A comprehensive review of chalcone derivatives as antileishmanial agents
Keywords: Leishmania; SAR; ADMET; Drug design;
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Branched pentapeptides as potent inhibitors of the vascular endothelial growth factor 165 binding to Neuropilin-1: Design, synthesis and biological activity
Keywords: Neuropilin-1; VEGF165; Neuropilin/VEGF165 binding inhibition; Structure-activity relationship; Peptide biostability; ABTS; 2,2â²-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt; Ahp; 7-aminoheptanoic acid; Aun; 11-aminoundecanoic acid;
Expression and functional evaluation of CaZNF830 during pepper response to Ralstonia solanacearum or high temperature and humidity
Keywords: Bacterial wilt; C2H2 domain; Capsicum annuum; SAR; Thermo-tolerance;
Ultra-high resolution blood volume fMRI and BOLD fMRI in humans at 9.4â¯T: Capabilities and challenges
Keywords: Vascular space occupancy; SS-SI VASO; Cerebral blood volume; 3D-EPI; 9.4â¯Tâ¯tesla MRI; Layer-dependent fMRI; STARC; pTx; BOLD; blood oxygenation level dependent; CBV; cerebral blood volume; CNR; contrast-to-noise ratio; CSF; cerebrospinal fluid; ÎCBV;
Redox and the circadian clock in plant immunity: A balancing act
Keywords: ROS; reactive oxygen species; H2O2; hydrogen peroxide; RNS; reactive nitrogen species; NO; nitric oxide; GSH1; γ-glutamylcysteine synthetase; SA; salicylic acid; JA; jasmonic acid; PAMP; pathogen-associated molecular pattern; PTI; pattern-triggered immun
Development of potent and proteolytically stable human neuromedin U receptor agonists
Keywords: Neuromedin U (NMU); NMU-8; Neuromedin U receptor agonists; Plasma stability; 1â²Nal; 1â²-naphtylalanine; 2â²Nal; 2â²-naphtylalanine; 7-OH-Tic; 7-hydroxy-L-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; ACN; acetonitrile; AUC; area under the curve;
Discovery and optimization of phthalazinone derivatives as a new class of potent dengue virus inhibitors
Keywords: Phthalazinone; Dengue virus; Inhibitor; Optimization; SAR;
K-space trajectories in 3D-GRASE sequence for high resolution structural imaging
Keywords: Gradient and spin echo (GRASE); Fast spin echo (FSE); Echo planar imaging (EPI); Parallel imaging; SAR; Trajectory;
Pyrazolo[1,5-a]pyrimidine TRPC6 antagonists for the treatment of gastric cancer
Keywords: Nonselective cation channels; TRPC channels; Ca2+ signaling; Anticancer; Drug discovery; [Ca2+]i; Intracellular Ca2+ concentration; CCh; Carbachol; EC50; Half maximal stimulation; FMP; FLIPR membrane potential; PLC; phospholipase C; SAR; Structure-activit
Identification of an oxime-containing C-glucosylarene as a potential inhibitor of sodium-dependent glucose co-transporter 2
Keywords: Oxime; Sodium-dependent glucose co-transporter; Aryl C-glycosides; Diabetes management; Ac2O; acetic anhydride; AMG; α-methyl-d-glucopyranoside; BF3·OEt2; boron trifluoride etherate; CHO; Chinese hamster ovary; DMAP; 4-N,N-dimethylaminopyridine; hERG; h
Identification of 5-benzylidene-2-phenylthiazolones as potent PRMT5 inhibitors by virtual screening, structural optimization and biological evaluations
Keywords: PRMT; protein arginine methyltransferase; SAM; sadenosylmethionine; MEP50; methylosome protein 50; MD; molecular dynamics; MM/PBSA; Molecular mechanics/Poisson-Boltzmann surface area; SAR; structure-activity relationship; PRMT5 inhibitor; Arginine methyla
