کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10098609 1610031 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Diffusion-weighted imaging and proton MR spectroscopy of white matter abnormalities in a case of phenylketonuria
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی رادیولوژی و تصویربرداری
پیش نمایش صفحه اول مقاله
Diffusion-weighted imaging and proton MR spectroscopy of white matter abnormalities in a case of phenylketonuria
چکیده انگلیسی
Phenylketonuria (PKU) is the most common congenital disorder of amino acid metabolism. We report diffusion-weighted imaging (DWI) and proton magnetic resonance (MRI) spectroscopy findings of white matter abnormalities in a 22-year-old woman with phenylketonuria. MRI demonstrated extensive abnormal signal changes in the periventricular white matter of cerebral hemispheres bilaterally. True restricted diffusion of water was identified in the corresponding abnormal white matter regions on DWI. Proton MR spectroscopy revealed mildly increased choline/creatine ratio, while the N-acetyl-l-aspartate/creatine ratio was normal. There was no phenylalanine peak at 3.80 and 7.36 ppm. The findings were most likely consistent with active inflammatory process causing progressive white matter degeneration.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Radiology Extra - Volume 54, Issue 1, April 2005, Pages 5-9
نویسندگان
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