Critical roles of the PI3K/Akt signaling pathway in T cell development
Keywords: Akt; PI3K; Thymocyte; TCR; Bcl-xL; Metabolism
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Primary cutaneous Epstein-Barr virus–related lymphoproliferative disorders in 4 immunosuppressed children
Keywords: EBER, Epstein-Barr virus–encoded early RNA; EBV, Epstein-Barr virus; ISH, in situ hybridization; LMP, latent membrane protein; LPD, lymphoproliferative disorders; PCR, polymerase chain reaction; PTLD, posttransplantation lymphoproliferative disorders; TCR
IKBKG (nuclear factor-κB essential modulator) mutation can be associated with opportunistic infection without impairing Toll-like receptor function
Keywords: NEMO; Toll-like receptors; IκB; Inhibitor of nuclear factor-κB; IKK; Inhibitor of nuclear factor-κB kinase; NEMO; Nuclear factor-κB essential modulator; NF-κB; Nuclear factor-κB; NK; Natural killer; TCR; T-cell receptor; TLR; Toll-like receptor;
Vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) provide co-stimulation in positive selection along with survival of selected thymocytes
Keywords: Thymus; Thymocyte; Cortex; Positive selection; T-cell selection; T-cell differentiation; MHC; TCR; Hematopoietic antigen presenting cell; ICAM-1; VCAM-1; CD3; Co-stimulation; Co-stimulatory molecule; F4/80;
The Peyer's patch is a critical immunoregulatory site for mucosal tolerance in experimental autoimmune encephalomylelitis (EAE)
Keywords: Autoimmunity; EAE/MS; Tolerance; T cell receptors; Peyer's patch; EAE; experimental autoimmune encephalomyelitis; MS; multiple sclerosis; MBP; myelin basic protein; CNS; central nervous system; PP; Peyer's patches; CFSE; 5,6-carboxy-succinimidyl-fluorensc
An in vivo functional genetic screen for suppressors of the Rag1â/â T-cell defect
Keywords: DN; double negative CD4âCD8â; DP; double positive CD4+CD8+; FTOC; fetal thymic organ culture; GFP; green fluorescent protein; TCR; T-cell receptor; TCRβ; T-cell receptor β chain; Rag; recombinase activating gene; T-cell development; T-cell leukaemia
Antigenic properties of HCMV peptides displayed by filamentous bacteriophages vs. synthetic peptides
Keywords: Synthetic carrier; HCMV epitopes; Biotechnology tools; Signal transduction; TCR
Engineering higher affinity T cell receptors using a T cell display system
Keywords: β2m; β2 microglobulin; BSA; bovine serum albumin; C; constant; CDR; complementarity determining region; mAb; monoclonal antibody; MHC; major histocompatibility complex; OVA; SIINFEKL peptide; PBS; phosphate buffered saline; pep; peptide; SIY; SIYRYYGL p
T cell receptor engagement of peptide-major histocompatibility complex class I does not modify CD8 binding
Keywords: TCR; CD8-co-receptor; T cell; Antigen recognition; KD; Surface plasmon resonance
Widespread distribution of DNA glycosylases removing oxidative DNA lesions in human and rodent brains
Keywords: 8-oxoG; 8-oxoguanine; AP; apurinic/apyrimidinic; BER; base excision repair; CP; caudatoputamen; CS; Cockayne syndrome; DAR; differentiation-associated repair; faPy; 2,6-diamino-4-hydroxy-5-formamidopyrimidine; GGR; global genomic repair; NEIL; Escherichia
TNF Receptor Type I-Dependent Activation of Innate Responses to Reduce Intestinal Damage-Associated Mortality
Keywords: Ab; antibody; BM; bone marrow; CEC; colonic epithelial cells; DSS; dextran sodium sulfate; JNK; c-Jun NH2-terminal kinase; KO; knockout; MAPK; mitogen-activated protein kinase; LP; lamina propria; PI3K; phosphoinositide-3 kinase; RAG; recombination activa
Expansion of hepatitis C-specific CD4+CD25+ regulatory T cells after viral clearance: A mechanism to limit collateral damage?
