Effects of long-term elevated glucose on collagen formation by mesangial cells
Keywords: diabetic nephropathy; mesangial cells; extracellular matrix; TGF-β; hyperglycemia; PKC
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Protein kinase Cα mediates feedback inhibition of EGF receptor transactivation induced by Gq-coupled receptor agonists
Keywords: DAG; diacylglycerol; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; ERK; extracellular signal-regulated kinase; GPCR; G-protein-coupled receptor; HB-EGF; heparin-bound EGF-like growth factor; MMP; matrix metalloprotease; PDB; phorbo
Prostanoids in nociception and pain
Keywords: CFA; complete Freund's adjuvant; COX; cyclooxygenase (EC 1.14.99.1); CSF; cerebrospinal fluid; DRG; dorsal root ganglion; GlyRα3; glycine receptor α3 subunit; GST; glutathione S transferases; LPS; lipopolysaccharide; mPGES; microsomal prostaglandin E sy
The aging brain, a key target for the future: The protein kinase C involvement
Keywords: Aging; Brain; PKC; RACK; ELAV; Signal transduction; Memory and Alzheimer's disease
Histamine affects STAT6 phosphorylation via its effects on IL-4 secretion: Role of H1 receptors in the regulation of IL-4 production
Keywords: Th1; T-helper type 1 lymphocyte; Th2; T-helper type 2 lymphocyte; STAT; Signal Transducer and Activator of Transcription; PMA; phorbol 12 myristate 13-acetate; H1 receptor; histamine receptor 1; H2 receptor; histamine receptor 2; H3 receptor; histamine re
Seasonal variations in haemocyte response in the mussel Mytilus galloprovincialis Lmk
Keywords: Catecholamines; IL-2; LPS; PKC; Mytilus; Haemocytes
Aldosterone rapidly activates protein kinase D via a mineralocorticoid receptor/EGFR trans-activation pathway in the M1 kidney CCD cell line
Keywords: Aldosterone; EGFR; PKC; Protein kinase D; Mineralocorticoid receptor
Ursodeoxycholic Acid Stimulates Cholangiocyte Fluid Secretion in Mice via CFTR-Dependent ATP Secretion
Keywords: CA; cholic acid; CFTR; cystic fibrosis transmembrane conductance regulator; EGF; epidermal growth factor; IBDU; isolated bile duct unit; KRB; NaHCO3/CO2-buffered Ringer; MEQ; 6-methoxy-N-ethylquinolinium chloride; P2Y; purinergic receptor 2Y; PKC; protein
ERK-dependent and -independent pathways trigger human neural progenitor cell migration
Keywords: Neural migration; ERK1/2; Normal human neural progenitor cells; EGFR; PKC; src
Nongenomic action of an insect steroid hormone in steroid-induced programmed cell death
Keywords: 20-Hydroxyecdysone; Programmed cell death; Nongenomic; Calcium; PKC; Caspase-like protease
Functional changes in the vanilloid receptor subtype 1 channel during and after acute desensitization
Keywords: capsaicin; vanilloid receptor; TRP channels; structure-function relationship; desensitization; CaMKII; Ca2+/calmodulin-dependent kinase II; GFP; green fluorescent protein; HEK; human embryonic kidney; I-V; current-voltage; PIP2; phosphatidylinositol 4
Beta catenin-independent activation of MyoD in presomitic mesoderm requires PKC and depends on Pax3 transcriptional activity
Keywords: Non-canonical Wnt signalling; PKC; MyoD; Pax3; Onset of myogenesis; Mouse embryo
Nonreceptor Tyrosine Kinases in Prostate
Keywords: Nonreceptor tyrosine kinase; prostate cancer; Src; FAK; ETK; Abl; v-Abl Abelson murine leukemia viral oncogene homolog; At; androgenindependent; Aid; v-akt murine thymoma viral oncogene homolog 1; AR; androgen receptor; ARG; Abelson-related gene; Bcr; bre
N-Benzyladriamycin-14-valerate (AD 198) cytotoxicty circumvents Bcr-Abl anti-apoptotic signaling in human leukemia cells and also potentiates imatinib cytotoxicity
