کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10162241 | 1114324 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Historical Data Analyses and Scientific Knowledge Suggest Complete Removal of the Abnormal Toxicity Test as a Quality Control Test
ترجمه فارسی عنوان
تجزیه و تحلیل داده های تاریخی و دانش علمی پیشنهاد کامل حذف آزمون سمیت غیر طبیعی به عنوان یک آزمون کنترل کیفیت
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کلمات کلیدی
آزمون سمیت غیر طبیعی، تحلیل و بررسی، بیوتکنولوژی، ایمنی عمومی، تست بیخوابی، فارماکوپه، کنترل کیفیت، علم نظارتی، سمیت، واکسن
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
چکیده انگلیسی
In the early 1900s, the abnormal toxicity test (ATT) was developed as an auxiliary means to ensure safe and consistent antiserum production. Today, the ATT is utilized as a quality control (QC) release test according to pharmacopoeial or other regulatory requirements. The study design has not been changed since around 1940. The evidence of abnormal toxicity testing as a prediction for harmful batches is highly questionable and lacks a scientific rationale. Numerous reviews of historical ATT results have revealed that no reliable conclusions can be drawn from this QC measure. Modern pharmaceutical manufacturers have thorough control of the manufacturing process and comply with good manufacturing practice rules. Contaminants are appropriately controlled by complying with the validated manufacturing processes and strict QC batch release confirming batch-to-batch consistency. Recognizing that product safety, efficacy, and stability can be ensured with strict QC measures, nowadays most regulatory authorities do not require the ATT for most product classes. In line with the replacement, reduction, and refinement (3Rs) initiative, the test requirement has been deleted from approximately 80 monographs of the European Pharmacopoeia and for the majority of product classes in the United States. For these reasons, it is recommended that the ATT should be consistently omitted world-wide and be removed from pharmacopoeias and other regulatory requirements. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:3349-3355, 2014
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 103, Issue 11, November 2014, Pages 3349-3355
Journal: Journal of Pharmaceutical Sciences - Volume 103, Issue 11, November 2014, Pages 3349-3355
نویسندگان
Joerg H.O. Garbe, Susanne Ausborn, Claire Beggs, Martin Bopst, Angelika Joos, Alexandra A. Kitashova, Olga Kovbasenco, Claus-Dieter Schiller, Martina Schwinger, Natalia Semenova, Lilia Smirnova, Fraser Stodart, Thomas Visalli, Lisette Vromans,