Keywords: Hepatitis C infection; regulatory T cells; autoimmunity; viral clearance; viral persistence; HCV; Hepatitis C virus; SI; Stimulation index; TCR; T-cell receptor; Treg; CD4+CD25+ regulatory T; UK; United Kingdom;
Yin-Yang 1 regulates effector cytokine gene expression and TH2 immune responses
Keywords: T lymphocyte; cytokine gene regulation; transcription factors; allergic inflammation; asthma; APC; Antigen-presenting cell; BAL; Bronchoalveolar lavage; CFSE; 5, 6-Carboxyfluorescein diacetate succinimidyl ester; ChIP; Chromatin immunoprecipitation; GAPDH
Innate responsiveness of CD8 memory T-cell populations nonspecifically inhibits allergic sensitization
Keywords: CD8 T cell; immunologic memory; innate immunity; allergy; TH1/TH2; dendritic cell; IL-12; BAL; Bronchoalveolar lavage; CD8 Tm; CD8 memory T cell; DC; Dendritic cell; NK; Natural killer; PAMP; Pathogen-associated molecular pattern; SEB; Staphylococcal ente
Novel mouse mutants with primary cellular immunodeficiencies generated by genome-wide mutagenesis
Keywords: N-ethyl-N-nitrosourea mutagenesis; immunodeficiency; Zap70; IgE; rodents; B6; C57BL/6JIco; C3H; C3HeB/FeJ; ENU; N-ethyl-N-nitrosourea; LAT; Linker for activation of T cells; NK; Natural killer; PLC; Phospholipase C; OVA; Ovalbumin; TCR; T-cell receptor; W
Transcription of DNA containing the 5-guanidino-4-nitroimidazole lesion by human RNA polymerase II and bacteriophage T7 RNA polymerase
Keywords: TCR; transcription-coupled repair; hRNAPII; human RNA polymerase II; T7RNAP; T7 RNA polymerase; NI; 5-guanidino-4-nitroimidazole; ONOOâ; peroxynitrite; NO; nitric oxide; O2â; superoxide anion; QM; quantum mechanics; MD; molecular dynamics; DNAP; DNA p
Activation-Induced Cytidine Deaminase Links Between Inflammation and the Development of Colitis-Associated Colorectal Cancers
Keywords: AID; activation-induced cytidine deaminase; IKK; IκB kinase; IL; interleukin; NF-κB; nuclear factor κB; PCR; polymerase chain reaction; siRNA; small interfering RNA; STAT; signal transducers and activators of transcription; TCR; T-cell receptor; TNF; t
A Prominent Role for Mucosal Cystine/Cysteine Metabolism in Intestinal Immunoregulation
Keywords: γGCS; γ-glutamylcysteine synthetase; GSH; reduced glutathione; LP-MO; lamina propria macrophages; LP-T; lamina propria T cells; PB-MO; peripheral blood monocytes; PB-T; peripheral blood T cells; TCR; T-cell receptor;
Human immature myeloid dendritic cells trigger a TH2-polarizing program via Jagged-1/Notch interaction
Keywords: Dendritic cells; TH1; TH2; Toll-like receptors; Notch; Jagged-1; Delta-4; STAT-4; STAT-6; IL-4; IL-12; BDCA; Blood dendritic cell antigen; DAPT; N(N-[3,5-difluorophenacetyl-L-alanyl])-S-phenylglycine t-butyl ester; DC; Dendritic cell; iDC; Immature dendri
A novel strategy for rapid and efficient isolation of human tumor-specific CD4+ and CD8+ T-cell clones
Keywords: T cells; Cloning; TCR; Vbeta; Tumor; Human
Antibodies to CD1d enhance thymic expression of invariant NKT TCR and increase the presence of NOD thymic invariant NKT cells
Keywords: CD1d; TCR; Repertoire development; NKT; Thymic selection; Regulation; DiabetesT1DM, Type 1 Diabetes Mellitus; FTOC, fetal thymus organ culture; SP4/SP8, single positive (CD4+/CD8− or CD8+/CD4−); DP, double positive (CD8+CD4+ cells); DN, double negative (C
Allergy prevention starts before conception: Maternofetal transfer of tolerance protects against the development of asthma
Keywords: Asthma; tolerance; pregnancy; primary prevention; AHR; Airway hyperreactivity; BAL; Bronchoalveolar lavage; BLG; β-Lactoglobulin; GITR; Glucocorticoid-induced tumor necrosis factor receptor; OVA; Ovalbumin; TCR; T-cell receptor;
Dynamic covariation between gene expression and genome characteristics
Keywords: BCR; B cell receptor; CBI; The Codon Bias Index; CUTG; Codon Usage Tabulated from GenBank; DNA; Deoxyribonucleic acid; EST; Expressed sequence tag; GExCo; Gene Expression Correlation; NCBI; The National Center for Biotechnology Information; RNA; Ribonucle
Method for assessing the similarity between subsets of the T cell receptor repertoire
Keywords: TCR; T cell receptor; NP; viral nucleoprotein; PA; viral acid polymerase; CDR; complementarity determining region; T cell receptor; Repertoire; Immune memory;
Epithelial: Lamina Propria Lymphocyte Interactions Promote Epithelial Cell Differentiation
Keywords: CD; Crohn's disease; CDX2; caudal-related homeoprotein 2; DSS; dextran sodium sulfate; IAP; intestinal alkaline phosphatase; IECs; intestinal epithelial cells; IEL; intraepithelial lymphocyte; IL-10; interleukin-10; KGF; keratinocyte growth factor; LPL;
Receptor mosaics of neural and immune communication: Possible implications for basal ganglia functions
Keywords: Ab; amyloid-beta protein; ABGA; antibasal ganglia antibody; AD; Alzheimer's disease; AGE; advanced glycation endproducts; AIDS; acquired immunodeficiency syndrome; ALS; amyotrophic lateral sclerosis; CA; cornu ammonis; CB; cannabinoid; CD; cluster designa
Myeloid-Derived Suppressor Cells in Inflammatory Bowel Disease: A New Immunoregulatory Pathway
Keywords: ARG; arginase; CL4; clone 4; DSS; dextran sulfate sodium; GM-CSF; granulocyte-macrophage colony-stimulating factor; HA; hemagglutinin; IFN; interferon; IL; interleukin; MDSC; myeloid-derived suppressor cell; MLN; mesenteric lymph nodes; NOS; nitric oxid
The Tritope Model for restrictive recognition of antigen by T-cells
Keywords: MHC; major histocompatibility complex; R; MHC-encoded restricting element; P; peptide; Ps; self-peptide; Pns; Nonself-peptide; RT; the restricting element mediating positive selection in thymus; TCR; T-cell antigen-receptor; Ig; immunoglobulin; RA; allo-R
Hypomorphic nuclear factor-κB essential modulator mutation database and reconstitution system identifies phenotypic and immunologic diversity
Keywords: NEMO; immunodeficiency; genetic database; Jurkat reconstitution; NF-κB activation; A20; 7-AAD; 7-Amino actinomycin D; DC; Dendritic cell; EDA; Ectodermal dysplasia and anhidrosis; EMSA; Electrophoretic mobility shift assay; FACS; Fluorescence-activated c
Preparation of the La0.8Sr0.2MnO3 films on STO and LAO substrates by excimer laser-assisted metal organic deposition using the KrF laser
Keywords: LSMO; TCR; STO; LAO; KrF laser;
Pulsed-laser crystallization and epitaxial growth of metal-organic films of Ca-doped LaMnO3 on STO and LSAT substrates
Keywords: 81.15.âz; 81.15.Np; 73.61.âr; 71.30.+h; LCMO; Excimer laser; MOD; TEM; TCR; Bolometer;
Electrical properties of the epitaxial La1−x−ySrxMnO3 films grown by excimer laser-assisted metal organic deposition
Keywords: LSMO; MOD; Excimer; TCR; Thin film; Sensor; STO
Characteristics of tantalum nitride thin film strain gauges for harsh environments
Keywords: Ta-N thin film; Strain gauge; TCR; GF; Harsh environments;
A study of electrical properties and microstructure of nitrogen-doped poly-SiC films deposited by LPCVD
Keywords: β-SiC; LPCVD; Nitrogen-doped; Poly-SiC; TCR
Repertoire-dependent immunopathology
Keywords: IL-4; IL-13; IgE; Alternatively activated macrophages; Eosinophils; TCR; T-cell receptor; CDR3; third complementarity determining region; Th; T-helper; IL; interleukin; MHC; major histocompatibility complex; TCR; T-cell receptor;
New insights for understanding the transcription-coupled repair pathway
Keywords: TCR; NER; Cockayne syndrome; Stalled RNA polymerase II; DNA lesions
Environment friendly perovskite ruthenate based thick film resistors
Keywords: Perovskite ruthenate; Thick film; Lead-free glass; Resistors; TCR; Gauge factor
Clinical Urological Outcomes Following Primary Tethered Cord Release in Children Younger Than 3 Years
Keywords: bladder; neural tube defects; urodynamics; urination disorders; spinal dysraphism; CIC; clean intermittent catheterization; DSD; detrusor-sphincter dyssynergia; DSM; diastematomyelia; DST; dermal sinus tract; FF; fatty filum; FUTI; febrile UTI; L; lipoma,
Molecular mechanisms involved in T cell receptor triggering
Keywords: T cell receptor; TCR; Triggering; Signal transduction; Antigen recognition
Microstructure and electrical performance of eco-friendly thick film resistor compositions fired at different firing conditions
Keywords: Perovskite ruthenate; Thick film resistor; Lead free; Microstructure; TCR
On temperature coefficient of resistance of boron-doped SiGe films deposited by sputtering
Keywords: SiGe; Boron; Thermal coefficient of resistance; TCR; Sputtering; TEM; Low-frequency noise
Potential of an altered peptide ligand of lipocalin allergen Bos d 2 for peptide immunotherapy
Keywords: Allergy; altered peptide ligand; Bos d 2; lipocalin allergen; peptide immunotherapy; T cells; T-cell receptors; TH1/TH2; APL; Altered peptide ligand; CDR3; Complementarity-determining region 3; CFSE; 5-(And-6)-carboxyfluorescein diacetate succinimidyl est
Protein kinase C theta (PKCθ): A key player in T cell life and death
Keywords: PKCθ; T cell; Signal transduction; TCR; CD28
The MYO9B Gene Is a Strong Risk Factor for Developing Refractory Celiac Disease
Keywords: CD; celiac disease; CI; confidence interval; EATL; enteropathy-associated T-cell lymphoma; GFD; gluten-free diet; OR; odds ratio; RCD II; refractory CD type II; SNP; single nucleotide polymorphism; TCR; T cell receptor;
The current status and future direction of percutaneous peptide immunization against melanoma
Keywords: DC; dendritic cell; LC; Langerhans cell; Th; T helper; CTL; cytotoxic T lymphocytes; Treg; regulatory T; NK; natural killer; IL; interleukin; TGF; transforming growth factor; TNF; tumor necrosis factor; HLA; human leukocyte antigen; TAA; tumor-associatd a
A chimeric TCR-β chain confers increased susceptibility to EAE
Keywords: TCR; TH1/TH2; EAE;
DNA repair in differentiated cells: Some new answers to old questions
Keywords: nucleotide excision repair; transcription-coupled repair; differentiation; BER; base excision repair; CPD; cyclobutane pyrimidine dimer; DAR; transcription domains-associated repair (formerly differentiation-associated repair); DSBR; double strand break r
Genome instability and DNA damage accumulation in gene-targeted mice
Keywords: DNA repair; knockout; mouse; spontaneous DNA damage; ABH; AlkB homolog; AP; apurimidinic; BER; base excision repair; bp; base pair; cyPu; 5â²,8-purine cyclodeoxynucleoside; DR; direct reversal; DSB; double-strand break; E. coli; Escherichia coli; ERCC1;
A native antibody-based mobility-shift technique (NAMOS-assay) to determine the stoichiometry of multiprotein complexes
Keywords: BN; Blue Native; BCR; B cell antigen receptor; Fab; antigen-binding fragment; HA-tag; hemagglutinin epitope; HC; heavy chain; LC; light chain; MPC; multiprotein complex; NAMOS; native antibody-based mobility shift; sc; single chain; TCR; T cell antigen re
Somatostatin modulates T cells development in adult rat thymus
Keywords: DN; Double negative; DP; Double positive; SP; Single positive; TCR; T cell receptor; SRIH; Somatotropin release inhibiting hormone; TEC; Thymus epithelial cells; SSTR; Somatostatin receptor; PI; Propidium iodide; Rodent; Thymus; T cells development; Somat