Keywords: AD 198; PKC; Imatinib; Bcr-Abl kinase; CML
Hemispheric differences in protein kinase C βII levels in the rat amygdala: Baseline asymmetry and lateralized changes associated with cue and context in a classical fear conditioning paradigm
Keywords: laterality; amygdala; protein kinase C; behavior; limbic system; asymmetryBLA, basal nucleus of the amygdala; CS, conditioned stimulus; EDTA, ethylenediaminetetraacetic acid; EGTA, ethylene glycol tetraacetic acid; LA, lateral nucleus of the amygdala; PKC
Evidence for a columnar organization of cones, Müller cells, and neurons in the retina of a cichlid fish
Keywords: mosaic; cone photoreceptor; bipolar cell; radial glia; Astatotilapia burtoni; GCL; ganglion cell layer; GS; glutamine synthetase; INL; inner nuclear layer; IPL; inner plexiform layer; OPL; outer plexiform layer; PKC; protein kinase C;
Sevoflurane immediate preconditioning alters hypoxic membrane potential changes in rat hippocampal slices and improves recovery of CA1 pyramidal cells after hypoxia and global cerebral ischemia
Keywords: preconditioning; sevoflurane; volatile anesthetics; ischemia; hypoxia; hippocampus; aCSF; artificial cerebrospinal fluid; CA1; cornus ammonis 1; PKC; protein kinase C; PKM; protein kinase M;
Initial three-dimensional reconstructions of protein kinase C δ from two-dimensional crystals on lipid monolayers
Keywords: PKC; protein kinase C; RD; regulatory domain; 3D; three-dimensional; 2D; two-dimensional; NMR; nuclear magnetic resonance; DOPC; dioleoylphosphatidylcholine; DOPS; dioleoylphosphatidylserine; DO; diolein; DAG; diacylglycerol; FRC; Fourier ring correlation
Direct interaction between ER membrane-bound PTP1B and its plasma membrane-anchored targets
Keywords: Bimolecular Fluorescence Complementation; Insulin receptor; PKC; PTP1B; Src
A role for diacylglycerol in annexin A7-mediated fusion of lung lamellar bodies
Keywords: DAG; diacylglycerol; DPE; dansyl phosphatidylethanolamine; F345; fluorescence at 345Â nm; PC; phosphatidylcholine; PE; phosphatidylethanolamine; PIP2; phosphatidylinositol-4,5-bisphosphate; PI; phosphatidylinositol; PS; phosphatidylserine; PKC; protein ki
G protein-coupled receptors control NMDARs and metaplasticity in the hippocampus
Keywords: NMDA receptor; G-protein coupled receptor; PKA; PKC; Src kinases; Synaptic efficacy; Longterm potentiation
Mechanical stress-initiated signal transduction in vascular smooth muscle cells in vitro and in vivo
Keywords: AgIIR; angiotensin II receptor; cAMP; cyclic adenosine monophosphate; EC; endothelial cells; eNOS; endothelial nitric oxide synthase; ERK; extracellular signal-regulated kinase; GPCR; G protein-coupled receptor; IGFR; insulin-like growth factor receptor;
Determination of the role of conventional, novel and atypical PKC isoforms in the expression of morphine tolerance in mice
Keywords: Antinociception; Tolerance; Morphine; PKC; Pseudosubstrate inhibitors; Receptors for activated C-kinase (RACK); Opioid; Pain; Analgesia;
Putative role of heparan sulfate proteoglycan expression and shedding on the proliferation and survival of cells after photodynamic therapy
Keywords: PDT; photodynamic therapy; PS; photosensitizer; ROS; reactive oxygen species; ECM; extracellular matrix; GAG; glycosaminoglycans; PG; proteoglycan; HS; heparan sulfate; DS; dermatan sulfate; CS; chondroitin sulfate; EC; endothelial cell; EJ-ras-EC; endoth
Ethanol induces apoptosis in hepatocytes by a pathway involving novel protein kinase C isoforms
Keywords: ALD; alcoholic liver disease; PKC; protein kinase C; MAPK; mitogen-activated protein kinase; ERK1/2; extracellular signaling-regulated kinase type 1 and type 2; JNK1/2; c-Jun N-terminal kinase type 1 and type 2; NF-κB; nuclear factor kappa B; AP-1; activ
Noradrenergic modulation of the hyperpolarization-activated cation current (Ih) in dopamine neurons of the ventral tegmental area
Keywords: VTA; Ih; norepinephrine; dopamine receptors; adrenergic receptors; ACSF; artificial cerebrospinal fluid; ANOVA; analysis of variance; DA; dopamine; DRG; dorsal root ganglion; EGTA; HTCaS, high-threshold calcium spike; MNTB; medial nucleus of the trapezoid
Activation of presynaptic kainate receptors suppresses GABAergic synaptic transmission in the rat globus pallidus
Keywords: IPSC; patch-clamp; striatum; PKC; paired-pulse facilitation; ACSF; artificial cerebrospinal fluid; ATPA; (RS)-2-amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl)propanoic acid; CNQX; 6-cynao-7-nitroquinoxaline-2,3-dione; CPPG; (RS)-α-cyclopropyl-4-phosphonop
p120 catenin and phosphorylation: Mechanisms and traits of an unresolved issue
Keywords: p120ctn; E-cadherin; Tyrosine kinase; Protein tyrosine phosphatase; PKC; Actin cytoskeleton; Rho GTPases;
Proteomic technologies in the study of kinases: Novel tools for the investigation of PKC in the heart
Keywords: PKC; Proteomics; Mitochondria; Heart
Activation of GABA receptors attenuates neuronal apoptosis through inhibiting the tyrosine phosphorylation of NR2A by Src after cerebral ischemia and reperfusion
Keywords: cerebral ischemia; GABA receptor; NMDA receptor; muscimol; baclofen; Src; CAMK II; CaM-dependent protein kinase II; DAPI; 4â²,6-diamidino-2-phenylindole dihydrochloride; DMSO; dimethyl sulfoxide; EBSS; Earl's balanced salt solution; h-DMEM; high-glucos
Troponin phosphorylation and regulatory function in human heart muscle: Dephosphorylation of Ser23/24 on troponin I could account for the contractile defect in end-stage heart failure
Keywords: Heart failure; Phosphorylation; Troponin; Troponin I; PKA; PKC; Contractility; Ca2+-regulation;
Iron dysregulation in Alzheimer's disease: Multimodal brain permeable iron chelating drugs, possessing neuroprotective-neurorescue and amyloid precursor protein-processing regulatory activities as therapeutic agents
Keywords: AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; APP; amyloid precursor protein; BDNF; brain-derived neurotrophic factor; Aβ; beta-amyloid peptide; β-CTF; beta-C-terminal fragment; EGCG; epigallocatechin gallate; DFO; desferrioxamine; ERK1/2
Regulation of mTOR and S6K1 activation by the nPKC isoforms, PKCε and PKCδ, in adult cardiac muscle cells
Keywords: Cardiomyocytes; PKC; mTOR; S6K1; Endothelin-1; Phenylephrine; Hypertrophy
The role of volume-sensitive ion transport systems in regulation of epithelial transport
Keywords: NKCC; Na+, K+, 2Clâ; RVI; volume regulatory increase; EATC; Ehrlich ascites tumour cells; SK; K channels having small conductance; IK; intermediate conductance; BK; large conductance; 2P-4TM; four transmembrane-spanning segments; TASK-2; acid sensitive
Cerebellar cortical-layer-specific control of neuronal migration by pituitary adenylate cyclase-activating polypeptide
Keywords: cerebellar development; granule cell; neuronal cell migration; cAMP; rate of cell movement; desensitization; E; embryonic day; EGL; external granular layer; Erk; extracellular signal-regulated; GalR1; galanin receptor 1; GRK; G-protein-coupled receptor ki
Brain regions and genes affecting postural control
Keywords: P; postnatal; PKC; protein kinase C; MPTP; methyl-phenyl-tetrahydroyridine; 6-OHDA; 6-hydroxydopamine; CO; cytochrome oxidase; EMG; electromyographic; Cerebellum; Basal ganglia; Motor coordination; Motor cortex; Gene knockout;
Altered Penile Vascular Reactivity and Erection in the Zucker Obese-Diabetic Rat
Keywords: Smooth Muscle; Endothelin-1; Rho-Kinase; PKC; Nitric Oxide Synthase; Metabolic Syndrome X;
Apoptosis and the cardiac action of insulin-like growth factor I
Keywords: Insulin-like growth factor; Apoptosis; Myocardium; Ischaemia; Reperfusion injury; Signaling; ARC; apoptotic repressor with CARD; ATP; adenosine triphosphate; bFGF; basic fibroblast growth factor (also known as FGF2); BAK; Bcl-2 antagonist/killer protein;
CCK causes PKD1 activation in pancreatic acini by signaling through PKC-δ and PKC-independent pathways
Keywords: PKD1 activation; Pancreas; Cholecystokinin; Gastrointestinal hormone; Growth factor; PKC
N-Methyl-d-aspartate (NMDA) receptor function and excitotoxicity in Huntington's disease
Keywords: 3-NP; 3-nitropropionic acid; ADP; adenosine 5â²-diphosphate; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid; AMPAR; AMPA receptor; AP-2; adaptor protein-2; ATP; adenosine 5â²-triphosphate; cAMP; cyclic adenosine 5â²-monophosphate; CNS; ce
The role of mitochondria in protection of the heart by preconditioning
Keywords: 5HD; 5-hydroxydecanoate; AMPK; AMP activated protein kinase; ANT; Adenine nucleotide translocase; APD; Action potential duration; BCDH; branched chain 2-oxoacid dehydrogenase; CrK; creatine kinase; CsA; cyclosporin A; CyP; cyclophilin; Cx43; connexin43; G
PKCα reduces the lipid kinase activity of the p110α/p85α PI3K through the phosphorylation of the catalytic subunit
Keywords: PI3K; PKC; Isoenzymes; Isoenzyme-specific functions; Signal transduction
Glycated albumin (Amadori product) induces activation of MAP kinases in monocyte-like MonoMac 6 cells
Keywords: AGEs; advanced glycation end products; AP-1; activator protein-1; ERK; extracellular signal-regulated kinase; GA; glycated albumin; IL-1β; interleukin 1β; MAPK; mitogen-activated protein kinases; NA; native, nonglycated albumin; NF-κB; nuclear factor-Î
Ca2+-dependent PKC activation mediates menthol-induced desensitization of transient receptor potential M8
Keywords: Cold/menthol receptor; TRPM8; PKC; PMA; Non-selective cation channel
Mechano-chemical signaling in F9 cells
Keywords: Cellular signal transduction; pp125FAK; PKC; PKA; pCREB; F9Wt; Mouse embryonic carcinoma cells;
Atypical protein kinase C in glucose metabolism
Keywords: PKC; protein kinase C; aPKC; atypical isoforms of PKC; Par6; partitioning-defective protein 6; Par3; partitioning-defective protein 3; PDK-1; 3-phosphoinositide-dependent protein kinase 1; PI3K; phosphatidylinositol 3-kinase; EGFP; enhanced greenfluoresce
Distinct mechanisms underlie distinct polyphenol-induced neuroprotection
Keywords: ROS, reactive oxygen species; PKC, protein kinase C; NMDA, N-methyl-D-aspartate; NMDAR, NMDA receptor; LDH, Lactate dehydrogenaseCurcumin; Tannic acid; Catechin; PKC; Calcium influx; Caspase-3
PKC phosphorylates MARCKS Ser159 not only directly but also through RhoA/ROCK
Keywords: MARCKS; PKC; RhoA; ROCK; Neuroblastoma; Phosphorylation
Involvement of HDAC1 and the PI3K/PKC signaling pathways in NF-κB activation by the HDAC inhibitor apicidin
Keywords: Histone deacetylase; HDAC inhibitor; Apicidin; NF-κB; PI3K; PKC
Signaling pathways regulating murine cardiac CREB phosphorylation
Keywords: CREB phosphorylation; Signaling pathways; Langendorff heart perfusion; PKA; CaMKII; p90RSK; PKC; Murine;