The effects of modifying RhoA and Rac1 activities on heterotypic contact inhibition of locomotion
Keywords: Contact inhibition of locomotion; RhoA; Rac1; Tumor invasion
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Striking crosstalk of ROCK signaling with endothelial function
Keywords: ROCK; RhoA; eNOS; NO; Endothelial function; Atherosclerosis
Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration
Keywords: CBDA, cannabidiolic acid; CBD, cannabidiol; COX-2, cyclooxygenase-2; PKA, cAMP-dependent protein kinase; Δ9-THC, Δ9-tetrahydrocannabinolCannabidiolic acid; RhoA; Fiber-type cannabis plant; Cannabidiol; MDA-MB-231 cells
Inhibition of RhoA but not ROCK induces chondrogenesis of chick limb mesenchymal cells
Keywords: Chondrogenesis; RhoA; ROCK; MLC; Actin filaments;
ROCK1 feedback regulation of the upstream small GTPase RhoA
Keywords: Rac1; RhoA; ROCK1; Tiam1
Tumor promoting effect of podoplanin-positive fibroblasts is mediated by enhanced RhoA activity
Keywords: Podoplanin; RhoA; Fibroblast; Microenvironment
Knockdown of pre-mRNA cleavage factor Im 25 kDa promotes neurite outgrowth
Keywords: 3′-Untranslated region; Pre-mRNA cleavage and polyadenylation factors; Neurite extension; Neuronal morphology; RhoA; Nerve growth factor
PKC and RhoA signals cross-talk in Escherichia coli endotoxin induced alterations in brain endothelial permeability
Keywords: Bacterial toxin; PKC; RhoA; Permeability; Blood brain barrier;
Effects of exercise and antioxidant supplementation on endothelial gene expression
Keywords: Exercise; Antioxidants; Endothelial cells; Gene expression; RhoA; IL-6;
RhoA affects oral morphine analgesia depending on functional variation in intestinal P-glycoprotein induced by repeated etoposide treatment
Keywords: RhoA; P-glycoprotein; Morphine; Intestine
Rho GTPase activity in the honey bee mushroom bodies is correlated with age and foraging experience
Keywords: Apis mellifera; Mushroom bodies; Neuroethology; Rac; RhoA;
Induction of cell cycle arrest by the carbazole alkaloid Clauszoline-I from Clausena vestita D. D. Tao via inhibition of the PKCδ phosphorylation
Keywords: Clauszoline-I; Cell cycle arrest; PKCδ; RhoA
Sphingosylphosphorylcholine induces stress fiber formation via activation of Fyn-RhoA-ROCK signaling pathway in fibroblasts
Keywords: SPC; sphingosylphosphorylcholine; SrcPTK; Src family protein tyrosine kinase; ROCK; Rho-kinase; LPA; L-α-lysophosphatidic acid; EPA; eicosapentaenoic acid; dn-RhoA; dominant negative RhoA; dn-ROCK; dominant negative ROCK; ca-Fyn; constitutively active Fy
SMN deficiency attenuates migration of U87MG astroglioma cells through the activation of RhoA
Keywords: Spinal muscular atrophy; SMN; Cell migration; Profilin; RhoA;
Leptin-induced Cardiomyocyte Hypertrophy Reveals both Calcium-dependent and Calcium-independent/RhoA-dependent Calcineurin Activation and NFAT Nuclear Translocation
Keywords: BSA; bovine serum albumin; C3; Clostridium botulinum C3 exoenzyme; DTT; dithiothreitol; ELIPA; enzyme linked inorganic phosphate assay; ERK1/2; extracellular signal regulated kinases 1/2; FBS; fetal bovine serum; FK-506; Tacrolimus; HBSS; Hank's balanced
Regulation of adherens junctions by Rho GTPases and p120-catenin
Keywords: Cell–cell adhesion; Metastasis; RhoA; Rac1; Cdc42; E-cadherin
Calcium Regulates Podocyte Actin Dynamics
Keywords: Cdc42; fibroblasts; synaptopodin; TRPC channels; TRPC5; TRPC6; Rac1; RhoA; tropomyosin;
Characterization of tissue biomechanics and mechanical signaling in uterine leiomyoma
Keywords: Mechanotransduction; RhoA; Leiomyoma; Mechanical properties; Extracellular matrix; AKAP13; Myometrium; Uterine fibroids; Rho-kinase; ROCK;
GCF2/LRRFIP1 promotes colorectal cancer metastasis and liver invasion through integrin-dependent RhoA activation
Keywords: GCF2; LRRFIP1; RhoA; Integrin; Colorectal cancer
Integrin β1 regulates leiomyoma cytoskeletal integrity and growth
Keywords: Uterine leiomyoma; Extracellular matrix; Integrin β1; Cytoskeletal integrity; RhoA; Laminins
GEF-H1-RhoA signaling pathway mediates LPS-induced NF-κB transactivation and IL-8 synthesis in endothelial cells
Keywords: Lipopolysaccharide; Guanine-nucleotide exchange factor; RhoA; p38; Nuclear factor-κB; Interleukin-8
TGFβ and BMP-2 regulate epicardial cell invasion via TGFβR3 activation of the Par6/Smurf1/RhoA pathway
Keywords: ALK; Activin Receptor-Like Kinases; AVC; Atrioventricular Endocardial Cushion; BMP; Bone Morphogenetic Protein; Cdc42; Cell division control protein 42 homolog; EMT; Epithelial-Mesenchymal Transformation; GFP; Green Fluorescent Protein; GIPC; GAIP-interac
Small GTPases Rap1 and RhoA regulate superoxide formation by Rac1 GTPases activation during the phagocytosis of IgG-opsonized zymosans in macrophages
Keywords: DHE; dihydroethidium; DMEM; Dulbecco's modified Eagle medium; Epac; exchange protein directly activated by cAMP; ERK; extracellular signal-regulated kinases; FBS; fetal bovine serum; FITC; fluorescein isothiocyanate; GAP; GTPase activating proteins; GDI;
Molecular pathways regulating contractility in rat uterus through late gestation and parturition
Keywords: parturition; progesterone; rhoA; rhoA-associated kinase; uterine activation;
Pulmonary, Gastrointestinal and Urogenital PharmacologyAtorvastatin synergizes with IFN-γ in treating human non-small cell lung carcinomas via potent inhibition of RhoA activity
Keywords: IFN-γ; Non-small-cell-lung carcinomas; NSCLCs; RhoA; Atorvastatin;
Involvement of lipid rafts in multiple signal transductions mediated by two isoforms of thromboxane A2 receptor: Dependency on receptor isoforms and downstream signaling types
Keywords: Thromboxane A2 receptor; Lipid raft; Phosphatidylinositol hydrolysis; RhoA; cAMP;
BMP2 signals loss of epithelial character in epicardial cells but requires the Type III TGFβ receptor to promote invasion
Keywords: ALK; Activin Receptor-Like Kinases; BMP; Bone Morphogenetic Protein; Cdc42; Cell division control protein 42 homolog; EMT; Epithelial-Mesenchymal Transformation; GFP; Green Fluorescent Protein; GIPC; GAIP-interacting protein, C terminus; Par6; Par-6 parti
Protein kinase A-mediated phosphorylation of RhoA on serine 188 triggers the rapid induction of a neuroendocrine-like phenotype in prostate cancer epithelial cells
Keywords: PCa; prostate cancer; cAMP; cyclic AMP; NE; neuroendocrine; PSA; prostate-specific antigen; PKA; cAMP-dependent protein kinase; bFGF; basic fibroblast growth factor; NGF; nerve growth factor; 6-Bnz-cAMP; N6-benzoyl-cAMP; Fsk; forskolin; C3T; cell-permeabl
Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)
Keywords: AP-1; activator protein-1; ASC; apoptosis-associated speck-like protein containing a CARD domain; ASK; apoptosis signal-regulating kinase; ATM; Ataxia Telangiectasia Mutated; ATR; ATM and Rad 3-related; BRCA1; breast cancer 1; CARD; caspase activation and
Fibroblast growth factors preserve blood–brain barrier integrity through RhoA inhibition after intracerebral hemorrhage in mice
Keywords: Fibroblast growth factor; Thrombin; Rac1; RhoA; Intracerebral hemorrhage; Brain injury; Blood–brain barrier; Brain edema; Behavior
Ovarian steroids increase spinogenetic proteins in the macaque dorsal raphe
Keywords: estradiol; immunocytochemistry; PSD-95; progesterone; RhoGTPase; serotonin; ANOVA; analysis of variance; Cdc42; cell division control protein 42 homolog; DAB; diaminobenzidine; DPX; dibutyl phthalate and xylene; E; estradiol; E+P; estradiol+progesterone;
RhoA co-ordinates with heterotrimeric G proteins to regulate efficacy
Keywords: G proteins; GTPases; GPCRs; Phosphatidic acid; Phospholipase D; Phospholipase C-β; RhoA;
Arachidonic acid stimulates formation of a novel complex containing nucleolin and RhoA
Keywords: AA, arachidonic acid; GST-RBD, glutathione S-transferase-linked Rho binding domain; MEM, minimal essential mediumNucleolin; RhoA; Rho kinase; Arachidonic acid; Cell adhesion
RhoA GTPase regulates radiation-induced alterations in endothelial cell adhesion and migration
Keywords: RhoA; Endothelial cells; Ionizing radiation; Cytoskeleton; Adhesion; Migration;
Binding of RhoA by the C2 domain of E3 ligase Smurf1 is essential for Smurf1-regulated RhoA ubiquitination and cell protrusive activity
Keywords: C2 domain; Smurf1; RhoA; Substrate selection; Nedd4-like ubiquitin ligase;
Extra-nuclear activation of progesterone receptor in regulating arterial smooth muscle cell migration
Keywords: Progesterone; Migration; cSrc; RhoA; Vascular smooth muscle cells;
Thromboxane-Induced Contractile Response of Human Coronary Arterioles Is Diminished After Cardioplegic Arrest
Keywords: 31; CABG; coronary artery bypass grafting; CaM PK; calmodulin phosphorylase kinase; CPB; cardiopulmonary bypass; CP/Rep; cardioplegia followed by reperfusion; DAPI; 4',6-diamidino-2-phenylindole; GRK; G protein-coupled receptor kinase; GSK; glycogen synth
RhoA/Rho kinase pathway contributes to the pathogenesis of thermal hyperalgesia in diabetic mice
Keywords: Diabetes; RhoA; Spinal cord; HMG-CoA reductase inhibitor; eNOS; Hyperalgesia;
E3 ubiquitin protein ligase, E6-associated protein (E6-AP) regulates PI3K-Akt signaling and prostate cell growth
Keywords: E6-AP; PI3K-AKT; Androgen receptor; Prostate gland; RhoA
Reactive oxygen species-dependent RhoA activation mediates collagen synthesis in hyperoxic lung fibrosis
Keywords: Oxygen toxicity; Lung; Fibroblasts; Collagen; RhoA; Reactive oxygen species; Free radicals;
Involvement of Sphingosineâ1âPhosphate/RhoA/RhoâKinase Signaling Pathway in Corporal Fibrosis Following Cavernous Nerve Injury in Male Rats
Keywords: Penis; Fibrosis; Postprostatectomy Erectile Dysfunction; TGFâBeta; S1P Receptor; Sphingosine Kinase; RhoA; Rho Kinase;
Signaling mechanisms of inhibition of phospholipase D activation by CHS-111 in formyl peptide-stimulated neutrophils
Keywords: CHS-111; Phospholipase D; RhoA; Arf6; Protein kinase C; Vav; Neutrophils
Chemokine triggered integrin activation and actin remodeling events guiding lymphocyte migration across vascular barriers
Keywords: Cdc42; cell division cycle 42; GEF; Guanine nucleotide exchange factor; GPCR; G-protein coupled receptor; LFA-1; Leukocyte function-associated antigen-1; LTB4; leukotriene B4; PAF; platelet activating factor; PI3K; Phosphatidylinositol 3-kinase; PIP2; pho
Atorvastatin modulates anti-proliferative and pro-proliferative signals in Her2/neu-positive mammary cancer
Keywords: Atorvastatin; Ras; RhoA; NF-κB; Her2-positive mammary cancer;
RhoA–ROCK–Myosin pathway regulates morphological plasticity of cultured olfactory ensheathing cells
Keywords: OECs, Olfactory ensheathing cells; FBS, fetal bovine serum; PLL, poly-L-lysine; LPA, lysophosphatidic acid; FRET, fluorescence resonance energy transfer; ROCK, Rho associated kinase; MLC, myosin light chainOlfactory ensheathing cells; RhoA; Morphological
RhoA and NF-κB are involved in lipopolysaccharide-induced brain microvascular cell line hyperpermeability
Keywords: lipopolysaccharide; tight junction; RhoA; NF-κB; permeability; brain microvascular endothelial cellsBBB, blood brain barrier; LPS, lipopolysaccharide; MLC, myosin light chain; TEER, transendothelial electrical resistance; TJs, tight junctions; ZO-1, zonul
Gα12 binds to the N-terminal regulatory domain of p120ctn, and downregulates p120ctn tyrosine phosphorylation induced by Src family kinases via a RhoA independent mechanism
Keywords: Heterotrimeric G protein; Galpha12; p120 catenin; RhoA; Phosphorylation; Cadherin;
Interaction of angio-associated migratory cell protein with the TPα and TPβ isoforms of the human thromboxane A2 receptor
Keywords: AAMP; angio-associated migratory cell protein; AoSMC; aortic smooth muscle cell; CoASMC; coronary artery smooth muscle cell; C-tail; carboxyl-terminal tail; FBS; foetal bovine serum; GPCR; G protein-coupled receptor; GST; glutathione-S-transferase; HA; ha
PerspectiveRhoA/Rho kinase signaling in the spinal cord and diabetic painful neuropathy
Keywords: RhoA; Spinal cord; Diabetes mellitus; Neuropathic pain; Neuron;
Biochemical and cellular effects of inhibiting Nedd8 conjugation
Keywords: Nedd8; Ubc12; Cullin RING E3 ligases; Ubiquitin; RhoA; Neddylation; Actin cytoskeleton; Protein degradation