کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10158296 | 1666522 | 2018 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cinobufacini protects against paclitaxel-induced peripheral neuropathic pain and suppresses TRPV1 up-regulation and spinal astrocyte activation in rats
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کلمات کلیدی
CRFDRGs - DRG هاAstrocyte - آستروسیتenzyme linked immunosorbent assay - آنزیم تست ایمونوسیورسانس مرتبط استinterleukin - اینترلوکینELISA - تست الیزاtumour necrosis factor-α - تومور نکروز عامل αproinflammatory cytokines - سیتوکین های ضد التهابیcorticotropin releasing factor - عامل آزاد کننده کورتیکوتروپینTNF-α - فاکتور نکروز توموری آلفاTRP channels - کانال های TRPdorsal root ganglia - گانگلیس ریشه پشتی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
تومور شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Chemotherapy-induced peripheral neuropathic pain is a major limiting factor affecting cancer patients. No effective treatment is currently available. Cinobufacini, an aqueous extract from toad skin, is a widely used anti-cancer drug in China. Clinical evidence has demonstrated the safety and effectiveness of cinobufacini in combination with chemotherapy to promote the therapeutic efficacy while alleviating side effects, especially cancer-related pain symptoms. In this study, the effects of cinobufacini were investigated in a rat model of paclitaxel-induced peripheral neuropathic pain (PIPNP) to better understand and expand its clinical application. A single injection of cinobufacini (2.5âg/kg, i.p.) alleviated pre-established PIPNP, as indicated by decreased mechanical and thermal hypersensitivity compared with paclitaxel-treated rats. Repeated cinobufacini (1.25 and 2.5âg/kg, i.p.), given during the induction of PIPNP, prevented the establishment of paclitaxel-induced mechanical and thermal hypersensitivity. This preventative effect was associated with suppressed paclitaxel-induced TRPV1 up-regulation and spinal astrocyte activation, as well as decreased production of spinal TNF-α and IL-1β. These findings reveal cinobufacini as a therapeutic potential to treat and prevent paclitaxel-induced peripheral neuropathic pain.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Pharmacotherapy - Volume 108, December 2018, Pages 76-84
Journal: Biomedicine & Pharmacotherapy - Volume 108, December 2018, Pages 76-84
نویسندگان
Xiyuan Ba, Jiali Wang, Shiyang Zhou, Xinxin Luo, Yun Peng, Shimin Yang, Yue Hao, Guangyi Jin,