Regulation of adherens junctions by Rho GTPases and p120-catenin
Keywords: Cell–cell adhesion; Metastasis; RhoA; Rac1; Cdc42; E-cadherin
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Calcium Regulates Podocyte Actin Dynamics
Keywords: Cdc42; fibroblasts; synaptopodin; TRPC channels; TRPC5; TRPC6; Rac1; RhoA; tropomyosin;
Mineralocorticoid receptors in the pathophysiology of chronic kidney diseases and the metabolic syndrome
Keywords: Aldosterone; Mineralocorticoid receptor; Metabolic syndrome; Podocytes; Rac1; Salt-sensitive hypertension
A neuronal transmembrane protein LRFN4 complexes with 14-3-3s and NCK1 to induce morphological change in monocytic cells via Rac1-mediated actin cytoskeleton reorganization
Keywords: LRFN; leucine-rich repeat and fibronectin type III domain-containing; PSD95; postsynaptic density 95; PDZ; postsynaptic density 95/discs large/zona occludin-1; SH; Src-homology; mAb; monoclonal antibody; F-actin; filamentous actin; CT; cytoplasmic region;
Small GTPases Rap1 and RhoA regulate superoxide formation by Rac1 GTPases activation during the phagocytosis of IgG-opsonized zymosans in macrophages
Keywords: DHE; dihydroethidium; DMEM; Dulbecco's modified Eagle medium; Epac; exchange protein directly activated by cAMP; ERK; extracellular signal-regulated kinases; FBS; fetal bovine serum; FITC; fluorescein isothiocyanate; GAP; GTPase activating proteins; GDI;
TGFβ and BMP-2 regulate epicardial cell invasion via TGFβR3 activation of the Par6/Smurf1/RhoA pathway
Keywords: ALK; Activin Receptor-Like Kinases; AVC; Atrioventricular Endocardial Cushion; BMP; Bone Morphogenetic Protein; Cdc42; Cell division control protein 42 homolog; EMT; Epithelial-Mesenchymal Transformation; GFP; Green Fluorescent Protein; GIPC; GAIP-interac
ReviewSpinal cord injury, dendritic spine remodeling, and spinal memory mechanisms
Keywords: SCI; Dendritic spines; Neuropathic pain; LTP; Memory; Spinothalamic tract; Synaptic plasticity; Rac1;
Fibroblast growth factors preserve blood–brain barrier integrity through RhoA inhibition after intracerebral hemorrhage in mice
Keywords: Fibroblast growth factor; Thrombin; Rac1; RhoA; Intracerebral hemorrhage; Brain injury; Blood–brain barrier; Brain edema; Behavior
A novel player in cellular hypertrophy: Giβγ/PI3K-dependent activation of the RacGEF TIAM-1 is required for α1-adrenoceptor induced hypertrophy in neonatal rat cardiomyocytes
Keywords: Cellular hypertrophy; Neonatal rat cardiomyocytes; α1-Adrenoceptor; Guanine nucleotide; Exchange factor; Tiam1; Gi protein; RhoGTPases; Rac1; p21 activated kinase
CIKS (Act1 or TRAF3IP2) mediates Angiotensin-II-induced Interleukin-18 expression, and Nox2-dependent cardiomyocyte hypertrophy
Keywords: Act1; activator of NF-κB; ACM; adult cardiomyocytes; ANF; atrial natriuretic factor; AP-1; activator protein-1; AT1; angiotensin II type 1 receptor; ATRAP; AT1-receptor-associated protein; ARAP1; type 1 Ang II-receptor-associated protein 1; C/EBP; CCAAT/
DISC1-binding proteins in neural development, signalling and schizophrenia
Keywords: DISC1; Schizophrenia; Neurodevelopment; Signalling; Synapse; Association studies; APP; Amyloid precursor protein; ATF4; Activating transcription factor 4; BACE1; β-site APP-cleaving enzyme-1; BBS4; Bardet-Biedl syndrome 4; CEP290; Centrosomal protein 2
Activation of H-Ras and Rac1 correlates with epidermal growth factor-induced invasion in Hs578T and MDA-MB-231 breast carcinoma cells
Keywords: EGF, epidermal growth factor; siRNA, small interfering RNAH-Ras; Rac1; Breast cancer; Invasion; Epidermal growth factor
Alteration of gene expression of IQGAP1 and Rho-family GTPases in the cadmium-induced ventral body wall defects in the chick model
Keywords: Ventral body wall defects; IQGAP1; Rac1; Cdc42; Chick embryo
Radioresistant head and neck squamous cell carcinoma cells: Intracellular signaling, putative biomarkers for tumor recurrences and possible therapeutic targets
Keywords: Head and neck squamous cell carcinoma; Radiation resistance; Rac1; Cell migration; Metastasis; Proteomics;
Syndecan-2 cytoplasmic domain regulates colon cancer cell migration via interaction with syntenin-1
Keywords: Syndecan-2; Syntenin-1; Colon cancer; Cell migration; Rac1;
Upregulation of fibronectin expression by COX-2 is mediated by interaction with ELMO1
Keywords: Cyclooxygenase 2; Adaptor proteins; Rac1; Fibronectin
Defective relocalization of ALS2/alsin missense mutants to Rac1-induced macropinosomes accounts for loss of their cellular function and leads to disturbed amphisome formation
Keywords: ALS2; Rac1; Macropinosome; Endosome; Autophagosome; AmphisomeALS, amyotrophic lateral sclerosis; GEF, guanine nucleotide exchange factor; RLD, regulator of chromosome condensation 1-like domain; DH, Dbl-homology; PH, pleckstrin-homology; VPS9, vacuolar pr
Interrupted reperfusion reduces the activation of NADPH oxidase after cerebral I/R injury
Keywords: I/R; ischemia/reperfusion; ROS; reactive oxygen species; O2â¢â; superoxide anion; â¢OH; hydroxide; Rac1-GTP; Rac1 in the GTP-bound form; MC; sensorimotor cortex; CA1; cornu ammonis 1; CPu; caudate putamen; Interrupted reperfusion; Ischemia/reperfusi
Increased lysyl oxidase expression and collagen cross-linking during atrial fibrillation
Keywords: Atrial fibrillation; Rac1; CTGF; Lysyl oxidase; Fibrosis
Estrogen induces neurite outgrowth via Rho family GTPases in neuroblastoma cells
Keywords: Estrogen; Medroxyprogesterone acetate; Neurite outgrowth; Rac1; Cdc42;
The small GTPase Rac1 is involved in the maintenance of stemness and malignancies in glioma stem-like cells
Keywords: EGF; epidermal growth factor; bFGF; basic fibroblast growth factor; siRNA; small interfering RNA; shRNA; small hairpin RNA; Rac1; Glioma stem-like cells; Migration and invasion; Radiation resistance;
Pharmacological inactivation of the small GTPase Rac1 impairs long-term plasticity in the mouse hippocampus
Keywords: Rac1; Plasticity; LTP; LTD; NSC23766; EHT1864
Inhibition of hypoxia-induced retinal neovascularization in mice with short hairpin RNA targeting Rac1, possibly via blockading redox signaling
Keywords: Rac1; hypoxia; retinal neovascularization; HIF-1α; VEGF; NF-κB
Simvastatin stimulates apoptosis in cholangiocarcinoma by inhibition of Rac1 activity
Keywords: Apoptosis; Cholangiocarcinoma; Rac1; Simvastatin
Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle
Keywords: Insulin signalling; Rac1; Actin; GLUT4; Skeletal muscle
Cudratricusxanthone G inhibits human colorectal carcinoma cell invasion by MMP-2 down-regulation through suppressing activator protein-1 activity
Keywords: AP-1; Cudratricusxanthone G (CTXG); Invasion; MMP-2; Rac1
Inactivation of Rac1 reduces Trastuzumab resistance in PTEN deficient and insulin-like growth factor I receptor overexpressing human breast cancer SKBR3 cells
Keywords: Trastuzumab resistance; Rac1; PTEN; IGF-IR; Akt; HER2
Unexpected wide substrate specificity of C. perfringens α-toxin phospholipase C
Keywords: Ala and A; alanine; Asp and D; aspartic acid; BcPLC; Bacillus cereus phospholipase C; BSA; bovine serum albumin; CbPLC; Clostridium bifermentans phospholipase C; CDCl3-d; deuterated chloroform; Chol; cholesterol; CpPLC; Clostridium perfringens phospholipa
Thymosin beta 4 induces colon cancer cell migration and clinical metastasis via enhancing ILK/IQGAP1/Rac1 signal transduction pathway
Keywords: Thymosin β4 (Tβ4); ILK; IQGAP1; Rac1; Migration
Hippocampal phenotypes in kalirin-deficient mice
Keywords: GEF; Synaptic plasticity; Dendrite; Dendritic spine; Rac1; Knockout; Fear conditioning;
Recombinant AexU effector protein of Aeromonas veronii bv. sobria disrupts the actin cytoskeleton by downregulation of Rac1 and induces direct cytotoxicity to β4-integrin expressing cell lines
Keywords: Aeromonas; AexU; Rac1; β4-Integrin; Cytotoxicity
Numb is a negative regulator of HGF dependent cell scattering and Rac1 activation
Keywords: Numb; E-cadherin; Cell adhesion; Hepatocyte growth factor; Rac1; EMT
Insulin promotes dendritic spine and synapse formation by the PI3K/Akt/mTOR and Rac1 signaling pathways
Keywords: Insulin; Dendritic spine; Synaptogenesis; Phosphatidylinositol 3-kinase; Rac1; Hippocampus
Modulation of dendritic spines and synaptic function by Rac1: A possible link to Fragile X syndrome pathology
Keywords: Rac1; Fragile X syndrome; Plasticity; LTP
