دانلود مقالات ISI درباره Sirtuins + ترجمه فارسی

Pro-Proliferative Function of Mitochondrial Sirtuin Deacetylase SIRT3 in Human Melanoma

Keywords: cdk; cyclin-dependent kinase; SA-β-Gal; senescence-associated beta-galactosidase; SAHF; senescence-associated heterochromatin foci; shNS; nonspecific shRNA; shRNA; short hairpin RNA; SIRTs; sirtuins; TMAs; tissue microarrays;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Garlic activates SIRT-3 to prevent cardiac oxidative stress and mitochondrial dysfunction in diabetes

Keywords: SIRT3; MnSOD; Garlic; Acetylation; Mitochondria; Diabetic cardiomyopathy; Sirtuins;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Dysregulation of sirtuins and key metabolic genes in skeletal muscle of pigs with spontaneous intrauterine growth restriction is associated with alterations of circulating IGF-1

Keywords: IUGR; intra-uterine growth restriction; IGF; insulin-like growth factor; d.p.c.; days post conception; d.p.b.; days post birth; Intrauterine growth restriction (IUGR); Sirtuins; Insulin/IGF-1; Acetylation; Epigenetics; Pig;

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2016 سفارش ترجمه

Sirtuin function in aging heart and vessels

Keywords: Sirtuins; Aging; Endothelium; Myocardium; Metabolism; Acetylation;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

SIRT3 regulates progression and development of diseases of aging

Keywords: mitochondria; sirtuins; SIRT3; aging; disease

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

The role of visfatin (PBEF/Nampt) in pregnancy complications

Keywords: Preterm labor; Pre-eclampsia; Gestational diabetes mellitus; Maternal plasma; Sirtuins; Visfatin;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Cold acclimation increases levels of some heat shock protein and sirtuin isoforms in threespine stickleback

Keywords: Cold acclimation; Fish; Heat shock proteins; Oxidative stress; Sirtuins

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Characterization of the SIRT family of NAD+-dependent protein deacetylases in the context of a mammalian model of hibernation, the thirteen-lined ground squirrel

Keywords: Hibernation; Sirtuins; Acetylation; SOD2; Skeletal muscle; Liver; Brown adipose tissue; White adipose tissue;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics

Keywords: Sirtuins; Small molecule inhibitors; Anticancer drugs; Chemotherapy; Quinazolinedione; Molecular design; NAD+-dependent deacetylases

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Sirtuins in vascular diseases: Emerging roles and therapeutic potential

Keywords: ACE; angiotensin converting enzyme; AICAR; 5-amino-4-imidazolecarboxamide riboside; AMPK; AMP-activated protein kinase; Ang II; angiotensin II; ApoE; apolipoprotein E; AT1R; angiotensin II type 1 receptor; ATM; ataxia telangiectasia mutated; ATP; adenosin

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

The plasticizer BBP selectively inhibits epigenetic regulator sirtuins

Keywords: BBP; benzyl butyl phthalate; PGC-1α; peroxisome proliferator-activated receptor gamma coactivator 1-alpha; NRF-1; nuclear respiratory factor 1; NRF-2; nuclear respiratory factor 2; Sirtuins; Benzyl butyl phthalate (BBP); Metabolic syndrome; Mitochondria;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Caloric restriction, resveratrol and melatonin: Role of SIRT1 and implications for aging and related-diseases

Keywords: Aβ; amyloid β protein; AMPK; adenosine monophosphate activated protein kinase; CGNs; cerebellar granule neurons; ETC; electron transport chain; H2O2; hydrogen peroxide; HO-1; heme oxygenase-1; LXR; liver X receptor; MAPK; mitogen-activated protein kinas

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Pyrroloquinoline quinone increases the expression and activity of Sirt1 and -3 genes in HepG2 cells

Keywords: Sirtuins; Pyrroloquinoline quinone; Metabolic syndrome; Mitochondria; Aging; Mitochondrial biogenesis regulators; CR; caloric restriction; mRNA; messenger RNA; NAMPT; nicotinamide phosphoribosyltransferase; NRF-1; nuclear respiratory factor 1; NRF-2; nucl

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2015 سفارش ترجمه

High altitude exposure alters gene expression levels of DNA repair enzymes, and modulates fatty acid metabolism by SIRT4 induction in human skeletal muscle

Keywords: High altitude; Sirtuins; Oxidative stress; DNA damage

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Studying SIRT6 regulation using H3K56 based substrate and small molecules

Keywords: Fluorometric assay; Histone deacetylase; Nicotinamide; SIRT6; Sirtuins

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

SIRT2 negatively regulates insulin resistance in C2C12 skeletal muscle cells

Keywords: Sirtuins; SIRT2; Insulin signaling; Insulin resistance; Skeletal muscle;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Decreased mitochondrial SIRT3 expression is a potential molecular biomarker associated with poor outcome in breast cancer

Keywords: Sirt3; Breast cancer; Clinical outcomes; Sirtuins; Metabolism; Mitochondria;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Differential effects of binge methamphetamine injections on the mRNA expression of histone deacetylases (HDACs) in the rat striatum

Keywords: Epigenetics; Sirtuins; Neurotoxicity; Gene expression;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

SIRT1 and other sirtuins in metabolism

Keywords: sirtuins; SIRT1; calorie restriction; aging; metabolism; CR mimetics; NAD+

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Cinnamon polyphenols regulate S100β, sirtuins, and neuroactive proteins in rat C6 glioma cells

Keywords: Polyphenols; S100β; Sirtuins; Phospho-NF-κB and Bcl-xl; Spice

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

NAD+ and sirtuins in aging and disease

Keywords: NAD+; sirtuins; poly-ADP-ribose polymerases; nicotinamide phosphoribosyltransferase; nicotinamide mononucleotide; nicotinamide riboside

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Inhibitory effects of resveratrol on hypoxia-induced inflammation in 3T3-L1 adipocytes and macrophages

Keywords: C/EBP; CCAAT-enhancer-binding protein; FAS; fatty acid synthase; GLUT1; glucose transporter 1; HIF1; hypoxic inducible factor 1; HSD1; hydroxysteroid dehydrogenase 1; ICAM; intercellular cell adhesion molecule; IL6; interleukin 6; NFkB; nuclear factor kap

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Original Full Length ArticleLow sirtuin 1 levels in human osteoarthritis subchondral osteoblasts lead to abnormal sclerostin expression which decreases Wnt/β-catenin activity

Keywords: Subchondral bone; Wnt signaling; Sclerostin; Sirtuins; Osteoarthritis;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

SIRT2: Tumour suppressor or tumour promoter in operable breast cancer?

Keywords: Breast cancer; Biological ageing; Sirtuins; Tumour suppressor; Tumour promoter; Biomarker; Immunohistochemistry; Tumour grade;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Pharmacological activation of NQO1 increases NAD+ levels and attenuates cisplatin-mediated acute kidney injury in mice

Keywords: cisplatin; NAD+; nephrotoxicity; NQO1; sirtuins;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2014 سفارش ترجمه

HDL and cognition in neurodegenerative disorders

Keywords: ABC; ATP-binding cassette transporter; AD; Alzheimer's disease; Akt; protein kinase B; ALS; amyotrophic lateral sclerosis; apo; apolipoprotein; Aβ; amyloid-β protein; BBB; blood-brain barrier; CAA; cerebral amyloid angiopathy; CE; cholesterol ester; C

دانلود رایگان متن کامل مقاله ISI 47 صفحه سال انتشار : 2014 سفارش ترجمه

Light-dark condition regulates sirtuin mRNA levels in the retina

Keywords: NAD; nicotinamide adenine dinucleotide; Nampt; nicotinamide phosphoribosyltransferase; PGC1α; peroxisome proliferator-activated receptor gamma coactivator; Tfam; transcription factor A, mitochondrial; LD condition; light/dark condition; DD condition; con

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Rapamycin preserves the follicle pool reserve and prolongs the ovarian lifespan of female rats via modulating mTOR activation and sirtuin expression

Keywords: P70S6K; ribosomal protein S6 kinase; mTOR; the mammalian target of rapamycin; SIRT; silent information regulator; Tsc; tuberous sclerosis complex; mTORC1; the mammalian target of rapamycin complex 1; POF; premature ovarian failure; PTEN; phosphatase and t

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Quinazolinecarboline alkaloid evodiamine as scaffold for targeting topoisomerase I and sirtuins

Keywords: epi; epimer; ent; enantiomer; Quinazolinecarboline alkaloids; Evodiamine; Sirtuins; Topoisomerase I;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Construction and functionalization of pyranone ring fused with pyran moiety: Design and synthesis of novel pyrano[4,3-b]pyran-5(4H)-ones as potential inhibitors of sirtuins

Keywords: Pyranochromendione; Pyranopyranone; Iodocyclization; Sirtuins;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylases

Keywords: Sirtuins; SIRT4; C. elegans; Biotin-dependent carboxylase; Pyruvate carboxylase; Protein acetylation;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2013 سفارش ترجمه

Calorie-restriction and longevity. End of a dream, at least for primates?

Keywords: Longevity; Calorie restriction; Primates; Sirtuins; Age-related diseases

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2013 سفارش ترجمه

Crystal structure analysis of human Sirt2 and its ADP-ribose complex

Keywords: Sirtuins; Crystal structure; Deacetylase; Co-substrate-induced conformational change; Aging

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Epigenetics, sirtuins and osteoarthritis

Keywords: Chromatin-modifying enzymes; Sirt1; OA; Cartilage; Sirtuins

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2012 سفارش ترجمه

Sirtuin inhibition attenuates the production of inflammatory cytokines in lipopolysaccharide-stimulated macrophages

Keywords: Inflammation; NAD-dependent enzymes; Cambinol; Sirtinol; Lipopolysaccharide; Macrophages; Sirtuins; Nuclear factor kappa B

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Association Study of Sirtuin 1 Polymorphisms with Bone Mineral Density and Body Mass Index

Keywords: Sirtuins; Osteoporosis; Obesity; Bone mineral density; Body mass index

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Longevity and aging, genetic and post-genetic mechanisms. Which target to choose for postponing and treating age-related diseases

Keywords: Longevity; Aging; Loss of function; Age-diseases; Sirtuins; Atherosclerosis; Aging of elastin

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Exploring the electrostatic repulsion model in the role of Sirt3 in directing MnSOD acetylation status and enzymatic activity

Keywords: s: ROS; reactive oxygen species; CR; caloric restriction; MnSOD; manganese superoxide dismutase; CuZnSOD; copper zinc superoxide dismutase; EcSOD; extracellular superoxide dismutase; O2−; superoxide; H2O2; hydrogen peroxide; HO; hydroxyl radical; Sirt1â

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Ischemic preconditioning: The role of mitochondria and aging

Keywords: Myocardial infarction; Mitochondria; Ischemic preconditioning; Sirtuins; Reactive oxygen species

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

SIRT3 gene expression: A link between inherited mitochondrial DNA variants and oxidative stress

Keywords: ATP; Adenosine triphosphate; FOXO; Forkhead box O; GAPDH; Glyceraldehyde-3-phosphate dehydrogenase; GPX1; Glutathione peroxidase 1; GSR; Glutathione reductase; NAD+/NADH; Nicotinamide adenine dinucleotide; ND5; NADH dehydrogenase 5; OXPHOS; Oxidative phos

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Multiple factors and pathways involved in hepatic very low density lipoprotein-apoB100 overproduction in Otsuka Long-Evans Tokushima fatty rats

Keywords: Type 2 diabetes; Inflammation; Lipogenesis; Sirtuins; VLDL-apoB100;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Oxidative stress, glutathione status, sirtuin and cellular stress response in type 2 diabetes

Keywords: Type 2 diabetes; Redox signaling; Cellular stress response; Glutathione status; Sirtuins; Vitagenes

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2

Keywords: Sirtuins; Histone deacetylase; Isostere; Rigid analogues; N-Unsubstituted-1,2,3-triazolyl pyridine

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

The role of sirtuins in modulating redox stressors

Keywords: SIRT1; SIRT3; Sirtuins; Mitochondria; Redox stress; Resveratrol; Metabolism; Free radicals

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Mitochondrial sirtuins: regulators of protein acylation and metabolism

Keywords: mitochondria; sirtuins; lysine acylation; metabolism

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Characterization and differential expression analysis of complete coding sequences of Vitis vinifera L. sirtuin genes

Keywords: Sir2; Sirtuins; Hystone deacetylase; Vitis vinifera;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Wine yeast sirtuins and Gcn5p control aging and metabolism in a natural growth medium

Keywords: Wine yeast; Sirtuins; Gcn5p; Chronological lifespan; Ald6p; Autophagy;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Regulation and protection of mitochondrial physiology by sirtuins

Keywords: Acetyl-CoA; acetyl-coenzyme A; AceCS2; acetyl-coenzyme A synthethase 2; ACC; Acetyl-CoA carboxylase; ADP; adenosine diphosphate; AIF; apoptosis-inducing factor; AMPK; 5′ adenosine monophosphate-activated protein kinase; ANT; adenine nucleotide transloca

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Mitochondrial sirtuins and metabolic homeostasis

Keywords: deacetylase; energy homeostasis; metabolism; mitochondria; sirtuins;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Expression patterns of sirtuin genes in porcine preimplantation embryos and effects of sirtuin inhibitors on in vitro embryonic development after parthenogenetic activation and in vitro fertilization

Keywords: Sirtuins; Porcine embryo; Nicotinamide; Sirtinol; In vitro culture;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه