Effect of the pH in the luminescence of ruthenium tris-bipyridine derivatives
Keywords: pKa; Ru(II) complexes; Luminescence; Amide;
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Building and breeding molecules to spy on cells and tumors
Keywords: GFP; green fluorescent protein; FRET; fluorescence resonance energy transfer; CFP; cyan fluorescent protein; YFP; yellow fluorescent protein; mRFP1; monomeric red fluorescent protein, 1st version; Kd; dissociation constant; ROS; reactive oxygen species; C
Cofactor fingerprinting with STD NMR to characterize proteins of unknown function: identification of a rare cCMP cofactor preference
Keywords: STD; saturation transfer difference; G6PDH; glucose-6-phosphate dehydrogenase; LDH; lactate dehydrogenase; PKA; protein kinase A; RSP2; radial spoke protein-2; Saturation transfer difference NMR; Radial spoke; Functional proteomics; cCMP; Cofactor specifi
PKA-mediated protein phosphorylation protects ezrin from calpain I cleavage
Keywords: PKA; Phosphorylation; Calpain I; Ezrin; Proteolysis;
Stability, pKa and plasma protein binding of roscovitine
Keywords: LC-MS-MS; Equilibrium dialysis; Ultrafiltration; pKa; Olomoucine; α1-Acid glycoprotein;
Theoretical calculations on the tautomerism of uric acid in gas phase and aqueous solution
Keywords: DFT calculations; pKa; Tautomerism; Uric acid;
Advancement of differentiation of oligodendrocyte progenitor cells by a cascade including protein kinase A and cyclic AMP-response element binding protein
Keywords: CREB; Oligodendrocyte; Phosphorylation; PKA; PKC;
Removal of acetic acid from aqueous solutions containing succinic acid and acetic acid by tri-n-octylamine
Keywords: Succinic acid; Acetic acid; Reactive extraction; Tri-n-octylamine; pKA;
Accounting for global protein deformability during protein-protein and protein-ligand docking
Keywords: cAMP; cyclic-3â²,5â²-adenosine monophosphate; MD; molecular dynamics; PC; principal components; PKA; cAMP-dependent protein kinase; RNAse; ribonuclease; Ligand-receptor interaction; Approximate normal mode; Receptor flexibility; Domain motion; Induced
Exploiting structural principles to design cyclin-dependent kinase inhibitors
Keywords: CDK; cyclin-dependent kinase; PKA; cAMP-dependent protein kinase; CMGC-I; CDK-like protein kinases; CML; Chronic myelogenous leukaemia; PfPK5; Plasmodium falciparum Protein Kinase 5; Cyclin-dependent kinase inhibitor; CDK; Drug design; Protein dynamic; Pr
Evaluation of the acidity constants of the 4-hidroxy-5-[salicylideneamino]-2-7-naphthalenedisulfonic acid (Azomethine-H) using UV-vis spectrophotometry
Keywords: Azomethine-H; pKa; SQUAD; Spectrophotometry study;
Development of 5-lipoxygenase inhibitors-lessons from cellular enzyme regulation
Keywords: AA; arachidonic acid; cPLA2; cytosolic phospholipase A2; FLAP; 5-lipoxygenase-activating protein; fMLP; N-formyl-methionyl-leucyl-phenylalanin; GM-CSF; granulocyte macrophage colony-stimulating factor; GPx; glutathione peroxidase; LPS; lipopolysaccharide;
MgATP-induced conformational change of the catalytic subunit of cAMP-dependent protein kinase
Keywords: cAMP; adenosine cyclic 3â²,5â²-monophosphate; ATP; adenosine 5â²-triphosphate; ADP; adenosine 5â²-diphosphate; PKA; cAMP-dependent protein kinase; EDTA; ethylenediaminetetraacetic acid; C; catalytic subunit of PKA; CF; 5,6-carboxyfluorescein succinimi
Suppression of respiratory burst in human neutrophils by new synthetic pyrrolo-benzylisoquinolines