Structure-based design of novel quinoxaline-2-carboxylic acids and analogues as Pim-1 inhibitors
Keywords: Quinoxaline; Pim-1; Kinase inhibitor; Anticancer targeted therapy; IC50; 50% inhibitory concentration; SAR; structure-activity relationships; Pim; proviral integration site of Moloney murine leukemia virus; CML; chronic myeloid leukemia; DYRK1A; dual spec
New insights in the structure-activity relationships of 2-phenylamino-substituted benzothiopyrano[4,3-d]pyrimidines as kinase inhibitors
Keywords: Benzothiopyranopyrimidines; KDR kinase; Antiproliferative activity; Kinase inhibitors; A-431; epidermoid carcinoma cell line; DMEDA; N,Nâ²-dimethylethylendiamine; HeLa; cervix adenocarcinoma cell line; h; human; HUVEC; human umbilical vein endothelial ce
Fragment-growing guided design of Keap1-Nrf2 protein-protein interaction inhibitors for targeting myocarditis
Keywords: ROS; reactive oxygen species; NQO-1; NADPH:quinone oxidoreductase 1; HO-1; heme oxygenase-1; ARE; antioxidant response element; Nrf2; nuclear factor erythroid 2-related factor 2; Keap1; Kelch-like ECH-associated protein 1; DMF; dimethyl fumarate; CDDO-Me;
Synthesis and biological evaluation of indole-based UC-112 analogs as potent and selective survivin inhibitors
Keywords: Selective survivin inhibitors; Structure-activity relationships; Antiproliferative activities; P-glycoprotein overexpression; ABC; ATP-binding cassette; IAP; inhibitor of apoptosis proteins; P-gp; P-glycoprotein; RI; resistance index; SAR; structure-activ
Synthesis and biological evaluation of a library of hybrid derivatives as inhibitors of influenza virus PA-PB1 interaction
Keywords: Anti-Influenza; PA-PB1; RdRp; Amino acid coupling; SPPS; Diphenyl-pyridine; AcOEt; Ethyl acetate; CC50; Half maximal cytotoxic concentration; cRNA; complementar RNA; DCM; dichloromethane; DDQ; 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone; DIPEA; N,N-Diisopro
Crystal structure of the Eg5 - K858 complex and implications for structure-based design of thiadiazole-containing inhibitors
Keywords: 1,3,4-thiadiazole; K858 enantiomers; Eg5; Antimitotic drugs; Eg5-K858 complex; Rational drug design; KSP; Kinesin spindle protein; MT; Microtubule; PDB; Protein Data Bank; PK; Pyruvate kinase; LDH; Lactate dehydrogenase; ITC; Isothermal titration calorime
Discovery and characterization of a potent Wnt and hedgehog signaling pathways dual inhibitor
Keywords: Wnt signaling pathway; Hedgehog signaling pathway; Porcupine; Smoothened; Antagonist; Stem cell; Cancer therapy; AUC; area under the plasma time-concentration curve; BCC; basal cell carcinoma; BPO; benzoyl peroxide; CL; clearance; CSC; cancer stem cells;
A Single Exposure to GSM-1800â¯MHz Signals in the Course of an Acute Neuroinflammatory Reaction can Alter Neuronal Responses and Microglial Morphology in the Rat Primary Auditory Cortex
Keywords: ACx; auditory cortex; BF; best frequency; EEG; electroencephalogram; EMF; electromagnetic fields; FRA; frequency response area; GSM; global system for communication; LPS; lipopolysaccharide; MUA; multi-unit activity; PBS; phosphate-buffered saline; SAR; s
Techniques for blood volume fMRI with VASO: From low-resolution mapping towards sub-millimeter layer-dependent applications
