دانلود مقالات ISI درباره Β-Arrestin + ترجمه فارسی

امضای سیگنال گیرنده نوع 1 نورونسنس با لیگاندهای درونی

The signaling signature of the neurotensin type 1 receptor with endogenous ligands

Keywords: Neurotensin (1-13) (PubChem CID: 25077406); Neurotensin (8-13) (PubChem CID: 5311318); Neuromedin N (PubChem CID: 9940301); SR48692 (PubChem CID: 119192); G protein-coupled receptor (GPCR); G protein; β-arrestin; Neurotensin receptor 1; Neurotensin; Neur

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

شواهد برای آگونیست های منفی و آنتاگونیست ها در گیرنده های اندوتلین

Evidence for biased agonists and antagonists at the endothelin receptors

Keywords: G protein coupled receptors; Endothelin; ETA; ETB; Biased agonism; Biased antagonism; β-Arrestin; Bosentan; Pathway selectivity; IRL1620;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2016 سفارش ترجمه

آگونیست گیرنده 2 کانابینوئید بسیار قوی و انتخابی: بهینه سازی ضربه اولیه یک سری آدمآانتیل ضربه ای که از غربالگری بالا

Highly potent and selective cannabinoid receptor 2 agonists: Initial hit optimization of an adamantyl hit series identified from high-through-put screening

Keywords: Cannabinoid receptor; Adamantane; β-Arrestin; Hit optimization;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

A carvedilol-responsive microRNA, miR-125b-5p protects the heart from acute myocardial infarction by repressing pro-apoptotic bak1 and klf13 in cardiomyocytes

Keywords: β-arrestin; Apoptotic genes; Biased G protein-coupled receptor signaling; Cardioprotection; MicroRNAs; βARs; β-adrenergic receptors; β-blockers; β-adrenergic receptor antagonists; CM; Cardiomyocyte; DCM; Dilated cardiomyopathy; Carv; Carvedilol; GPCR

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

Regulation of inflammation by β-arrestins: Not just receptor tales

Keywords: βarr; β-arrestin; IL; interleukin; IκBα; inhibitor α of NFκB; IKK; IκB kinase; MEF; mouse embryo fibroblast; LPA; lysophosphatidic acid; TLR4; Toll-like receptor-4; TNF; tumor necrosis factor; TNFR1; TNF receptor-1; TRAF; TNFR-associated factor; 7T

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2018 سفارش ترجمه

Dissecting the signaling features of the multi-protein complex GPCR/β-arrestin/ERK1/2

Keywords: GPCRs; G protein-coupled receptors; TM; transmembrane; ECLs; extracellular loops; ICLs; intracellular loops; GRKs; G protein-coupled receptor kinases; MAPKs; mitogen activated protein kinases; ERK1/2; extracellular signal-regulated kinases 1 and 2; JNK; c

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2018 سفارش ترجمه

Assessments of cellular melatonin receptor signaling pathways: β-arrestin recruitment, receptor internalization, and impedance variations

Keywords: Melatonin receptors; Technical assessments; β-arrestin; Internalization; CellKey®; Partial agonists;

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2018 سفارش ترجمه

Elucidating structural and molecular mechanisms of β-arrestin-biased agonism at GPCRs via MS-based proteomics

Keywords: 7TMR; GPCR; Arrestin; β-Arrestin; Biased agonism; Biased agonist; Mass spectrometry; Proteomics; Pharmacology; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2018 سفارش ترجمه

β-Arrestin2 directly or through GRK2 inhibits PKCβII activation in a ubiquitination-dependent manner

Keywords: PKC; GRK2; β-arrestin; Mdm2; Ubiquitination;

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2018 سفارش ترجمه

The hypotensive effect of activated apelin receptor is correlated with β-arrestin recruitment

Keywords: 7TMR; seven transmembrane receptor; Akt; protein kinase B; APJ; apelin receptor; βarr; β-arrestin; BRET; bioluminescence resonance energy transfer; cAMP; cyclic adenosine monophosphate; ERK1/2; extra-cellular regulated kinase 1/2; GPCR; G protein-couple

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2018 سفارش ترجمه

Human melanocortin 1 receptor-mediated ubiquitination of nonvisual arrestins. Role of Mahogunin Ring Finger 1 E3 ligase

Keywords: ARRB; β-arrestin; β2AR; β2-adrenergic receptor; GRK; G protein-coupled receptor kinase; GPCR; G protein-coupled receptor; LOF; loss-of-function; αMSH; α melanocyte-stimulating hormone; MCR; melanocortin receptor; MC1R; melanocortin 1 receptor; MGRN1;

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2018 سفارش ترجمه

Label-free cell signaling pathway deconvolution of angiotensin type 1 receptor reveals time-resolved G-protein activity and distinct AngII and AngIIIIV responses

Keywords: AngII; Angiotensin II; AT1R; angiotensin type 1 receptor; βarr; β-Arrestin; DMR; dynamic mass redistribution; ERK; extracellular signal-regulated kinase; GPCR; G protein coupled receptor; PTX; pertussis toxin; PI3K; phosphoinoside 3-kinase; rVSMC; rat v

دانلود رایگان متن کامل مقاله ISI 52 صفحه سال انتشار : 2018 سفارش ترجمه

Impact of paroxetine on proximal β-adrenergic receptor signaling

Keywords: βAR; β-adrenergic receptor; βarr; β-arrestin; EC50; half-maximal effective concentration; FRET; fluorescence resonance energy transfer; GRK; G protein-coupled receptor; IC50; half-maximal inhibitory concentration; ISO; isoproterenol; mCFP; monomeric c

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

The EGF receptor inhibits the signaling of dopamine D3 receptor through the phosphorylation of GRK2 on tyrosine residues

Keywords: EGFR; Dopamine D3 receptor; Protein kinase C; GRK2; β-Arrestin;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

GPCRs and EGFR - Cross-talk of membrane receptors in cancer

Keywords: GPCR; EGFR transactivation; Bias signaling; β-Arrestin; Cancer;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Functional consequences of chemically-induced β-arrestin binding to chemokine receptors CXCR4 and CCR5 in the absence of ligand stimulation

Keywords: βArr; β-arrestin; AP2; adaptor protein 2; Dmr A/C; dimer A/C; FKBP12; 12 kDa FK506-binding protein; FRB; FKBP12-rapamycin-binding; GPCR; G protein-coupled receptor; MCF; mean channel fluorescence; mTOR; mechanistic target of rapamycin; p38; p38 mitogen

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Residues W320 and Y328 within the binding site of the μ-opioid receptor influence opiate ligand bias

Keywords: GPCR; μ-opioid receptor; Ligand bias; Opioid; cAMP; β-arrestin; ANOVA; analysis of variance; BSA; bovine serum albumin; cAMP; 3′,5'-cyclic adenosine monophosphate; CI; confidence intervals; DAMGO; D-Ala2,N-MePhe4,Gly-ol]-enkephalin; E/[A]; concentra

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

β-Arrestin biased dopamine D2 receptor partial agonists: Synthesis and pharmacological evaluation

Keywords: GPCR; Dopamine receptor; Ligand bias; Functional selectivity; β-Arrestin; G protein;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2017 سفارش ترجمه

The association of single-nucleotide polymorphisms in the oxytocin receptor and G protein-coupled receptor kinase 6 (GRK6) genes with oxytocin dosing requirements and labor outcomes

Keywords: β-arrestin; desensitization; genotype; G protein-coupled receptor; G protein-coupled receptor kinase 6; GRK6; induction of labor; labor; oxytocin; oxytocin receptor; pregnancy; single-nucleotide polymorphism;

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2017 سفارش ترجمه

β-arrestin is critical for early shear stress-induced Akt/eNOS activation in human vascular endothelial cells

Keywords: β-arrestin; Mechanotransduction; Shear stress; Nitric oxide; Endothelial cells;

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2017 سفارش ترجمه

MC1R signaling. Intracellular partners and pathophysiological implications

Keywords: AC; adenylyl cyclase; ACTH; adrenocorticotropic hormone; ARRB; β-arrestin; ASIP; agouti signal protein; CBD103; dog β-defensin-3; CREB; cAMP responsive-element binding protein; EDN1; endothelin 1; ER; endoplasmic reticulum; ERK; extracellular signal-reg

دانلود رایگان متن کامل مقاله ISI 69 صفحه سال انتشار : 2017 سفارش ترجمه

The polymorphic deleted-form of the human α2B-adrenergic receptor and its wild-type counterpart display post-receptor signaling pathway differences in LLC-PK1 cells

Keywords: α2B-adrenergic receptor; β-arrestin; MAPK; Akt; NF-κB;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2016 سفارش ترجمه

RGS2 modulates the activity and internalization of dopamine D2 receptors in neuroblastoma N2A cells

Keywords: Dopamine D2 receptors; RGS2; Gαi/o signaling; Internalization; β-arrestin; D2Rs; dopamine D2 receptors; RGS2; regulators of G protein signaling protein 2; GPCRs; G protein coupled receptors; ERK; extracellular signal-regulated kinases; AP2; adaptor prot

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

RalA employs GRK2 and β-arrestins for the filamin A-mediated regulation of trafficking and signaling of dopamine D2 and D3 receptor

Keywords: Dopamine D2 receptor; Dopamine D3 receptor; Filamin A; RalA; GRK2; β-arrestin;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Agonist-induced changes in RalA activities allows the prediction of the endocytosis of G protein-coupled receptors

Keywords: Epsin; Angiotensin; LPA; β-Arrestin; β-Adrenoceptor;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

Beta-arrestin 2 rather than G protein efficacy determines the anxiolytic-versus antidepressant-like effects of nociceptin/orphanin FQ receptor ligands

Keywords: N/OFQ; Anxiety; Depression; G protein; β-arrestin; NOP receptor partial agonist; BRET; Elevated plus maze; Forced swim test; Mouse; N/OFQ; nociceptin/orphanin FQ; NOP; N/OFQ peptide receptor; GPCR; G protein-coupled receptor; HEK293; Human Embryonic Kidn

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2016 سفارش ترجمه

Characterization of the interaction between the dopamine D4 receptor, KLHL12 and β-arrestins

Keywords: GPCR; β-arrestin; KLHL12; ubiquitination; dopamine D4 receptor; β2AR; β2-adrenergic receptor; ADHD; attention deficit hyperactivity disorder; BTB; bric à brac 1, tramtrack, and broad-complex; co-IP; co-immunoprecipitation; CXCR4; C-X-C chemokine recep

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2016 سفارش ترجمه

Neuropeptide Y receptor mediates activation of ERK1/2 via transactivation of the IGF receptor

Keywords: Neuropeptide Y; G protein-coupled receptor; Extracellular-regulated protein kinase; Human embryonic kidney; IGFR; β-arrestin;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

PKCβII inhibits the ubiquitination of β-arrestin2 in an autophosphorylation-dependent manner

Keywords: Conventional PKC; β-Arrestin; Ubiquitination; Autophosphorylation; GPCR kinase 2; G protein-coupled receptor;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

The carboxy-terminal tail or the intracellular loop 3 is required for β-arrestin-dependent internalization of a mammalian type II GnRH receptor

Keywords: GnRH receptor; Internalization; G protein-coupled receptor kinase; β-Arrestin; ERK; DMEM; Dulbecco's modified Eagle medium; EC50; concentration that stimulates half-maximal IP production; ERK; extracellular signal-regulated kinases; FSH; follicle-stimula

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Proinflammatory receptor switch from Gαs to Gαi signaling by β-arrestin-mediated PDE4 recruitment in mixed RA synovial cells

Keywords: Chronic arthritis; TNF; Sympathetic neurotransmitters; G protein-coupled receptors; PDE4; β-arrestin;

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2015 سفارش ترجمه

HSP27 phosphorylation modulates TRAIL-induced activation of Src-Akt/ERK signaling through interaction with β-arrestin2

Keywords: HSP27; β-Arrestin; Src; TRAIL; Akt; ERK;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Endothelin-1/Endothelin A receptor-mediated biased signaling is a new player in modulating human ovarian cancer cell tumorigenesis

Keywords: β-arrestin; Biased G protein-coupled receptor signaling; Endothelin axis; Metastatic genes;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Specific interactions between Epac1, β-arrestin2 and PDE4D5 regulate β-adrenergic receptor subtype differential effects on cardiac hypertrophic signaling

Keywords: βARs; β-adrenergic receptors; β-arr; β-arrestin; ANF; Atrial Natriuretic Factor; HDAC4; histone deacetylase 4; Epac; exchange protein directly activated by cAMP; Iso; isoproterenol; RA; Ras association domain; β-Adrenergic receptor subtypes; Epac; β

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

β-Arrestin signal complex plays a critical role in adipose differentiation

Keywords: GHSR1a; growth hormone secretagogue receptor type 1a; PPARγ; peroxisome proliferator-activated receptor; C/EBPα; CCAAT/enhancer-binding protein α; C/EBPβ; CCAAT/enhancer-binding protein β; C/EBPδ; CCAAT/enhancer-binding protein δ; PI3K; phosphatidy

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2013 سفارش ترجمه

β-Arrestin1-mediated recruitment of c-Src underlies the proliferative action of glucagon-like peptide-1 in pancreatic β INS832/13 cells

Keywords: β-Cell mass; Incretin; GLP-1; c-Src; β-Arrestin; Proliferation;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Label-free impedance responses of endogenous and synthetic chemokine receptor CXCR3 agonists correlate with Gi-protein pathway activation

Keywords: Label-free impedance measurement; CXCR3; Chemokine; β-Arrestin; G-protein; Biased ligands;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Role for CD74 and CXCR4 in clathrin-dependent endocytosis of the cytokine MIF

Keywords: Cytokine; Chemokine; G protein-coupled receptor (GPCR); Uptake; MIF receptor; Endosomal signaling; Dynamin; β-Arrestin; Heteromeric receptor complex; Inflammation;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2012 سفارش ترجمه

The expression change of β-arrestins in fibroblast-like synoviocytes from rats with collagen-induced arthritis and the effect of total glucosides of paeony

Keywords: TGP; total glucosides of paeony; RA; rheumatoid arthritis; CIA; collagen-induced arthritis; GRK; G-protein-coupled receptor kinases; FLS; fibroblast-like synoviocytes; GTW; glucosides of tripterygium wilfordii; GPCRs; G protein-coupled receptors; AA; adju

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Bradykinin B2 receptor-mediated transport into intact cells: Anti-receptor antibody-based cargoes

Keywords: Bradykinin; B2 receptor; β-Arrestin; Receptor endocytosis;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Dexamethasone enhances the norepinephrine-induced ERK/MAPK intracellular pathway possibly via dysregulation of the α2-adrenergic receptor: Implications for antidepressant drug mechanism of action

Keywords: 5-HT; serotonin; AP-1; activator protein 1; AR; adrenergic receptor; BDNF; brain derived neurotrophic factor; DEX; dexamethasone; FCS; fetal calf serum; GC; glucocorticoid; GPCR; G-protein-coupled receptor; GR; glucocorticoid receptor; GRK; G-protein rece

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

Complementary roles of the DRY motif and C-terminus tail of GPCRS for G protein coupling and β-arrestin interaction

Keywords: Dopamine D2 and D3 receptor; DRY motif; β-arrestin; G protein;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

β-Arrestin2 enhances β2-adrenergic receptor-mediated nuclear translocation of ERK

Keywords: ERK; extracellular signal-regulated kinase; βAR; β-adrenergic receptor; GRK2-ct; carboxyl terminal region of GRK2; GRK2; G protein-coupled receptor kinase 2; PP2; 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine; GPCR; G protein-coupled r

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه

Agonist-induced up-regulation of human somatostatin receptor type 1 is regulated by β-arrestin-1 and requires an essential serine residue in the receptor C-tail

Keywords: AC; adenylyl cyclase; CaM; calcium calmodulin; CHO-KI; Chinese hamster ovary cell line; FBS; fetal bovine serum; GPCR; G protein-coupled receptor; GRK; GPCR kinase; hSSTR; human somatostatin receptor; MAPK; mitogen activated protein kinase; PKA; protein k

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2005 سفارش ترجمه

Activation and nuclear translocation of ERK1/2 by the formyl peptide receptor is regulated by G protein and is not dependent on β-arrestin translocation or receptor endocytosis

Keywords: GPCR; G protein-coupled receptor; ERK1/2; extracellular signal regulated kinases 1 and 2; FPR; N-formyl peptide receptor; GRK; G protein-coupled receptor kinase; fMLF; N-formyl-methionyl-leucyl-phenylalanine; CHO; Chinese hamster ovary; MAPK; mitogen-acti

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2005 سفارش ترجمه