دانلود مقالات ISI درباره Tdp-43 + ترجمه فارسی

Aggregate formation prevents dTDP-43 neurotoxicity in the Drosophila melanogaster eye

Keywords: TDP-43; TAR DNA-binding protein-43; TBPH/dTDP-43; TAR DNA-binding protein-43 Drosophila melanogaster ortholog; ALS; Amyotrophic Lateral Sclerosis; 12xQ/N; Repeated TDP-43 amino acid sequence 331-369; UAS; upstream activating sequence; TDP-43; TBPH; ALS;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Widespread RNA metabolism impairment in sporadic inclusion body myositis TDP43-proteinopathy

Keywords: TDP-43; Inclusion body myositis; RNA; MAPT; hnRNP; Amyotrophic lateral sclerosis;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

The ALS/FTLD-related RNA-binding proteins TDP-43 and FUS have common downstream RNA targets in cortical neurons

Keywords: ALS; FTLD; TDP-43; FUS; TranscriptomeALS, amyotrophic lateral sclerosis; Cugbp1, CUG triplet  repeat, RNA-binding protein 1; DAVID, Database for  Annotation, Visualization and Integrated Discovery; FTLD, frontotemporal lobar degeneration; FUS, fused in sa

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Reduced cellular Ca2+ availability enhances TDP-43 cleavage by apoptotic caspases

Keywords: ALS; amyotrophic lateral sclerosis; BAPTA-AM; 1,2-bis (o-aminophenoxy) ethane-N,N,N′,N′-tetraacetic acid acetoxymethyl ester; BSA; bovine serum albumin; CHAPS; 3-[(3-cholamidopropyl) dimethylammonio]-1-propanesulfonate; CoCl2; cobalt chloride; DMEM; D

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Tar DNA-binding protein-43 (TDP-43) regulates axon growth in vitro and in vivo

Keywords: TDP-43; ALS; FTD-TDP; Motor neuron; Chick embryo; Axon growth cytoskeleton; Cytoplasmic mislocalisation; Neurotoxicity;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Genetic link between Cabeza, a Drosophila homologue of Fused in Sarcoma (FUS), and the EGFR signaling pathway

Keywords: Caz; Cabeza; ALS; Amyotrophic Lateral Sclerosis; FUS; Fused in Sarcoma; EGFR; Epidermal growth factor-receptor; SOD1; Cu/Zn superoxide dismutase; TDP-43; TAR DNA-binding protein of 43 kDa gene; CNS; central nervous system; APF; after pupal formation; ERK

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

SQSTM1 mutations - Bridging Paget disease of bone and ALS/FTLD

Keywords: ALS; amyotrophic lateral sclerosis; aPKC; atypical protein kinase C; C9orf72; chromosome 9 open reading frame 72; FTD; frontotemporal dementia; FTLD; frontotemporal lobar degeneration; FUS/TLS; fused in sarcoma/translocated in liposarcoma; GWAS; genome-wi

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Military-related traumatic brain injury and neurodegeneration

Keywords: Chronic traumatic encephalopathy; Veterans; Neurodegeneration; Traumatic brain injury; Tauopathy; TDP-43; Alzheimer's disease;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

ALS-associated peripherin spliced transcripts form distinct protein inclusions that are neuroprotective against oxidative stress

Keywords: Amyotrophic lateral sclerosis (ALS); Peripherin; Splicing; Inclusion; Aggregation; Stress; Intermediate filament; TDP-43;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

Research ReportMotor neuron expression of the voltage-gated calcium channel cacophony restores locomotion defects in a Drosophila, TDP-43 loss of function model of ALS

Keywords: ALS; Cacophony; Drosophila; TDP-43; Neurodegeneration; Calcium channel;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

H63D HFE genotype accelerates disease progression in animal models of amyotrophic lateral sclerosis

Keywords: GSH; glutathione; HH; hemochromatosis; HO-1; hemeoxygenase-1; NFH; heavy-chain neurofilament protein; Nrf2; nuclear factor E2-related factor 2; SOD; superoxide dismutase; TDP-43; TAR DNA-binding protein 43; TfR; transferrin receptor; H63D HFE; SOD1(G93A);

