دانلود مقالات ISI درباره Tdp-43 + ترجمه فارسی

Ferrosenescence: The iron age of neurodegeneration?

Keywords: TE; transposable elements; IRP-2; iron regulatory protein-2; BACE-1; beta-secretase 1; APP; amyloid precursor protein; FPN; ferroportin; Tf; transferrin; TFR-1; transferrin receptor-1; IRE; iron-responsive elements; mtDNA; mitochondrial DNA; DNMT-3A and D

دانلود رایگان متن کامل مقاله ISI 65 صفحه سال انتشار : 2018 سفارش ترجمه

Driven to decay: Excitability and synaptic abnormalities in amyotrophic lateral sclerosis

Keywords: Motor neuron disease; Dendrite; Spine density; SOD1; TDP-43;

دانلود رایگان متن کامل مقاله ISI 66 صفحه سال انتشار : 2018 سفارش ترجمه

TAR DNA-Binding Protein 43 and Disrupted in Schizophrenia 1 Coaggregation Disrupts Dendritic Local Translation and Mental Function in Frontotemporal Lobar Degeneration

Keywords: Coaggregation; DISC1; FTLD; Local translation; Psychiatric behaviors; TDP-43;

دانلود رایگان متن کامل مقاله ISI 68 صفحه سال انتشار : 2018 سفارش ترجمه

Oligodendrogliopathy in neurodegenerative diseases with abnormal protein aggregates: The forgotten partner

Keywords: 5-HT; 5-hydroxytryptamine; Aβ; β-amyloid; ABCA8; ATP binding cassette subfamily A member 8; AD; Alzheimer's disease; ADP; adenosine diphosphate; AGD; argyrophilic grain disease; ALS; amyotrophic lateral sclerosis; AMBRA-1; autophagy and beclin 1 regul

دانلود رایگان متن کامل مقاله ISI 131 صفحه سال انتشار : 2018 سفارش ترجمه

Als and Ftd: Insights into the disease mechanisms and therapeutic targets

Keywords: ALS; Dementia; FTD; Genetics; Motor neuron disease; TDP-43; Riluzole; Stem cells;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

ALS-causing cleavages of TDP-43 abolish its RRM2 structure and unlock CTD for enhanced aggregation and toxicity

Keywords: Amyotrophic lateral sclerosis (ALS); TDP-43; Inter-domain interactions; ALS-Causing cleavage; C-terminal domain (CTD); NMR spectroscopy;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

CHI3L1 and CHI3L2 overexpression in motor cortex and spinal cord of sALS patients

Keywords: ALS; amyotrophic lateral sclerosis; sALS; sporadic ALS; FALS; familial ALS; CNS; central nervous system; CHI3L1; chitinase 3 like 1; CHI3L2; chitinase 3 like 2; CLPs; chitinase-like proteins; SIVE; Simian Immunodeficiency Virus Encephalitis; TDP-43; TAR D

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

TDP-43 expression influences amyloidβ plaque deposition and tau aggregation

Keywords: TDP-43; TARDBP; APP; Calcineurin; Alzheimer's disease; APP/PS1; Tau;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

TAR DNA-binding protein 43 inhibits inflammatory response and protects chondrocyte function by modulating RACK1 expression in osteoarthritis

Keywords: Osteoarthritis; TDP-43; RACK1 expression; Gene; Ariticular cartilage;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

DCTN1-related neurodegeneration: Perry syndrome and beyond

Keywords: Atypical parkinsonism; DCTN1; Dynactin; FTD; Genetics; TDP-43; Perry syndrome; PSP; Review; ALS; amyotrophic lateral sclerosis; CAP-Gly; cytoskeleton-associated protein, glycine-rich; DCTN1; dynactin 1; FTD; frontotemporal dementia; HD; Huntington's dis

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

TDP-43 upregulation mediated by the NLRP3 inflammasome induces cognitive impairment in 2 2′,4,4′-tetrabromodiphenyl ether (BDE-47)-treated mice

Keywords: Polybrominated diphenyl ethers; NLRP3 inflammasome; TDP-43; Parkin; Cognitive impairment;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

TDP-43 proteolysis is associated with astrocyte reactivity after traumatic brain injury in rodents