Early Requirement of Rac1 in a Mouse Model of Pancreatic Cancer
Keywords: Genetically Engineered Mice; Ductal Cell; Cytoskeleton; Signaling; ADM; acinar-ductal metaplasia; BrdU; bromodeoxyuridine; CK19; cytokeratin 19; CytD; cytochalasin D; EGFR; epidermal growth factor receptor; LatA; latrunculin A; PanIN; pancreatic intraepit
Up-regulated type I collagen expression by the inhibition of Rac1 signaling pathway in human dermal fibroblasts
Keywords: Rac1; MMP1; Type I collagen; Tissue remodeling; Wound healing;
Integrin-linked kinase is a central mediator in angiotensin II type 1- and chemokine receptor CXCR4 signaling in myocardial hypertrophy
Keywords: Chemokines; Integrin-linked kinase; Rac1; Hypertrophy; Heart failure
HSP90β interacts with Rac1 to activate NADPH oxidase in Helicobacter pylori-infected gastric epithelial cells
Keywords: Helicobacter pylori; HSP90β; Rac1; NADPH oxidase; AGS cells;
Up-regulation of circulating hemocyte population in response to bacterial challenge is mediated by octopamine and 5-hydroxytryptamine via Rac1 signal in Spodoptera exigua
Keywords: Hemocyte; Monoamine; Octopamine; 5-hydroxytyptamine; Rac1; Rho family; Spodoptera exigua
Pathway-based genome-wide association analysis identified the importance of EphrinA-EphR pathway for femoral neck bone geometry
Keywords: PAK1; p21-activated kinase 1; FAK1; PTK2 protein tyrosine kinase 2; EphA7; Eph receptor A7; PIK3CG; phosphoinositide-3-kinase, catalytic, gamma; PAK7; p21-activated kinase 7; RASA1; RAS p21 protein activator 1; FYN; FYN oncogene related to SRC, FGR, YES;
PTHrP promotes colon cancer cell migration and invasion in an integrin α6β4-dependent manner through activation of Rac1
Keywords: PTHrP; Integrin α6β4; Phosphatidylinositol 3-kinase; Tiam1; Rac1
Kalirin loss results in cortical morphological alterations
Keywords: Dendrites; Synaptic plasticity; Prefrontal cortex; Rac1; Knockout; KALRN; Small GTPase; Dendritic spine
NGF-induced moesin phosphorylation is mediated by the PI3K, Rac1 and Akt and required for neurite formation in PC12 cells
Keywords: Moesin; NGF; Akt; PI3K; Rac1; Neurite outgrowth
Icariin exterts negative effects on human gastric cancer cell invasion and migration by vasodilator-stimulated phosphoprotein via Rac1 pathway
Keywords: Icariin; Human gastric cancer cell; Rac1; VASP (vasodilator-stimulated phosphoprotein); Cell migration; Cell invasion
Research ArticleAdvanced glycation end products induce production of reactive oxygen species via the activation of NADPH oxidase in murine hepatic stellate cells
Keywords: AGE; advanced glycation end product; ROS; reactive oxygen species; NADPH oxidase; nicotinamide adenine dinucleotide phosphate-oxidase; NAFLD; nonalcoholic fatty liver disease; HSC; hepatic stellate cell; RAGE; receptor for AGE; Rac1; Ras-related C3 botuli
Illumina-microarray analysis of mycophenolic acid-induced cell death in an insulin-producing cell line and primary rat islet cells: New insights into apoptotic pathways involved
Keywords: Mycophenolic acid; INS-1E; Islet cells; Apoptosis; RhoGDI-α; Rac1;
G protein-coupled receptor kinase 2 activates radixin, regulating membrane protrusion and motility in epithelial cells
Keywords: GRK2; ERM protein; Radixin; Rac1; Membrane protrusion; Cell migration; Quinocarmycin/quinocarcin analog DX-52-1
Research ReportChemokine-like factor 1, a novel cytokine, induces nerve cell migration through the non-extracellular Ca2+-dependent tyrosine kinases pathway
Keywords: CKLF1; chemokine-like factor 1; PYK2; proline-rich tyrosine kinase 2; F-actin; filamentous actin; CCR4; chemokine (C-C motif) receptor 4; PYK2-DN; PYK2-dominant-negative; Rac1; Ras-related C3 botulinum toxin substrate 1; Rac1-DN; Rac1-dominant-negative; P
Balanced Vav2 GEF activity regulates neurite outgrowth and branching in vitro and in vivo
Keywords: Axon pathfinding; Xenopus; GEF; Rac1; L1; Commissural interneuron; Growth cone
Rac1 activity changes are associated with neuronal pathology and spatial memory long-term recovery after global cerebral ischemia
Keywords: Cerebral ischemia; Rac1; Neurodegeneration; Neuronal plasticity; Learning and memory