A pulsed injection parahydrogen generator and techniques for quantifying enrichment
Keywords: PASADENA; Parahydrogen; Orthohydrogen; Hyperpolarization; SABRE; PHIP;
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Effect of lipid oxidation products on the formation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in model systems
Keywords: 7-MeIgQx; 2-amino-1,7-dimethylimidazo[4,5-g]quinoxaline; 8-MeIQx; 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline; 7,9-DiMeIgQx; 2-amino-1,7,9-trimethylimidazo[4,5-g]quinoxaline; ACs; amino-carbolines; AIAs; aminoimidazole-azaarenes; HAs; heterocyclic aroma
Inhibition of heterocyclic amine formation by water-soluble vitamins in Maillard reaction model systems and beef patties
Keywords: HA; heterocyclic amine; MeIQ; 2-amino-3,4-dimethylimidazo[4,5-f]quinoline; MeIQx; 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline; MRPs; Maillard reaction products; PhIP; 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine; SPE; solid phase extraction; Heterocy
Level anti-crossings in ParaHydrogen Induced Polarization experiments with Cs-symmetric molecules
Keywords: Parahydrogen; Hyperpolarization; Enhanced NMR; Symmetric molecules; Hyperpolarization transfer; PHIP; Level Anti-crossings;
Antioxidant capacity and inhibitory effect of grape seed and rosemary extract in marinades on the formation of heterocyclic amines in fried beef patties
Keywords: HAs; heterocyclic amines; IQ; 2-amino-3-methylimidazo[4,5-f]quinoline (CAS No. 76180-96-6); IQx; 2-amino-3-methylimidazo[4,5-f]quinoxaline (CAS No. 108354-47-8); MeIQ; 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (CAS No. 77094-11-2); MeIQx; 2-amino-3,8-di
On the spin order transfer from parahydrogen to another nucleus
Keywords: Hyperpolarization; Parahydrogen; PASADENA; PHIP; 13C;
Process and reaction monitoring by low-field NMR spectroscopy
Keywords: ALTADENA; adiabatic longitudinal transport after dissociation engenders nuclear alignment; ATR; attenuated total reflection; CFD; computational fluid dynamics; CPACT; center of process analysis an control technology; CPMG; Multi-echo sequence according to
Creation and evolution of net proton hyperpolarization arising from para-hydrogenation
Keywords: PHIP; Hyperpolarization; paraHydrogen; Spin relaxation;
Assessment of the influence of some spice extracts on the formation of heterocyclic amines in meat
Keywords: Heterocyclic amines; PhIP; Cooked beef; Spices; Anti-oxidants; DPPH;
Acute effects of ethanol on the transfer of nicotine and two dietary carcinogens in human placental perfusion
Keywords: Toxicokinetics; Fetal exposure; Nicotine; NDMA; PhIP; Food carcinogens
13C hyperpolarization of a barbituric acid derivative via parahydrogen induced polarization
Keywords: Hyperpolarization; PHIP; 13C NMR; Barbituric acid; Polarization transfer;
Inability to confirm estrogenicity of the heterocyclic amine PhIP in two in vitro assays
Keywords: 2-Amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine; PhIP; Endocrine disruption; In vitro cell-based assay; Food estrogens
Validation of an in vitro screening test for predicting the tumor promoting potential of chemicals based on gene expression
Keywords: TPA; 12-O-Tetradecanoylphorbol-13-acetate; MeIQ; 2-amino-3,4-dimethylimidazo[4,5-f]quinoline; PhIP; 2-amino-1-methyl-6-phenylimidazo(4,5-B)pyridine; In vitro screening; Molecular marker; Transformation assay; Tumor promoter; Genotoxicity; Carcinogen;
Development and validation of a liquid chromatography–tandem mass spectrometry assay for the analysis of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and its metabolite 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OH-PhIP) in plasma
Keywords: Heterocyclic amines; Liquid chromatography; Mice; Matrix effects; Metabolites; N-OH-PhIP; PhIP; Tandem mass spectrometry; Tissue
