کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10162259 | 1114324 | 2014 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Study of the Contribution of the State of Water to the Gel Properties of a Photocrosslinked Polyacrylic Acid Hydrogel using Magnetic Resonance Imaging
ترجمه فارسی عنوان
بررسی نقش دولت آب به خواص ژل یک پلی هیدروژل پلی آکریلیک اسکلت با استفاده از تصویربرداری رزونانس مغناطیسی
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
چکیده انگلیسی
Photocrosslinked polyacrylic acid (PAA-HEMA) hydrogels are a promising candidate for use in dermatological patch adhesives. To gain further knowledge about the properties of this gel, we investigated the T1 relaxation time and the diffusion coefficient (D) of water in the hydrogels using magnetic resonance (MR) imaging. Hydrogels with different formulations and process factors were prepared and tested. The observed data were analyzed by ANOVA, which clarified the mode of action of the formulation and process factors based on these MR parameters. Various gel properties (i.e., gel fraction, swelling capacity, gel strength, and water-retention ability) were also measured, followed by a Bayesian network (BN) analysis. The BN allowed us to summarize well the relationships between the formulation and process factors, MR parameters, and gel properties. T1 was associated with the swelling and water-retention properties of the hydrogel, whereas D was associated with gel formation and gel strength. Furthermore, this study clarified that T1 and D mostly represented the hydration and water-compartmentalization effects of the hydrogel, respectively. In conclusion, the state of water seems to play an important role in the properties of the PAA-HEMA hydrogel. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:3532-3541, 2014
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 103, Issue 11, November 2014, Pages 3532-3541
Journal: Journal of Pharmaceutical Sciences - Volume 103, Issue 11, November 2014, Pages 3532-3541
نویسندگان
Yoshinori Onuki, Naoki Hasegawa, Chihiro Kida, Yasuko Obata, Kozo Takayama,