Prognostic value of FOXP3 and TGF-β expression in both peripheral blood and lymph nodes in patients with B-Non Hodgkin’s lymphoma
Keywords: FOXP3; TGF; Non Hodgkin’s lymphoma; NHL
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Human leukocyte antigen (HLA)-G and cervical cancer immunoediting: A candidate molecule for therapeutic intervention and prognostic biomarker?
Keywords: 3â²UTR; untranslated region; 5â²URR; upstream regulatory region; ADC; cervical adenocarcinoma; AGUS; atypical glandular cells; APC; antigen presenting cells; ATG; start codon; Cd; cytoplasmatic domain; CD; cluster of differentiation; CIN; cervical intra
Regulation of chondrogenesis by protein kinase C: Emerging new roles in calcium signalling
Keywords: ADAMTS; a disintegrin and metalloproteinase with thrombospondin motifs; ADSC; adipose-derived stem cell; ATP; adenosine triphosphate; BMP; bone morphogenic protein; cAMP; cyclic adenosine monophosphate; COMP; cartilage oligomeric matrix protein; CREB; cAM
Activated Macrophages Create Lineage-Specific Microenvironments for Pancreatic Acinar- and β-Cell Regeneration in Mice
Keywords: Macrophage Polarization; Tissue Damage; Pancreatitis; Diabetes; NOD; ADM; acinar-to-ductal metaplasia; DTR; diphtheria toxin receptor; Fizz1; found in inflammatory zone 1; IL; interleukin; Mac1-SAP; saporin-conjugated anti-Mac1 antibody; NOD; nonobese dia
Loss of SMAD4 Alters BMP Signaling to Promote Colorectal Cancer Cell Metastasis via Activation of Rho and ROCK
Keywords: Colon Cancer; Signal Transduction; Transcription; Tumor Progression; BMP; bone morphogenetic protein; BMPR; bone morphogenetic protein receptor; CRC; colorectal cancer; EMT; epithelial-mesenchymal transition; GSK; glycogen synthase kinase; mRNA; messeng
The myokine decorin is regulated by contraction and involved in muscle hypertrophy
Keywords: αMEM; α-modified Eagle's medium; EPS; electrical pulse stimulation; IL; interleukin; IVE; in vivo electroporation; SkMc; skeletal muscle cells; TGF; transforming growth factor; TA; tibialis anterior; Skeletal muscle; Myokines; Exercise;
Human cytochrome P450 epoxygenases: Variability in expression and role in inflammation-related disorders
Keywords: Inflammation; Cytochrome P450; Epoxygenase; Epoxyeicosatrienoic acids; Variability; AA; arachidonic acid; AhR; aryl hydrocarbon receptor; AP-1; activator protein-1; bZIP; basic leucine zipper; CAR; constitutive androstane receptor; CCRP; cytoplasmic CAR r
Extrahepatic Platelet-Derived Growth Factor-β, Delivered by Platelets, Promotes Activation of Hepatic Stellate Cells and Biliary Fibrosis in Mice
Keywords: Mouse Model; Chronic Liver Injury; PSC; PBC; ALT; alanine aminotransferase; α-SMA; α-smooth muscle actin; ASP; aspirin supplemented; COX; cyclooxygenase; DDC; 3,5-diethoxycarbonyl-1,4-dihydrocollidine; ELISA; enzyme-linked immunosorbent assay; HSC; hepa
Down-regulation of MicroRNA-494 via Loss of SMAD4 Increases FOXM1 and β-Catenin Signaling in Pancreatic Ductal Adenocarcinoma Cells
Keywords: Pancreatic Cancer; Gene Regulation; Signal Transduction; Tumor Progression; FOXM1; Forkhead box M1; LMD; laser-assisted microdissection; miRNA; microRNA; mRNA; messenger RNA; PanIN; pancreatic intraepithelial neoplasia; PCR; polymerase chain reaction; PDA
Identification of genes influencing formation of the Type III Brush Hair in Yangtze River Delta white goats by differential display of mRNA
Keywords: CMTM3; CKLF-like MARVEL transmembrane domain containing 3; S100A4; S100 calcium binding protein A4; PKIG; protein kinase inhibitor gamma; BMP; bone morphogenetic protein; FGF; fibroblast growth factor; TGF; transforming growth factor; EGF; epidermal growt
The naïve effector cells of collagen type I during acute experimental pancreatitis are acinar cells and not pancreatic stellate cells
Keywords: AP; acute pancreatitis; CP; chronic pancreatitis; PSCs; pancreatic stellate cells; ECM; synthesize extracellular matrix; TGF; transforming growth factor; PCR; polymerase chain reaction; Collagen type I; TGF-β1; Acinar cells; Acute pancreatitis;
T helper and regulatory T cell cytokine profile in active, stable and narrow band ultraviolet B treated generalized vitiligo
Keywords: IL; interleukin; IFN; interferon; Th; T helper; Treg; regulatory T cell; NB-UVB; narrowband ultra violet B; GV; generalized vitiligo; TGF; transforming growth factor; TNF; tumor necrosis factor; T helper cells; Regulatory T cells; Cytokines; Narrowband ul
Avian CD4+CD25+ regulatory T cells: Properties and therapeutic applications
Keywords: Regulatory T; Tregs; Suppressive; IL-10; TGF; Persistance;
Ephrin-A1 expression induced by S100A8 is mediated by the toll-like receptor 4
Keywords: Eph; erythropoietin-producing hepatocellular; LLC; Lewis lung carcinoma; MD-2; myeloid differentiation protein 2; SAA3; serum amyloid A3; TGF; transforming growth factor; VEGF; vascular endothelial growth factor; Eph; Ephrin; Metastasis; S100A8; TLR4;
Research ArticlemiR-133a mediates TGF-β-dependent derepression of collagen synthesis in hepatic stellate cells during liver fibrosis
Keywords: miRNA; microRNA; RNA; ribonucleic acid; FACS; fluorescence activated cell sorting; HSC; hepatic stellate cells; ECM; extracellular matrix; TGF; transforming growth factor; TNF; tumour necrosis factor; CD; cluster of differentiation; UV; ultraviolet; CCl4;
Effects of orally administering the antimicrobial peptide buforin II on small intestinal mucosal membrane integrity, the expression of tight junction proteins and protective factors in weaned piglets challenged by enterotoxigenic Escherichia coli
Keywords: Antimicrobial peptide; Buforin II; Intestinal mucosal membrane integrity; Protective factors; Tight junction proteins; Weaned piglets; AGPs; antimicrobial growth promoters; ETEC; enterotoxigenic E. coli; HGF; hepatocyte growth factor; Reg; regeneration pr
Effect of serum on diesel exhaust particles (DEP)-induced apoptosis of airway epithelial cells in vitro
Keywords: DEP; diesel exhaust particles; FCS; foetal calf serum; NAC; N-acetylcysteine; JNK; c-junN-terminal kinase; NF-κB; nuclear factor-kB; COPD; chronic obstructive pulmonary disease; IL; interleukin; GM-CSF; granulocyte macrophage-colony stimulating factor; R
Syncytin-1 modulates placental trophoblast cell proliferation by promoting G1/S transition
Keywords: PCNA; proliferating cell nuclear antigen; CDK; cyclin dependent kinase; IUGR; intrauterine growth restriction; CHO; Chinese hamster ovary; hCS; human chorionic somatomammotropin; hCG; human chorionic gonadotropin; ASCT; alanine-serine-cysteine transpo
Elevated cytokine responses to Vibrio harveyi infection in the Japanese pufferfish (Takifugu rubripes) treated with Lactobacillus paracasei spp. paracasei (06TCa22) isolated from the Mongolian dairy product
