in three different protocols for the development of morphine dependence
Keywords: پرک; Naloxone; Withdrawal; Morphine - dependence; pERK; Circadian clock; Striatum;
Protein tyrosine phosphatase 1B regulates endothelial endoplasmic reticulum stress; role in endothelial dysfunction
Keywords: پرک; Shear stress; Nitric oxide; Protein kinase RNA-like endoplasmic reticulum kinase; Mesenteric resistance artery; Ach; Acetylcholine; ATF6; Activated Transcription Factor 6; BAX; Bcl-2-Associated X Protein; BCL2; B-Cell Lymphoma 2; CHOP; C/EBP Homologous
Persistent Extracellular Signal-Regulated Kinase Activation by the Histamine H4 Receptor in Spinal Neurons Underlies Chronic Itch
Keywords: پرک; ERK; extracellular signal-regulated kinase; PBS; phosphate buffered saline; pERK; phosphorylation of extracellular signal-regulated kinase;
PERK as a hub of multiple pathogenic pathways leading to memory deficits and neurodegeneration in Alzheimer's disease
Keywords: پرک; Alzheimer's disease; PERK; eIF2α; Translation; BACE1; Aβ; Tau; Learning and memory;
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults
Keywords: پرک; Isoflavone; 7-O-methylbiochanin A; Oxidative stress; Nrf2 activator; ARE; antioxidant response element; COPD; chronic obstructive pulmonary disease; γ-GCS; γ-glutamyl cysteine synthetase; GSH; glutathione; HO-1; heme oxygenase-1; Keap1; Kelch-like ECH-a
Vitamin D attenuates pressure overload-induced cardiac remodeling and dysfunction in mice
Keywords: پرک; ANP; atrial natriuretic peptide; ATF-6; activating transcription factor 6; BNP; brain natriuretic peptide; BW; body weight; CHOP; C/EBP homologous protein; DHE; dihydroethidine; EF; ejection fraction; ER; endoplasmic reticulum; FS; fractional shortening;
Curcumin induces osteoblast differentiation through mild-endoplasmic reticulum stress-mediated such as BMP2 on osteoblast cells
Keywords: پرک; ER; endoplasmic reticulum; BMP; bone morphogenetic protein; Runx2; Runt-related transcription factor 2; OC; osteocalcin; UPR; unfolded protein response; PERK; PKR-like endoplasmic reticulum kinase; IRE-1; inositol-requiring enzyme 1; ATF; activating trans
Targeting SLC25A10 alleviates improved antioxidant capacity and associated radioresistance of cancer cells induced by chronic-cycling hypoxia
Keywords: پرک; Chronic cycling hypoxia; Radiation resistance; Metabolic reprogramming; Antioxidant capacity; SLC25A11; B2M; β2-microglobulin; BMA; butylmalonate; ctrl; control; DAB; diaminobenzidine; DHE; dihydroethidium; eIF2α; eukaryotic initiation factor 2α; ETC;
Endoplasmic reticulum stress precedes oxidative stress in antibiotic-induced cholestasis and cytotoxicity in human hepatocytes
Keywords: پرک; Ac-DEVD-AMC; N-acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin; AKT; protein kinase B; AMP; ampicillin; ATB; antibiotic; ATF6; activating transcription factor 6; BC; bile canaliculi; BSEP; bile salt export pump; CDF; 5(6)-carboxy-2,7-dichlorofluorescein;
Paraptosis in human glioblastoma cell line induced by curcumin
Keywords: پرک; Cell Death; Paraptosis; Curcumin; Endoplasmic Reticulum Stress Response; miRNAs; AKT; Serine-threonine kinase; ATF6; Activating transcription factor 6; BCL2; B- Cell lymphoma 2; BIP; Immunoglobulin-heavy-chain binding protein; CHOP; C/EBPhomologous protei
Mitochondria-associated membranes (MAMs): An emerging platform connecting energy and immune sensing to metabolic flexibility
Keywords: پرک; Organelle communication; Mitochondria-associated membranes; Nutrients; Microbiome; Innate immunity; Insulin sensitivity; Metabolic diseases; Ca2+; calcium; CLRs; C-type lectin receptors; CypD; cyclophilin D; DAMPs; Danger-Associated Molecular patterns; ER
ER stress and cancer: The FOXO forkhead transcription factor link
Keywords: پرک; Endoplasmic reticulum; ER stress; Cancer; FOXO; Forkhead transcription factors; Unfolded protein response; AKT; Protein Kinase B; AKT1; Protein Kinase B Alpha; AMPK; AMP-activated protein kinase; ASK1; Apoptosis Signal Regulated Kinase 1; ATF4; Activating
A Novel Role for Lymphotactin (XCL1) Signaling in the Nervous System: XCL1 Acts via its Receptor XCR1 to Increase Trigeminal Neuronal Excitability
Keywords: پرک; aCSF; artificial cerebrospinal fluid; CCI; chronic constriction injury; CGRP; calcitonin gene-related peptide; Cy3; indocarbocyanine; ERK; extracellular signal-regulated kinase; GFAP; glial fibrillary acidic protein; IB4; isolectin B4; Iba1; ionized calci
Antiproliferative effect of p-Coumaric acid targets UPR activation by downregulating Grp78 in colon cancer
Keywords: پرک; Cancer chemoprevention; Colon cancer; p-Coumaric acid; Grp78 (78â¯kDa glucose regulated protein); ER stress; Apoptosis; Grp78; 78â¯kDa glucose regulated protein; DMH; dimethylhydrazine; PERK; protein kinase R-like ER kinase; IRE1α; inositol-requiring e
Novel oxindole derivatives prevent oxidative stress-induced cell death in mouse hippocampal HT22â¯cells
Keywords: پرک; ER stress; Ferroptosis; Oxidative stress; Oxindole; Oxytosis; Rasagiline; ATF6; activated transcription factor 6; ARE; antioxidant response element; DMEM; Dulbecco's modified Eagle's medium; ER; endoplasmic reticulum; Grp78; 78-kDa glucose-regulated prote
Portal myofibroblasts are sensitive to CCN-mediated endoplasmic reticulum stress-related apoptosis with potential to attenuate biliary fibrogenesis
Keywords: پرک; CCN proteins; ER stress; Unfolded protein response; Matricellular proteins; Portal myofibroblasts; TUDCA; α-SMA; α-smooth muscle actin; ATF6; activating transcription factor 6; BDL; bile duct ligation; eIF2α; eukaryotic translation initiation factor 2Î
Binge ethanol exposure induces endoplasmic reticulum stress in the brain of adult mice
Keywords: پرک; Alcohol use isorder; Brain damage; Endoplasmic reticulum tress; mTOR signaling; Neurodegeneration; Oxidative stress; ATF6; Activating transcription factor 6; IRE1α; Inositol-requiring kinase.; PERK; Protein kinase RNA-like endoplasmic reticulum kinase.;