ER calcium discharge stimulates GDNF gene expression through MAPK-dependent and -independent pathways in rat C6 glioblastoma cells
Keywords: ER stress; GDNF; MAPK; PKC; Glioblastoma
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p63 and p73, members of the p53 gene family, transactivate PKCδ
Keywords: PKC, protein kinase C; TA, transactivation domain; ΔN, amino terminal truncated protein; Dox, doxycycline; BSA, bovine serum albumin; RE, responsive element; NHEK, normal human epidermal keratinocytesp53 family members; Epidermis; Keratinocytes; Skin; PKC
Activation of Mitogen-activated protein kinase (MAPK) by GnRH is cell-context dependent
Keywords: GnRH; GnRH receptor; ERK; JNK; p38; PKC; Pituitary cells; Prostate cancer cells
Metabolic regulation and chemotherapy
Keywords: GPRT; guanine phosphoribosyltransferase (EC 2.4.2.8); IMP DH; inosine 5'-monophosphate dehydrogenase (EC 1.1.1.205); IP3; inositol-1; 4; 5-trisphosphate; MTX; methotrexate; NCI; National Cancer Institute; R-5-P; ribose-5-phosphate; PI; 1-phosphatidylino
Alteration of protein kinase C conformation in red blood cells: A potential marker for Alzheimer's disease but not for Parkinson's disease
Keywords: PKC; RBC; Fluorescence; Diagnosis; Alzheimer's disease
Control of cardiac myofilament activation and PKC-βII signaling through the actin capping protein, CapZ
Keywords: CapZ; actin capping protein; PIP2; l-α-phosphatidylinositol-4,5-bisphosphate; PKC; protein kinase C; EGTA; ethylene glycol-bis(2-aminoethylether)-N,N,Nâ²,Nâ²-tetraacetic acid; MOPS; 3-morpholinopropanesulfonic acid; PMSF; phenylmethyl-sulfonyl fluoride
2-Hydroxyestradiol-17β-induced oocyte maturation in catfish (Heteropneustes fossilis) involves protein kinase C and its interaction with protein phosphatases
Keywords: Catfish; 2-Hydroxyestradiol-17β; GVBD; Okadaic acid; PKC; PMA; Protein phosphatases
TrkA signalling pathways in human airway smooth muscle cell proliferation
Keywords: Airway smooth muscle; NGF (nerve growth factor); p38 MAPK; ERK1/2 MAPK; PKC; ras/raf; TrkA; Hyperplasia
Lead cations affect the control of both meiosis arrest and meiosis resumption of the mouse oocyte in vitro at least via the PKC pathway
Keywords: Oocyte; Meiosis; Pb2+; Calcium; PKC
Signal transduction pathways involved in mechanical regulation of HB-GAM expression in osteoblastic cells
Keywords: Heparin-Binding Growth-Associated Molecule; Osteoblastic cells; Mechanical loading; Mechanotransduction; Signal transduction; PKC; PKA; MAPK
A novel function of Nur77: Physical and functional association with protein kinase C
Keywords: Nur77; PKC; Ligand binding domain; Glycine-rich loop; Activation protein-1; Nuclear factor-κB
Inositol hexaphosphate represses telomerase activity and translocates TERT from the nucleus in mouse and human prostate cancer cells via the deactivation of Akt and PKCα
Keywords: Inositol hexaphosphate; Telomerase; TERT; Akt; PKC; Prostate cancer
Role of PTHrp and PTHrp-engaged pathways in MCF-7 cells migration/invasion
Keywords: PTHrp; PKA; PKC; MMPs; MCF-7; Invasivity
Astragaloside IV improved barrier dysfunction induced by acute high glucose in human umbilical vein endothelial cells
Keywords: Endothelial cell; High glucose; Monolayer permeability; PKC; Actin filament
Investigation of sanguinarine and chelerythrine effects on CYP1A1 expression and activity in human hepatoma cells
Keywords: AhR; aryl hydrocarbon receptor; BNF; beta-naphtoflavon; DMSO; dimethylsulfoxide; EROD; 7-ethoxyresorufine-O-deethylase; FCS; foetal calf serum; CHE; chelerythrine; HepG2; human hepatoma cells; 3-MC; 3-methylcholanthrene; NF-κB; nuclear factor kappa beta;
Galanin attenuates β-amyloid (Aβ) toxicity in rat cholinergic basal forebrain neurons
Keywords: Alzheimer's disease; AR-M1896; Diagonal band of Broca; Neuroprotection; Neurodegeneration; Apoptosis; PKC; Akt; Caspase
Metformin reduces angiotensin-mediated intracellular production of reactive oxygen species in endothelial cells through the inhibition of protein kinase C
Keywords: Diabetes; ROS; Metformin; Endothelial cells; Angiotensin; PKC
Adenylyl cyclase type II activity is regulated by two different mechanisms: Implications for acute and chronic opioid exposure
Keywords: Adenylyl cyclase type II; Opioid receptor; G-proteins; cAMP; PKC; Superinhibition
