کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10146967 | 1646421 | 2018 | 35 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
From electrochemistry to enzyme kinetics of cytochrome P450
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کلمات کلیدی
KPISPECYP17A1DDABCytochrome P450 17A1electroanalysis - الکتروآنالیزscreen-printed electrode - الکترود چاپ شده روی صفحه نمایشInhibition - بازداریpotassium phosphate buffer - بافر فسفات پتاسیمBioelectrochemistry - بیوالکترو شیمیاییDrug interactions - تداخل داروییdidodecyldimethylammonium bromide - دیودیدیل دی متیل آمونیوم برومیدCytochrome P450 - سیتوکروم پی۴۵۰Enzyme kinetics - سینتیک آنزیمCyclic voltammetry - ولتامتری چرخهای
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
This review is an attempt to describe advancements in the electrochemistry of cytochrome P450 enzymes (EC 1.14.14.1) and to study molecular aspects and catalytic behavior of enzymatic electrocatalysis. Electroanalysis of cytochrome P450 demonstrates how to translate theoretical laws and equations of classical electrochemistry for the calculation of the kinetic parameters of enzymatic reactions and then translation of kinetic parameters to interpretation of drug-drug interactions. The functional significance of cytochrome P450s (CYPs) includes the metabolism of drugs, foreign chemicals, and endogenic compounds. The pharmaceutical industry needs sensitive and cost-effective systems for screening new drugs and investigation of drug-drug interactions. The development of different types of CYP-based biosensors is now in great demand. This review also highlights the characteristics of electrode processes and electrode properties for optimization of the cytochrome P450 electroanalysis. Electrochemical cytochrome P450-biosensors are the most studied. In this review, we analyzed electrode/cytochrome P450 systems in terms of the mechanisms underlying P450-catalyzed reactions. Screening of potential substrates or inhibitors of cytochromes P450 by means of electrodes were described.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosensors and Bioelectronics - Volume 121, 15 December 2018, Pages 192-204
Journal: Biosensors and Bioelectronics - Volume 121, 15 December 2018, Pages 192-204
نویسندگان
Victoria V. Shumyantseva, Alexey V. Kuzikov, Rami A. Masamrekh, Tatiana V. Bulko, Alexander I. Archakov,