کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9029468 1561661 2005 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Significance and role of early-lesions in experimental colorectal carcinogenesis
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Significance and role of early-lesions in experimental colorectal carcinogenesis
چکیده انگلیسی
Preneoplastic or precancerous lesions in the large bowel have attracted much attention, and aberrant crypt foci (ACF) topographically identified in the colonic mucosa have found application as effective endpoint lesions for detection of chemopreventive agents as well as carcinogenic risk assessment of environmental agents. While many ACF are regarded as hyperplastic in nature, lacking the potential lesion to give rise to neoplasia, a subset termed dysplastic ACF, or newly identified “mucin depleted foci (MDF)”, and “β-catenin accumulated crypts (BCAC)” are suggested to be more reliably related to colorectal tumorigenesis in rodents. ACF and MDF can be visualized on the surface of colonic mucosa and BCAC were recently identified by our laboratory in rodents en face in cross sections. In particular, BCAC having a similar pattern of β-catenin gene mutation to that observed in colonic carcinomas appear to be direct precursors. This review provides a review and discussion of the relevant literature relative to early lesions in colorectal carcinogenesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemico-Biological Interactions - Volume 155, Issues 1–2, 30 June 2005, Pages 1-9
نویسندگان
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