Are strong Brønsted acids necessarily strong Lewis acids?
Keywords: DFT; Brønsted acids; Lewis acids; pKa; Electron transfer;
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Activation of presynaptic kainate receptors suppresses GABAergic synaptic transmission in the rat globus pallidus
Keywords: IPSC; patch-clamp; striatum; PKC; paired-pulse facilitation; ACSF; artificial cerebrospinal fluid; ATPA; (RS)-2-amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl)propanoic acid; CNQX; 6-cynao-7-nitroquinoxaline-2,3-dione; CPPG; (RS)-α-cyclopropyl-4-phosphonop
Flight and fight: A comparative view of the neurophysiology and genetics of honey bee defensive behavior
Keywords: Aggressive behavior; Apis mellifera; Behavior genetics; Tango; 14-3-3 epsilon; Homer; PKA; Neuromodulator; Biogenic amine; Darkener of apricot
Relocalization of the polypyrimidine tract-binding protein during PKA-induced neurite growth
Keywords: Polypyrimidine tract binding protein; PTB; PKA; Nucleocytoplasmic transport; Neurite growth; Phosphorylation; mRNA localization;
The hormonal herbicide, 2,4-dichlorophenoxyacetic acid, inhibits Xenopus oocyte maturation by targeting translational and post-translational mechanisms
Keywords: Oocyte maturation; Signal transduction; PKA; Mos; MAPK; Cytoplasmic polyadenylation; Endocrine disruptor; 2,4-D
Troponin phosphorylation and regulatory function in human heart muscle: Dephosphorylation of Ser23/24 on troponin I could account for the contractile defect in end-stage heart failure
Keywords: Heart failure; Phosphorylation; Troponin; Troponin I; PKA; PKC; Contractility; Ca2+-regulation;
Manipulations of PKA in chick limb development reveal roles in digit patterning including a positive role in Sonic Hedgehog signaling
Keywords: Chick; Limb; Sonic hedgehog; Gli3; PKA
Opposing effects of Bad phosphorylation at two distinct sites by Akt1 and JNK1/2 on ischemic brain injury
Keywords: Bad phosphorylation; JNK; Akt; SP600125; bpV(pic); Cerebral ischemia; JNK; c-Jun N-terminal kinase; MAPK; mitogen-activated protein kinase; PI3K; phosphoinositide 3-kinase; ERK; Extracellular signal regulated kinase; PKA; protein kinase A; RTK; receptor t
Intermittent hypoxia changes HIF-1α phosphorylation pattern in endothelial cells: Unravelling of a new PKA-dependent regulation of HIF-1α
Keywords: Intermittent hypoxia; HIF-1α; PKA; Neo-angiogenesis; Tumor
Modulation of the cAMP signaling pathway after traumatic brain injury
Keywords: cAMP; Fluid-percussion; Inflammation; Interleukin-1β; PKA; Phosphodiesterase; Rolipram; TNF-α; Traumatic brain injury; TBI
Differential control of two forms of glutamate release by group III metabotropic glutamate receptors at rat entorhinal synapses
Keywords: presynaptic metabotropic receptors; entorhinal cortex; glutamate release; AC; adenylyl cyclase; ACPT-1 (1S; 3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid; ACSF; artificial cerebrospinal fluid; AgTx; agatoxin IVA; AP; action potential; CPPG; (RS)-cyc
The role of volume-sensitive ion transport systems in regulation of epithelial transport
Keywords: NKCC; Na+, K+, 2Clâ; RVI; volume regulatory increase; EATC; Ehrlich ascites tumour cells; SK; K channels having small conductance; IK; intermediate conductance; BK; large conductance; 2P-4TM; four transmembrane-spanning segments; TASK-2; acid sensitive
Alcohol and airways function in health and disease
Keywords: Cilia; Mucociliary clearance; Cigarette smoke; Alcohol; Ethanol; cAMP; PKA; PKG; Lung epithelium; COPD; Chronic obstructive pulmonary disease; Acetaldehyde dehydrogenase 2; ALDH2
Cerebellar cortical-layer-specific control of neuronal migration by pituitary adenylate cyclase-activating polypeptide
Keywords: cerebellar development; granule cell; neuronal cell migration; cAMP; rate of cell movement; desensitization; E; embryonic day; EGL; external granular layer; Erk; extracellular signal-regulated; GalR1; galanin receptor 1; GRK; G-protein-coupled receptor ki