Keywords: ALS; Amyotrophic lateral sclerosis; ANOVA; A two-way analysis of variance; FTLD; Frontotemporal lobar degeneration; GFAP; Glial fibrillary acidic protein; TBI; Traumatic brain injury; TDP-43; Transactivation response DNA-binding protein 43; TX; High-salt

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2017 سفارش ترجمه

Sigma 1 receptor activation modifies intracellular calcium exchange in the G93AhSOD1 ALS model

Keywords: ALS; amyotrophic lateral sclerosis; AMPA; Α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; CTCF; corrected total cell fluorescence; ERMCC; ER mitochondria Ca2+ cycle; G93A; G93AHSOD1; MAM; mitochondria-associated ER membrane; NE-100; 4-methoxy-3-(2-

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2017 سفارش ترجمه

TDP-43 in the hypoglossal nucleus identifies amyotrophic lateral sclerosis in behavioral variant frontotemporal dementia

Keywords: Amyotrophic lateral sclerosis; Behavioral variant frontotemporal dementia; TDP-43; Hypoglossal nucleus;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

Inter-domain interactions of TDP-43 as decoded by NMR

Keywords: Amyotrophic lateral sclerosis (ALS); Frontotemporal dementia (FTD); TDP-43; Inter-domain interaction; Prion-like domain; NMR spectroscopy;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling

Keywords: ALS; Amyotrophic lateral sclerosis; ARE; Antioxidant response element; FTLD; Frontotemporal lobar degeneration; IKKβ; Inhibitor of nuclear factor kappa-B kinase subunit beta; Keap1; Kelch-like ECH-associated protein 1; KIR; Keap1-interacting region; LIR;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Research report14-3-3 eta isoform colocalizes TDP-43 on the coarse granules in the anterior horn cells of patients with sporadic amyotrophic lateral sclerosis

Keywords: 14-3-3 proteins; Eta isoform; Amyotrophic lateral sclerosis; TDP-43; SNAP25; Anterior horn cells;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Research ReportTBPH/TDP-43 modulates translation of Drosophila futsch mRNA through an UG-rich sequence within its 5′UTR

Keywords: Drosophila; TBPH; TDP-43; Futsch; MAP1B; Neurodegeneration;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Differentiation of control and ALS mutant human iPSCs into functional skeletal muscle cells, a tool for the study of neuromuscolar diseases

Keywords: Induced Pluripotent Stem Cells; Amyotrophic Lateral Sclerosis; FUS/TLS; TDP-43; Skeletal muscle

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

ReviewThe extreme N-terminus of TDP-43 mediates the cytoplasmic aggregation of TDP-43 and associated toxicity in vivo

Keywords: TDP-43; Aggregation; The extreme N-terminus; Toxicity; In vivo; AAV;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Structural insights into the multi-determinant aggregation of TDP-43 in motor neuron-like cells

Keywords: Amyotrophic lateral sclerosis; ALS; TDP-43; Protein aggregation; Neurodegeneration; N-terminal domain; Oligomers; Large aggregates; Cysteine;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Analysis of RNA metabolism in peripheral WBCs of TDP-43 KI mice identifies novel biomarkers of ALS

Keywords: ALS; Biomarker; TDP-43; RNA metabolism; Peripheral blood cells;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

In vitro prion-like behaviour of TDP-43 in ALS

Keywords: pTDP-43; phosphorylated TDP-43; IF; Immunofluorescence; WB; Western blotting; SS; Sarkosyl soluble; SI; Sarkosyl Insoluble; FL WT; Full length wild type TDP-43 plasmid; NC; Normal control; FCX; Frontal cortex; MC; Motor cortex; TCX; Temporal cortex; SC L;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

ReviewProtein folding alterations in amyotrophic lateral sclerosis

Keywords: Amyotrophic lateral sclerosis; Protein misfolding; Protein disulphide isomerase (PDI); Superoxide dismutase 1 (SOD1); Disulphide bonds; ER stress; TDP-43; FUS; C9ORF72;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2016 سفارش ترجمه

Interplay between TDP-43 and docosahexaenoic acid-related processes in amyotrophic lateral sclerosis

Keywords: Motor neuron; Lipidomic; Oxidative stress; TDP-43; Polyunsaturated fatty acids; Mitochondria;

دانلود رایگان متن کامل مقاله ISI 47 صفحه سال انتشار : 2016 سفارش ترجمه

Expression of microRNAs in human post-mortem amyotrophic lateral sclerosis spinal cords provides insight into disease mechanisms

Keywords: AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; AQP1; aquaporin 1; BCDIN3D; BCDIN3 domain-containing methyltransferase; BioGRID; Biological Genomic Repository for Interaction Datasets; C9ORF72; chromosome 9 open reading frame 72; CCL2; chemok

دانلود رایگان متن کامل مقاله ISI 50 صفحه سال انتشار : 2016 سفارش ترجمه

Impaired protein degradation in FTLD and related disorders

Keywords: Autophagy-lysosome system; Frontotemporal lobar degeneration (FTLD); Neurodegeneration; Neuronal ceroid lipofuscinosis (NCL); TDP-43; Ubiquitin-proteasome system (UPS);

دانلود رایگان متن کامل مقاله ISI 55 صفحه سال انتشار : 2016 سفارش ترجمه

TDP-43/FUS in motor neuron disease: Complexity and challenges

Keywords: AD; Alzheimer's disease; Ago2; Argonaute 2; ALS; Amyotrophic lateral sclerosis; ALS/PD; amyotrophic lateral sclerosis and Parkinsonism-dementia complex; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ATF3; activating transcription factor 3

دانلود رایگان متن کامل مقاله ISI 61 صفحه سال انتشار : 2016 سفارش ترجمه

Regulation of MALAT1 expression by TDP43 controls the migration and invasion of non-small cell lung cancer cells in vitro

Keywords: MALAT1; Non-small cell lung cancer; TDP-43; Cellular migration and invasion;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

The role of SIGMAR1 gene mutation and mitochondrial dysfunction in amyotrophic lateral sclerosis

Keywords: Amyotrophic lateral sclerosis; SIGMAR1; Mitochondrial injury; Energy production; TDP-43

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

An age-related reduction of brain TBPH/TDP-43 levels precedes the onset of locomotion defects in a Drosophila ALS model

Keywords: 12xQ/N; repeated TDP-43 amino acid sequence 331-369; ALS; amyotrophic lateral sclerosis; CNS; central nervous system; TDP-43; TAR DNA-binding protein-43; TBPH; TAR DNA-binding protein-43 Drosophila melanogaster ortholog; TDP-43/TBPH levels; aggregation;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Aberrant activation of AMP-activated protein kinase contributes to the abnormal distribution of HuR in amyotrophic lateral sclerosis

Keywords: A2AR; A2A adenosine receptor; AD; Alzheimer's disease; AICAR; 5-aminoimidazole-4-carboxamide ribonucleotide; ALS; amyotrophic lateral sclerosis; AMPK; AMP-activated protein kinase; AREs; adenylate- and uridylate-rich elements; ELAV; embryonic lethal abn

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

A phosphomimetic mutant TDP-43 (S409/410E) induces Drosha instability and cytotoxicity in Neuro 2A cells

Keywords: TDP-43; FUS; Drosha; Phosphomimetic mutant TDP-43 (S409/410E);

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Heroin abuse exaggerates age-related deposition of hyperphosphorylated tau and p62-positive inclusions

Keywords: Aging; α-Synuclein; Heroin; Neuropathology; Opiate; Tau; TDP-43; p62;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

TDP-35 sequesters TDP-43 into cytoplasmic inclusions through binding with RNA

Keywords: ALS; amyotrophic lateral sclerosis; DNase; deoxyribonuclease; FISH; fluorescent in situ hybridization; FTLD; frontotemporal lobar degeneration; GFP; green fluorescent protein; IF; immunofluorescence; ITC; isothermal titration calorimetry; RIP; RNA immunop

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Functional complementation in Drosophila to predict the pathogenicity of TARDBP variants: evidence for a loss-of-function mechanism

Keywords: TDP-43; Loss-of-function; ALS; FTD; AD; Drosophila;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

The distinct genetic pattern of ALS in Turkey and novel mutations

Keywords: ALS; Turkey; SOD1; C9orf72; TDP-43; FUS;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Traumatic brain injury causes frontotemporal dementia and TDP-43 proteolysis

Keywords: ALS; amyotrophic lateral sclerosis; CI; confidence interval; FTD; frontotemporal dementia; FTLD; frontotemporal lobar degeneration; HRs; hazard ratios; SARK; sarkosyl; TBI; traumatic brain injury; TDP-43; TAR-DNA binding protein 43; traumatic brain injury