Review on the analysis of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and its phase I and phase II metabolites in biological matrices, foodstuff and beverages
Keywords: PhIP; Metabolites; Review; Chromatography; Mass spectrometry
A food-born heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), suppresses tumor necrosis factor-α expression in lipoteichoic acid-stimulated RAW 264.7 cells
Keywords: Dietary carcinogen; Heterocyclic amine; PhIP; Lipoteichoic acid; Immunotoxicity
ABCG2/BCRP decreases the transfer of a food-born chemical carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in perfused term human placenta
Keywords: PhIP; ABC transporter; ABCG2; Placenta; Transfer
Copper, zinc-superoxide dismutase enhances the mutagenicity in Salmonella typhimurium induced by 2-amino-6-methyldipyrido[1,2-a:3â²,2â²-d]imidazole
Keywords: AA; 2-aminoanthracene; AF; 2-aminofluorene; AFB1; aflatoxin B1; BP; benzo[a]pyrene; CDNB; 1-chloro-2,4-dinitrobenzene; CuZn-SOD; copper, zinc-containing superoxide dismutase; CYP; cytochrome P450; DAF; 2,7-diaminofluorene; DMN; N,N-dimethylnitrosamine; G6
High potency of bioactivation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mouse colon epithelial cells with ApcMin mutation
Keywords: Bioactivation; Heterocyclic aromatic amines; PhIP; Apc gene; Min Mutation; Colorectal carcinogenesis; Ah receptor; CYP1A
Hyperpolarized long-lived states in solution NMR: Three-spin case study in low field
Keywords: Hyperpolarization; PHIP; ALTADENA; Extended lifetime; Low field; Relaxation;
Hair dye use, meat intake, and tobacco exposure and presence of carcinogen-DNA adducts in exfoliated breast ductal epithelial cells
Keywords: DNA adducts; Hair dyes; 4-Aminobiphenyl; PhIP; Breast; Aromatic amines; Tobacco;
Rhodium(I) hydrogenation in water: Kinetic studies and the detection of an intermediate using 13C{1H} PHIP NMR spectroscopy
Keywords: Hydrogenation; Rhodium; Water-soluble phosphines; Mechanism; para-Hydrogen; PHIP
On-line capillary based quantitative analysis of a heterocyclic amine in human urine
Keywords: On-line; In-capillary; Nanospray; Nanoelectrospray; Tandem mass spectrometry; Capillary electrophoresis; Blue chitin; PhIP; Heterocyclic amines; Food analysis;
Myricetin stimulates the absorption of the pro-carcinogen PhIP
Keywords: Myricetin; PhIP; Caco-2; ABC transporter; Apparent permeability;
Induction of aberrant crypt foci in DNA mismatch repair-deficient mice by the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP)
Keywords: DNA mismatch repair; Mlh1; PhIP; Carcinogenesis; Colon; Aberrant crypt foci; Colorectal cancer; Lynch syndrome; Diet and cancer
Impact of genetic background on spontaneous or 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced intestinal tumorigenesis in Min/+ mice
Keywords: Intestinal tumorigenesis; PhIP; Differential susceptibility; Mouse strains; Min/+; C57BL/6J; AKR/J; A/J
Inhibition of PhIP-induced mammary carcinogenesis in female rats by ingestion of freeze-dried beer
Keywords: FD beer; Chemoprevention; PhIP; Mammary carcinogenesis; DNA adducts
Determination of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in hemoglobin using on-line coupling of restricted access material to liquid chromatography–mass spectrometry
Keywords: Heterocyclic amines; PhIP; Biomarker; Hemoglobin; RAM; mass spectrometry
Hydroxyl-specific fluorescence labeling of ABP-deoxyguanosine, PhIP-deoxyguanosine, and AFB1-formamidopyrimidine with BODIPY-FL
Keywords: DNA adducts; BODIPY; Aflatoxin; Aminobiphenyl; PhIP; Laser-induced fluorescence
Human sensitivity to PhIP: A novel marker for prostate cancer risk
Keywords: Prostate cancer; PhIP; Peripheral blood lymphocytes; Susceptibility
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) induces genetic changes in murine intestinal tumours and cells with ApcMin mutation
