Bisphenol S (BPS) triggers the migration of human non-small cell lung cancer cells via upregulation of TGF-β
Keywords: BPS; NSCLC; Migration; TGF-β; Smad-2/3;
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Effects of fasting and re-feeding on mstn and mstnb genes expressions in Cranoglanis bouderius
Keywords: MSTN; myostatin; MSTNb; myostatinb; TGF-β; transforming growth factor-β; MS222; 3-aminobenzoic acid ethyl ester methane sulfonate; S.E.; standard error; Fig.; Figure; Tab.; Table; pI; theoretical isoelectic point; MW; molecular weight; CDS; coding seque
Rethinking genotype-phenotype correlations in papillorenal syndrome: a case report on an unusual congenital camptodactyly and skeletal deformity with a heterogeneous PAX2 mutation of hexanucleotide duplication
Keywords: AROS; acro-renal-ocular syndrome; BMPs; bone morphogenetic proteins; CT; Computed Tomography; Krd; kidney and renal defects; MRI; magnetic resonance imaging; OD; oculus dexter; OMIM; Online Mendelian Inheritance Man; OS; oculus sinister; PAX2; paired box
Efficacy Against Human Prostate Cancer by Prostate-specific Membrane Antigen-specific, Transforming Growth Factor-β Insensitive Genetically Targeted CD8+ T-cells Derived from Patients with Metastatic Castrate-resistant Disease
Keywords: PSMA; TGF-β; CD8+ T-cells; Prostate cancer; mCRPC;
LncRNA HOXA-AS2 and its molecular mechanisms in human cancer
Keywords: lncRNA; HOXA-AS2; Diagnosis; Therapeutic target; Prognosis; APL; Acute promyelocytic leukemia; ATRA; All trans retinoic acid; Bax; BCL2-Associated X; BC; Breast cancer; Bcl-2; B-cell lymphoma-2; c-Myc; MYC proto-oncogene; CRC; Colorectal cancer; DDIT3; DN
TGF-β plays a vital role in triple-negative breast cancer (TNBC) drug-resistance through regulating stemness, EMT and apoptosis
Keywords: Triple negative breast cancer; Drug resistance; EMT; TGF-β; Cancer stem cell; Apoptosis;
TGF-β autocrine signaling at secretory-stage enamel
Keywords: ALP; alkaline phosphatase; BMP; bone morphogenic protein; ELISA; enzyme-linked immunosorbent assay; HPLC; high performance liquid chromatography; MMP; matrix metalloproteinase; qPCR; quantitative polymerase chain reaction; RT-PCR; reverse transcription-po
Dihydroartemisinin ameliorates sepsis-induced hyperpermeability of glomerular endothelium via up-regulation of occludin expression
Keywords: DHA; dihydroartemisinin; AKI; acute kidney injury; LPS; lipopolysaccharide; UACR; urine albumin creatinine ratio; HRGECs; human renal glomerular endothelial cells; TNF-α; tumor necrosis factor-α; VE-cadherin; vascular endothelial cadherin; TGF-β; trans
G protein coupled receptors can transduce signals through carboxy terminal and linker region phosphorylation of Smad transcription factors
Keywords: Transactivation; Smads; TGF-β; G protein coupled receptor; Phosphorylation;
Could BMP-2 and BMP-7 be biomarkers of coronary artery disease? A pilot clinical study
Keywords: Coronary artery calcification; BMP-2 - BMP-7; SMAD signaling pathway; TGF-β;
TGF-β activity in cow milk and fermented milk products: An in vitro bioassay with oral fibroblasts
Keywords: Cow's milk; Yoghurt; Sour milk; Butter milk; Whey; TGF-β; Oral health; Gingival fibroblasts;
Effects of microRNAs on skeletal muscle development
Keywords: HDAC4; histone deacetylase 4; SRF; serum response factor; Pax3; paired box protein pax-3; Pax7; paired box protein pax-7; 3â²UTR; 3â² untranslated region; MEF2A; myocyte-specific enhancer factor 2A; Mef2d; myocyte-specific enhancer factor 2D; Myf5; myog
Biomimetic scaffold containing PVDF nanofibers with sustained TGF-β release in combination with AT-MSCs for bladder tissue engineering
Keywords: SMC; smooth muscle cell; PVDF; poly (vinylidene fluoride); AT-MSCs; adipose tissue derived mesenchymal stem cells; TCPS; tissue culture polystyrene; ECM; extracellular matrix; TGF-β; transforming growth factor beta-1; SEM; scanning electron microscopy; H
Follistatin supplementation during in vitro embryo culture improves developmental competence of bovine embryos produced using sex-sorted semen
