کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10162168 1114320 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Stable Isotopic Analysis of Porcine, Bovine, and Ovine Heparins
ترجمه فارسی عنوان
تجزیه ایزوتوپ پایدار از هپارین ها از گوسفند، گاو و گوسفند
کلمات کلیدی
هپارین تجزیه و تحلیل ایزوتوپ پایدار، حیوانات، تجزیه و تحلیل مولفه اصلی، طیف سنجی جرمی، تحلیل و بررسی،
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
چکیده انگلیسی
The assessment of provenance of heparin is becoming a major concern for the pharmaceutical industry and its regulatory bodies. Batch-specific [carbon (δ13C), nitrogen (δ15N), oxygen (S18O), sulfur (δ34S), and hydrogen (δD)] stable isotopic compositions of five different animal-derived heparins were performed. Measurements readily allowed their differentiation into groups and/or subgroups based on their isotopic provenance. Principle component analysis showed that a bivariate plot of δ13C and δ18O is the best single, bivariate plot that results in the maximum discrimination ability when only two stable isotopes are used to describe the variation in the data set. Stable isotopic analyses revealed that (1) stable isotope measurements on these highly sulfated polysaccharide (molecular weight ~ 15 kDa) natural products (“biologics”) were feasible; (2) in bivariate plots, the δ13C versus δ18O plot reveals a well-defined relationship for source differentiation of hogs raised in the United States from hogs raised in Europe and China; (3) the δD versus δ18O plot revealed the most well-defined relationship for source differentiation based on the hydrologic environmental isotopes of water (D/H and 18O/16O); and (4) the δ15N versus δ18O and δ34S versus δ18O relationships are both very similar, possibly reflecting the food sources used by the different heparin producers.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 104, Issue 2, February 2015, Pages 457-463
نویسندگان
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