کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10134888 | 1645649 | 2018 | 27 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dispersive magnetic solid phase extraction exploiting magnetic graphene nanocomposite coupled with UHPLC-PDA for simultaneous determination of NSAIDs in human plasma and urine
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
A novel, rapid, simple graphene/Fe3O4 based dispersive magnetic solid phase extraction was developed for the simultaneous separation/preconcentration and determination of non steroidal anti-inflammatory drugs with ultra high performance liquid chromatography coupled with photodiode array detection. Several parameters influencing the extraction efficiency of the investigated analytes such as the extraction time, the amount of graphene/Fe3O4, the sample pH, the ionic strength and the elution solvent were evaluated and optimized. Under optimal conditions, the linearity was in the range of 0.002-25âμg/mL for furprofen, diclofenac and ketoprofen, 0.003-25 for flurbiprofen, naproxen and fenbufen, 0.004-25 for indoprofen with a good coefficient of determination (R2> 0.9991) for each analyte. The inter-and- intra day accuracy (BIAS%) for human plasma and urine ranged between â7.15% to 6.20% and â5.17% to 4.87%, respectively.The precision (RSD%) in human plasma and urine was less than 8.67% and 8.92%, respectively. The proposed method was applied to the determination of NSAIDs in human plasma and urine.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 161, 30 November 2018, Pages 280-288
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 161, 30 November 2018, Pages 280-288
نویسندگان
Vincenzo Ferrone, Maura Carlucci, Valeria Ettorre, Roberto Cotellese, Paola Palumbo, Antonella Fontana, Gabriella Siani, Giuseppe Carlucci,