Keywords: Follistatin; TGF-β; AKT; SMAD; Oocytes quality; Bovine; Sorted semen;
Evaluation of the efficacy of nicotine in treatment of allergic asthma in BALB/c mice
Keywords: nAChR; nicotinic acetylcholine receptor; OVA; Ovalbumin; Treg; Regulatory T cell; TGF-β; transforming growth factor beta; IL-4; interleukin 4; Th2; T helper 2; H & E method; hematoxylin and eosin method; BAL fluid; bronchoalveolar lavage fluid; FBS; feta
SIRT3-mediated cardiac remodeling/repair following myocardial infarction
Keywords: MI; myocardial infarction; HIF; hypoxia inducible factor-1α; SOD2; superoxide dismutase; FOXO3A; forkhead box O3a; OPA1; optic atrophy 1; MMPs; matrix metalloproteinases; TGF-β; transforming growth factor-β; PARP-1; poly (ADP ribose)- polymerase 1; VEG
Therapeutic effects of Smilax glabra and Bolbostemma paniculatum on rheumatoid arthritis using a rat paw edema model
Keywords: TFL; Smilax glabra Roxb. liliaceae; TBM; Bolbostemma paniculatum Maxim. Franquet (Cucurbitaceae); RA; rheumatoid arthritis; BFCM; n-butyl alcohol fraction of the couplet medicine; NSAIDs; non-steroidal anti-inflammatory drugs; DMARDs; disease-modifying an
Induction of inactive TGF-β1 monomer formation by hydrogen sulfide contributes to its suppressive effects on Ang II- and TGF-β1-induced EMT in renal tubular epithelial cells
Keywords: Hydrogen sulfide; Epithelial-mesenchymal transition; Disulfide bond; TGF-β; Angiotensin II;
Immune active cells with 4-1BB signal enhancement inhibit hepatitis B virus replication in noncytolytic manner
Keywords: IACs; immune active cells; CHB; chronic hepatitis B; ECCE; engineered cells for costimulatory enhancement; HBV; hepatitis B virus; PBMCs; peripheral blood mononuclear cells; rhIFN-γ; recombinant human interferon γ; rhIL-2; recombinant human interleukin
MicroRNA-21a-5p promotes fibrosis in spinal fibroblasts after mechanical trauma
Keywords: SCI; spinal cord injury; miRNA; microRNA; SD; scratch damage; ECM; extracellular matrix; CNS; central nervous system; FN; fibronectin; Col1a1; type I a1collagen; Col1a2; type I a2 collagen; Col IV; type IV collagen; qRT-PCR; quantitative real-time PCR; GA
Chemokines and cytokines on the neuroimmunoaxis: Inner ear neurotrophic cytokines in development and disease. Prospects for repair?
Keywords: BDNF; brain-derived neurotrophic factor; BMP; bone morphogenetic protein(s) (e.g. BMP2, BMP4 etc.); CNS; central nervous system; CCL2; chemokine (C-C) motif ligand 2 (also called MCP1, monocyte chemoattractant protein 1); CCR2; C-C chemokine receptor type
Discovery of 1-(4-((3-(4-methylpiperazin-1-yl)propyl)amino)benzyl)-5-(trifluoromethyl)pyridin-2(1H)-one, an orally active multi-target agent for the treatment of diabetic nephropathy
Keywords: ACR; albumin-to-creatinine ratio; AUC0-t; area under the curve; BuOH; n-butanol; BUN; blood urea nitrogen; Cmax; peak concentration; C13-NMR; C13-nuclear magnetic resonance; CCr; creatinine clearance rate; CCR2; CCchemkin receptor 2; CDCl3; Deuterotrichlo
Transcriptome profiling reveals candidate cleft palate-related genes in cultured Chinese sturgeons (Acipenser sinensis)
Keywords: CL; craniofacial defect affecting the lip only; CLP; craniofacial defect affecting the lip and palate; CP; craniofacial defect affecting the palate only; IRF6; Interferon regulatory factor 6; MAFB; MAF bZIP transcription factor B; ARHGAP29; Rho GTPase act
Culture supernatants of oral cancer cells induce impaired IFN-α production of pDCs partly through the down-regulation of TLR-9 expression
Keywords: pDCs; plasmacytoid dendritic cells; TLR-9; toll-like receptor 9; OSCC; oral squamous cell carcinoma; DC; dendritic cells; IFN-α; interferon-alpha; APCs; antigen presenting cells; LN; lymph node; CpG-ODN; CpG-Oligodeoxyribonucleotides; HIOEC; human immort
The reciprocal link between EVI1 and miRNAs in human malignancies
Keywords: EVI1; ecotropic virus integration site-1; MiR; microRNA; 3â²-UTR; 3â²-untranslated regions; AML; acute myeloid leukemia; DNA; deoxyribonucleic acid; RNA; ribonucleic acid; NF-κβ; nuclear factor kappa β; CHIP; Chromatin Immunoprecipitation; c-Myb; c-m
Distinct metabolic programs induced by TGF-β1 and BMP2 in human articular chondrocytes with osteoarthritis
Keywords: Articular chondrocytes; BMP2; Metabolism; Osteoarthritis; TGF-β;
Impaired mammary tumor formation and metastasis by the point mutation of a Smad3 linker phosphorylation site
Keywords: IVIS; in vivo imaging system; qPCR; quantitative polymerase chain reaction; TALEN; transcription activator-like effector nuclease; TNBC; triple negative breast cancer; FACS; fluorescence-activated cell sorting; ANOVA; analysis of variation; TGF-β; Smad3
Cathelicidin-WA polarizes E. coli K88-induced M1 macrophage to M2-like macrophage in RAW264.7 cells
Keywords: CWA; cathelicidin-WA; AMP; antimicrobial peptide; STAT1; signal transducer and activator of transcription 1; p-STAT1; phosphorylated signal transducer and activator of transcription 1; STAT6; signal transducer and activator of transcription 6; p-STAT6; ph
Role of vitamin D in pregnancy and Toll-like receptor pathway
Keywords: NF-κB; nuclear factor kappa B; TLR; Toll-like receptors; 25(OH)D; 25-hydroxyvitamin D; VDR; vitamin D receptor; DBP; vitamin D-binding protein; 1,25(OH)2D; 1,25-dihydroxyvitamin D; SGA; small for gestational age; IL; interleukine; IFN-γ; interferon-gamm
Peptide TQS169 prevents osteoporosis in rats by enhancing osteogenic differentiation and calcium absorption
Keywords: Low-calcium diet; MC3T3-E1 cell; Ossotide; Osteogenic differentiation; Osteoporosis; ALP; alkaline phosphatase; BMD; bone mineral density; COL I; collagen type I; OCN; osteocalcin; OPG; osteoprotegerin; RUNX2; runt-related transcription factor 2; TGF-β;
New developments in mechanotransduction: Cross talk of the Wnt, TGF-β and Notch signalling pathways in reaction to shear stress
Keywords: Wnt; Notch; TGF-β; Endothelium; Shear stress; Mechanotransduction;
Identification of key microRNAs, transcription factors and genes associated with congenital obstructive nephropathy in a mouse model of megabladder
Keywords: CON; Congenital obstructive nephropathy; DEMs; Differentially expressed miRNAs; PPI; Protein-protein interaction; Vegfa; Vascular endothelial growth factor A; Nr4a2; Nuclear receptor subfamily 4, group A, member 2; Jdp2; Jun dimerisation protein 2; Klf6;
MiR-133a acts as an anti-oncogene in Hepatocellular carcinoma by inhibiting FOSL2 through TGF-β/Smad3 signaling pathway
Keywords: miR-133a; FOSL2; Hepatocellular; Carcinoma; TGF-β;
miR-23c suppresses tumor growth of human hepatocellular carcinoma by attenuating ERBB2IP
Keywords: HCC; hepatocellular carcinoma; TACE; transarterial chemoembolization; miRNA; microRNAs; LIHC; liver hepatocellular carcinoma; ELAVL1; ELAV like RNA binding protein 1; GSK3β; glycogen synthase kinase 3 beta; ECM; extracellular matrix; CRC; colorectal canc
A new diethylcarbamazine formulation (NANO-DEC) as a therapeutic tool for hepatic fibrosis
Keywords: ALT; alanine transaminase; AST; aspartate transaminase; ALP; alkaline phosphatase; CCl4; carbon tetrachloride; CK-MB; creatine kinase-MB; COX-2; cyclooxygenase 2; DEC; diethylcarbamazine; EMC; extracellular matrix; HSC; hepatic stellate cell; IL-1β; inte
Tranilast-delivery surgical sutures to ameliorate wound healing by reducing scar formation through regulation of TGF-β expression and fibroblast recruitment
Keywords: Fibroblasts; Scar reduction; Surgical suture; Sustained drug delivery; TGF-β;
A Yin and Yang in Epithelial Immunology: The Roles of the αE(CD103)β7 Integrin in T Cells
Keywords: CTL; cytotoxic T-lymphocyte; FoxP3; forkhead-box-P3; GvHD; graft-versus-host-disease; ICAM-1; intercellular adhesion molecule-1; LFA-1; lymphocyte function-associated antigen 1; TGF-β; transforming growth factor-β; Treg; regulatory T cell; TRM; resident
Enhanced chondrogenesis of human bone marrow mesenchymal Stem Cell (BMSC) on nanofiber-based polyethersulfone (PES) scaffold
Keywords: BMSC; bone marrow mesenchymal Stem Cell; MSC; marrow mesenchymal Stem Cell; PES; polyethersulfone; OA; osteoarthritis; SEM; scanning electron microscope; TGF-β; transforming growth factor-β; FGF; fibroblast growth factor; BMP; bone morphogenetic protein
Consumption of ellagic acid and dihydromyricetin synergistically protects against UV-B induced photoaging, possibly by activating both TGF-β1 and wnt signaling pathways
Keywords: MMP-1; matrix metalloproteinase-1; UV; ultraviolet; EGA; ellagic acid; DHM; dihydromericetin; NF-κB; nuclear factor kappa B; ROS; reactive oxygen species; SOD; superoxide dismutase; GSH; glutathione; Px; peroxidase; TGF-β; transforming growth factor-β;
Hyaluronan in experimental injured/inflamed cartilage: In vivo studies
Keywords: ACAN; aggrecan; ADAMTS-5; A disintegrin and metalloproteinase with thrombospondin motifs 5; A2AR; adenosine type 2 receptor; Bax; BCL2 associated X protein; Bcl-2; B-cell lymphoma 2; CD44; cluster determinant 44; Col2A; collagen type II alpha; Col1a1; col
TGF-β regulates the ERK/MAPK pathway independent of the SMAD pathway by repressing miRNA-124 to increase MALAT1 expression in nasopharyngeal carcinoma
Keywords: NPC; nasopharyngeal carcinoma; TGF-β; transforming growth factor beta; EMT; epithelial-mesenchymal transition; lncRNA; long noncoding RNA; AFAP1-AS1; actin filament-associated protein 1 antisense RNA1; MALAT1; metastasis-associated lung adenocarcinoma
The physiopathologic interplay between stem cells and tissue niche in muscle regeneration and the role of IL-6 on muscle homeostasis and diseases
Keywords: IL-; interleukin; SC; satellite cell; ECM; extracellular matrix; MuSCs; muscle stem cells; ROS; reactive oxygen species; Treg; regulatory T cells; Pax7; Paired box protein 7; Myf5; myogenic factor 5; MyoD; myoblast determination protein; MRF; muscle regul
Exosomes as a liquid biopsy for lung cancer
Keywords: Alix; ALG 2 interacting protein X; ALK; anaplastic lymphoma kinase; AREG; Amphiregulin; Atg2; autophagy related protein 2; AUC; area under the curve; BAL; bronchoalveolar lavage; circRNA; circular RNA; CSE; cigarette smoke extract; CTC; circulating tumor
Neutrophils and PMN-MDSC: Their biological role and interaction with stromal cells
Keywords: BM; bone marrow; BV8; prokineticin 2; CHOP; C/EBP homologous protein; EMT; epithelial-mesenchymal transition; ER; endoplasmic reticulum; G-CSF; granulocyte colony stimulating factor; GM-CSF; granulocyte-macrophage-colony stimulating factor; HBV; hepatit
Pro-fibrotic phenotype of human skin fibroblasts induced by periostin via modulating TGF-β signaling
Keywords: ECM; extracellular matrix; SSc; systemic sclerosis; TGF-β; transforming growth factor-β; rPn; recombinant periostin; α-SMA; α -smooth muscle actin; Egr-1; early growth response-1; MMP; matrix metalloproteinase; IPF; idiopathic pulmonary fibrosis; R-Sm
Cytokines in milk and the role of TGF-beta
Keywords: breast milk; cytokines; TGF-β; immune system; mammary gland; dairy products;
Contraction-dependent TGF-β1 activation is required for thrombin-induced remodeling in human airway smooth muscle cells
Keywords: Asthma; Airway remodeling; Airway smooth muscles; Thrombin; TGF-β;
Mogroside IVE attenuates experimental liver fibrosis in mice and inhibits HSC activation through downregulating TLR4-mediated pathways
Keywords: α-SMA; α-smooth muscle actin; ALT; alanine aminotransferase; AST; aspartate aminotransferas; CCl4; carbon tetrachloride; Col I; collagen I; ECM; extracellular matrix; HIF; hypoxia inducible factor; HSCs; hepatic stellate cells; JNK; c-Jun N-terminal kin
Double sword role of EZH2 in leukemia
Keywords: EZH1,2; enhancer of Zeste 1 and 2; SUZ12; suppressor of zeste 12 homolog; EED; embryonic ectoderm development; AEBP2; adipocyte enhancer-binding protein 2; RBAP46/48; retinoblastoma binding proteins 46 and 48; PRC; polycomb-repressive complex; PcG; Polyco
Bacillus subtilis CFR5 isolated from fermented soybean attenuates the chronic pancreatitis
Keywords: BSC; Bacillus subtilis CFR5; AP; acute pancreatitis; CP; chronic pancreatitis; IL-1; interleukin-1; IL-2; interleukin-2; IL-4; interleukin-4; IL-5; interleukin-5; IL-6; interleukin-6; IL-10; interleukin-10; IL-13; interleukin-13; TNF-α; tumor necrosis fa