Keywords: AC; adenylate cyclase; CB; cytochalasin B; cyclic AMP; cyclic adenosine 3â²,5â²-monophosphate; cyclic GMP; cyclic guanosine 3â²,5â²-monophosphate; DMSO; dimethyl sulfoxide; FMLP; formyl-l-methionyl-l-leucyl-l-phenylalanine; H89; N-(2-((p-bromocinnamyl
Learning twice is different from learning once and from learning more
Keywords: memory; learning; inhibitory avoidance; consolidation; hippocampus; striatum; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole propionate; ANI; anisomycin; AP3; 2-amino-3-phosphone pentanoate; AP5; d-2-amino-5-phosphonepentanoate; CaMKII; Ca2+/calmodulin-dep
Role of the Small Heat Shock Proteins in Regulating Vascular Smooth Muscle Tone
Keywords: HSP; heat shock protein; HSV; human saphenous vein; IEF; isoelectric focusing; PAGE; polyacrylamide gel electrophoresis; PCA; pig coronary artery; PKA; cAMP-dependent protein kinase; PKG; cGMP-dependent protein kinase; SDS; sodium dodecyl sulfate; SNP; so
QSAR study on pKa vis-Ã -vis physiological activity of sulfonamides: a dominating role of surface tension (inverse steric parameter)
Keywords: QSAR; pKa; Proton-ligand formation constant; Steric parameter; Surface tension; Regression analysis; Topological index; Sulfonamide;
The action of PKA on smooth muscle myosin phosphorylation
Keywords: PKA; Binding assay; Phosphorylation; Myosin Mg2+-ATPase activity
Expression of recombinant MDA-BF-1 with a kinase recognition site and a 7-histidine tag for receptor binding and purification
Keywords: Bone metastasis-related factor-1; Glycoprotein; Insect cell expression system; Receptor; PKA; Affinity chromatography; IMAC;
Sequence analysis, endocrine regulation, and signal transduction of GnRH receptors in teleost fish
Keywords: Glycosylation; Phosphorylation; Disulfide bond; PKC; PKA; G protein; GPCR; Tilapia; GnRH; Receptor;
Progesterone inhibits gallbladder motility through multiple signaling pathways
Keywords: ACh; acetylcholine; cAMP; cyclic adenosine monophosphate; CCK; cholecystokinin octapeptide; 20-P; 20α-hydroxyprogesterone; 17-P; 17-hydroxyprogesterone; NO; nitric oxide; P; progesterone; PKA; protein kinase A; PKG; protein kinase G; Rp-cAMPs; Rp-adenosi
New drug targets in the signaling pathways activated by antidepressants
Keywords: ACTH; adrenocorticotropin; AVP; arginine vasopressin; BDNF; brain-derived neurotrophic factor; CREB; cAMP-responsive element binding protein; CRH; corticotropin-releasing hormone; HPA; hypothalamus-pituitary-adrenal; MARS; Munich antidepressant respon
Peptide inhibitors of G protein-coupled receptor kinases
Keywords: Gβγ; βγ subunits of heterotrimeric GTP-binding proteins; GPCR; G protein-coupled receptor; GRK; G protein-coupled receptor kinase; IBMX; 3-isobutyl-1-methylxanthine; PKA; protein kinase A; PKC; protein kinase C; ROS; rod outer segments; G-protein-coup
Activation of phospholipase D by 8-Br-cAMP occurs through novel pathway involving Src, Ras, and ERK in human endometrial stromal cells
Keywords: Phospholipase D; Human endometrial stromal cells; 8-Br-cAMP; ERK; Ras; Src; PKA
Modulation of the steroidogenic activity of luteinizing hormone by insulin and insulin-like growth factor-I through interaction with the cAMP-dependent protein kinase signaling pathway in the trout ovary
Keywords: LH; Insulin; IGF-I; Testosterone; cAmp; PKA; Theca; Ovary; Trout;
Kinetic comparison of procaspase-3 and caspase-3
Keywords: Procaspase-3; Caspase-3; Kinetics; pKa; Cysteine; Histidine; Inactivation; IAM; DEPC;
Probing the sweet determinants of brazzein: Wild-type brazzein and a tasteless variant, brazzein-ins(R18a-I18b), exhibit different pH-dependent NMR chemical shifts
Keywords: Brazzein; Sweet-taste determinants; NMR spectroscopy; pKa; Mutagenesis;
Bilateral injection of isoproterenol into hippocampus induces Alzheimer-like hyperphosphorylation of tau and spatial memory deficit in rat
Keywords: AD; Alzheimer's disease; AKAP79; 79 kDa A-kinase-anchoring-protein; AP; anterior to posterior; Cβ; β catalytic subunit of PKA; CaMKII; calcium/calmodulin-dependent kinase II; cdk-5; cyclin-dependent kinase-5; CREB; cAMP-responsive element binding prot
Study on supramolecular complexing ability vis-à-vis estimation of pKa of substituted sulfonamides: Dominating role of Balaban index (J)
Keywords: QSAR; pKa; Sulfonamide; Topological index; Molar volume; Molar refraction
Chloroquine induces the expression of inducible nitric oxide synthase in C6 glioma cells
Keywords: ATF-2; activating transcription factor 2; DMEM; Dulbecco's modified Eagle medium; FCS; fetal calf serum; iNOS; inducible nitric oxide synthase; l-NAC; l-nitro-acetyl-cysteine; LPS; lipopolysaccharide; MAPK; mitogen-activated protein kinase; MEK; MAPK/Erk
Enhancement of superficial pseudohyphal growth by overexpression of the SFG1 gene in yeast Saccharomyces cerevisiae
Keywords: Mitogen-activated protein kinase; cAMP-dependent protein kinase; Pseudohyphae; PHD1; GFP; green fluorescent protein; FRE; filamentous response element; MAPK; mitogen-activated protein kinase; MEK; MAPK kinase; MEKK; MEK kinase; PAK; p21-activated protein
A soluble adenylyl cyclase from sea urchin spermatozoa
Keywords: AC; Adenylyl cyclase; sAC; Soluble adenylyl cyclase; sacs; sAC genes; susAC; Sea urchin soluble adenylyl cyclase; CaM; Calmodulin; C1; Catalytic domain-1; C2; Catalytic domain-2; DTT; Dithiothreitol; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic ac
Phosphorylation of HIV Nef by cAMP-dependent protein kinase
Keywords: HIV; SIV; PKA; Nef; Phosphorylation; Protein kinase;
Calcium/calmodulin-dependent protein kinase II (CaMKII), through NMDA receptors and L-Voltage-gated channels, modulates the serine phosphorylation of GluR6 during cerebral ischemia and early reperfusion period in rat hippocampus
Keywords: Disorders of the nervous system; Ischemia; Brain ischemia; Serine phosphorylation; GluR6; CaMKII; PKA;
Direct binding of estradiol enhances Slack (sequence like a calcium-activated potassium channel) channels' activity
Keywords: estrogen; ion channel; neuron; electrophysiology; non-genomic; estrogen receptor; BSA; bovine serum albumin; cDNA; complementary deoxyribonucleic acid; CNS; central nervous system; E2; 17β-estradiol; EGTA; ethylene glycol-bis-(b-aminoethyl ether) N,N,Nâ
Cellular mechanisms underlying an effect of “early handling” on pCREB and BDNF in the neonatal rat hippocampus
Keywords: Neural basis of behavior; Neural plasticity; 5-HT; serotonin; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ANOVA; analysis of variance; BDNF; brain-derived neurotrophic factor; CA1 area; field 1 of Ammon's horn; CNQX; 6-cyano-7-nitroquinox
Ionisations within a subtilisin-glyoxal inhibitor complex
Keywords: Z; benzyloxycarbonyl; Oxyanion; pKa; Protease; Tetrahedral intermediate;
VIP enhances synaptic transmission to hippocampal CA1 pyramidal cells through activation of both VPAC1 and VPAC2 receptors
Keywords: Neurotransmitters, modulators, transporters, and receptors; Peptides: anatomy and physiology; VPAC1; VPAC2; PKA; PKC; Hippocampal slices; fEPSPs;
DARPP-32 Phosphorylation Opposes the Behavioral Effects of Nicotine