Keywords: Apc; Min; Microsatellites; AKR/J; A/J; PhIP; Allelic ratio; Chromosome; Intestine; Tumour
Role of nucleotide excision repair deficiency in intestinal tumorigenesis in multiple intestinal neoplasia (Min) mice
Keywords: Min mouse; Xpa−/− mouse; PhIP; Intestinal tumorigenesis; DNA adducts; Nucleotide excision repair; Xeroderma pigmentosum group A
Mlh1-dependent suppression of specific mutations induced in vivo by the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP)
Keywords: Mismatch repair; Mlh1; PhIP; Mutagenesis; Colon
Cytochrome P450 expression and metabolic activation of cooked food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in MCF10A breast epithelial cells
Keywords: PhIP; Heterocyclic amines; Cooked food mutagens; DNA adducts; Human breast epithelial cells; CYP; P450; Breast carcinogenesisAh receptor, aryl hydrocarbon receptor; EROD, ethoxyresorufin O-deethylase; PhIP, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine;
Human glutathion S-transferase A1 polymorphism and susceptibility to urothelial cancer in the Japanese population
Keywords: GSTA1; Polymorphism; Urothelial cancer; GST; Glutathione S-transferase; PhIP; 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine;
Adenomatous polyposis coli influences micronuclei induction by PhIP and acrylamide in mouse erythrocytes
Keywords: Micronuclei; PhIP; Acrylamide; Glycidamide; Colchicine; Min-mouse; Flow cytometry;
Differential staining of dysplastic aberrant crypt foci in the colon facilitates prediction of carcinogenic potentials of chemicals in rats
Keywords: PhIP; HCA; Dysplastic ACF; Differential staining; Colon carcinogenesis;
Significance and role of early-lesions in experimental colorectal carcinogenesis
Keywords: ACF; aberrant crypt foci; MDF; mucin depleted foci; BCAC; β-catenin-accumulated crypts; AOM; azoxymethane; PhIP; 2-amino-1-methyl-6-imidazo[4,5-b]pyridine; NAT; N-acetyltransferase; DMH; 1,2-dimethylhydrazine; APC; adenomatous polyposis coli; FAP; famili
Coffee diterpenes prevent the genotoxic effects of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and N-nitrosodimethylamine in a human derived liver cell line (HepG2)
Keywords: Coffee diterpenes; Cafestol; Kahweol; N-nitrosodimethylamine; PhIP; Metabolic enzymes; Antimutagenicity; Micronucleus; HepG2; AFB1, aflatoxin B1; B(a)P, benzo[a]pyrene; CÂ +Â K, cafestol and kahweol; CDNB, 1-chloro-2,4-dinitrobenzene; CYP, cytochrome P-45
Characterization of organic anion transporter regulation, glutathione metabolism and bile formation in the obese Zucker rat
Keywords: Glutathione; Bile acids; Glutathione conjugates; Organic anion transport; Isolated rat liver perfusion; Steatosis; BCRP; breast cancer resistance protein; BDBF; bile salt-dependent bile flow; BIBF; bile salt-independent bile flow; Bsep; bile salt export p
Genotoxicity test system based on p53R2 gene expression in human cells: Examination with 80 chemicals
Keywords: B[a]P; benzo[a]pyrene; p,pâ²-DDE; 2,2-bis(4-chlorophenyl)-1,1-dichloroethylene; ENNG; N-ethyl-Nâ²-nitro-N-nitrosoguanidine; PhIP; 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine; Trp-P-2; 3-amino-1-methyl-5H-pyrido[4,3-b]indole; Genotoxicity; Ames test;
Mutant KRAS in aberrant crypt foci (ACF): Initiation of colorectal cancer?
Keywords: ACF; aberrant crypt foci; PhIP; 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine; IQ; 2-amino-3-methylimidazo[4,5-f]quinoline; MeIQ; 2-amino-3,4-dimethylimidazo[4,5-f]quinoline; PCNA; proliferating cell nuclear antigen; iNOS; inducible nitric oxide synthas
Age at exposure and Apc status influence the levels of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-DNA adducts in mouse intestine and liver
Keywords: PhIP; Min/+ mouse; DNA adducts; Cell proliferation; Apoptosis; Nucleotide excision repair; Xeroderma pigmentosum group A;