Prostaglandins PGE2 and PGI2 promote endothelial barrier enhancement via PKA- and Epac1/Rap1-dependent Rac activation
Keywords: Permeability; Lung endothelium; Small GTPases; Cytoskeleton; PKA; GEFs
The NMDA receptor antagonist CPP blocks the effects of predator stress on pCREB in brain regions involved in fearful and anxious behavior
Keywords: ACC; anterior cingulate cortex; ACo; anterior cortical amygdala; AP; anterior-posterior; ALB; anxiety-like behavior; BAOT; bed nucleus of the accessory olfactory tract; BNST; bed nucleus of the stria terminalis; BLa; basolateral amygdala; BLv; ventral b
N-Methyl-d-aspartate (NMDA) receptor function and excitotoxicity in Huntington's disease
Keywords: 3-NP; 3-nitropropionic acid; ADP; adenosine 5â²-diphosphate; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid; AMPAR; AMPA receptor; AP-2; adaptor protein-2; ATP; adenosine 5â²-triphosphate; cAMP; cyclic adenosine 5â²-monophosphate; CNS; ce
Polymer-drug conjugation, recent achievements and general strategies
Keywords: Polymer conjugation; Drug-delivery; PEG; PEGylation; Polymer therapeutics; Ã
; Amstrong; AL-PEG; PEG aldehyde; BTC-PEG; PEG benzotriazolyl carbonate; CDI-PEG; PEG carbonylimidazole; CT-2103; PGA-paclitaxel conjugate; Da; Dalton; EGF; epidermal gro
Mechanisms of action of glucagon-like peptide 1 in the pancreas
Keywords: GLP-1 receptor; Exendin 4; Insulin synthesis and secretion; Exendin (9-39); β cell; Islet of Langerhans; Proliferation; Differentiation; cAMP; PKA; Epac; PI3 kinase; FoxO1; IRS2; PDX-1
Dual roles of the A kinase-anchoring protein Yotiao in the modulation of a cardiac potassium channel: A passive adaptor versus an active regulator
Keywords: IKs; KCNQ1; AKAP; Yotiao; PKA; Phosphorylation; Sympathetic nervous system
Møller-Plesset perturbation theory calculations of the pKa values for a range of carboxylic acids
Keywords: Perturbation theory; MP3; Carboxylic acids; pKa; PCM; Acidity;
Hypothesis: VPAC G protein-coupled receptors for vasoactive intestinal peptide constitute a dynamic system for signaling T cells from plasma membrane and nuclear membrane complexes
Keywords: VIP; vasoactive intestinal peptide; GPCR; G protein-coupled receptor; VPAC1; type 1 VIP receptor; VPAC2; type 2 VIP receptor; T cell; T lymphocyte; LPA; lysophosphatidic acid; S1P; sphingosine 1-phosphate; LPA1; type 1 LPA receptor; iNOS; inducible nitric
Phosphodiesterases and compartmentalized cAMP signalling in the heart
Keywords: Phosphodiesterases; cAMP; PKA; Cardiac myocytes; Heart failure; Compartmentalized signalling; β Adrenergic receptors; FRET
Circadian clocks regulate adenylyl cyclase activity rhythms in human RPE cells
Keywords: Adenylyl cyclase; Forskolin; PKA; Circadian clock; Per genes; HRPE cells
Mechano-chemical signaling in F9 cells
Keywords: Cellular signal transduction; pp125FAK; PKC; PKA; pCREB; F9Wt; Mouse embryonic carcinoma cells;
Involvement of PKA, MAPK/ERK and CaMKII, but not PKC in the acute antidepressant-like effect of memantine in mice
Keywords: Memantine; Depression; Forced swimming test; PKA; MAPK/ERK; CaMKII
BRSK2 is activated by cyclic AMP-dependent protein kinase A through phosphorylation at Thr260
Keywords: BRSK2; PKA; Phosphorylation; AMPK subfamily
Phosphorylation of transglutaminase 2 by PKA at Ser216 creates 14-3-3 binding sites
Keywords: Transglutaminase 2; PKA; 14-3-3; Phosphorylation; BH3 domain
Block of spontaneous termination of paroxysmal depolarizations by forskolin (buccal ganglia, Helix pomatia)
Keywords: cAMP; Status epilepticus; Paroxysmal depolarization shifts (PDS); Spontaneous decrease of PDS; Pentylenetetrazol; PKA;
Subcellular dynamics of protein kinase A activity visualized by FRET-based reporters
Keywords: PKA; FRET; Kinase; Live-cell imaging; Compartmentalization; Mitochondria; Circular permutation
Spatial organisation of AKAP18 and PDE4 isoforms in renal collecting duct principal cells
Keywords: PKA; AKAP; AKAP18; PDE4; Renal principal cells; IMCD cells
Signaling pathways regulating murine cardiac CREB phosphorylation
Keywords: CREB phosphorylation; Signaling pathways; Langendorff heart perfusion; PKA; CaMKII; p90RSK; PKC; Murine;
The CART gene: Structure and regulation
Keywords: CART gene; Promoter; CREB; CRE; PKA; Cocaine
Protein tyrosine phosphatases regulate arachidonic acid release, StAR induction and steroidogenesis acting on a hormone-dependent arachidonic acid-preferring acyl-CoA synthetase
Keywords: ACS4; Arachidonic acid; PTPs; Steroidogenesis; PKA;
cAMP regulates vasopressin-induced AQP2 expression via protein kinase A-independent pathway
Keywords: Aquaporin-2; Arginine vasopressin; cAMP; ERK; CREB; PKA
Constitutive activity of H3 autoreceptors modulates histamine synthesis in rat brain through the cAMP/PKA pathway
Keywords: Histamine H3 receptors; Inverse agonism; PKA; Signal transduction; Protean agonism
The pH-dependence of amide chemical shift of Asp/Glu reflects its pKa in intrinsically disordered proteins with only local interactions
Keywords: pKa; Nuclear magnetic resonance; Unfolded state of proteins
Perspectives on integration of cell extrinsic and cell intrinsic pathways of signaling required for differentiation of noradrenergic sympathetic ganglion neurons
Keywords: HAND2; Phox2a; PKA; BMP; Intracellular signaling; Noradrenergic sympathetic ganglion neurons; cAMP
Relations between extraction protocols for activated sludge extracellular polymeric substances (EPS) and complexation properties of Pb and Cd with EPS: Part II. Consequences of EPS extraction methods on Pb2+ and Cd2+ complexation
Keywords: Extracellular polymeric substances; Extraction method; Complexation properties; Cd; Pb; pKa
D1 receptor modulation of memory retrieval performance is associated with changes in pCREB and pDARPP-32 in rat prefrontal cortex
Keywords: Object recognition memory; Temporal order memory for objects; Spatial working memory; Prefrontal cortex; D1 receptors; PKA; CREB and DARPP-32
Regulation of the rat brain Na+-driven Cl-/HCO3- exchanger involves protein kinase A and a multiprotein signaling complex
Keywords: NCBE; PKA; EBP50; Ezrin; Actin; Bicarbonate transport; Astrocyte
Anti-fibrotic effects of theophylline on lung fibroblasts
Keywords: Theophylline; Airway remodeling; Asthma; COPD; TGF-β; Collagen; cAMP; PKA; Fibroblast
Buffer pH and pKa values as affected by added glycerol and sucrose
Keywords: Buffer; pH; pKa; Phosphate; Polyol; Sucrose; Glycerol
Signal transduction pathways involved in mechanical regulation of HB-GAM expression in osteoblastic cells
Keywords: Heparin-Binding Growth-Associated Molecule; Osteoblastic cells; Mechanical loading; Mechanotransduction; Signal transduction; PKC; PKA; MAPK
Role of PTHrp and PTHrp-engaged pathways in MCF-7 cells migration/invasion
Keywords: PTHrp; PKA; PKC; MMPs; MCF-7; Invasivity
Intra-hippocampal inhibition of protein kinase AII attenuates morphine-induced conditioned place preference
Keywords: PKA; H-89; Morphine; Conditioned place preference; Hippocampus; CA1; Rat
Signalling mechanisms regulating lipolysis
Keywords: Lipolysis; Adipocytes; Adrenergic receptor; PKC; PKA;
NHE3 inhibits PKA-dependent functional expression of CFTR by NHERF2 PDZ interactions
Keywords: CFTR; NHE3; NHERF2; PKA; PDZ domains; Ezrin
Catalytic subunit of cAMP-dependent protein kinase from a catch muscle of the bivalve mollusk Mytilus galloprovincialis: Purification, characterization, and phosphorylation of muscle proteins
Keywords: cAMP-dependent protein kinase; PKA; Catalytic subunit; Phosphorylation of proteins; Catch muscle; Mollusk; Mytilus
Calculations of pKa values of carboxylic acids in aqueous solution using density functional theory
Keywords: Density functional theory; Carboxylic acids; pKa; PCM