Keywords: Addiction; dependence; dopamine; PKA; striatum; plasticity;
Left ventricular assist device support normalizes left and right ventricular beta-adrenergic pathway properties
Keywords: LV; left ventricle/ventricular; LVAD; left ventricular assist device; PKA; protein kinase A; RV; right ventricle/ventricular; RyR; ryanodine receptor; SERCA2a; sarcoplasmic reticulum Ca2+-ATPase, isoform 2a;
Synaptic and subcellular localization of A-kinase anchoring protein 150 in rat hippocampal CA1 pyramidal cells: Co-localization with excitatory synaptic markers
Keywords: protein kinase A; calcineurin; post-synaptic density; GABAA receptors; receptor phosphorylation; receptor targeting; AKAP; A-kinase anchoring protein; AKAP150-IR; A-kinase anchoring protein 150 immunoreactivity; EM; electron microscopic; GABAA; GABA recep
The cAMP signalling pathway activates CREB through PKA, p38 and MSK1 in NIH 3T3 cells
Keywords: CREB; PKA; P38; MSK1; Forskolin; NIH 3T3 cells;
Adrenaline potentiates insulin-stimulated PKB activation via cAMP and Epac: implications for cross talk between insulin and adrenaline
Keywords: PI 3-kinase; PKA; 8-pCPT-2â²-O-Me-cAMP; p70S6K; Akt;
Ca2+-calmodulin-dependent phosphodiesterase (PDE1): Current perspectives
Keywords: AC; Adenylyl cyclase; [Ca2+]i; cytosolic Ca2+ concentration; CaM; calmodulin; CaMKII; Ca2+-CaM-dependent kinase II; CCE; capacitative Ca2+ entry; CNG; cyclic nucleotide-gated channel; InsP3; inositol trisphosphate; PDE; cyclic nucleotide phosphodiesterase
Multiple, PKA-dependent and PKA-independent, signals are involved in cAMP-induced PRL expression in the eosinophilic cell line Eol-1
Keywords: PRL; prolactin; PKA; protein kinase A; CREB; cAMP response element binding protein; CRE; cAMP response element; cptcAMP; 8-(4-chloro-phenyl-thio)-cAMP; Me-cptcAMP; 8-(4-chloro-phenyl-thio)-2-O-methyl cAMP; PKI; myristoylated protein kinase inhibitor fragm
Evaluation of the role of AMP-activated protein kinase and its downstream targets in mammalian hibernation
Keywords: ACC; acetyl-CoA carboxylase (EC 6.4.1.2); AMPK; AMP-activated protein kinase; B; brain; BAT; brown adipose tissue; GS; glycogen synthase (EC 2.4.1.11); eEF2; eukaryotic elongation factor-2; eEF2K; eukaryotic elongation factor-2 kinase; HSL; hormone-sensit
Inhibition of leukocyte function and interleukin-2 gene expression by 2-methylarachidonyl-(2â²-fluoroethyl)amide, a stable congener of the endogenous cannabinoid receptor ligand anandamide
Keywords: F-Me-AEA; 2-methylarachidonyl-(2â²-fluoroethyl)amide; 2-Ara-Gl; 2-arachidonyl-glycerol; CB1; cannabinoid receptor type 1 (brain receptor); CB2; cannabinoid receptor type 2 (peripheral receptor); IL-2; interleukin-2; AA; arachidonic acid; Î9-THC; delta-9
Coupling phosphoryl transfer and substrate interactions in protein kinases
Keywords: Cbp; Csk binding protein; Cbp peptide; phosphotyrosine peptide derived from Cbp with sequence ISAMpYSSVMK; Csk; COOH terminal Src kinase; Kemptide; peptide substrate with sequence LRRASLG; Npl3; nuclear protein localization 3; PKA; cAMP-dependent protein
PKA-dependent growth stimulation of cells derived from human pulmonary adenocarcinoma and small airway epithelium by dexamethasone
Keywords: Lung adenocarcinoma; Dexamethasone; cAMP; PKA; CREB; ERK1/2; Cell proliferation;
The negative immunoregulatory effects of fluoxetine in relation to the cAMP-dependent PKA pathway
Keywords: Antidepressants; Depression; Cytokines; cAMP; PKA; Second messengers; Fluoxetine;