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2014 سفارش ترجمه

Research ReportC57BL/6J congenic Prp-TDP43A315T mice develop progressive neurodegeneration in the myenteric plexus of the colon without exhibiting key features of ALS

Keywords: ALS; TDP-43; RNA binding; Transgenic animal models; Proteinopathy; Prion; Neurodegeneration; Myenteric plexus;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2014 سفارش ترجمه

Lysosome size, motility and stress response regulated by fronto-temporal dementia modifier TMEM106B

Keywords: Fronto-temporal dementia; Progranulin; Lysosome; TFEB; TDP-43; Neurodegeneration;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2014 سفارش ترجمه

Chronological requirements of TDP-43 function in synaptic organization and locomotive control

Keywords: ALS; Drosophila; Neuromuscular junction; Syntaxin1A; TDP-43;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2014 سفارش ترجمه

Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation

Keywords: ALS; Amyotrophic lateral sclerosis; APP; Amyloid precursor protein; BDNF; brain derived neurotrophic factor; CNS; Central nervous system; ER; endoplasmic reticulum; FTLD-MND; Fronto-temporal lobar degeneration with co-occurrence of motor neuron disease; F

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2014 سفارش ترجمه

Intrathecal infusion of BMAA induces selective motor neuron damage and astrogliosis in the ventral horn of the spinal cord

Keywords: AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ALS; amyotrophic lateral sclerosis; ALS/PDC; amyotrophic lateral sclerosis-Parkinsonism Dementia Complex of Guam; BMAA; beta-N-methylamino-l-alanine; Ca-AMPA receptors; Ca2 + permeable AMPA r

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2014 سفارش ترجمه

TARDBP mutations in Parkinson's disease

Keywords: TDP-43; Amyotrophic lateral sclerosis; Parkinson's disease;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2013 سفارش ترجمه

TDP-43 pathology in a patient carrying G2019S LRRK2 mutation and a novel p.Q124E MAPT

Keywords: LRRK2; MAPT; Parkinson's disease; TDP-43; tau;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

International meeting of the French society of neurology 2013Frontotemporal lobar degeneration and amyotrophic lateral sclerosis: Molecular similarities and differencesDégénérescences lobaires fronto-temporales et sclérose latérale amyotrophique : s

Keywords: Frontotemporal lobar degeneration (FTLD); Frontotemporal dementia (FTD); Amyotrophic lateral sclerosis (ALS); TDP-43; FUS; C9ORF72; Sclérose latérale amyotrophique; Démence frontotemporale; TDP-43; FUS; C9ORF72;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Mitochondria and ALS: Implications from novel genes and pathways

Keywords: ALS; Amyotrophic Lateral Sclerosis; CFP; Cyan Fluorescent Protein; ER; Endoplasmic Reticulum; FUS/TLS; Fused in Sarcoma/Translocated in Liposarcoma; GSH; Glutathione; HAT; Histone Acetyl Transferase; HDAC; Histone Deacetylase; ROS; Reactive Oxygen Species

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Frontotemporal lobar degeneration: Diversity of FTLD lesions

Keywords: Frontotemporal lobar degeneration; Frontotemporal dementia; Tau; FUS; TDP-43; Pick's disease; Progranulin; C9ORF72; VCP; Multisystem proteinopathy; NIFID; BIBD; Dégénérescence lobaire frontotemporale; Démence frontotemporale; Tau; FUS; TDP-43; Maladie

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Evaluation of longevity enhancing compounds against transactive response DNA-binding protein-43 neuronal toxicity

Keywords: TDP-43; Amyotrophic lateral sclerosis; C. elegans; Neurodegeneration; Longevity; Proteotoxicity;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Ubiquilin-2 (UBQLN2) binds with high affinity to the C-terminal region of TDP-43 and modulates TDP-43 levels in H4 cells: Characterization of inhibition by nucleic acids and 4-aminoquinolines

Keywords: TDP-43; UBQLN2; 4-Aminoquinoline; Protein-protein interaction;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Quantitative neurofibrillary tangle density and brain volumetric MRI analyses in Alzheimer's disease presenting as logopenic progressive aphasia

Keywords: Primary progressive aphasia; Logopenic variant of primary progressive aphasia; Alzheimer's disease; Neurofibrillary tangles; Hippocampus; MRI; Apolipoprotein E; TDP-43; Voxel-based morphometry; Alzheimer's dementia;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Molecular mechanism of oxidation-induced TDP-43 RRM1 aggregation and loss of function

Keywords: TDP-43; trans-activation region DNA-binding protein of 43-kDa; RRM; RNA recognition motif; ALS; amyotrophic lateral sclerosis; FTLD; frontotemporal lobar degeneration; AD; Alzheimer's disease; PD; Parkinson's disease; HD; Huntington's disease; NTD;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

ELAV proteins along evolution: Back to the nucleus?

Keywords: RBP; RNA-binding protein; elav; embryonic lethal abnormal vision; miRNA; microRNA; rbp9; RNA-binding protein 9; fne; found in neurons; ARE; AU-rich element; UTR; untranslated region; RRM; RNA recognition motif; PABP; polyA-binding protein; eiF4A; eukaryot

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Overexpression of human mutated G93A SOD1 changes dynamics of the ER mitochondria calcium cycle specifically in mouse embryonic motor neurons

Keywords: ALS; amyotrophic lateral sclerosis; AMPA; α-amino-5-methyl-3-hydroxyisoxazolone-4-propionat; CaBP; calcium binding proteins; CPA; cyclopiazonic acid; CsA; cyclosporine A; eIF2α; eukaryotic translation initiation factor 2 α; EMD; earth mover's distance;

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2013 سفارش ترجمه

A cellular model for sporadic ALS using patient-derived induced pluripotent stem cells

Keywords: ALS; amyotrophic lateral sclerosis; iPSC; induced pluripotent stem cells; TDP-43; TARDBP, TAR DNA binding protein; SOD1; superoxide dismutase 1; FTLD; fronto-temporal lobar degeneration; iPSC-MN; induced pluripotent stem cell-derived motor neurons; iPSC-C

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2013 سفارش ترجمه

Neurocognitive speed associates with frontotemporal lobar degeneration TDP-43 subtypes

Keywords: Cognitive speed; Dementia; Frontotemporal lobar degeneration; Neuropathology; Neuropsychology; TDP-43;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

A unique mouse model for investigating the properties of amyotrophic lateral sclerosis-associated protein TDP-43, by in utero electroporation

Keywords: Amyotrophic lateral sclerosis; TDP-43; In utero electroporation; Inclusion body;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Pharmacological reduction of ER stress protects against TDP-43 neuronal toxicity in vivo

Keywords: TDP-43; ALS; Genetic models; Small molecules; ER stress; Neurodegeneration; C. elegans; Zebrafish

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Actualités dans le traitement étiologique de la sclérose latérale amyotrophique

Keywords: sclérose latérale amyotrophique; neurologie; motoneurone; traitement; survie; amyotrophic lateral sclerosis; neurology; motoneuron; treatment; survival; AALSRS; appel ALS rating scale; ALSFRS; amyotrophic lateral sclerosis functional rating scale; AMM;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2013 سفارش ترجمه

Large-scale screening of TARDBP mutation in amyotrophic lateral sclerosis in Japanese

Keywords: ALS; Sporadic ALS; Familial ALS; TDP-43; TARDBP mutation; Mutational frequency; Single-nucleotide polymorphism;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Overexpression of TDP-43 causes partially p53-dependent G2/M arrest and p53-independent cell death in HeLa cells

Keywords: ALS; amyotrophic lateral sclerosis; FACS; fluorescence activated cell sorting; FTLD-U; frontotemporal lobar degeneration with ubiquitin-positive inclusions; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; TDP-43; transactive response DNA-binding protein-

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

The N-terminus of TDP-43 promotes its oligomerization and enhances DNA binding affinity

Keywords: TDP-43; DNA/RNA binding; Oligomerization; Neurodegenerative disease; N-terminus;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Research reportMitochondrial dysfunction in human TDP-43 transfected NSC34 cell lines and the protective effect of dimethoxy curcumin

Keywords: ALS; Dimethoxy curcumin; Electron transport chain; Mitochondrial transmembrane potential; TDP-43; UCP2;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Right temporal variant frontotemporal dementia with motor neuron disease

Keywords: Frontotemporal dementia; Motor neuron disease; TDP-43; Voxel based morphometry (VBM); Positron emission tomography (PET)

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Proteinopatie TDP-43 – od zwyrodnienia czołowo-skroniowego do wtrętowego zapalenia mięśni

Keywords: TDP-43; stwardnienie boczne zanikowe; zwyrodnienie czołowo-skroniowe; proteinopatie TDP-43; wtrętowe zapalenie mięśniTDP-43; amyotrophic lateral sclerosis; frontotemporal lobar degeneration; inclusion body myositis

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Recent advances in p97/VCP/Cdc48 cellular functions

Keywords: AAA; ATPases associated with diverse cellular activities; VCP; valosin-containing protein; ER; endoplasmic reticulum; ERAD; ER associated degradation; IBMPFD; inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia; ALS;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Association of UBQLN1 mutation with Brown-Vialetto-Van Laere syndrome but not typical ALS

Keywords: Amyotrophic lateral sclerosis; Drosophila motor neuron disease; TDP-43; Ubiquilins;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Frontotemporal lobar degeneration-related proteins induce only subtle memory-related deficits when bilaterally overexpressed in the dorsal hippocampus

Keywords: Tau; TDP-43; Gene transfer; Hippocampus; Learning and memory; Neurodegeneration; Neurodegenerative diseases; Adeno-associated virus;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Methylene blue administration fails to confer neuroprotection in two amyotrophic lateral sclerosis mouse models

Keywords: methylene blue; superoxide dismutase; TDP-43; ALS; neuroinflammationALS, amyotrophic lateral sclerosis; DRG, dorsal root ganglia; IR, immunoreactivity; MB, methylene blue; SOD1, Cu/Zn superoxide dismutase; VR, ventral root

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

FUS and TDP43 genetic variability in FTD and CBS

Keywords: Frontotemporal dementia; Corticobasal syndrome; Genetics; FUS; TDP-43;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Oxidative stress induced by glutathione depletion reproduces pathological modifications of TDP-43 linked to TDP-43 proteinopathies

Keywords: TDP-43; TAR DNA-binding protein of 43 kDa; ALS; amyotrophic lateral sclerosis; hnRNP; heterogeneous nuclear ribonucleoprotein; hNFL; human low molecular weight neurofilament; Cdk6; cyclin-dependent kinase 6; ROS; reactive oxygen species; EA; ethacrynic a

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Wild type TDP-43 induces neuro-inflammation and alters APP metabolism in lentiviral gene transfer models

Keywords: TDP-43; Tar DNA binding protein; Aβ; β-amyloid; FTLD; fronto-temporal lobar dementia; ALS; amyotrophic lateral sclerosis; Lv; lentivirus; GFAP; glial neurofibrillary proteins; IBA-1; ionized calcium binding adaptor molecule 1; TNF-α; tumor necrosis fac

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

ReviewTDP-43 aggregation in neurodegeneration: Are stress granules the key?

Keywords: TARDBP; TDP-43; FUS; Stress granule; FTD; FTLD; Frontotemporal lobar degeneration; ALS; Amyotrophic lateral sclerosis; Neurodegeneration; Independent model; Precursor model;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Research ReportRole of selected mutations in the Q/N rich region of TDP-43 in EGFP-12xQ/N-induced aggregate formation

Keywords: TDP-43; Aggregation; Q/N regions; Polyglutamine; Autoregulation; Disease mutations; Splicing;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

ReviewMisregulated RNA processing in amyotrophic lateral sclerosis

Keywords: Amyotrophic lateral sclerosis; Frontotemporal dementia; TDP-43; FUS/TLS; C9orf72; RNA processing;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

Alteration in cell cycle-related proteins in lymphoblasts from carriers of the c.709-1G>A PGRN mutation associated with FTLD-TDP dementia

Keywords: FTLD; Lymphocytes; Cell cycle; pRb; CDK6; TDP-43;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه

ReviewRodent models of TDP-43: Recent advances

Keywords: TDP-43; Transgenic; Conditional knockout;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه