کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8260196 | 1534656 | 2014 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
BDNF impairment is associated with age-related changes in the inner retina and exacerbates experimental glaucoma
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کلمات کلیدی
PI3KONHiOpTrkBGCLAPPRGCERGBDNF - BDNF یا فاکتور نورونزایی مشتقشده از مغز H&E - H & Eelectroretinogram - الکتروترینوگرامamyloid beta - بتا آمیلوئیدOptic nerve head - سر عصبی نوریRetinal ganglion cells - سلول های گانگلیونی شبکیهbrain derived neurotrophic factor - عامل مغز استخوان مغز استخوان استBrain-derived neurotrophic factor - فاکتور نوروتروفی مشتق شده از مغزphosphatidylinositol 3 kinase - فسفاتیدیلینوزیتول 3 کینازIntraocular pressure - فشار داخل چشمganglion cell layer - لایه سلول گانگلیونیPSTR - نگه داریدSignal transduction - هدایت سیگنالhaematoxylin and eosin - هماتوکسیلین و ائوزینamyloid precursor protein - پروتئین پیش ماده آمیلوئیGlaucoma - گلوکوم TrkB receptor - گیرنده TrkB
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
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چکیده انگلیسی
Brain-derived neurotrophic factor (BDNF) stimulation of its high-affinity receptor TrkB results in activation of pro-survival cell-signalling pathways that can afford neuroprotection to the retina. Reduction in retrograde axonal transport of neurotrophic factors such as BDNF from the brain to the neuronal cell bodies in the retina has been suggested as a critical factor underlying progressive and selective degeneration of ganglion cell layer and optic nerve in glaucoma. We investigated the role of BDNF in preserving inner retinal homeostasis in normal and glaucoma states using BDNF+/â mice and compared it with wild type controls. This study demonstrated that BDNF+/â animals were more susceptible to functional, morphological and molecular degenerative changes in the inner retina caused by age as well as upon exposure to experimental glaucoma caused by increased intraocular pressure. Glaucoma induced a down regulation of BDNF/TrkB signalling and an increase in levels of neurotoxic amyloid β 1-42 in the optic nerve head which were exacerbated in BDNF+/â mice. Similar results were obtained upon analysing the human optic nerve head tissues. Our data highlighted the role of BDNF in maintaining the inner retinal integrity under normal conditions and the detrimental effects of its insufficiency on the retina and optic nerve in glaucoma.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1842, Issue 9, September 2014, Pages 1567-1578
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1842, Issue 9, September 2014, Pages 1567-1578
نویسندگان
Vivek Gupta, Yuyi You, Jonathan Li, Veer Gupta, Mojtaba Golzan, Alexander Klistorner, Maarten van den Buuse, Stuart Graham,