Keywords: BOLD; blood oxygenation level dependent; CAIPIRINHA (CAIPI); Controlled Aliasing in Parallel Imaging Results in Higher Acceleration; CBV; cerebral blood volume; CNR; contrast-to-noise ratio; CSF; cerebrospinal fluid; ÎCBV; change in CBV; EPI; echo planar
Comparative thermoregulation between different species of dung beetles (Coleoptera: Geotrupinae)
Keywords: CTmax; Critical thermal maximum; HCR; Heat coma range; HRT; Heat regulation temperature; HSR; Heat stress range; rHCR; Rate of increase in the body temperature per unit of time during the heat coma range (HCR); rHSR; Rate of increase in the body temperatu
Discovery of potent calpain inhibitors based on the azolo-imidazolidenone scaffold
Keywords: Calpain inhibitors; Azolo-imidazolidenone; SAR; Uncompetitive inhibition; Blockade of apoptosis;
The hypotensive effect of activated apelin receptor is correlated with β-arrestin recruitment
Keywords: 7TMR; seven transmembrane receptor; Akt; protein kinase B; APJ; apelin receptor; βarr; β-arrestin; BRET; bioluminescence resonance energy transfer; cAMP; cyclic adenosine monophosphate; ERK1/2; extra-cellular regulated kinase 1/2; GPCR; G protein-couple
1H-Benzo[d]imidazoles and 3,4-dihydroquinazolin-4-ones: Design, synthesis and antitubercular activity
Keywords: Mycobacterium tuberculosis; Tuberculosis; Molecular hybridization; Drug-resistant strains; SAR; Cardiotoxicity;
Structural basis for potent inhibition of d-amino acid oxidase by thiophene carboxylic acids
Keywords: Flavoenzyme; Schizophrenia; Drug discovery; X-ray crystallography; Molecular dynamics; DAO/DAAO; d-amino acid oxidase; D-Ser; d-serine; SAR; Structure-activity relationship; MD; molecular dynamics; H-bond; hydrogen bond; DOPA; dihydroxyphenylalanine; CPC;
Optimal-permittivity Dielectric Liners for a 4.7Â T Transceiver Array
Keywords: MRI; magnetic resonance imaging; BNC; Bayonet Neill-Concelman; HDC; high dielectric constant; ROI; region of interest; SAR; specific absorption rate; SNR; signal-to-noise ratio; Dielectric pads; Matching layer; Array coils; Optimal permittivity; Dielect
Ultra-high resolution brain metabolite mapping at 7 T by short-TR Hadamard-encoded FID-MRSI
Keywords: Ac; acetate; AD; acquisition delay; CAIPIRINHA; controlled aliasing in parallel imaging results in higher acceleration; Cho; choline; CRLB; Cramér-Rao lower bound; Cr; creatine; CSF; cerebrospinal fluid; DIR; double inversion recovery; EPSI; echo-planar
Groundwater analysis of Dholera geothermal field, Gujarat, India for suitable applications
Keywords: DMIC; Delhi-Mumbai Industrial Corridor; WHO; World Health Organization; TDS; Total Dissolved Solids; ORC; Organic Rankine cycle; EC; Electrical Conductivity; HVAC; Heating, ventilation, and air conditioning; SAR; Sodium Adsorption Ratio; Geothermal energy
Development of novel oxazolo[5,4-d]pyrimidines as competitive CB2 neutral antagonists based on scaffold hopping
Keywords: Cannabinoid; CB2 receptor; Neutral antagonist; oxazolo[5,4-d]pyrimidine; Boc; tert-butyloxycarbonyl; cAMP; cyclic adenosine monophosphate; CHO; Chinese hamster ovary cells; CHO-CB2; Chinese hamster ovary cells expressing CB2 receptors; CHO-WT; Chinese ham
Design, synthesis and biological activities of 2,3-dihydroquinazolin-4(1H)-one derivatives as TRPM2 inhibitors
Keywords: TRPM2; 2,3-Dihydroquinazolin-4(1H)-ones; Inhibitors; SAR; Virtual screening;
Dry mycelium of Penicillium chrysogenum activates defense via gene regulation of salicylic acid and jasmonic acid signaling in Arabidopsis
