کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10904010 | 1086551 | 2014 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Genetic link between Cabeza, a Drosophila homologue of Fused in Sarcoma (FUS), and the EGFR signaling pathway
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کلمات کلیدی
EGFREGFR pathwayTDP-43SOD1ERKAPFCu/Zn superoxide dismutase - Cu / Zn سوپر اکسید دیسموتازFUs - FUSamyotrophic lateral sclerosis - اسکلروز جانبی آمیوتروفیکALS - بیماری اسکلروز جانبی آمیوتروفیکfused in sarcoma - در سارکوم متصل شده استCNS - دستگاه عصبی مرکزیCabeza - سرcentral nervous system - سیستم عصبی مرکزیRetina - شبکیهCaz - موردDrosophila - مگس سرکهepidermal growth factor-receptor - گیرنده فاکتور رشد اپیدرمی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Genetic link between Cabeza, a Drosophila homologue of Fused in Sarcoma (FUS), and the EGFR signaling pathway Genetic link between Cabeza, a Drosophila homologue of Fused in Sarcoma (FUS), and the EGFR signaling pathway](/preview/png/10904010.png)
چکیده انگلیسی
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease that causes progressive muscular weakness. Fused in Sarcoma (FUS) that has been identified in familial ALS is an RNA binding protein that is normally localized in the nucleus. However, its function in vivo is not fully understood. Drosophila has Cabeza (Caz) as a FUS homologue and specific knockdown of Caz in the eye imaginal disc and pupal retina using a GMR-GAL4 driver was here found to induce an abnormal morphology of the adult compound eyes, a rough eye phenotype. This was partially suppressed by expression of the apoptosis inhibitor P35. Knockdown of Caz exerted no apparent effect on differentiation of photoreceptor cells. However, immunostaining with an antibody to Cut that marks cone cells revealed fusion of these and ommatidia of pupal retinae. These results indicate that Caz knockdown induces apoptosis and also inhibits differentiation of cone cells, resulting in abnormal eye morphology in adults. Mutation in EGFR pathway-related genes, such as rhomboid-1, rhomboid-3 and mirror suppressed the rough eye phenotype induced by Caz knockdown. Moreover, the rhomboid-1 mutation rescued the fusion of cone cells and ommatidia observed in Caz knockdown flies. The results suggest that Caz negatively regulates the EGFR signaling pathway required for determination of cone cell fate in Drosophila.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Cell Research - Volume 326, Issue 1, 1 August 2014, Pages 36-45
Journal: Experimental Cell Research - Volume 326, Issue 1, 1 August 2014, Pages 36-45
نویسندگان
Mai Shimamura, Akane Kyotani, Yumiko Azuma, Hideki Yoshida, Thanh Binh Nguyen, Ikuko Mizuta, Tomokatsu Yoshida, Toshiki Mizuno, Masanori Nakagawa, Takahiko Tokuda, Masamitsu Yamaguchi,