Homozygous nonsense mutation in SYNJ1 associated with intractable epilepsy and tau pathology
Keywords: Tauopathy; Seizures; Whole-exome sequencing; Synaptojanin;
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Studying tauopathies in Drosophila: A fruitful model
Keywords: Frontotemporal dementia; Tau; Tauopathy; Drosophila
Connecting the dots between tau dysfunction and neurodegeneration
Keywords: tauopathy; Alzheimer; actin; chromatin; cell cycle; therapeutics
Thr175-phosphorylated tau induces pathologic fibril formation via GSK3β-mediated phosphorylation of Thr231 in vitro
Keywords: Amyotrophic lateral sclerosis; Microtubule-associated protein tau; Glycogen synthase kinase 3 β; Tauopathy;
Perineuronal net digestion with chondroitinase restores memory in mice with tau pathology
Keywords: Chondroitinase ABC; Microtubule-associated protein; Tauopathy; Memory dementia perineuronal net; Object recognition TEST;
Glycogen synthase kinase-3 beta (GSK-3β) signaling: Implications for Parkinson's disease
Keywords: Parkinson's disease; Glycogen synthase kinase 3; Neuroinflammation; Alpha-Synuclein; Tauopathy; ER stress; Mitochondrial dysfunction;
Intraneuronal accumulation of misfolded tau protein induces overexpression of Hsp27 in activated astrocytes
Keywords: Truncated tau protein; Tauopathy; Alzheimer's disease; Hsp27; Transgenic rat; Astrocyte;
Activated human microglia stimulate neuroblastoma cells to upregulate production of beta amyloid protein and tau: implications for Alzheimer's disease pathogenesis
Keywords: Amyloid precursor protein; Tauopathy; Ibuprofen; Aspirin; Glutathione; Neurofibrillary tangles; IL-10;
Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer's disease mouse and reduces human P301L-tau content at the presymptomatic stage
Keywords: ACAT (SOAT); Alzheimer's disease; Autophagy; Neuron; Tauopathy;
Increased pro-nerve growth factor and decreased brain-derived neurotrophic factor in non-Alzheimer's disease tauopathies
Keywords: Alzheimer's disease; Tauopathy; Tau; Neurotrophin; Nerve growth factor; Brain-derived neurotrophic factor; Pick's disease; Corticobasal degeneration; Progressive supranuclear palsy; Post mortem brain;
March separate, strike together — Role of phosphorylated TAU in mitochondrial dysfunction in Alzheimer's disease
Keywords: Alzheimer's disease; Axonal transport; DRP1; Mitochondrion; Tauopathy
Severe amygdala dysfunction in a MAPT transgenic mouse model of frontotemporal dementia
Keywords: Frontotemporal dementia; Tau; Tauopathy; Amygdala; Neurodegeneration;
Temsirolimus attenuates tauopathy in vitro and in vivo by targeting tau hyperphosphorylation and autophagic clearance
Keywords: Temsirolimus; Tauopathy; Autophagy; GSK-3β; Spatial cognitive deficits;
Age-related decline in white matter integrity in a mouse model of tauopathy: an in vivo diffusion tensor magnetic resonance imaging study
Keywords: Tauopathy; Neurodegenerative disease; Alzheimer's disease; FTDP-17; rTg4510; Diffusion tensor MRI; White matter integrity; Electron microscopy; Ultrastructure;
Military-related traumatic brain injury and neurodegeneration
Keywords: Chronic traumatic encephalopathy; Veterans; Neurodegeneration; Traumatic brain injury; Tauopathy; TDP-43; Alzheimer's disease;
Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice
Keywords: Cdk5; cyclin-dependent kinase 5; FTDP-17; frontal temporal dementias with Parkinsonism linked to chromosome 17; GSK-3β; glycogen synthase kinase 3β; MAPK (Erk1/2); mitogen-activated protein kinase; SAPK; stress-activated protein kinase; Environmental ne
Neurofibrillary tangle-like tau pathology induced by synthetic tau fibrils in primary neurons over-expressing mutant tau