Keywords: Penicillium chrysogenum; Transcriptome; Signaling pathway; Arabidopsis thaliana; BY2; Nicotiana tabacum L. Bright Yellow-2; COG; Cluster of Orthologous Groups of proteins; DEGs; differentially expressed genes; DMP; aqueous extract of the Dry mycelium of P
Terminalia laxiflora and Terminalia brownii contain a broad spectrum of antimycobacterial compounds including ellagitannins, ellagic acid derivatives, triterpenes, fatty acids and fatty alcohols
Keywords: HPLC-DAD; High performance liquid chromatography with diode-array detection; UHPLC/QTOF-MS; Ultra-high performance liquid chromatography coupled to quadrupole time of flight mass spectrometry; [M-H]-; deprotonated molecular ion; Rt; retention time; Rf; re
N-Thiazolylamide-based free fatty-acid 2 receptor agonists: Discovery, lead optimization and demonstration of off-target effect in a diabetes model
Keywords: AUCu; unbound area-under-the-curve; (S)-BINAP; (S)-(-)-(1,1â²-binaphthalene-2,2â²-diyl)bis(diphenylphosphine); CLu; unbound systemic clearance rate; Compd; compound; DIEA; N,N-diisopropyl ethylamine, EtOAc, ethyl acetate; FFA2 receptor; free fatty acid-
d-Amino acids in molecular evolution in space - Absolute asymmetric photolysis and synthesis of amino acids by circularly polarized light
Keywords: Ala; alanine; Glu; glutamic acid; Met; methionine; Leu; leucine; Tyr; tyrosine; Phe; phenylalanine; Asp; aspartic acid; Ser; serine; Arg; arginine; His; histidine; Pro; proline; Asn; asparagine; NVal; norvaline; NLeu; norleucine; Ile; isoleucine; ABA; ami
HDAC3 is a potential validated target for cancer: An overview on the benzamide-based selective HDAC3 inhibitors through comparative SAR/QSAR/QAAR approaches
Keywords: Cancer; Benzamide; Selective HDAC3 inhibitors; SAR; QSAR; QAAR;
SAR-revealed slip partitioning on a bending fault plane for the 2014 Northern Nagano earthquake at the northern Itoigawa-Shizuoka tectonic line
Keywords: Itoigawa-Shizuoka tectonic line; Kamishiro Fault; 2014 Northern Nagano earthquake; SAR; Crustal deformation; Slip partitioning;
Functional properties and mechanism of action of PPTQ, an allosteric agonist and low nanomolar positive allosteric modulator at GABAA receptors
Keywords: Ago-PAM; allosteric agonist and positive allosteric modulator; C/R; concentration-response; ECD; extracellular domain; FMP; FLIPR Membrane Potential Blue; GABA; γ-Aminobutyric acid; GABAAR; GABAA receptor; methaqualone; 2-methyl-3-(o-tolyl)-quinazolin-4(
Quantitative sodium MR imaging: A review of its evolving role in medicine
Keywords: AD; Alzheimer's disease; ATP; adenosine triphosphate; Clâ; chloride ion; CSC; cartilage sodium concentration; CSF; cerebrospinal fluid; CVF; cell volume fraction; DCE; dynamic contrast enhancement; DSC; dynamic susceptibility contrast; ECM; extracellula
Recent advances of RAF (rapidly accelerated fibrosarcoma) inhibitors as anti-cancer agents
Keywords: MAPK; RAF inhibitors; Anti-cancer agents; Abl; Abelson murine leukemia viral oncogene; ATP; Adenine triphosphate; Bcl-2; B-cell lymphoma; CNS; Central nervous system; COX-2; Cyclo-oxygenase enzyme-2; CR; Conserved region; CRD; Cysteine-rich domain; DFG; A
Design, synthesis, and biological evaluation of new 1,2,3-triazolo-2â²-deoxy-2â²-fluoro- 4â²-azido nucleoside derivatives as potent anti-HBV agents
