
Engineering α4β2 nAChRs with reduced or increased nicotine sensitivity via selective disruption of consensus sites in the M3-M4 cytoplasmic loop of the α4 subunit
Keywords: Nicotinic acetylcholine receptor; Nicotine; Two-electrode voltage clamp; Nicotine sensitivity; Phosphorylation; nachr; nicotinic acetylcholine receptor; ACh; acetylcholine; PKA; protein kinase A; PKB; protein kinase B; PKC; protein kinase C; CKII; casein