Phorbol ester potentiates the growth inhibitory effects of troglitazone via up-regulation of PPARγ in A549 cells
Keywords: TPA; PPARγ; Reactive oxygen species; G0/G1 arrest; PKC; ERK
Localization of the scaffolding protein RACK1 in the developing and adult mouse brain
Keywords: Neurotransmitters, modulators, transporters, and receptors, Signal transduction: gene expressionScaffolding; Protein; PKC; RACK1; Brain; Distribution; Expression
Signalling mechanisms regulating lipolysis
Keywords: Lipolysis; Adipocytes; Adrenergic receptor; PKC; PKA;
Structure of human protein kinase C eta (PKCη) C2 domain and identification of phosphorylation sites
Keywords: Protein kinase C; PKC; Eta; C2 domain; Structure; Phosphorylation; Novel isoform; X-ray
Synthesis and biological activity of N,N-dialkylaminoalkyl-substituted bisindolyl and diphenyl pyrazolone derivatives
Keywords: Staurosporine; Bisindolopyrazolones; PKC; TNF-α; Apoptosis
Involvement of protein kinase C in 5-HT-evoked thermal hyperalgesia and spinal fos protein expression in the rat
Keywords: 5-HT; 5-hydroxytryptamine; 8-OH-DPAT; (±)-8-hydroxy-2-(di-n-propylamino)tetralin; α-m-5-HT; α-methylserotonin; c-fos-LI; c-Fos-like immunoreactivity; DMSO; dimethylsulphoxide; i.pl.; intraplantar or intraplantarly; PBS; phosphate-buffered saline; PKC;
Inhibition of matrix metalloproteinase activity in DU145 human prostate cancer cells by flavonoids from lowbush blueberry (Vaccinium angustifolium): possible roles for protein kinase C and mitogen-activated protein-kinase-mediated events
Keywords: Flavonoids; MMP; PKC; MAP kinase; Blueberry; Cells
Phosphorylation at the hydrophobic site of protein kinase C Apl II is increased during intermediate term facilitation
Keywords: Aplysia; learning and memory; phosphoinositide dependent kinase I; persistent protein kinase; rapamycin; autophosphorylation; PDBu; phorbol dibutyrate; PDK-1; phosphoinositide-dependent kinase I; PI-3 kinase; phosphoinositide-3 kinase; PKC; protein kinase
Antiproliferative effects of tocopherols (vitamin E) on murine glioma C6 cells: homologue-specific control of PKC/ERK and cyclin signaling
Keywords: TOCs; tocopherols and tocotrienols; TQs; tocopheryl quinones; CEHCs; carboxyethyl-hydroxychromans; PKC; protein kinase C; PXR; pregnane X receptor; RXR; retinoid X receptor; COX-2; cyclooxygenase-2; PPARγ; peroxisome proliferator activated receptor γ; F
Glomerular clusterin is associated with PKC-α/β regulation and good outcome of membranous glomerulonephritis in humans
Keywords: membranous glomerulonephritis; nephrotic syndrome; clusterin; PKC
Effects of PKC412, Nilotinib, and Imatinib Against GIST-Associated PDGFRA Mutants With Differential Imatinib Sensitivity
Keywords: Bcr-Abl; breakpoint cluster region-Abelson; GIST; gastrointestinal stromal tumor; PDGFR; platelet-derived growth factor receptor; PDGFRA; platelet-derived growth factor receptor α; PKC; protein kinase C;
Activation of P2Y1 receptor triggers two calcium signaling pathways in bone marrow erythroblasts
Keywords: Bone marrow; Erythroblast; P2Y1 receptor; Intracellular calcium; CaMKII; PKC
The different facets of protein kinases C: old and new players in neuronal signal transduction pathways
Keywords: PKC; RACK1; ELAV proteins; Memory; Aging and Alzheimer's disease;
Sustained activation of Src-family tyrosine kinases by ischemia: A potential mechanism mediating extracellular signal-regulated kinase cascades in hippocampal dentate gyrus
Keywords: cerebral ischemia; ERKs; Raf-1; Ras; RKIP; Src family tyrosine kinases; ERK; extracellular signal-regulated kinase; IP; immunoprecipitation; locostatin; (4S)-3-[(E)-but-2-enoyl]-4-benzyl-2-oxazolidinone; NMDAR; NMDA receptor; p-ERK; phosphorylated extrace
Optimal Sox-based fluorescent chemosensor design for serine/threonine protein kinases
Keywords: Serine/Threonine kinase; Fluorescent assay; Akt; Cdk2; PKA; Pim2; PKC; MK2
Substance P induces expression of the corticotropin-releasing factor receptor 1 by activation of the neurokinin-1 receptor
Keywords: CRF1 receptor; corticotropin-releasing factor receptor; MAPK; mitogen-activated protein kinase; NK; neurokinin; NK-1-R; neurokinin-1 receptor; PKC; protein kinase C; SP; substance P; Affective disorder; Depression; HPA axis; Somatostatin receptor type 4;
Glutamate-dependent translational regulation in cultured Bergmann glia cells: Involvement of p70S6K
Keywords: p70S6K; glutamate receptors; Bergmann glia; mTOR; translational control; Akt I; 1L-6-hydroxymethyl-chiro-inositol 2-(R)-2-O-methyl-3-O-octadecylcarbonate; AMPA; amino α-3-hydroxy-5-methyl-4-isoaxazolepropionate; ANOVA; analysis of variance; BAPTA-AM; 1,2
Nicotine-induced upregulation of human neuronal nicotinic α7-receptors is potentiated by modulation of cAMP and PKC in SH-EP1-hα7 cells
Keywords: α7; Nicotinic receptor; Nicotine; [3H]Methyllycaconitine; cAMP; PKC; Upregulation
Tocopherol-mediated modulation of age-related changes in microglial cells: Turnover of extracellular oxidized protein material
Keywords: AGE; advanced glycation end products; BSA; bovine serum albumin; DMEM; Dulbecco's modified Eagle's medium; IFN; interferon; IL; interleukin; DMSO; dimethyl sulfoxide; HBSS; Hank's balanced salt solution; MBP; myelin basic protein; PKC; protein kinase C; P
A novel method for detecting neutralizing antibodies against therapeutic proteins by measuring gene expression
Keywords: BL; blocker; CE; capture extender; EPO; erythropoietin; LE; label extender; GM-CSF; granulocyte-macrophage colony-stimulating factor; MAPK; MAP kinase; PI3-K; phosphatidylinositol 3-kinase; PKA; protein kinase A; PKC; protein kinase C; r; recombinant; S
Extracellular signal regulated MAP-kinase signalling in osmotically stressed trout hepatocytes
Keywords: Trout hepatocyte; MAP kinase; ERK; Volume regulation; Calcium; PKC
Phosphorylation: A molecular switch in opioid tolerance
Keywords: Phosphorylation; Protein kinase; Phosphatase; PKC; CaMKII; PKA; PKG; GRK; CREB; NO; cAMP; cGMP; Calmodulin; Calcium; NMDA
Roles of PKC, PI3K and JNK in multiple transduction of CCN2/CTGF signals in chondrocytes
Keywords: CCN family; CTGF; Chondrocyte; MAPK; PKC
The Hepatitis C Envelope 2 Protein Inhibits LFA-1-Transduced Protein Kinase C Signaling for T-Lymphocyte Migration
Keywords: ICAM-1; intracellular adhesion molecule 1; LFA-1; leukocyte function-associated molecule-1; MIP; macrophage inflammatory protein; NK; natural killer; PBTL; peripheral blood T lymphocytes; PKC; protein kinase C; TCR; T-cell receptor;
Regulation of death and survival in astrocytes by ADP activating P2Y1 and P2Y12 receptors
Keywords: BrdUTP; 5-bromo-2â²-deoxyuridine 5â²-triphosphate; caspase-3; cytosolic aspartate-specific protease-3; DMEM; Dulbecco's modified Eagle's medium; Erk1/2; extracellular signal-regulated protein kinases 1 and 2; FACS; fluorescence-activated cell sorting; F
Mechanosensitive synoviocytes: A Ca2+–PKCα–MAP kinase pathway contributes to stretch-induced hyaluronan synthesis in vitro
Keywords: Synoviocyte; Joint; Hyaluronan; Hyaluronan synthase; Stretch; Mechanosensitive; PKC; ERK1/2; Calcium; PKA; CTGF
PKCδ-mediated IRS-1 Ser24 phosphorylation negatively regulates IRS-1 function
Keywords: Insulin receptor substrate; PKC; Insulin resistance; Serine phosphorylation; shRNA;
Apigenin-induced-apoptosis is mediated by the activation of PKCδ and caspases in leukemia cells
Keywords: Apigenin-induced-apoptosis; PKC; Caspase; Leukemia
The very C-terminus of protein kinase CÉ is critical for the full catalytic competence but its hydrophobic motif is dispensable for the interaction with 3-phosphoinositide-dependent kinase-1
Keywords: aPKC; atypical PKC; cPKC; classic PKC; MD; molecular dynamics; nPKC; novel PKC; PAGE; polyacrylamide gel electrophoresis; PDK-1; 3-phosphoinositide-dependent kinase-1; PKA; cAMP-dependent protein kinase; PKB; protein kinase B; PKC; protein kinase C; RMSD;
ERK is an anti-inflammatory signal that suppresses expression of NF-κB-dependent inflammatory genes by inhibiting IKK activity in endothelial cells
Keywords: VEGF; vascular endothelial growth factor; HUVECs; human umbilical vein endothelial cells; bFGF; basic fibroblast growth factor; EGF; epidermal growth factor; TNF-α; tumor necrosis factor-α; IL-1β; interleukin-1β; KDR; Flk-1/kinase-insert domain contai
Signal pathways involved in the regulation of prostaglandin E synthase-1 in human gingival fibroblasts
Keywords: mPGES-1; PGE2; PPARγ; PGF2α; PKC; p38 MAP kinase; Gingival fibroblasts; Inflammatory mediators