Keywords: α-syn:; α-synuclein; ICC:; immunocytochemistry; mAb:; monoclonal antibody; NFT:; neurofibrillary tangle; Tg:; transgenic; Pff:; preformed fibril; ThT:; thioflavin T; Tau; Protein aggregation; Tauopathy; Transmission;
Non-invasive, in vivo monitoring of neuronal transport impairment in a mouse model of tauopathy using MEMRI
Keywords: Alzheimer's disease; MEMRI; Axonal transport; Neuronal transport; Tauopathy;
Active glycogen synthase kinase-3 and tau pathology-related tyrosine phosphorylation in pR5 human tau transgenic mice
Keywords: Alzheimer's disease; AT100; Fyn; Phosphotyrosine; Pyk2; Tauopathy;
Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine 307) phosphorylation
Keywords: Zinc; Protein phosphatase 2A; Tauopathy; Src; Tyrosine phosphorylation;
Tau pathology modulates Pin1 post-translational modifications and may be relevant as biomarker
Keywords: Alzheimer's disease; Tauopathy; Pin1; Microtubule-associated protein tau; Proteomics; Phosphorylation; Acetylation; Posttranslational modification; Biomarker;
Focal expression of adeno-associated viral-mutant tau induces widespread impairment in an APP mouse model
Keywords: Alzheimer's disease; Tau; Tauopathy; Viral vectors; Adeno-associated virus; Neurodegeneration; Memory; Alzheimer's precursor protein;
p73 haploinsufficiency causes tau hyperphosphorylation and tau kinase dysregulation in mouse models of aging and Alzheimer's disease
Keywords: p73; p53 family; Tau phosphorylation; Pin1; Alzheimer's disease; Aging; Neurodegeneration; GSK-3β; c-Abl; Cdk5; Tauopathy; Paired helical filaments; TgCRND8
Endoplasmic reticulum: The unfolded protein response is tangled in neurodegeneration
Keywords: Endoplasmic reticulum; Neurodegeneration; Tauopathy; Unfolded protein response;
Limited cleavage of tau with matrix-metalloproteinase MMP-9, but not MMP-3, enhances tau oligomer formation
Keywords: FCS; fluorescence correlation spectroscopy; Itotal; total fluorescence intensity; MMP; matrix-metalloproteinase; SIFT; scanning for intensely fluorescent targets; Tau; Matrix-metalloproteinase; Tauopathy; Alzheimer's disease; Aggregation; Oligomer; Neurod
Adult-onset focal expression of mutated human tau in the hippocampus impairs spatial working memory of rats
Keywords: AAV; Hippocampus; Learning; Memory; P301L; Tauopathy;
A mouse model of human repetitive mild traumatic brain injury
Keywords: Traumatic brain injury; Mild; Repetitive; Concussive; Head acceleration; Tauopathy;
GSPE interferes with tau aggregation in vivo: implication for treating tauopathy
Keywords: GSPE; JNPL3 mouse model; tauopathy; hyperphosphorylation;
Aminothienopyridazine inhibitors of tau aggregation: Evaluation of structure–activity relationship leads to selection of candidates with desirable in vivo properties
Keywords: Alzheimer’s disease; Tauopathy; Aminothienopyridazine; Tau aggregation inhibitor; K18PL
Altered expression of brain acetylcholinesterase in FTDP-17 human tau transgenic mice
Keywords: Acetylcholinesterase; Cholinergic; Tau; Alzheimer's disease; Tauopathy; Transgenic;
Loss of dopaminoreceptive neuron causes L-dopa resistant parkinsonism in tauopathy
Keywords: Tauopathy; Parkinsonism; Dopaminoreceptive cell; Degeneration;
Phosphorylation in the amino terminus of tau prevents inhibition of anterograde axonal transport
Keywords: Alzheimer's disease; Fyn kinase; Axonal transport; Tau filaments; Tauopathy; Protein phosphatase; Glycogen synthase kinase; Kinesin; Tyrosine phosphorylation;
T-817MA, a neuroprotective agent, attenuates the motor and cognitive impairments associated with neuronal degeneration in P301L tau transgenic mice
Keywords: AD; Alzheimer's disease; FTDP-17; frontotemporal dementia and parkinsonism linked to chromosome 17; P301L mice; transgenic mice expressing FTDP-17 mutation P301L of human tau; T-817MA; 1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl} azetidin-3-ol maleate;
Tau-positive grains are constant in centenarians’ hippocampus
Keywords: Dementia; Argyrophilic grain disease; Coiled bodies; Tau; Tauopathy; Aging; Centenarians; RD4; Gallyas
Focal expression of mutated tau in entorhinal cortex neurons of rats impairs spatial working memory
Keywords: Alzheimer's disease; Hippocampal formation; Learned alternation; P301L; Retrohippocampal area; Tauopathy; Y-maze
Differential regional distribution of phosphorylated tau and synapse loss in the nucleus accumbens in tauopathy model mice
Keywords: Tauopathy; Synapse; Nucleus accumbens; Phosphorylated tau; Anxiety; Wild-type tau;
Zebrafish models of Tauopathy
Keywords: Tau; Tauopathy; Progressive supranuclear palsy; Zebrafish; Alzheimer's disease; Transgenic; Neurodegeneration
Rescue of neurons from undergoing hallmark tau-induced Alzheimer's disease cell pathologies by the antimitotic drug paclitaxel
Keywords: Tau; Microtubules; Taxol; Paclitaxel; Alzheimer's disease; Tauopathy;
Tau inclusions in retinal ganglion cells of human P301S tau transgenic mice: Effects on axonal viability
Keywords: Tau; Retinal ganglion cells; Axonopathy; Tauopathy; Alzheimer disease; Frontotemporal dementia
SJLB mice develop tauopathy-induced parkinsonism
Keywords: Tauopathy; Parkinsonism; Transgenic mouse; FTDP-17; Behavioral analysis
Drosophila notal bristle as a novel assessment tool for pathogenic study of Tau toxicity and screening of therapeutic compounds
Keywords: Notum; PP2A; Alsterpaullone; Tauopathy;
Amyloid-β peptide alteration of tau exon-10 splicing via the GSK3β-SC35 pathway
Keywords: Aβ; Alzheimer's disease; GSK3β; Tau exon 10 splicing; SC35; Tauopathy; SH-SY5Y; Fronto-temporal dementia; Progressive supranuclear palsy; Corticobasal degeneration
Structural and functional changes in tau mutant mice neurons are not linked to the presence of NFTs
Keywords: Patch clamp; In vitro slice; Dendrite; Dendritic spine; Tauopathy; FTDP-17; Alzheimer's disease; Transgenic model; Frontal; Pyramidal cell
Alzheimer's disease: Old problem, new views from transgenic and viral models
Keywords: Alzheimer; Transgenic; Adeno-associated virus; Neurodegeneration; Tauopathy; Neurofibrillary tangles
An okadaic acid-induced model of tauopathy and cognitive deficiency
Keywords: OA, okadaic acid; cdk5, cyclin-dependent kinase 5; GSK-3, glycogen synthase kinase-3; NFTs, neurofibrillary tangleAlzheimer's disease; Tauopathy; Cognitive deficiency; Tau phosphorylation; Neurofibrillary tangles; Oxidative stress
Intrafamilial clinical phenotypic heterogeneity with MAPT gene splice site IVS10+16C>T mutation
Keywords: Diagnosis; FTDP-17; Heterogeneity; IVS10+16C>T mutation; MAPT gene; Tauopathy
Clinical and pathological features of an Alzheimer's disease patient with the MAPT ΔK280 mutation
Keywords: Tau; Alzheimer; Tauopathy; Exon 10
NAP protects memory, increases soluble tau and reduces tau hyperphosphorylation in a tauopathy model
Keywords: NAP, NAPVSIPQ; AD, Alzheimer's disease; ADNP, activity-dependent neuroprotective protein; MWM, Morris water maze; htau, human tau; DM-Tau-tg, double mutant tau transgenic mice; NFTs, neurofibrillary tangles; w.t., wild-typeTau; Tauopathy; NAP; Neurodegene
La schizophrénie tardive est-elle secondaire à des processus neurodégénératifs? Une revue de la littérature
Keywords: Schizophrénie; Schizophrénie à début tardif; Maladie d'Alzheimer; Pathologie cérébrovasculaire; Tauopathie; Schizophrenia; Late-onset schizophrenia; VLOSP; Alzheimer's disease; Cerebrovascular disease; Tauopathy;
A Caenorhabditis elegans model of tau hyperphosphorylation: Induction of developmental defects by transgenic overexpression of Alzheimer's disease-like modified tau
Keywords: Tauopathy; Neurodegenerative disease; Animal model; Cytoskeleton; Phosphorylation; Aggregation