Lisinopril inhibits nuclear transcription factor kappa B and augments sensitivity to silymarin in experimental liver fibrosis

The proposed mechanism of action for silymarin and lisinopril in interfering with NFκB pathway. DAG, diacyl glycerol; IkB, inhibitory kappa B protein; IKK, IκB kinase; MMP-2, matrix metalloproteinase 2; NFkB, nuclear transcription factor kappa B; PKC, protein kinase C; PLC, phospholipase C; TGF-β, transforming growth factor beta; TIMP-1, tissue inhibitor of metalloproteinase 1; TNF-α, tumor necrosis factor alpha; VEGF, vascular endothelial growth factor.215