Keywords: 2â²-deoxy-2â²-β-fluoro-4â²-azido-β-d-arabinofuranosyl 1,2,3-triazole nucleoside; Anti-HBV activity; Nucleoside reverse transcriptase inhibitor (NRTI); Lamivudine-resistant HBV mutants; Viral DNA replication; HBV; hepatitis B virus; HCV; hepatitis C v
ERK1/2 inhibitors: New weapons to inhibit the RAS-regulated RAF-MEK1/2-ERK1/2 pathway
Keywords: Akt; oncogene in the transforming retrovirus, AKT8; AP-1; activator protein 1; ARAF; v-raf murine sarcoma 3611 viral oncogene homologue; ASK1; apoptosis signal-regulating kinase 1; BCL2; B-cell lymphoma 2; BCL-XL; B-cell lymphoma extra large; BRAF; v-raf
Potential therapeutic applications of the genus Annona: Local and traditional uses and pharmacology
Keywords: ABTS; 2,2-Azinobis-3-Ethylbenzothizoline-6-Sulphonate; ACGs; Acetogenins; AEF; Acetogenin-Enriched Fraction; ATP; Adenosine Triphosphate; COX; Cyclooxygenase; CYP; Cytochrome P450; DNA; Deoxyribonucleic Acid; DPPH; 1,1-Diphenyl-2-Picrylhydrazyl; EC50; Eff
β-Carboline alkaloid monomers and dimers: Occurrence, structural diversity, and biological activities
Keywords: β-Carboline; Monomer; Dimer; Occurrence; Structural diversity; Biological activity; SAR; Mechanism;
Autophagy as a pharmacological target in hematopoiesis and hematological disorders
Keywords: 3-MA; 3-methyladenine; ALL; acute lymphoblastic leukemia; AMKL; acute megakaryoblastic leukemia; AML; acute myeloid leukemia; AMPK; 5â²-adenosine monophosphate-activated protein kinase; APL; acute promyelocytic leukemia; Atg; autophagy-related proteins;
Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral β-lactam bridged combretastatin A-4 analogues as potent antitumor agents
Keywords: 1,4-Diaryl-2-azetidinone; Combretastatin A-4; Tubulin polymerization; Antitumor; SAR; structure-activity relationship; DABCO; 1,4-diazabicyclo[2.2.2]octane; TBAF; tetrabutylammonium fluoride; NMO; 4-methylmorpholine N-oxide; TBAB; tetrabutylammonium bromi
Tools and drugs for uracil nucleotide-activated P2Y receptors
Keywords: ADP; Adenosine 5â²-diphosphate; AP4A; P1,P4-Di(adenosine-5â²)-tetraphosphate; AR; Adenosine receptor; AR-C118925; 5-{[5-(2,8-Dimethyl-5H-dibenzo[a,d]cyclohepten-5-yl)-3,4-dihydro-2-oxo-4-thioxo-1(2H)-pyrimidinyl]methyl}-N-(1H-tetrazol-5-yl)-2-furancarbo
Synthesis and in vitro biological evaluation of novel coumarin derivatives containing isoxazole moieties on melanin synthesis in B16 cells and inhibition on bacteria
Keywords: Vitiligo; Melanin synthesis; Antimicrobial activity; Coumarin derivatives; SAR;
Discovery of the selective sphingomyelin synthase 2 inhibitors with the novel structure of oxazolopyridine
Keywords: SMS; sphingomyelin synthase; SM; sphingomyelin; PC; phosphatidylcholine; CHD; coronary heart disease; SMase; sphingomyelinase; SPT; serine palmitoyl transferase; AS; atherosclerosis; SMSr; SMS related protein; SAR; structure-activity relationships; IC50;
Preliminary SAR on indole-3-carbinol and related fragments reveals a novel anticancer lead compound against resistant glioblastoma cells
Keywords: Indole-3-carbinol; 3,3â²-Diindoloylmethane; Glioblastoma; Cancer; SAR;
ReviewAre Thraustochytrids algae?
Keywords: Biotechnology; Chromalveolate; Endosymbiosis; Labyrinthulomycota; PUFA; Stramenopile; CASH; a hypothetical clade consisting of Cryptophytes, Alveolates, Stramenopiles, and Haptophytes; SAR; a clade consisting of Stramenopiles, Alveolates, and Rhizaria;