Keywords: Cytokine response; Japanese pufferfish; Lactobacillus paracasei spp. paracasei; Immunomodulation; Vibrio harveyi infection; HK; head kidney; IFN; interferon; IL; interleukin; TGF; transforming growth factor; TNF; tumor necrosis factor; RT-PCR; reverse tra
Nebivolol attenuates prooxidant and profibrotic mechanisms involving TGF-β and MMPs, and decreases vascular remodeling in renovascular hypertension
Keywords: DHE; dihydroethidium; ECM; extracellular matrix; ERK 1/2; extracellular regulated kinase 1/2; 2K1C; 2 kidney, one clip; MMP; matrix metalloproteinase; SBP; systolic blood pressure; TGF; transforming grown factor; TBARS; thiobarbituric acid-reactive substa
The mechanism of action of glatiramer acetate in multiple sclerosis and beyond
Keywords: MS; Multiple sclerosis; EAE; Experimental autoimmune encephalomyelitis; CNS; Central nervous system; BBB; Blood brain barrier; MBP; Myelin basic protein; MOG; Myelin oligodendrocyte glycoprotein; PLP; Myelin proteolipid protein; GA; Glatiramer acetate; AP
p38 mitogen-activated protein kinase (p38 MAPK)-mediated autoimmunity: Lessons to learn from ANCA vasculitis and pemphigus vulgaris
Keywords: AIH; autoimmune hepatitis; ANCA; anti-neutrophil cytoplasmic antibody; DSG; desmoglein; DUSP; dual specificity phosphatase; EAE; experimental autoimmune encephalomyelitis; GADD45; growth arrest and DNA damage inducible gene 45; GC; germinal center; HSP; h
Increased Th17-Inducing Activity of CD14+ CD163low Myeloid Cells in Intestinal Lamina Propria of Patients With Crohn's Disease
Keywords: Dendritic Cell; Macrophage; Helper T Cell; Inflammatory Bowel Disease; CD; Crohn's disease; CDi; inflamed region of CD; CDn; noninflamed region of CD; DC; dendritic cell; IBD; inflammatory bowel disease; IFN; interferon; IL; interleukin; int; intermedia
Total coumarins from Urtica dentata Hand prevent murine autoimmune diabetes via suppression of the TLR4-signaling pathways
Keywords: BMDC; bone marrow-derived dendritic cell; DC; dendritic cell; IFN; interferon; IL; interleukin; IRF-3; interferon regulatory factor; MHC; major histocompatibility complex; MTT.; 3-(4,5-dimethylthiazolyl)-2,5-diphenyltetrazolium bromide; MyD88; myeloid dif
BMP2 and GDF5 induce neuronal differentiation through a Smad dependant pathway in a model of human midbrain dopaminergic neurons
Keywords: BMP(s); bone morphogenetic protein(s); BMPR(s); bone morphogenetic protein receptor(s); caBMPRIb; constitutively active BMPRIb; DA; dopaminergic/dopamine; DIV; day(s) in vitro; GDF(s); growth differentiation factor(s); GDNF; glial cell line-derived neurot
The sources of salidroside and its targeting for multiple chronic diseases
Keywords: 6-OHDA; 6-hydroxydopamine; Aβ; β-amyloid protein; MPTP; 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine; MPP+; N-methyl-4-phenylpyridine; AD; Alzheimer's disease; PD; Parkinson's disease; STZ; streptozotocin; PI3K; phosphatidylinositol 3-kinase; ROS; react
The Management of Eosinophilic Esophagitis
Keywords: Eosinophilic esophagitis; Eosinophil; Dietary management; Empiric diet; Six-food elimination diet; Elimination diet; Targeted elimination diet; Elemental diet; Skin testing; Atopy patch testing; Swallowed steroid therapy; APT; Atopy patch test; EGD; Esoph
DNA methylation and MeCP2 regulation of PTCH1 expression during rats hepatic fibrosis
Keywords: α-SMA, alpha-smooth muscle actin; Col1a1, alpha1(1) collagen mRNA; ECM, extracellular matrix; MeCP2, Methyl-CpG-binding protein 2; FBS, fetal bovine serum; HM, hepatic myofibroblast; HSC, hepatic stellate cell; MTD, myofibroblast transdifferentiation; TGF
Wound Healing: A Paradigm for Regeneration
Keywords: ADSC; adipose-derived stem cell; ECM; extracellular matrix; MMP; matrix metalloproteinase; TGF; transforming growth factor;
Antifibrinolytics attenuate inflammatory gene expression after cardiac surgery
Keywords: CPB; cardiopulmonary bypass; DNA; deoxyribonucleic acid; GDF; growth differentiation factor; GE; gene expression; IFN; interferon; IL; interleukin; MOF; multiorgan failure; mRNA; messenger ribonucleic acid; PCR; polymerase chain reaction; RNA; ribonucleic
Transforming Growth Factor β Signaling Controls Activities of Human Intestinal CD8+T Suppressor Cells
Keywords: Regulatory T Cells; Treg Cells; Immune Regulation; Inflammatory Bowel Disease; CFSE; carboxyfluorescein succinimidyl ester; ChIP; chromatin immunoprecipitation; ENG; endoglin; IEC; intestinal epithelial cell; IFN; interferon; IL; interleukin; LP; lamina p
Translating an Understanding of the Pathogenesis of Hepatic Fibrosis to Novel Therapies
Keywords: Cirrhosis; Wound Healing; Fibrogenesis; Scar; Tissue; Injury; CTGF; connective tissue growth factor; HCV; hepatitis C virus; MMP; metalloproteinase; NASH; nonalcoholic steatohepatitis; PDGF; platelet-derived growth factor; PPAR; peroxisomal proliferator a
Analytical modeling of pulse-pileup distortion using the true pulse shape; applications to Fermi-GBM
Keywords: Pulse pileup; Deadtime; GBM; TGF;
Transforming Growth Factor-β Signaling in Hepatocytes Promotes Hepatic Fibrosis and Carcinogenesis in Mice With Hepatocyte-Specific Deletion of TAK1
Keywords: Liver Cancer; Mouse Model; Signal Transduction; Oncogene; ALT; alanine aminotransferase; CTGF; connective tissue growth factor; DEN; n-nitrosodiethylamine; GFP; green fluorescent protein; HCC; hepatocellular carcinoma; IKK; IκB kinase; IL; interleukin; J
Advances in Regenerative Orthopedics
Keywords: ACI; autologous chondrocyte implantation; BMP; bone morphogenetic protein; cDNA; complementary DNA; DBM; demineralized bone matrix; FDA; Food and Drug Administration; GAM; gene-activated matrix; GDF; growth differentiation factor; iPS; induced pluripotent
IL-13 Signaling via IL-13Rα2 Induces Major Downstream Fibrogenic Factors Mediating Fibrosis in Chronic TNBS Colitis
Keywords: Egr; early growth response gene; ELISA; enzyme-linked immunosorbent assay; IGF; insulin-like growth factor; IL; interleukin; LPMC; lamina propria mononuclear cell; siRNA; small interfering RNA; SMA; smooth muscle actin; TGF; transforming growth factor; TN
Loss of Protein Tyrosine Phosphatase Nonreceptor Type 22 Regulates Interferon-γ-Induced Signaling in Human Monocytes
Keywords: SOCS1; ICAM1; MCP1; Th17; CD; Crohn's disease; ERK; extracellular signal-regulated kinase; IBD; inflammatory bowel disease; ICAM; intracellular adhesion molecule; IFN-γ; interferon γ; IκB; inhibitor of κB; IL; interleukin; Jak; Janus kinase; JNK; c-
Tissue Engineering of Skin
Keywords: ASC; adipose-derived stem cells; ECM; extracellular matrix; EGF; epidermal growth factor; ES; engineered skin; HA; hyaluronic acid; PDGF; platelet-derived growth factor; TE; tissue engineering; TGF; transforming growth factor;
Serotonin: A key molecule in acute and chronic liver injury!
Keywords: 5-HTP; 5-hydroxytryptophan; 5-HIAA; 5-hydroxyindol acetic acid; HGF; hepatocyte growth factor; HSC; hepatic stellate cell; HTR; serotonin receptor; MAO; monoamine oxidase; NASH; non-alcoholic steatotic hepatitis; PDGF; platelet-derived growth factor; SERT
Complement factor C5 deficiency significantly delays the progression of biliary fibrosis in bile duct-ligated mice
Keywords: α-SMA; alpha-smooth muscle actin; BA; bile acid; BDL; bile duct ligation; Col; collagen; FXR; farnesoid X receptor; HE; Hematoxilin&Eosin; Ntcp; Na-dependent taurocholate transporter; MMP; matrix metalloproteinase; Mrp; multidrug resistance associated pr
Signalling from dead cells drives inflammation and vessel remodelling
Keywords: VSMCs; Vascular smooth muscle cells; IL-1; interleukin-1; MCP-1; monocyte chemoattractant protein 1; TRAIL; Tumour necrosis factor-related apoptosis inducing ligand; TNF; Tumour necrosis factor; IFN; interferon; ECM; extracellular matrix; eNOS; endothelia
Aggressive Cardiovascular Phenotype of Aneurysms-Osteoarthritis Syndrome Caused by Pathogenic SMAD3 Variants
Keywords: aneurysm; aorta; cerebrovascular disorders; genetics; SMAD3; AF; atrial fibrillation; AOS; aneurysms-osteoarthritis syndrome; aPWV; aortic pulse wave velocity; CTA; computed tomography angiography; LDS; Loeys-Dietz syndrome; MFS; Marfan syndrome; NT-proBN
Analysis of gene expression profiles in alveolar epithelial type II-like cells differentiated from human alveolar epithelial progenitor cells
Keywords: ABCA3; ATP-binding cassette, sub-family A (ABC1), member 3; AEPC; alveolar epithelial progenitor cell; ATI; alveolar epithelial type I; ATII; alveolar epithelial type II; CDH1; cadherin 1, type 1; C/EBP; CCAAT/enhancer-binding protein; CEBPD; CCAAT/enhanc
Tumor necrosis factor superfamily member LIGHT induces epithelial-mesenchymal transition in A549 human alveolar epithelial cells
Keywords: EMT; epithelial-mesenchymal transition; LIGHT; homologous to lymphotoxins, exhibits inducible expression and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes; TNFSF; tumor necrosis factor superfamily; TGF; transforming gr
GLP-2 enhances barrier formation and attenuates TNFα-induced changes in a Caco-2 cell model of the intestinal barrier
Keywords: CD; Crohn's disease; DSS; dextran sodium sulphate; EDTA; ethylenediaminetetraacetic acid; GLPâ2; glucagonâlike peptide 2; IFNγ; interferon gamma; IL; interleukin; IGF; insulin growth factor; MAGUK; membrane associated guanylate kinase; MLCK; myosin l
Pathogenesis of Varicose Veins
Keywords: CADASIL; cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy; ECM; extracellular matrix; MMP; matrix metalloproteinase; mRNA; messenger RNA; SMC; smooth muscle cell; TGF; transforming growth factor;
Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: A randomized controlled trial
Keywords: AE; adverse event; AST; aspartate aminotransferase; ALT; alanine aminotransferase; BMI; body mass index; HCV; hepatitis C virus; HOMA; homeostatic model assessment; IL; interleukin; MMP; matrix metalloproteinase; NAFLD; nonalcoholic fatty liver disease; N
Anti-inflammatory and cicatrizing activities of thymol, a monoterpene of the essential oil from Lippia gracilis, in rodents
Keywords: AUC; area under the time-curve; BK; bradykinin; COL; collagen-based films; COLTHY; collagen-based containing thymol; CTR; undressed wounds; Ctr; Control; Dexa; dexamethasone; IL; interleukin; MIF; macrophage migration inhibitory factor; MPO; myeloperoxida
Combined α-tocopherol and ascorbic acid protects against smoke-induced lung squamous metaplasia in ferrets
Keywords: AP-1; activator protein-1; AT; α-tocopherol; AA; ascorbic acid; ERK; extracellular signal-regulated kinase; JNK; Jun N-terminal kinase; MAP; mitogen-activated protein; PCNA; proliferating cellular nuclear antigen; MDA; malondialdehyde; MEK; mitogen-activ
Multiplex assays of inflammatory markers, a description of methods and discussion of precautions - Our experience through the last ten years
Keywords: Inflammatory markers; Multiplex; Luminex; Pre-analytical; Internal assay markers; ELISA; enzyme-linked immunosorbent assay; DBSS; dried blood spot samples; IL; interleukin; TNF; tumor necrosis factor; sIL-6rα; soluble IL-6 receptor-α; IFN; interferon; G