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Long noncoding RNAs in TDP-43 and FUS/TLS-related frontotemporal lobar degeneration (FTLD)

Keywords: Frontotemporal lobar degeneration; TDP-43; FUS/TLS; Long noncoding RNA; Neurodegeneration;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

p-SMAD2/3 and DICER promote pre-miR-21 processing during pressure overload-associated myocardial remodeling

Keywords: Ago; Argonaute; AS; aortic stenosis; BAMBI; BMP and activin membrane-bound inhibitor; DGCR8; DiGeorge Syndrome Critical Region 8; LV; left ventricle; miRNA; microRNA; pre-miRNA; microRNA precursor; pri-miRNA; microRNA primary transcript; R-SBE; RNA-SMAD b

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Molecular chaperones and neuronal proteostasis

Keywords: 17-AAG; 17-allylamino-17-demethoxygeldanamycin; 17-DMAG; 17-dimethylamino-ethylamino-17-demethoxygeldanamycin; Aβ; amyloid beta; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; ARSACS; autosomal recessive spastic ataxia of Charlevoix-Saguena

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

From nucleation to widespread propagation: A prion-like concept for ALS

Keywords: ALS; Prion-like transmission; Stress granules; TDP-43; FUS; C9orf72;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Analysis of β-N-methylamino-l-alanine (L-BMAA) neurotoxicity in rat cerebellum

Keywords: L-BMAA; Cerebellum neurodegeneration; Ultrastructure; GSK3; TDP-43; AutophagyL-BMAA, β-N-methylamino-l-alanine; ALS, amyotrophic lateral sclerosis; ALS/PDC, amyotrophic lateral sclerosis/Parkinson-dementia complex; CNS, central nervous system; ER, endopla

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

TARDBP pathogenic mutations increase cytoplasmic translocation of TDP-43 and cause reduction of endoplasmic reticulum Ca2 + signaling in motor neurons

Keywords: TDP-43; Ca2 + dysregulation; Bcl-2; Motor neurons;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Epigenomics of Alzheimer's disease

Keywords: AD; Alzheimer's disease; APOE; apolipoprotein E; APP; amyloid precursor protein; BACE-1; beta-site APP-cleaving enzyme 1 gene; CG; cytosine-guanine dinucleotide; ChIP-Seq; chromatin immunoprecipitation-sequencing; CVD; cerebrovascular disease; GWAS; gen

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2015 سفارش ترجمه

From transcriptomic to protein level changes in TDP-43 and FUS loss-of-function cell models

Keywords: RBPs; RNA-binding proteins; ALS; amyotrophic lateral sclerosis; FTD; frontotemporal dementia; HTS; high-throughput screening; F.C.; fold change; S.I.; splicing index; GO; Gene Ontology; KEGG; Kyoto Encyclopedia of Genes and Genomes; WB; Western blot; TDP-

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2015 سفارش ترجمه

TDP-43 activates microglia through NF-κB and NLRP3 inflammasome

Keywords: TDP-43; Microglia; CD14; NF-κB; NLRP3 inflammasome;

دانلود رایگان متن کامل مقاله ISI 50 صفحه سال انتشار : 2015 سفارش ترجمه

Frontotemporal lobar dementia and amyotrophic lateral sclerosis associated with c9orf72 expansion

Keywords: Frontotemporal dementia; FTLD; FTLD-ALS; ALS; PGRN; C9ORF72; MAPT; TDP-43; Loss-of-function; RNA foci; Dipeptide repeats; Démence lobaire frontotemporale; DLFT; Sclérose latérale amyotrophique; SLA; DLFT-SLA; PGRN; C9ORF72; MAPT; TDP-43; Perte de fonct

دانلود رایگان متن کامل مقاله ISI 61 صفحه سال انتشار : 2015 سفارش ترجمه

Targeted high-throughput sequencing identifies a TARDBP mutation as a cause of early-onset FTD without motor neuron disease

Keywords: Amyotrophic lateral sclerosis; Frontotemporal dementia; Frontotemporal lobe dementia; Next-generation sequencing; Panel diagnostics; Genetics; TDP-43;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Transcriptome-wide analysis of TDP-43 binding small RNAs identifies miR-NID1 (miR-8485), a novel miRNA that represses NRXN1 expression

Keywords: Novel intronic miRNA; CA repeat; TDP-43; NRXN1;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه