Keywords: فسفاتیدیلینوزیتول 3 کیناز; Ache; acetylcholinesterase; AD; Alzheimer's disease; Adra2a, Adra2b, Adra1b; adrenoceptor alpha 2a, alpha 2b, beta 1; Akt1; Akt serine/threonine protein kinase 1/protein kinase B; ApoE; apolipoprotein E; Bche; butyrylcholinesterase; BDNF; brain derived ne
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Keywords: فسفاتیدیلینوزیتول 3 کیناز; BMI; body mass index; ARC; arcuate nucleus of hypothalamus; NPY; neuropeptide Y; AgRP; agouti-related peptide; POMC; pro-opiomelanocortin; CART; cocaine- and amphetamine-related transcript; LepRb; leptin receptor; JAK2; janus kinase 2; STAT3; signal trans
Keywords: فسفاتیدیلینوزیتول 3 کیناز; BBB; blood brain barrier; ARC; arcuate nucleus of hypothalamus; NPY; neuropeptide Y; AgRP; agouti-related peptide; POMC; pro-opiomelanocortin; αMSH; α-melanocyte stimulating hormone; LepRb; leptin receptor; JAK2; janus kinase 2; STAT3; signal transducer
Keywords: فسفاتیدیلینوزیتول 3 کیناز; 2 DE; 2-dimensional electrophoresis; ABPP; activity-based protein profiling; BFGF; basic fibroblast growth factor; CML; chronic myeloid leukemia; CRC; colorectal cancer; DIGE; differential in gel electrophoresis; EGF(R); epidermal growth factor (receptor)
Keywords: فسفاتیدیلینوزیتول 3 کیناز; Colon cancer; Proliferation; Glucagon-like peptide 2; Cancer therapy; (5-FU); 5-Fluorouracil; Akt; protein kinase B; APC; adenomatous polyposis coli; CAFs; carcinoma-associated fibroblasts; CDK; cyclin-dependent kinase; DPP-IV; dipeptidyl peptidase IV; GL
Keywords: فسفاتیدیلینوزیتول 3 کیناز; BM; basement membrane; ECM; extracellular membrane; EMT; epithelial mesenchymal transition; FAK; focal adhesion kinase; MAPK; mitogen-activated protein kinase; LOH; loss of heterozygosity; NCOR1; nuclear receptor co-repressor 1; MMP; matrix metalloprotein
MicroRNA-21a-5p promotes fibrosis in spinal fibroblasts after mechanical trauma
Keywords: فسفاتیدیلینوزیتول 3 کیناز; SCI; spinal cord injury; miRNA; microRNA; SD; scratch damage; ECM; extracellular matrix; CNS; central nervous system; FN; fibronectin; Col1a1; type I a1collagen; Col1a2; type I a2 collagen; Col IV; type IV collagen; qRT-PCR; quantitative real-time PCR; GA
4â²-hydroxywogonin inhibits colorectal cancer angiogenesis by disrupting PI3K/AKT signaling
Keywords: فسفاتیدیلینوزیتول 3 کیناز; 4â²-hydroxywogonin; Colorectal cancer; Vascular endothelial growth factor-A; PI3K; AKT; Angiogenesis; 4â²-HW; 4â²-hydroxywogonin; PI3K; phosphatidylinositol 3 kinase; VEGF-A; vascular endothelial growth factor-A; GAPDH; glyceraldehyde-3-phosphate dehyd
Impairment of Akt activity by CYP2E1 mediated oxidative stress is involved in chronic ethanol-induced fatty liver
Keywords: فسفاتیدیلینوزیتول 3 کیناز; AFL; alcoholic fatty liver; ALD; alcoholic liver disease; ALT; alanine transaminase; AMPK; AMP-activated protein kinase; AST; aspartate transaminase; CMZ; chlormethiazole; CYP2E1; cytochrome P4502E1; 4-HNE; 4-hydroxynonenal; IGF-1; insulin-like growth fac
Akt/PKB signaling regulates cigarette smoke-induced pulmonary epithelial-mesenchymal transition
Keywords: فسفاتیدیلینوزیتول 3 کیناز; COPD; chronic obstructive pulmonary disease; NSCLC; non small cell lung cancer; CS; Cigarette smoke; CSE; cigarette smoke extract; 1TGF-β; transforming growth factor β1; α-SMA; alpha-smooth muscle actin; EMT; epithelial-mesenchymal transition; ATNA; an
Dysregulation of fibrosis related genes in HCV induced liver disease
Keywords: فسفاتیدیلینوزیتول 3 کیناز; Alb; Albumin; ALK PH; Alkaline phosphatase; ALT; Alanine amino transferase; APO; Apolipoprotein; AST; Aspartate transaminase; AUC; Area Under Curve; BIL.D; Direct bilirubin; BIL T; Total bilirubin; BMI; Body mass index; cDNA; Complementary DNA; CTGF; Conn
Therapeutic Targeting of TAZ and YAP by Dimethyl Fumarate in Systemic Sclerosis Fibrosis
Keywords: فسفاتیدیلینوزیتول 3 کیناز; Akt; protein kinase B; CTGF; connective tissue growth factor; DMF; dimethyl fumarate; EDN1; endothelin 1; GSK-3; glycogen kinase 3; HC; healthy control; MMP; matrix metalloproteinase; NRF2; nuclear factor (erythroid-derived 2)-like 2; PAAm; polyacrylamide
Emerging roles of microRNAs in the metabolic control of immune cells
Keywords: فسفاتیدیلینوزیتول 3 کیناز; Non-coding RNAs; Immunometabolism; T cells; Macrophages; Metabolic reprogramming; ATP; adenosine triphosphate; TCA; tricarboxylic acid cycle; PPP; pentose phosphate pathway; FAO; fatty acid oxidation; PEP; phosphoenolpyruvate; α-KG; alpha-ketoglutarate;
Regulation and function of runt-related transcription factors (RUNX1 and RUNX2) in goat granulosa cells
Keywords: فسفاتیدیلینوزیتول 3 کیناز; RUNX1; runt-related transcription factor 1; RUNX2; runt-related transcription factor 2; hCG; human chorionic gonadotropin; LH; Luteinizing Hormone; FSK; forskolin; PMA; phorbol 12-myristate 13-acetate; PI3K; phosphatidylinositol 3 kinase; PKA; protein kin
A partnership with the proteasome; the destructive nature of GSK3
Keywords: فسفاتیدیلینوزیتول 3 کیناز; AMPK; AMP-activated protein kinase; ARE; antioxidant response element; β-TrCP; beta-transducin repeat containing protein; CKI; casein kinase-1; CHD; chromatin helicase DNA-binding factor; CRY; cryptochrome; EMT; epithelial-mesenchymal transition; FGD; fa
Gln223Arg polymorphism in the Caucasian population and Pro1019Pro polymorphism in the Chinese population are risk factors for OSAS: An updated meta-analysis of 1159 subjects
Keywords: فسفاتیدیلینوزیتول 3 کیناز; ACC; acetyl-CoA carboxylase; AMPK; 5â² adenosine monophosphate-activated protein kinase; CI; confidence intervals; CNKI; Chinese National Knowledge Infrastructure; Grb2; growth factor receptor-bound protein 2; HWE; Hardy-Weinberg equilibrium; IRS; insu
OP16, a novel ent-kaurene diterpenoid, potentiates the antitumor effect of rapamycin by inhibiting rapamycin-induced feedback activation of Akt signaling in esophageal squamous cell carcinoma
Keywords: فسفاتیدیلینوزیتول 3 کیناز; Akt; protein kinase B; DMSO; dimethyl sulfoxide; ESCC; esophageal squamous cell carcinoma; FBS; fetal bovine serum; IC50; half maximal inhibitory concentration; mTOR; mammalian target of rapamycin; PI3K; phosphatidylinositol 3 kinase; Rapa; rapamycin; Rap
Potential of GPCRs to modulate MAPK and mTOR pathways in Alzheimer's disease
Keywords: فسفاتیدیلینوزیتول 3 کیناز; AD; Alzheimer's disease; AGC; protein kinase A/protein kinase G/protein kinase C; Akt; protein kinase B; ATG13; autophagy-related gene 13; Aβ; amyloid-beta; BDNF; brain-derived neurotrophic factor; CaMKII; Ca2+/calmodulin-dependent kinase II; cAMP; cyc
MiR-18b suppresses high-glucose-induced proliferation in HRECs by targeting IGF-1/IGF1R signaling pathways
Keywords: فسفاتیدیلینوزیتول 3 کیناز; DR; diabetic retinopathy; PDR; proliferative diabetic retinopathy; HRECs; human retinal endothelial cells; REC; retinal microvascular endothelial cell; VEGF; vascular endothelial growth factor; IGF-1; insulin growth factor-1; IGF1R; insulin growth factor-
Xinmailong mitigated epirubicin-induced cardiotoxicity via inhibiting autophagy
Keywords: فسفاتیدیلینوزیتول 3 کیناز; ACE; angiotensin-converting enzyme; ACE2; angiotensin-converting enzyme 2; Ang; angiotensin; AT1; type-1A angiotensin II receptor; Atg7; autophagy related 7; Bax; Bcl-2 associated X protein; Bcl2; B cell lymphoma2; CHF; congestive heart failure; DOX; Doxo
SH2 domain-containing inositol 5-phosphatase (SHIP2) regulates de-novo lipogenesis and secretion of apoB100 containing lipoproteins in HepG2 cells
Keywords: فسفاتیدیلینوزیتول 3 کیناز; De-novo lipogenesis; VLDL; SH2 domain-containing inositol 5-phosphatase (SHIP2); Insulin resistance; HepG2; Liver; ACC; acyl COA carboxylase; FAS; fatty acid synthase; FOXO1; forkhead box protein O1; GFP; green fluorescent protein; MTP; microsomal transfe
Regulation of ceramide generation during macrophage apoptosis by ASMase and de novo synthesis
Keywords: فسفاتیدیلینوزیتول 3 کیناز; ASMase; acid sphingomyelinase; BMDMs; bone marrow-derived macrophages; C1P; ceramide 1-phosphate; M-CSF; macrophage colony stimulating factor; MTS; [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulphophenyl)-2H-tetrazolium, inner salt]; SP
Research ReportDiallyl trisufide protects against oxygen glucose deprivation -induced apoptosis by scavenging free radicals via the PI3K/Akt -mediated Nrf2/HO-1 signaling pathway in B35 neural cells
Keywords: فسفاتیدیلینوزیتول 3 کیناز; DATS; diallyl trisulfide; OGD; oxygen glucose deprivation; Nrf2; nuclear factor E2-related factor 2; HO-1; Heme oxygenase-1; PI3K; phosphatidylinositol 3 kinase; Akt; protein kinase B; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide; DC
ARF1 regulates adhesion of MDA-MB-231 invasive breast cancer cells through formation of focal adhesions
Keywords: فسفاتیدیلینوزیتول 3 کیناز; ARF; ADP-ribosylation factor; DMEM; Dulbecco's Modified Eagle Medium; DMSO; dimethyl sulfoxide; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; FAK; focal adhesion kinase; GAP; GTP activating protein; HCC70; Human Breast Cancer Cell
The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration
Keywords: فسفاتیدیلینوزیتول 3 کیناز; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors; ATP; adenosine triphosphate; Aβ; amyloid β peptide; AD; Alzheimer's disease; APP; amyloid precursor protein; AMP; adenos
BDNF impairment is associated with age-related changes in the inner retina and exacerbates experimental glaucoma
Keywords: فسفاتیدیلینوزیتول 3 کیناز; BDNF; brain derived neurotrophic factor; TrkB; tropomyosin related kinase B receptor; APP; amyloid precursor protein; ONH; optic nerve head; GCL; ganglion cell layer; H&E; haematoxylin and eosin; RGC; retinal ganglion cells; IOP; intraocular pressure; PI3
Syndecan 4 regulation of PDK1-dependent Akt activation
Keywords: فسفاتیدیلینوزیتول 3 کیناز; S4; syndecan 4; PI3K; phosphatidylinositol 3 kinase; myrPKCα; myristoylated protein kinase C; PAK; p21 protein (CDC42/Rac)-activated kinase; Syndecan; PKC; AKT; Angiogenesis;
JNK pathway may be involved in isoflurane-induced apoptosis in the hippocampi of neonatal rats
Keywords: فسفاتیدیلینوزیتول 3 کیناز; Akt; protein kinase B; AP-1; activator-protein 1; Bcl-2; B cell lymphoma/lewkmia-2; CNS; central nervouse system; DG; dentate gyrus; GSK-3β; glycogen synthase kinase 3β; i.c.v; intracerebroventricular; JNK; c-jun N-terminal kinase; PI3K; phosphatidylino
Immobilized amyloid Aβ peptides support platelet adhesion and activation
Keywords: فسفاتیدیلینوزیتول 3 کیناز; AD; Alzheimer disease; PLC; phospholipase C; PI3K; phosphatidylinositol 3 kinase; APP; amyloid precursor protein; PKC; protein kinase C; Amyloid Aβ peptide; Human platelet; Adhesion; Cerebrovascular inflammation;
IL-10 modulates serotonin transporter activity and molecular expression in intestinal epithelial cells
Keywords: فسفاتیدیلینوزیتول 3 کیناز; GI; gastrointestinal; 5-HT; 5-hydroxytryptamine, serotonin; SERT; serotonin transporter; IBS; Irritable Bowel Syndrome; IBD; Inflammatory Bowel Diseases; IL-10; Interleukin-10; IL-10R; Interleukin-10 receptor; IL10RA; Interleukin-10 receptor subunit alpha
Oxidative stress induced by P2X7 receptor stimulation in murine macrophages is mediated by c-Src/Pyk2 and ERK1/2
Keywords: فسفاتیدیلینوزیتول 3 کیناز; P2X7R; P2X7 receptor channels; LPS; lipopolysaccharide; IL-1β; interleukin-1β; TNFα; tumor necrosis factor α; ROS; reactive oxygen species; JNK; c-Jun N-terminal kinase; ERK1/2; extracellular regulated kinases 1 and 2; MAPKs; mitogen-activated protein
Insulin-like growth factor 1 (IGF1) and its active peptide (1-3)IGF1 enhance the expression of synaptic markers in neuronal circuits through different cellular mechanisms
Keywords: فسفاتیدیلینوزیتول 3 کیناز; IGF1; insulin-like growth factor 1; (1-3)IGF1; active peptide of IGF1 (aminoacids 1-3); IGF1R; insulin-like growth factor 1 receptor; MAPK; mitogen activated protein kinase; PI3K; phosphatidylinositol 3 kinase; Growth factors; Synaptic transmission; I
Serotonin modulates hepatic 6-phosphofructo-1-kinase in an insulin synergistic manner
Keywords: فسفاتیدیلینوزیتول 3 کیناز; 5-HT; serotonin; 5-HT2A; subtype 2A of the serotonin receptor; PI3K; phosphatidylinositol 3 kinase; PFK; 6-phosphofructo-1-kinase; F6P; fructose-6-phosphate; F1,6BP; fructose-1,6-bisphosphate; F2,6BP; fructose-2,6-bisphosphate; PKC; protein kinase C; PLC;
The regulation of cancer cell death and metabolism by extracellular matrix attachment
Keywords: فسفاتیدیلینوزیتول 3 کیناز; ECM; extra cellular matrix; ROS; reactive oxygen species; PPP; pentose phosphate pathway; TCA; tricarboxylic acid; PDH; pyruvate dehydrogenase; PDK4; pyruvate dehydrogenase kinase 4; ANGPTL4; angiopoietin-like 4; PK; pyruvate kinase; TIGAR; TP53-induced g
3-Phosphoinositide-Dependent Kinase 1 Controls Breast Tumor Growth in a Kinase-Dependent but Akt-Independent Manner
Keywords: فسفاتیدیلینوزیتول 3 کیناز; PDK1; 3-phosphoinositide-dependent protein kinase 1; PI3K; phosphatidylinositol 3 kinase; PIP3; phosphatidylinositol 3,4,5 triphosphate; PH; pleckstrin homology; shRNA; short hairpin RNA;
Serine phosphorylation regulates disabled-1 early isoform turnover independently of Reelin
Keywords: فسفاتیدیلینوزیتول 3 کیناز; ApoER2; apolipoprotein E receptor 2; CsA; cyclosporine A; Cdk; cyclin dependent kinase; Dab1; Disabled-1; CHX; cycloheximide; CPTS; 3,4',4â³,4-copper phthalocyanine tetrasulfonic acid, tetrasodium salt; CsA; cyclosporine A; ED; embryonic day; GSK3; glyco
Bone morphogenetic protein 4 stimulates attachment of neurospheres and astrogenesis of neural stem cells in neurospheres via phosphatidylinositol 3 kinase-mediated upregulation of N-cadherin
Keywords: فسفاتیدیلینوزیتول 3 کیناز; attachment; TGFβ family; Akt pathway; cell adhesion molecules; central nervous system; bFGF; basic fibroblast growth factor; BMPs; bone morphogenetic proteins; BMP4; bone morphogenetic protein 4; DAPI; 4',6-diamidino-2-phenylindole; EGF; epidermal growth
EP2 receptor activation by prostaglandin E2 leads to induction of HO-1 via PKA and PI3K pathways in C6 cells
Keywords: فسفاتیدیلینوزیتول 3 کیناز; Prostaglandins; Prostaglandin EP2 receptor; Protein kinase A; Phosphatidylinositol 3 kinase; Heme oxygenase; Brain cells
Diacylglycerol kinase alpha, from negative modulation of T cell activation to control of cancer progression
Keywords: فسفاتیدیلینوزیتول 3 کیناز; Diacylglycerol kinase; DGK; Sphingosine kinase; SPK; Ceramide kinase; CERK; Vascular endothelial growth factor; VEGF; Hepatocyte growth factor; HGF; Epidermal growth factor; EGF; Protein kinase C; PKC; Protein kinase D; PKD; Peroxisome proliferator-activa
Pertussis toxin promotes macrophage survival through inhibition of acid sphingomyelinase and activation of the phosphoinositide 3-kinase/protein kinase B pathway
Keywords: فسفاتیدیلینوزیتول 3 کیناز; PTX; Pertussis toxin; BMDM; bone marrow-derived macrophages; C1P; ceramide 1-phosphate; C2-; acetyl; M-CSF; macrophage colony stimulating factor; MAPK; mitogen-activated protein kinase; ERK; extracellular regulated kinase; MEK; MAPK/ERK kinase; MTS; [3-(4
Involvement of the ERK/MAP kinase signalling pathway in milli-calpain activation and myogenic cell migration
Keywords: فسفاتیدیلینوزیتول 3 کیناز; BCA; bicinchoninic acid; DMEM; Dulbecco's modified Eagle medium; DMSO; dimethyl sulfoxide; DTT; DL-dithiothreitol; EGF; epidermal growth factor; EGTA; ethylene glycol-bis(2-aminoethylether)-N,N,Nâ²,Nâ²-tetraacetic acid; ERK; extracellular-signal regulat
Molecular effectors of multiple cell death pathways initiated by photodynamic therapy
Keywords: فسفاتیدیلینوزیتول 3 کیناز; 1O2; singlet oxygen; ÎÏm; mitochondrial transmembrane potential; [Ca2+]cyt; cytosolic Ca2+-concentration; AlPc; aluminum phthalocyanine; ALA; 5-aminolevulinic acid; AIF; apoptosis inducing factor; ANT; adenine nucleotide translocator; Apaf-1; apoptosis
TGF-β1 induces COX-2 expression and PGE2 synthesis through MAPK and PI3K pathways in human mesangial cells
Keywords: فسفاتیدیلینوزیتول 3 کیناز; transforming growth factor-β1; cyclooxygenase; prostaglandin-E2; mesangial cells; mitogen-activated protein kinase; phosphatidylinositol 3 kinase
Angiotensin II regulates phosphoinositide 3 kinase/Akt cascade via a negative crosstalk between AT1 and AT2 receptors in skin fibroblasts of human hypertrophic scars
Keywords: فسفاتیدیلینوزیتول 3 کیناز; Angiotensin II; Receptor; Phosphatidylinositol 3 kinase; Akt; Fibroblast
Intracellular signal transduction pathways induced by leptin in C2C12 cells
Keywords: فسفاتیدیلینوزیتول 3 کیناز; Leptin; C2C12 cells; Signal transduction; PI3K; phosphatidylinositol 3 kinase; Akt/PKB; protein kinase B; GSK3; glycogen synthase kinase 3; PKC-ζ; protein kinase C ζ; ERKs; extracellular signal-regulated kinases; P38 MAPK; p38 mitogen-activated protein